Category: 80636-30-2

Lai, John T. et al. published their research in Synthesis in 1982 | CAS: 80636-30-2

3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.SDS of cas: 80636-30-2

Hindered amines. Part 4. 3,3-Dialkyl-1,2,3,4-tetrahydro-2-quinoxalinones and cis- and trans-3,3-dialkyldecahydro-2-quinoxalinones was written by Lai, John T.. And the article was included in Synthesis in 1982.SDS of cas: 80636-30-2 This article mentions the following:

Tetrahydroquinoxalinones I [R = H; R1 = Me, R2 = Me, hexyl; R1R2 = (CH2)4, (CH2)5] were obtained by treating o-(H2N)2C6H4 with R1R2CO and CHCl3. I (R = 6-Me, 7-Me, 6-Cl, 7-Cl, R1 = R2 = Me) were obtained from 3,4-(H2N)2C6H3R and Cl3CCMe2OH. Rh-C hydrogenation of I (R = H) gave cis–II. trans–II were obtained from HOCR1R2CN and 1,2-cyclohexanediamine. In the experiment, the researchers used many compounds, for example, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2SDS of cas: 80636-30-2).

3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.SDS of cas: 80636-30-2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Tanimori, Shinji et al. published their research in Research on Chemical Intermediates in 2014 | CAS: 80636-30-2

3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Electric Literature of C10H12N2O

Efficient synthesis of useful heterocycles via transition metal-catalyzed cascade processes was written by Tanimori, Shinji;Inaba, Ushio;Kato, Yoshihiro;Ura, Haruna;Kashiwagi, Hiroaki;Nishimura, Takeshi;Kirihata, Mitsunori. And the article was included in Research on Chemical Intermediates in 2014.Electric Literature of C10H12N2O This article mentions the following:

This paper reports our recent results from synthesis of some useful heterocycles, for example oxazolidinones, indoles, and quinoxalinones, by transition metal-catalyzed cascade processes. The scope and limitations of these procedures and the reaction mechanism for formation of the heterocycles are also discussed. In the experiment, the researchers used many compounds, for example, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2Electric Literature of C10H12N2O).

3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Electric Literature of C10H12N2O

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Soederberg, Bjoern C. G. et al. published their research in Organic Letters in 2002 | CAS: 80636-30-2

3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Reference of 80636-30-2

A Novel Palladium-Catalyzed Synthesis of 1,2-Dihydroquinoxalines and 3,4-Dihydroquinoxalinones was written by Soederberg, Bjoern C. G.;Wallace, Jeffery M.;Tamariz, Joaquin. And the article was included in Organic Letters in 2002.Reference of 80636-30-2 This article mentions the following:

Reactions of enamines, derived from 2-nitroanilines and α-substituted aldehydes, with carbon monoxide (6 atm) in the presence of a catalytic amount of bis(dibenzylideneacetone)palladium(0) (Pd(dba)2) and 1,3-bis(diphenylphosphino)propane (dppp) afford readily separated mixtures of 1,2-dihydroquinoxalines and 3,4-dihydroquinoxalinones. Addition of a catalytic amount of 1,10-phenanthroline to the reaction mixture substantially improved the yield of products. In the experiment, the researchers used many compounds, for example, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2Reference of 80636-30-2).

3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Reference of 80636-30-2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

9/27/21 News Chemical Properties and Facts of 80636-30-2

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C10H12N2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 80636-30-2, in my other articles.

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A palladium-catalyzed reductive N-heteroannulation of enamines derived from 2-nitrobenzenamines forming mixtures of 1,2-dihydroquinoxalines and 3,4-dihydroquinoxalin-2-ones is described. The reactions are performed using bis(dibenzylideneacetone)palladium(0), 1,3-bis(diphenylphosphino)propane, and 1,10-phenanthroline in DMF under 6 atm of carbon monoxide at 70 C.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C10H12N2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 80636-30-2, in my other articles.

Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N993 | ChemSpider

 

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Compounds of the formula I or Ia in which n and the substituents R1, R5 and x have the meaning mentioned have an antiviral activity.

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Quinoxaline – Wikipedia,
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22-Sep-2021 News Chemical Properties and Facts of 80636-30-2

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(4RS)-1-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-12,12a-dihydroimidazo<1,5-a>pyrrolo<2,1-c>quinoxalin-10(11H)-one (1a), 5-benzoyl-3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-4,5-dihydroimidazo<1,5-a>quinoxaline (13b), and tert-butyl (4S)-12,12a-dihydroimidazo<1,5-a>pyrrolo<2,1-c>quinoxaline-1-carboxylate (1e), as well as other imidazo<1,5-a>quinoxaline amides and carbamates, represent a new series of compounds which bind with high affinity to the GABAA/benzodiazepine receptor.These compound exhibit a wide range of intrinsic efficacies as measured by <35S>TBPS binding ratios.The synthesis of 1a begins with the addition of DL-glutamic acid to 1-fluoro-2-nitrobenzene, followed by reduction of the nitro group and subsequent ring closure to form 3-(carbethoxymethyl)-1,2,3,4-tetrahydroquinoxalin-2-one, followed by a second ring closure to afford (4RS)-1,5-dioxo-1,2,3,4,5,6-hexahydropyrrolo<1,2-a>quinoxaline as the key intermediate.Appendage of a substituted imidazo ring via the anion of 5-cyclopropyl-1,2,4-oxadiazol-3-yl gives 1a.The (-) and (+)-isomers of 1a were prepared from 1-fluoro-2-nitrobenzene and L- and D-glutamic acid, respectively. 1a and its enantiomers demonstrated affinity for <3H>flunitrazepam binding site with Ki’s of 0.87, 0.62, and 0.65 nM, respectively.

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Quinoxaline – Wikipedia,
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The reaction of aromatic 1,2-diamines with trichloromethylcarbinols under mild, basic phase-transfer conditions provided expedient access to 3,3-disubsituted quinoxalin-2(1H)-ones in good to moderate yields. The use of unsymmetrical aryl diamines gave a regioisomeric mixture of products with the ratio shown to be dependent on the electronic nature of the aromatic substituents. 2,3-Diaminopyridines could also be used, showing excellent selectivity for the dihydro[3,2-b]pyridopyrazin-2-one isomer.

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September 13,2021 News More research is needed about 80636-30-2

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Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.

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Quinoxaline – Wikipedia,
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A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1H)-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. Owing to the inter- and intramolecular processes, involving self association, proton exchange, conformational, and/or tautomeric exchanges between several forms for most of the bis-benzimidazolylquinoxalines signals of bridged and neighboring carbon atoms and the hydrogen atoms of the neighboring carbon atoms of benzimidazole fragments in the NMR spectra are broadened. The conjugation between the benzimidazole fragments and the quinoxaline core of the molecules is increased from the quinoxaline derivative (10c) to its thiadiazol[f]- (17) and pyrrolo[a]-(19) annulated derivatives, resulting in a greater planarity of the molecule as a whole.

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Quinoxaline – Wikipedia,
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Reactions of enamines, derived from 2-nitroanilines and alpha-substituted aldehydes, with carbon monoxide (6 atm) in the presence of a catalytic amount of bis(dibenzylideneacetone)palladium(0) (Pd(dba)(2)) and 1,3-bis(diphenylphosphino)propane (dppp) afford readily separated mixtures of 1,2-dihydroquinoxalines and 3,4-dihydroquinoxalinones. Addition of a catalytic amount of 1,10-phenanthroline to the reaction mixture substantially improved the yield of products. [reaction: see text]

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Reference：
Quinoxaline – Wikipedia,
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