Category: 6639-82-3

Ruthenium(II) 鐣?sup>6-arene complexes containing a dinucleating ligand based on 1,8-naphthyridine was written by Tang, Wei-Hung;Liu, Yi-Hung;Peng, Shie-Ming;Liu, Shiuh-Tzung. And the article was included in Journal of Organometallic Chemistry in 2015.Recommanded Product: 6639-82-3 This article mentions the following:

Ruthenium arene half-sandwich complexes, [(鐣?sup>6-p-cymene)₂Ru₂(娓?L)Cl₂](PF₆)₂ (3b, L = N,N,N’,N’-tetra-2-pyridinyl-1,8-naphthyridine-2,7-diamine) and [(鐣?sup>6-p-cymene)Ru(L’)Cl](PF₆) [4, L’ = tri-2-pyridinylamine], were synthesized and characterized by spectroscopic and anal. techniques. The mol. structure of [(鐣?sup>6-p-cymene)₂Ru₂(娓?L)Cl₂]Cl₂ (3a) was further determined by single-crystal x-ray anal. The use of these ruthenium complexes as pre-catalysts for oxidative coupling of 1,2-diols/1,2-aminoalc. with o-phenylenediamines leading to quinoxalines was investigated. Complex 3b appeared to be a good catalyst for this transformation. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Recommanded Product: 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Recommanded Product: 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ag-Catalyzed Minisci C-H difluoromethylarylation of N-heteroarenes was written by Xie, Xiaojuan;Zhang, Yifang;Hao, Jian;Wan, Wen. And the article was included in Organic & Biomolecular Chemistry in 2020.Safety of 6-Methoxyquinoxaline This article mentions the following:

A mild silver-catalyzed decarboxylative difluoromethylarylation of electron-deficient N-heteroarenes e.g., I has been developed by using aryldifluoro acetic acids RC(F₂)C(O)OH [R = 4-methoxyphenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-1-yl, etc.] as difluoromethyl sources. This protocol provides an efficient and straightforward access to difluoromethylated heteroarenes e.g., II in moderate to excellent yields with good selectivities. Furthermore, this reaction was applicable to bioactive heteroarenes, providing a straightforward approach for the late-stage C-H difluoromethylation of pharmacophores. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Safety of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Safety of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Rhodium-catalyzed transfer hydrogenation of quinoxalines with water as a hydrogen source was written by Zhang, Xia;Chen, Jingchao;Khan, Ruhima;Shen, Guoli;He, Zhenxiu;Zhou, Yongyun;Fan, Baomin. And the article was included in Organic & Biomolecular Chemistry.Safety of 6-Methoxyquinoxaline This article mentions the following:

Rhodium-catalyzed transfer hydrogenation of quinoxalines with water as a hydrogen source is reported. The reaction allows the simple preparation of 1,2,3,4-tetrahydroquinoxalines under mild conditions. The deuterium-labeling experiment confirmed that water is the sole hydrogen source in the transfer hydrogenation reaction. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Safety of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson閳ユ獨, and Alzheimer閳ユ獨 diseases. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Safety of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis of quinoxaline- and isoquinolene-5,8-quinones was written by Tsizin, Yu. S.;Chernyak, S. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Formula: C9H8N2O This article mentions the following:

6-Methoxyquinoxaline underwent successive nitration at C-5 and hydrogenation-reduction to give 5-amino-6-methoxyquinoxaline, which was oxidized by Fremy’s salt to give the quinoxaline quinone I. II was prepared similarly. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Formula: C9H8N2O).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Formula: C9H8N2O

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nickel-catalyzed electrochemical Minisci acylation of aromatic N-heterocycles with α-keto acids via ligand-to-metal electron transfer pathway was written by Ding, Hang;Xu, Kun;Zeng, Cheng-Chu. And the article was included in Journal of Catalysis in 2020.Reference of 6639-82-3 This article mentions the following:

A nickel-catalyzed electrochem. methodol. for the Minisci acylation of aromatic electron-deficient heterocycles with α-keto acids had been developed. The reaction was performed in an undivided cell under constant current conditions, featuring broad scope of substrates and avoiding the conventional utilization of silver-based catalysts in conjunction with excess amount of oxidants. Cyclic voltammetric anal. disclosed that a ligand-to-metal electron transfer process may be involved in the generation of the key acyl radicals. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Reference of 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Reference of 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis and characterization of new rhodamine dyes with large Stokes shift was written by Tian, Zhidan;Tian, Baozhu;Zhang, Jinlong. And the article was included in Dyes and Pigments in 2013.Safety of 6-Methoxyquinoxaline This article mentions the following:

Two new rhodamine dyes (Rh Q-H, Rh Q-Me) containing 1, 4-diethyl-1, 2, 3, 4-tetrahydroquinoxaline as an effective electron donor are designed and synthesized. The structures of the novel compounds are confirmed by ¹H NMR, ¹³C NMR and ESI. Due to an excited-state intramol. charge transfer (ICT), the new dyes exhibit longer absorption (>580 nm) and emission (>640 nm) compared with the model compounds, rhodamine 101 and rhodamine 6G. The new rhodamine dyes show large Stokes shift of 40-50 nm in commonly used solvents. Notably, when measured in a mixture of H₂O/EtOH solution, significant stokes shift of 65-68 nm are achieved, which is among the largest Stokes shifts ever reported for rhodamine dyes. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Safety of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Safety of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nickel-catalyzed dehydrogenative coupling of aromatic diamines with alcohols: selective synthesis of substituted benzimidazoles and quinoxalines was written by Bera, Atanu;Sk, Motahar;Singh, Khushboo;Banerjee, Debasis. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Application In Synthesis of 6-Methoxyquinoxaline This article mentions the following:

The first nickel-catalyzed dehydrogenative coupling of primary alcs. and ethylene glycol with aromatic diamines for selective synthesis of mono- and di-substituted benzimidazoles and quinoxalines is reported. The earth-abundant, non-precious and simple NiCl₂/1,10-phenanthroline system enables the synthesis of N-heterocycles releasing water and hydrogen gas as byproducts. Mechanistic studies involving deuterium labeling experiments and quant. determination of hydrogen gas evaluation were performed. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Application In Synthesis of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Application In Synthesis of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Iodine-alcohol molecular complexes was written by Derwish, Ghazi A. W.. And the article was included in Proc. Intern. Symp. Mol. Struct. Spectry., Tokyo in 1962.SDS of cas: 6639-82-3 This article mentions the following:

The absorption spectra of I in 12 aliphatic n-, sec-, tert-, and iso-alcs. show bands at about 455, 360, 290, and 220 mμ. The band at ∼455 mμ is shifted ∼450 cm.-1 to higher wavelengths in comparison to the ternary systems, I-alc.-inert solvent, while its intensity is enhanced. This is probably due to a solvation of the I-alc. complex by the polar alc. mols. Frequency and extinction of the band at 220230 mμ increase with increasing ionization potential of the corresponding alc., and the frequency is much higher than in the ternary systems involving inert solvents. These differences may be due to different extents of H bonding. The bands at ∼360 and ∼290 mμ, appearing after a few hrs. standing, are ascribed to I₃^–. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3SDS of cas: 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.SDS of cas: 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Hydroxyquinoxalines and -phenazines and experiments on the preparation of hydroxyquinoxaline di-N-oxides was written by King, F. E.;Clark, N. G.;Davis, P. M. H.. And the article was included in Journal of the Chemical Society in 1949.Application of 6639-82-3 This article mentions the following:

6,7-Dimethoxyquinoxaline (I) (1 g.) and 3 g. AlCl₃ in 20 cc. C₆H₆, refluxed 15 hrs., give 82% 6,7-dihydroxyquinoxaline, m. about 260° (decomposition); di-Ac derivative, buff, m. 112°. 6-Methoxyquinoxaline (II) yields 37% of the 6-HO compound (III), m. 242° (decomposition); acetate, m. 80-1°. p-C₆H₄(OMe)₂ and HNO₃ in AcOH give 80% of the 2,3- and 2,5-di-NO₂ derivatives (IV); reduction in MeOH over Raney Ni at 2-3 atm., addition to (CHO)₂.NaHSO₃ (V) and a little HCl, the mixture refluxed 2 hrs., the MeOH evaporated, and the 2,5,1,4-(H₂N)₂C₆H₂(OMe)₂ removed (finally with NaNO₂), give 12% 5,8-dimethoxyquinoxaline, yellow, m. 146°; demethylation with AlCl₃ in C₆H₆ gives 60% of the 2,8-di-HO compound, orange, m. about 230°; diacetate, m. 209°. 2,3-(O₂N)₂C₆H₃OMe (2.5 g.), reduced over Raney Ni and the product refluxed 2 hrs. with 5 g. V in 30 cc. H₂O and a little HCl, gives 59% 5-methoxyquinoxaline, pale yellow, m. 72-3°; the 5-HO compound, yellow, m. 100-1° (30%); acetate, m. 103-4°. 3,4,1,2-(O₂N)₂C₆H₂(OMe)₂ similarly yields 36% 5,6-dimethoxyquinoxaline, yellow, m. 69-70°; the 5,6-di-HO compound yellow, m. about 190° (decomposition); diacetate, m. 112°. 4,5,1,3-(O₂N)₂C₆H₂(OMe)₂ yields 68% 5,7-dimethoxyquinoxaline, m. 110°; 5,7-di-HO compound, bright yellow, m. about 250° (decomposition); diacetate, m. 113°. The HO compounds can be distinguished by their color reactions with 2 N HCl, 2 N NaOH, and aqueous and alc. FeCl₃, which are given. The diamine solution from 5 g. IV and 2 g. 1,2-cyclohexanedione in 10 g. AcOH containing 5 g. AcONa gives 24% 1,4-dimethoxy-5,6,7,8-tetrahydrophenazine (VI), yellow, m. 152 °; 2 g. VI and 1 g. Pd-C, heated 1 hr. at 200-30°, give 50% 1,4-dimethoxyphenazine, blood-red, m. 185°; AlCl₃ in C₆H₆ (refluxed 16 hrs.) gives 91% 1,4-dihydroxyphenazine (VII), deep red, m. 230°; diacetate, tarnished gold, m. 193.5-4°. 3,4,1,2-(H₂N)₂C₆H₂(OMe)₂ yields 60% of the 1,2-di-MeO isomer of VI, m. 82-3° [picrate, yellowish brown, m. 128° (decomposition)]; 4,5,1,3-(O₂N)₂C₆H₂(OMe)₂ yields 94% of the 1,3-isomer, yellow needles from aqueous EtOH; 2,3-isomer (VIII) (88% from 4,5,1,2-(H₂N)₂C₆H₂(OMe)₂), lemon-yellow, m. 119-20°; the 1,3- and 2,3-isomers could not be dehydrogenated. 2,3-H₂N (p-MeC₆H₄N:N)C₆H₃Me (2 g.) and 20 cc. cyclohexanone, refluxed 2 hrs. with 1 drop concentrated HCl, give 45% 2-methyl-5,6,7,8-tetrahydrophenazine, yellow, m. 81°. I (1 g.) in 25 cc. AcOH, heated 20 hrs. at 60° with 5 cc. 100-volume H₂O₂, gives 60% of the 1,4-dioxide, pale yellow, decomposing about 250°; 1,4-dioxide of II, pale yellow, m. 207-10° (decomposition), 42%; of III, yellow, m. 245° (decomposition), 33%; 9,10-dioxide of VIII, pale yellow, decompose 215-20°, 66%. VII is not identical with the phenazine obtained by the reduction of iodinin (C.A. 32, 5402.6). In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Application of 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Application of 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis, Photophysical Properties, and Antimicrobial Activity of Novel Styryl Colorants Derived from 7-Methoxy-1,4-diphenethyl-1,2,3,4-tetrahydroquinoxaline-6-carbaldehyde was written by Jarag, K. J.;Jagtap, A. R.;Borse, B. N.;Shukla, S. R.;Shankarling, G. S.. And the article was included in Journal of Heterocyclic Chemistry in 2012.Safety of 6-Methoxyquinoxaline This article mentions the following:

The novel 1,4-diphenethyl-1,2,3,4-tetrahydro-7-methoxyquinoxalin-6-carbaldehyde was synthesized by reductive alkylation of 6-methoxy quinoxaline with Ph acetic acid and was further subjected to Knoevenagel condensation with various active methylene compounds to synthesize novel styryl colorants. Photophys. properties of styryl colorants were studied using UV-visible and fluorescence spectroscopy. These colorants displayed orange to violet hue and showed fluorescence emission maxima in the region of 560-640 nm, and displayed a large Stokes shift (85-104 nm). Compounds were subjected to thermogravimetric anal. which showed excellent stability up to 310°C. These styryl compounds were evaluated for their antimicrobial study as antifungal against Candida albicans C. albicans and Aspergillus niger and antibacterial against Escherichia coli and Staphylococcus aureus. The results revealed good antimicrobial activity against tested organisms. The synthesized chromophores were characterized using elemental anal., FTIR, ¹³C-NMR and ¹H-NMR spectroscopy and mass spectrometry. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Safety of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Safety of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider