27-Sep News Simple exploration of 82031-32-1

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Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described

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This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.

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The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

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Pharmaceutical compounds, their methods of manufacture, and methods of treatment of mammals with pharmaceutical compounds are provided.

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Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I), stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed

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The relationship between chemical structure and gelation ability was examined for a series of nine Hg-containing compounds. Both solid-state properties (dissolution enthalpies/entropies and packing structure) and gel properties (strength, morphology, cation selectivity, and anion tolerance) were examined. Overall, the results reveal a complex relationship between chemical structure and properties. The remediation potential of these Hg-triggered gelations was also investigated, revealing that >98% of the Hg2+ in water can be removed through gel formation.

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The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.

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Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

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A novel quinoxalinamine-containing fluorescent probe (LK) was designed and synthesized based on coordination for real-time detection of Pd2+. LK was easily obtained in high yield by the Suzuki cross-coupling reaction. The quinoxaline group provides the sensor LK with good water-solubility, which is important for monitoring in biological systems. The probe possessed large Stokes shifts and excellent selectivity for detecting Pd2+ in the presence of various potential interfering metal ions. The detection limit (22 nM) was far lower than the criterion of the World Health Organization in drinking water. Moreover, LK displayed high sensitivity for identification of Pd2+ in real water samples. More importantly, the sensor LK succeeded in imaging detection of Pd2+ in live cells with good membrane permeability and low toxicity.

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An effective copper-catalyzed direct C-H/N-H cross-coupling of quinoxalin-2(1H)-ones with diverse unprotected 2-quinoxalinones and 2-quinolinones has been developed. This protocol provides a convenient route, with broad substrate scope, good functional group tolerance, and high atom economy, to various important quinoxalin-2(1H)-one-containing biheteroaryls, which are privileged structures in many biologically active compounds.

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