Category: 6639-87-8

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 6639-87-8, name is 6-Nitroquinoxaline, introducing its new discovery. COA of Formula: C8H5N3O2

Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents

Plasmodium falciparum thioredoxin reductase (PfTrxR: NADPH + Trx(S) 2 + H+ ? NADP+ + Trx(SH)2) is a high Mr flavin-dependent TrxR that reduces thioredoxin (Trx) via a CysXXXXCys pair located penultimately to the C-terminal Gly. In this respect, PfTrxR differs significantly from its human counterpart which bears a Cys-Sec redox pair at the same position. PfTrxR is essentially involved in antioxidant defense and redox regulation of the parasite and has been previously validated by knock-out studies as a potential drug target for malaria chemotherapy. Moreover, human TrxR is present in most cancer cells at levels tenfold higher than in normal cells. Here we report the discovery of a series of potent inhibitors of PfTrxR. The three most promising inhibitors, 3 (IC50PfTrxR=2muMandIC50hTrxR=50muM), 7 (IC50PfTrxR=2muMandIC50hTrxR= 140muM), and 11 (IC50PfTrxR=0.5muMandIC50hTrxR=4muM) were selective for the parasite enzyme. Detailed mechanistic characterization of the effects of these compounds on the PfTrxR-catalyzed reaction showed clear uncompetitive inhibition with respect to both substrate and cofactor. For the most specific PfTrxR inhibitor 7, an alkylation mechanism study based on a thiol conjugation model was performed. Furthermore, all three compounds were active in the lower micromolar range on the chloroquine-resistant P. falciparum strain K1 in vitro.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N941 | ChemSpider

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REGIOSELECTIVITY IN THE REACTION OF NITROQUINOXALINE-N-OXIDES WITH PHOSPHORYL CHLORIDE

6-nitro-, 2-methyl-6-nitro- and 2,3-dimethyl-6-nitroquinoxaline have been transformed into their N-oxides by MCPBA in chloroform; the nitro group orients the oxygen atom preferentially to nitrogen atom N1, but the N4:N1 selectivity is diminished in the methylated derivatives.Under the action of POCl3 (the Meisenheimer reaction), the N-oxides of the unmethylated compounds are transformed into chloro-nitroquinoxalines having lost the N-oxide oxygen atom.The orientation of the entering chloride ion is discussed on the basis of electronic effects induced by the N-oxide and nitro groups, and it is suggested that the last step, the elimination of “HPO2Cl2” is a concerted process.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N963 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C8H5N3O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2

New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models

Parkinson’s disease (PD) is a neurodegenerative disorder of aging characterized by motor symptoms that result from the loss of midbrain dopamine neurons and the disruption of dopamine-mediated neurotransmission. There is currently no curative treatment for this disorder. To discover druggable neuroprotective compounds for dopamine neurons, we have designed and synthesized a second-generation of quinoxaline-derived molecules based on structure-activity relationship studies, which led previously to the discovery of our first neuroprotective brain penetrant hit compound MPAQ (5c). Neuroprotection assessment in PD cellular models of our newly synthesized quinoxaline-derived compounds has led to the selection of a better hit compound, PAQ (4c). Extensive in vitro characterization of 4c showed that its neuroprotective action is partially attributable to the activation of reticulum endoplasmic ryanodine receptor channels. Most interestingly, 4c was able to attenuate neurodegeneration in a mouse model of PD, making this compound an interesting drug candidate for the treatment of this disorder.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C8H5N3O2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6639-87-8

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N955 | ChemSpider

Reference of 6639-87-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 6639-87-8, 6-Nitroquinoxaline, introducing its new discovery.

6- endo -dig Cycloisomerization of N -Propargyl Aminoquinoxalines: A New Route to 1,4,8-Triazaphenanthrenes

We report the preparation of novel 1,4,8-triazaphenanthrenes and show that the target compounds are efficiently obtained from the corresponding 6-aminoquinoxalines after N-propargylation followed by copper-catalyzed 6-endo-dig cycloisomerization and aromatization. The cyclization was found to be completely regioselective.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N973 | ChemSpider

Synthetic Route of 6639-87-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2. In a Patent£¬once mentioned of 6639-87-8

PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE

There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected from -S(=O)(=O)- and -C(=O)-, and Y is -NR3-; or X is selected from -S(=O)(=O)- and -S-, and Y is -C(R4)(R5)-; L is an optional linker; and R3, R4 and R5 are each independently selected from H and hydrocarbyl; and wherein when R2 comprises the following structural moiety, Formula (II) wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1-C(=O)-NR3-L-R2; R1-S(=O)(=O)-C(R4)(R5)-L-R2; R1-S-C(R4)(R5)-L-R2; R1-NR3-S(=O)(=O)-L-R2; R1-NR3-C(=O)-L-R2; R1-C(R4)(R5)-S(=O)(=O)-L-R2; and R1-C(R4)(R5)-S-L-R2. These compounds are useful as 11beta-hydroxysteriod dehydrogenase inhibitors in the treatment of i.a. diabetes.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N939 | ChemSpider

6639-87-8, Name is 6-Nitroquinoxaline, belongs to quinoxaline compound, is a common compound. HPLC of Formula: C8H5N3O2In an article, once mentioned the new application about 6639-87-8.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N937 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C8H5N3O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2

Electroreduction and acid-base properties of dipyrrolylquinoxalines

The electroreduction and acid-base properties of dipyrrolylquinoxalines of the form H2DPQ, H2DPQ(NO2), and H 2DPQ(NO2)2 were investigated in benzonitrile (PhCN) containing 0.1 M tetra-n-butylammonium perchlorate (TBAP). This study focuses on elucidating the complete electrochemistry, spectroelectrochemistry, and acid-base properties of H2DPQ(NO2)n (n = 0, 1, or 2) in PhCN before and after the addition of trifluoroacetic acid (TFA), tetra-n-butylammonium hydroxide (TBAOH), tetra-n-butylammonium fluoride (TBAF), or tetra-n-butylammonium acetate (TBAOAc) to solution. Electrochemical and spectroelectrochemical data provide support for the formation of a monodeprotonated anion after disproportionation of a dipyrrolylquinoxaline radical anion produced initially. The generated monoanion is then further reduced in two reversible one-electron-transfer steps at more negative potentials in the case of H2DPQ(NO2) and H 2DPQ(NO2)2. Electrochemically monitored titrations of H2DPQ(NO2)n with OH-, F-, or OAc- (in the form of TBA+X- salts) give rise to the same monodeprotonated H2DPQ(NO 2)n produced during electroreduction in PhCN. This latter anion can then be reduced in two additional one-electron-transfer steps in the case of H2DPQ(NO2) and H2DPQ(NO 2)2. Spectroscopically monitored titrations of H 2DPQ(NO2)n with X- show a 1:2 stoichiometry and provide evidence for the production of both [H 2DPQ(NO2)n]- and XHX-. The spectroscopically measured equilibrium constants range from log beta2 = 5.3 for the reaction of H2DPQ with TBAOAc to log beta2 = 8.8 for the reaction of H2DPQ(NO 2)2 with TBAOH. These results are consistent with a combined deprotonation and anion binding process. Equilibrium constants for the addition of one H+ to each quinoxaline nitrogen of H2DPQ, H2DPQ(NO2), and H2DPQ(NO2) 2 in PhCN containing 0.1 M TBAP were also determined via electrochemical and spectroscopic means; this gave rise to log beta2 values ranging from 0.7 to 4.6, depending upon the number of nitro substituents present on the H2DPQ core. The redox behavior of the H2DPQ(NO2)n compounds of the present study were further analyzed through comparisons with simple quinoxalines that lack the two linked pyrrole groups, i.e., Q(NO2)n where n = 0, 1, or 2. It is concluded that the pyrrolic substituents play a critical role in regulating the electrochemical and spectroscopic features of DPQs.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C8H5N3O2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6639-87-8, in my other articles.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N948 | ChemSpider

Related Products of 6639-87-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2. In a Patent£¬once mentioned of 6639-87-8

Hair dye compositions and certain 1,2,3,4-tetrahydronitroquinoxalines useful therein

The invention relates to the use of compounds corresponding to formula (I) STR1 in which one of the substituents R1 or R2 is a nitro group while the other is hydrogen, halogen, an amino group, a mono- or dialkylamino group containing C1-4 alkyl groups, a C1-4 alkyl or alkoxy group, R3 and R4 independently of one another represent hydrogen or a C1-4 alkyl group, A is a >CHR6 – or a >C=O- group, where R6 is hydrogen or a C1-4 alkyl group, and R5 is hydrogen or a C1-4 alkyl group, or salts thereof as substantive dyes in hair-dyeing compositions. When the substituent groups in formula I represent one of the combinations I-IV shown in the table below, the compounds are novel and are useful in hair-dyeing compositions. ______________________________________R1 R2 R3 R4 R5 A______________________________________I: H NO2 H CH3 H CH2II: H NO2 CH3 CH3 H CH2III: NH2 NO2 H H H CH2IV: H NO2 H H CH3 CH2.______________________________________

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N936 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of 6-Nitroquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 6639-87-8

Novel highly regioselective syntheses of unsymmetrical 2,3-disubstituted quinoxalines

Non-symmetrical 2,3-disubstituted quinoxalines are not easily obtained in good yields because of the lack of regioselectivity of the Hinsberg condensation, or the large number of steps required for achieving their preparation. Two efficient methods leading to non-symmetrical 2,3-disubstituted quinoxalines, carried out in smooth conditions, have been developed in our laboratory. These methods enable the synthesis of pharmacologically active quinoxaline derivatives.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N953 | ChemSpider

Related Products of 6639-87-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6639-87-8, Name is 6-Nitroquinoxaline, molecular formula is C8H5N3O2. In a Article£¬once mentioned of 6639-87-8

Vicarious Nucleophilic Substitution of Hydrogen versus Bis – Annulation in the Reaction of Chloromethyl Aryl Sulfone Carbanion with Electrophilic Arenes

The carbanion of chloromethyl aryl sulfone reacts with 1-Cyanonaphthalene to form a bis-annulated product whereas with 1-nitronaphthalene vicarious nucleophilic substitution of hydrogen takes place.This result and the bis-annulation of quinoxalines and naphthyridines which was reported earlier are rationalized in terms of the negative charge delocalization in the intermediate ?-adducts.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N958 | ChemSpider