Category: 6640-47-7

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The reactions of imidazoquinoxaline and 1,3,5-H3btc acid under different condition have been investigated. The different degree of hydrolysis reaction leads to two different adducts being produced, namely, [(HdiamQuin)+(H2btc)-] (1), and [(diamQuin)4(ImiQuin)·4H2O] (2). Both compounds were characterized by X-ray crystallography. Crystal data for 1: monoclinic, space group Pn with a = 9.868(2), b = 5.3172(11), c = 15.387(3) A, beta = 91.10(3), C17H14N4O6, Mr = 370.32, V = 807.2(3) A3, Z = 2, Dc = 1.524 g/cm3, mu(MoKalpha) = 0.118 mm-1, F(000) = 384, the final R = 0.0385 and wR = 0.0869 for 2294 observed reflections (I > 2sigma(I)). Crystal data for 2: triclinic, space group P-1 with a = 9.825(2), b = 14.144(3), c = 16.054(3) A, alpha = 101.06(3), beta = 102.55(3), gamma = 92.46(3), C44H40N20O4, Mr = 912.96, V = 2128.8(7) A3, Z = 2, Dc = 1.424 g/cm3, mu(MoKalpha) = 0.099 mm-1, F(000) = 952, the final R = 0.0554 and wR = 0.1662 for 6563 observed reflections (I > 2sigma(I)). X-ray diffraction analysis reveals that compound 1 is a salt. Imidazoquinoxaline was wholly hydrolyzed into 2,3-diaminoquinoxaline and protonated as a cation with H2btc- acting as an anion. However, in compound 2, the imidazoquinoxaline is only partly hydrolyzed, and the resulting 2,3-diaminoquinoxaline forms adduct with the intacted imidazoquinoxaline. Both are further aggregated into 3D frameworks by strong hydrogen bonding even pi-pi interactions.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N264 | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C8H8N4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 6640-47-7, name is Quinoxaline-2,3-diamine. In an article，Which mentioned a new discovery about 6640-47-7

The invention belongs to the field of pharmaceutical chemistry, in particular relates to a toll-like receptor regulation has the effect of a compound, its preparation and use. The present invention provides a compound of the following formula X shown. The compounds of formula X can be used as the toll-like receptor modulators, its activity is high. In addition, compounds of the invention have high efficiency and low toxicity, anti-drug resistance and the like, it has clinical application value. And, the compounds of the invention of simple synthesis steps, therefore with greater economic value. (by machine translation)

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N247 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 6640-47-7, name is Quinoxaline-2,3-diamine, introducing its new discovery. Formula: C8H8N4

Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3- diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.

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Quinoxaline | C8H6N250 | ChemSpider

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2H-benzimidazoles (isobenzimidazoles). Part 10. Synthesis of polysubstituted o-phenylenediamines and their conversion into heterocycles, particularly 2-substituted benzimidazoles with known or potential anthelminthic activity

Polysubstituted o-phenylenediamines were synthesised in moderate to high yield by reductive cleavage of the corresponding 2H-benzimidazole-2-spirocyclohexane with sodium dithionite in aqueous ethanol and converted into methyl benzimidazole-2-carbamates and 2-methylthio- and 2-trifluoro-methylbenzimidazoles with known or potential anthelminthic activity. 5-(Pyrimidin-2-ylthio)-benzimidazole and 11-(pyridin-2-ylthio)dibenzo[a,c]phenazine were synthesized too. Attempts to oxidise 1,3-dihydro-2H-4,9-diazanaphth[2,3-d]imidazole, prepared by condensation of 2,3-diaminoquinoxaline with cyclohexanone, to an analogue of the title system failed.

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Quinoxaline – Wikipedia,
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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C8H8N4. Introducing a new discovery about 6640-47-7, Name is Quinoxaline-2,3-diamine

Ground- and Excited-State Protonation of Aminoquinoxalines

Excited-state second protonation of 2-aminoquinoxaline occurs in aqueous perchloric acid at a rate of 1.1×1010 L.mol-1.s-1.The reaction is very sensitive to solvent structure and is blocked in acidic poly(vinyl alcohol) and heptane solutions of trifluoroacetic acid.Calculations of effective valence electron potentials provide a good reactivity index for pKa changes in excited 2-aminoquinoxaline and 2,3-diaminoquinoxaline.

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Quinoxaline | C8H6N263 | ChemSpider

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ELECTROCHEMICAL OXIDATION OF ORGANIC COMPOUNDS IN FLUOROSULFONIC ACID. IX. VOLTAMMETRIC CHARACTERISTICS OF THE OXIDATION OF SUBSTITUTED PHENOLS, THEIR DERIVATIVES, AND HETEROCYCLIC COMPOUNDS IN FLUOROSULFONIC ACID AND ACETONITRILE

The electrochemical oxidation of phenols and their alkyl ethers not containing strong electron-withdrawing substituents in fluorosulfonic acid takes place in the form of the benzenonium ions and is irreversible in character.With the introduction of substituents of the -M type into the benzene ring the oxidation process affects the unprotonated molecules to a first approximation and in many cases goes reversibly to the radical-cations.Comparison of the oxidation potentials of the substrates in acetonitrile and fluorosulfonic acid made it possible to reveal certain characteristics of the fine structure of these radical-cations, which is determined by the ability of the latter to interact with the medium.Heterocyclic cations whose oxidation potentials in acetonitrile lie beyond the limit of the discharge of the supporting electrolyte can be oxidized in fluorosulfonic acid.Cations of the quinolinium, isoquinolinium, acridinium, acridizinium, imidazolium, and other series, which have irreversible many-electron waves in acetonitrile, give well-defined reversible peaks for oxidation to the corresponding radical-dications in fluorosulfonic acid.In phenyl- and benzyl-substituted cations the substituents and not the positively charged heterocycle itself can undergo oxidation.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N261 | ChemSpider

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Permanganate Oxidation of Quinoxaline and Its Derivatives

The oxidation reaction of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described.Neutral oxidation of 2-chloro- and 2,3-dichlorodioxalines 2-4 afforded the corresponding chloro- and dichloropyrazinedicarboxilic acids 13 and 14 in good yield.On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alkaline medium gave different products, with the quinoxalin-2(1H)-one (5) forming 1,4-dihydroquinoxaline-2,3-dione (9), while various substituted quinoxalin-2,3-dione derivatives (see 9-11) gave a new type of dimeric products.The structural assignments for the new compounds were based on spectroscopic data.

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Quinoxaline | C8H6N260 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: quinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6640-47-7, Name is Quinoxaline-2,3-diamine, molecular formula is C8H8N4

REACTIONS OF FUROXANS WITH PHOSPHORUS YLIDES

Benzofuroxan (1) reacts with phosphorus ylide 2 to give benzimidazole derivatives 8 and 10, whereas reaction of 1 with ylide 12 furnishes quinoxaline 17 via an initial Wittig-type reaction.Similarly the reaction between the furoxano<3,4-b>quinoxalines 19a or 19b and the ylide 2 yielded compounds 22a and 22b, respectively.In these reactions as well as in the reactions of the above furoxans with other phosphorus ylides, a significant deoxygenation of the furoxans to furazans with subsequent oxidation of the ylides is generally observed.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N251 | ChemSpider

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2,3-Dichloroquinoxaline as a versatile building block for heteroaromatic nucleophilic substitution: A review of the last decade

Nucleophilic aromatic substitution (SNAr) is a class of reaction that has become very important over time. This type of transformation usually proceeds without the use of metal catalysts, making it very important for pharmaceutical and industrial purposes. Nevertheless, in order to obtain the desired substituted product, activated substrates are required to allow SNAr reactions under mild conditions. In this context, quinoxaline derivatives are one class of N-heteroarenes that has attracted great attention from the scientific community because of the large variety of applications for their derivatives in many fields, such as biological and technological areas. There are several reported methods for the synthesis of quinoxaline derivatives. Nonetheless, reactions of 2,3-dichloroquinoxaline (DCQX) with nucleophilic species has become a viable alternative because of the possibility to form new carbon-heteroatom bonds (e.g. C[sbnd]O, C[sbnd]N, and C[sbnd]S) directly at C2 and/or C3 positions of the quinoxaline moiety. This current review brings an overview of the last decade on the remarkable versatility of DCQX as a substrate for SNAr reactions. Herein, we show several examples in which DCQX reacts with N-, O-, S-, P- and C-nucleophiles, including controlled processes for the selective formation of mono- and disubstituted substrates. Almost all polyfunctionalized quinoxalines synthesized using this approach have shown applications in different areas such as in biological and technological fields.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N259 | ChemSpider

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Imidazoquinoxaline fungicides

Compounds of the formula STR1 wherein R1 is hydrogen, alkali metal, alkyl, substituted alkyl, alkylsulfenyl or acyl; R2 is alkyl or cyclopropyl; R3 is hydrogen, chlorine, bromine or fluorine; n and p are 0 or 1 and A is a mineral acid are useful as fungicides. A representative compound is 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline.

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