Category: 7251-61-8

7251-61-8, 2-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7251-61-8, 2-Methyl-quinoxaline (11 g) in a 250 ml round-bottom flask was dissolved with dioxane and heated at 70 C. A mixture of selenium dioxide (8.5 g) with dioxane (29 ml) and water (5.9 ml) was added dropwise into the flask within 90 min. The solution was then stirred at 85 C for 4 h, and then filtered and processed with activated carbon for 30 min. Dioxane was distilled under reduced pressure and the residue was extracted with 30 mL (3 ¡Á 10 mL) ether. Then the combined organic phase was washed with 30 mL wateter (3 ¡Á 10 mL). The ether was dried with MgSO4 at room temperature overnight. The solvent was dried under reduced pressure and the crude product was isolated as brownish solid (9 g). The solid was refluxed with n-hexane for 3 h and heat-filtered after treated with activated carbon for 20 min. Then, n-hexane was distilled to obtain a deep-yellow acicular crystal (48%). 1H-NMR (CDCl3): delta = 7.95 (Ph-H, 2H, m), 8.24 (Ph-H, 2H, m), 9.43 (N=CH, 1H, s), 10.29 (CHO, 1H, s); 13C-NMR(CDCl3):delta = 129.6, 130.4, 131.1, 132.8, 141.9, 142.4, 144.5, 146.0, 192.7; Mp = 106.6-107.2 C.

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Article; Li, Zongyang; Zhang, Jiaheng; Li, Yubo; Gao, Haixiang; Journal of Molecular Structure; vol. 1035; (2013); p. 69 – 75;,
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7251-61-8, 2-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A 25 mL pressure vial was charged with 2-methylquinoline (1a) (71.5 mg, 0.50 mmol, 1.0 equiv.), I2 (317.3 mg, 1.25 mmol, 2.5 equiv.) and DMSO (3.0 mL). The vial was sealed and the resulting mixture was stirred at 110 C for 4-6 h under an air atmosphere, after disappearance of the reactant (monitored by TLC), then added benzohydrazide (2a) (81.6 mg, 0.6 mmol, 1.2 equiv.) , K2CO3 (414.0 mg, 3.0 mmol, 6.0 equiv.) at 110 C for another 4-6 h. After the reaction completed, and added 50 mL water to the mixture, then extracted with EtOAc 3 times (3 ¡Á 50 mL). The extract was washed with 10% Na2S2O3 solution (w/w), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was puried by flash column chromatography on silica gel to yield the corresponding product 3aa as a yellow solid (72% yield)., 7251-61-8

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Article; Shang, Zhi-Hao; Sun, Ji-Na; Guo, Jiang-Shan; Sun, Yuan-Yuan; Weng, Wei-Zhao; Zhang, Zhen-Xiao; Li, Zeng-Jing; Zhu, Yan-Ping; Tetrahedron; vol. 76; 6; (2020);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8

To 2-methyl-quinoxaline (1 g, 7 mmol) in 1,4-dioxane (30 ml) was added selenium dioxide (2.3 g, 21 mmol) and the mixture heated to 60C for 2 hours. After cooling the reaction mixture, it was filtered over celite and partitioned between water and ethylacetate. The combined organic phases were successively washed with water (50 ml x 2) and brine (50 ml x 2), dried over anhydrous sodium sulphate and evaporated under vacuo, to afford 0.6 g of the crude title compound as a brown solid, which was used without purification in the next step. ?H NMR (400 MHz, DMSOd6) No. 7.98 – 8.09 (3H, m), 8.21-8.24 (1H, m), 8.28 – 8.31 (lH, m), 10.19 (IH, s).

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Patent; TORRENT PHARMACEUTICALS LTD; WO2005/97746; (2005); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7251-61-8,2-Methylquinoxaline,as a common compound, the synthetic route is as follows.,7251-61-8

To a 80 mL microwave tube was added 2-methylquinoxaline (0.576 g, 4 mmol), Fe (NO3)3¡¤ 9H2O (0.808 g, 2 mmol) and DMSO (50 mL) were heated to 135 C for 3 min at 150 W in a CEM Discover microwave reactor.After completion of the reaction, the mixture was cooled to room temperature, filtered and the filtrate was poured into saturated NaHCO3Aqueous solution, ethyl acetate (3 x 30 mL), and the combined organic layers were washed with anhydrous Na2SO4After drying, it was concentrated under reduced pressure and recrystallized from n-hexane (35 mL) to give 0.506 g of a yellow target product in 80% yield.

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Patent; ZHEJIANG UNIVERSITY OF TECHNOLOGY; XIE, YUANYUAN; XIE, TINGHUI; HUANG, YINGYI; GAN, BING; YAN, YIYAN; LI, PINGPING; (10 pag.)CN106083713; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

7251-61-8, 2-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7251-61-8, Selenium dioxide (7.69 g, 69.35mmol) was added to a mixture of 1,4-dioxane (60 mL) and H2O (2.5 mL) and heated to reflux. 2-Methylquinoxaline (5 g, 34.67 mmol) was dissolved in 1,4-dioxane (10 mL) and added dropwise to the heated solution. A colour change to red-brown was observed. After heating for 4 h the hot mixture was filtered through Celite and washed with 1,4-dioxane (2 ¡Á 25 mL). The filtrate was allowed to cool and remove the solvent by evaporation. Chromatography of the residue (EtOAc-cyclohexane, 1:5) gave 6 as yellow needles (4.34 g, 79%); Rf = 0.42 (EtOAc-cyclohexane 1:5); mp 98-100 C; 1H-NMR (400MHz, CDCl3) d = 10.29 (s, 1H, CHO), 9.43(s, 1H), 8.20-8.27 (m, 2H), 7.90-7.95 (m, 2H); 13C-NMR (100MHz, CDCl3) delta192.7 (CHO), 145.9, 144.9 (each C), 142.5 (CH), 141.9 (C), 132.9, 131.1, 130.5, 129.6 (each CH); LRMS (ESI): Found 159.0 [M+H]+, C9H7N2O requires 159.1.

The synthetic route of 7251-61-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jarikote, Dilip V.; Li, Wei; Jiang, Tao; Eriksson, Leif A.; Murphy, Paul V.; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 826 – 835;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider