Category: 7712-28-9

7712-28-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 7712-28-9, C11H10N2O3. A document type is Article, introducing its new discovery.

Synthesis of potential chemotherapic quinoxalinone derivatives by biocatalysis or microwave-assisted Hinsberg reaction

In recent years, great efforts have been dedicated to the design of compounds acting as selective inhibitors of the HIV-1 reverse transcriptase (RT). Due to the promissory results previously attained with some quinoxaline derivatives, we aimed to improve the specific standard Hinsberg synthetic pathway by means of biocatalysis or microwave (MW) irradiation. Both techniques rendered the products in very good yields. However, employing the microwave-assisted organic synthesis (MAOS), in the absence of solvent, the same reactions may be completed in minutes. Some of these quinoxalinone derivatives exhibited good inhibitor activity against some human tumoral cells and the lymphoma related to HIV-1.

Interested yet? Keep reading other articles of 1271-51-8!, 7712-28-9

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1749 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7712-28-9,3-(3-Hydroxyquinoxalin-2-yl)propanoic acid,as a common compound, the synthetic route is as follows.,7712-28-9

Intermediate 1 (1.75 g, 8 mmol) was dissolved in 25 ml of ethanol, 0.1 ml of concentrated sulfuric acid was added, and refluxed at 78 C.At night, TLC detected that the reaction was completed. The reaction was quenched with ice water and the reaction was completely precipitated and neutralized with NaHCO3 to pH = 7.The mixture was filtered under EtOAc (EtOAc)EtOAc.PE/EA = 10/1 to 5/1 column chromatography, yielding 1.62 g of Compound 2 pure product, yield 82.2%.

The synthetic route of 7712-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong University; Li Xun; Wu Jifeng; (32 pag.)CN108997230; (2018); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

7712-28-9, 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7712-28-9, General procedure: In a typical reaction, AMA 2:3 (10mmol), the corresponding carboxylic acid (1mmol) and the alcohol (2ml) were mixed in the provided reaction glass tube equipped with a screw cap and magnetic agitation until a wet mixture was achieved. The reaction mixture was irradiated with microwaves (Anton Parr Monowave 300 reactor) at 120C for 10-25min. On cooling, the mixture was diluted with DCM (41mL), and filtered over celite. Then the filtrate was washed with Na2CO3 (ss) and water. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to give the ester.

As the paragraph descriping shows that 7712-28-9 is playing an increasingly important role.

Reference£º
Article; Estrin, Dario; Fabian, Lucas; Gomez, Natalia; Moglioni, Albertina; Salvatori, Melina; Taverna Porro, Marisa; Turk, Gabriela; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

7712-28-9, 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7712-28-9, In a typical reaction, AMA 2:3 (10mmol), the corresponding carboxylic acid (1mmol) and the alcohol (2ml) were mixed in the provided reaction glass tube equipped with a screw cap and magnetic agitation until a wet mixture was achieved. The reaction mixture was irradiated with microwaves (Anton Parr Monowave 300 reactor) at 120C for 10-25min. On cooling, the mixture was diluted with DCM (41mL), and filtered over celite. Then the filtrate was washed with Na2CO3 (ss) and water. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to give the ester. 4.3.6.1 Methyl 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoate (23) (0075) Alcohol: Methanol. Reaction time: 10min. Yield: 95%. Mp: 208-209C. IR (cm-1): 1730, 1655, 1615, 1510, 1490, 1565. MS (m/z): 232.3. 1H-RMN (300MHz) delta (ppm) (DMSO-d6): 2.79 (t; J=7.01Hz; 2H; CH2); 3.06 (t; J=6.83Hz; 2H; CH2); 3.60 (s; 3H; OCH3); 7.23-7.33 (m; 2H; ArH); 7.48 (t; J=7.99Hz; 1H; ArH), 7.68 (d; J=8.40; 1H; ArH), 12.36 (s.a.; 1H; NH).13C-RMN (75MHz) delta (ppm) (DMSO-d6): 28.0 (CH2); 29.8 (CH2); 51.8 (OCH3); 115.7; 123.6; 128.6; 130.0; 131.9; 132.2; 155.0 (C=N); 160.4 (C=O); 173.4 (CO).

7712-28-9 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid 151480, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Estrin, Dario; Fabian, Lucas; Gomez, Natalia; Moglioni, Albertina; Salvatori, Melina; Taverna Porro, Marisa; Turk, Gabriela; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider