6924-66-9| Page 4 of 4 | Heterocyclic Building Blocks-quinoxaline

New learning discoveries about 6924-66-9

As the paragraph descriping shows that 6924-66-9 is playing an increasingly important role.

6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6924-66-9, PyBOP (153 mg, 295 mumol) was added to a mixture of 8-amino-2-(4-fluorophenyl)-2- azaspiro[4.5]decan-1 -one (isomer 1 , Intermediate 118) (64.4 mg, 246 muiotaetaomicronIota), quinoxaline-5- carboxylic acid (56.3 mg, 307 muiotaetaomicronl) and N,N-diisopropylethylamine (210 mul, 1 .2 mmol) in DMF (1 .0 ml) and the mixture was stirred over night at room temperature. For work-up, water was added and the mixture was extracted with dichloromethane. The organic phase was washed with water, filtered through a silicone filter and concentrated to give the title compound 93.0 mg (89 % yield).LC-MS (Method 1 ): Rt= 1 .12 min; MS (ESIneg): m/z = 417 [M-H]-1H-NMR (400 MHz, DMSO-d6): delta [ppm] = 9.77 (d, 1 H), 9.09-9.05 (m, 2H), 8.43 (dd, 1 H), 8.26 (dd, 1 H), 7.97 (dd, 1 H), 7.75-7.68 (m, 2H), 7.26-7.19 (m, 2H), 3.96-3.84 (m, 1 H), 3.79 (t, 2H), 2.12-1 .99 (m, 4H), 1.75-1 .60 (m, 4H), 1 .59-1 .45 (m, 2H)

As the paragraph descriping shows that 6924-66-9 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

Brief introduction of 6924-66-9

The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

PyBOP (206 mg, 396 muiotaetaomicronIota) was added to a mixture of 8-amino-2-(2-chloro-4-fluorophenyl)-2- azaspiro[4.5]decan-1 -one (isomer 1 ) (100 mg, 330 muiotaetaomicronIota, Intermediate 112), quinoxaline-5- carboxylic acid (71 .9 mg, 413 muiotaetaomicronIota) and N,N-diisopropylethylamine (290 muIota, 1 .7 mmol) in DMF (3.7 ml) and the mixture was stirred over night at room temperature. For work-up, the reaction mixture was concentrated and the residue was purified by preparative HPLC to give the title compound 65.0 mg (43 % yield).LC-MS (Method 1 ): Rt= 1 .14 min; MS (ESIpos): m/z = 453 [M+H]+ 1H-NMR (400 MHz, DMSO-d6): delta [ppm] = 9.78 (d, 1 H), 9.10-9.06 (m, 2H), 8.44 (dd, 1 H), 8.27 (dd, 1 H), 7.98 (dd, 1 H), 7.62-7.58 (m, 1 H), 7.49 (dd, 1 H), 7.35-7.28 (m, 1 H), 3.96-3.85 (m, 1 H), 3.66-3.60 (m, 2H), 2.16 (t, 2H), 2.09-2.00 (m, 2H), 1 .76-1 .66 (m, 4H), 1.60-1 .38 (m, 2H)

The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.