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The preparation method of the quinoxaline-containing triketone compound disclosed by the invention as shown in the following general formula, mainly comprises contacting. with a compound represented by the formula (I) in the presence of a base and a solvent . (II). The preparation method of (I) comprises the following general formula: R. 1 , R2 , R3 , R4 As defined. in the specification, the quinoxaline-containing triketone compound of the present invention has a high herbicidal activity, especially for controlling broad-leaved weeds and/or gramineous weeds, preventing and treating effects even better than some commercially available commercial herbicides. (by machine translation)

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N800 | ChemSpider

 

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The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, Rl and R2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

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Quinoxaline – Wikipedia,
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The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous alkaline suspension of a 5- or 6-halomethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.

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Quinoxaline – Wikipedia,
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The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous suspension of a 5- or 6-hydroxymethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.

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Quinoxalines are prepared by reaction of oxalic acid with an o-phenylenediamine, halogenation in the presence of a solvent and oxidation to a quinoxaline carboxylic acid derivative.

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We here report the synthesis of compounds structurally related to the high-affinity dopamine D3 receptor ligand N-[4-[4-(2,3- dichlorophenyl)piperazin-1-yl]butyl]-7-methoxy-2-benzofurancarboxamide (1). All compounds were specifically designed as potential PET radioligands for brain D3 receptors visualization, having lipophilicity within a range for high brain uptake and weak nonspecific binding (2 < ClogP < 3.5) and bearing a methoxy substituent for easy access to labeling with the positron emitter isotope 11C. N-[4-[4-(5-methoxy-2-benzisoxazolyl) piperazin-1-yl]butyl]-4-(4-morpholinyl)benzamide (22), N-[4-[4-(5-methoxy-2- benzisoxazolyl)piperazin-1-yl]butyl]-4-(1H-imidazol-1-yl)benzamide (23), and N-[4-[4-(5-methoxy-2-benzisoxazolyl)piperazin-1-yl]butyl]-5-(2-furanyl) -1H-pyrazole-3-carboxamide (24) displayed good D3 receptor affinities (Ki values 38.0, 22.6, and 21.3 nM, respectively) and were selective over D2 receptor. Moreover, compounds 22-24 were able to permeate the Caco-2 cell monolayer, differently from compound 1. Although the goal to identify potential PET radioligands with subnanomolar affinities for D 3 receptor was not achieved, the proposed strategy could be a starting point for future developments. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 6925-00-4, you can also check out more blogs about6925-00-4

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Quinoxaline – Wikipedia,
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Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are various substituent groups; and one of X1 and X2 is N or CR?, and the other is NR? or CHR? wherein R? is hydrogen, OH, C1-6alkyl, or C3-7cycloalkyl; or when one of X1 and X2 is N or CR? then the other may be S or O; and their use as pharmaceuticals.

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The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1 , R2 and n are as described in the description.

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Novel compounds useful for treating and/or preventing HCMV infections are provided.

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Quinoxaline – Wikipedia,
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A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles (15a-l) have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 4-[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]b enzenesulfonamide (15b) and 4-[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]be nzenesulfonamide (15c) showed more than 90% inhibition at 0.5 muM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct, but inhibited p38alpha MAP kinase activity only 11 and 8% at a concentration of 10 muM, respectively.

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Quinoxaline – Wikipedia,
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