Category: 83570-42-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

Titanium tetraisopropoxide (0.08 mL, 0.27 mmol) was added to a stirred suspension of Intermediate 3b (57 mg, 0.25 mmol) and l-(quinoxalin-6-yl)ethanone (CAS: 83570-42- 7; 50 mg, 0.29 mmol) in THF (1.5 mL) at rt and under N2 atmosphere. The mixture was stirred into a sealed tube at 80 C for 16 h. Then sodium cyanoborohydride (28 mg, 0.45 mmol) was added and the mixture was further stirred at 80 C for 16 h. Then, NaHC03 (aq. sat. soltn.) and DCM were added to the mixture. The solvent was evaporated in vacuo and the crude product was purified by flash column (0323) chromatography (silica gel, 7N solution of NH3 in MeOH in DCM, from 0/100 to 10/90) and then by RP HPLC (Stationary phase: C18 XBridge 30 x 100 mm 5 muetaiota; mobile phase: gradient from 81 % 1 OmM NH4CO3H pH 9 solution in water, 19% (0324) CH3CN to 64% lOmM NH4CO3H pH 9 solution in water, 36% CH3CN). The desired fractions were collected and concentrated in vacuo to yield product 7 (10 mg, 10%> yield) as yellow oil., 83570-42-7

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres Avelino; MARTINEZ VITURRO, Carlos Manuel; (116 pag.)WO2018/141984; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: The following compounds were prepared following a reductive amination procedure like the one described for the preparation of product 11 starting from the corresponding amine and methylketone intermediates using triethyl amine, sodium cyanoborohydride and titanium tetraisopropoxide in DCM. Changes of solvent, reductant are mentioned inTable B below., 83570-42-7

The synthetic route of 83570-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, After dissolving 6-(quinoxalin-6-yl)ethan-1-one (4.6 g, 27.0 mmol) synthesized in Step 1 and diethyl oxalate (7.3 mL, 53.9 mmol) in ethanol (9 mL), a 2 M ethoxysodium solution (26.9 mL, 53.9 mmol) was slowly added dropwise thereto at 50C, and the result was refluxed for 2 hours. After cooling the result to room temperature, the solvent was vacuum concentrated, and the result was acidified by adding 2 M HCl dropwise thereto. Dichloromethane was introduced thereto for extraction, and the organic layer was dried using anhydrous magnesium sulfate and then filtered. The filtrate was concentrated and purified using column chromatography to obtain a target compound (6.7 g). 1H NMR spectrum (300 MHz, CDCl3) delta 8.96(s, 2H), 8.78(s, 1H), 8.35(dd, 1H), 8.24(d, 1H), 7.27(s, 1H), 4.44(q, 2H), 1.45(t, 3H).

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; Hanmi Pharmaceutical Co., Ltd.; LEE, Kyung Ik; JUNG, Young Hee; SONG, Ji Young; JUN, Seung Ah; (89 pag.)EP3480193; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, General procedure: The following compounds were prepared following a reductive amination procedure like the one described for the preparation of product 11 starting from the corresponding amine and methylketone intermediates using triethyl amine, sodium cyanoborohydride and titanium tetraisopropoxide in DCM. Changes of solvent, reductant are mentioned inTable B below.

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: The following compounds were prepared following a reductive amination procedure like the one described for the preparation of product 11 starting from the corresponding amine and methylketone intermediates using triethyl amine, sodium cyanoborohydride and titanium tetraisopropoxide in DCM. Changes of solvent, reductant are mentioned inTable B below., 83570-42-7

83570-42-7 1-(Quinoxalin-6-yl)ethanone 22631249, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, To a stirred solution of 1-(quinoxalin-6-yl)ethan-1-one (0.8 g,4.65 mmol) in dry methanol (20 mL) at 0 C, NaBH4 (0.36 g, 9.30 mmol) was added portion wise and the resulting mixture was stirred for 1 h. After completion of the reaction (monitored by TLC), the mixture was quenched with ice cold water and the aqueous layer was extracted with DCM (2 x 40 mL). The combined organic layer was washed with water (20 mL), dried over anhydrous Na2S04 and concentrated under vacuum. The resulting crude material was forwarded to the next step without any further purification. Yield: 75% (600 mg, dark brown liquid). 1H NMR (400 MHz, DMSO-cfe): delta 8.91-8.89 (m, 2H), 8.03 (t, J = 1 1.6 Hz, 2H), 7.87-7.86 (m, 1 H), 5.49 (d, J = 5.9 Hz, 1 H), 4.98-4.97 (m, 1 H), 1.42 (d, J = 8.6 Hz, 3H). LCMS: (Method A) 175.0 (M+H), Rt. 1.89 min, 95.0% (Max).

83570-42-7 1-(Quinoxalin-6-yl)ethanone 22631249, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON S.A.; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (134 pag.)WO2019/37860; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Titanium tetraisopropoxide (0.1 mL, 0.34 mmol) was added to a stirred suspension of Intermediate 3a (71 mg, 0.31 mmol) and l-(quinoxalin-6-yl)ethanone (CAS: 83570-42- 7; 63 mg, 0.37 mmol) in THF (1.5 mL) at rt and under N2 atmosphere. The mixture was stirred into a sealed tube at 80 C for 16 h. Then sodium cyanoborohydride (30 mg, 0.48 mmol) was added and the mixture was further stirred at 80 C for 16 h. Then, NaHC03 (aq. sat. soltn.) and DCM were added to the mixture. The solvent was evaporated in vacuo and the crude product was purified by flash column (0320) chromatography (silica gel, 7N solution of NH3 in MeOH in DCM, from 0/100 to 10/90) and then by RP HPLC (Stationary phase: CI 8 XBridge 30 x 100 mm 5 muetaiota; mobile phase: gradient from 81% lOmM NH4CO3H pH 9 solution in water, 19% CH3CN to 64% lOmM NH4CO3H pH 9 solution in water, 36% CH3CN). The desired fractions were collected and concentrated in vacuo to yield product 6 (15 mg, 13% yield) as yellow oil., 83570-42-7

83570-42-7 1-(Quinoxalin-6-yl)ethanone 22631249, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres Avelino; MARTINEZ VITURRO, Carlos Manuel; (116 pag.)WO2018/141984; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

83570-42-7,83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Titanium tetraisopropoxide (0.062 mL, 0.21 mmol) was added to a stirred solution of intermediate 17 (40 mg, 0.19 mmol), i-(6-quinoxalinyl)ethanone (CAS: 83570-42-7;45 mg, 0.26 mmol) in MeOH (1 mL) at rt and under N2 atmosphere. The mixture was stirred at 80C for 16 h. Then sodium cyanoborohydride (20 mg, 0.32 mmol) was added and the mixture was stirred at 80C for 5 h and then at rt for 60 h. The volatiles were evaporated in vacuo. The residue thus obtained was purified by flash column chromatography (silica, 7N solution of NH3 in MeOH in DCM, 0/100 to 10/90). Thedesired fractions were concentrated in vacuo to yield a fraction that was further purified by reverse phase HPLC (Stationary phase: C18 XBridge 30 x 100 mm 5 jim, mobile phase: gradient from 81% 10mM NH4CO3H pH 9 solution in water, 19% CH3CN to 64% 10mM NH4CO3H pH 9 solution in water, 36% CH3CN). The desired fractions were collected and extracted with EtOAc and DCM/2-PrOH (9/1). The desiredfractions were collected and concentrated in vacuo to yield product 11 as yellow oil (7.7 mg, 11% yield).

The synthetic route of 83570-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

83570-42-7, To a stirred solution of 1-(quinoxalin-6-yl)ethan-1 -one (0.8 g,4.65mmol) in dry MeOH (20 mL), sodium borohydride (0.36 g, 9.3 mmol ) was added portion wise at 0 C and the resulting mixture was stirred for 1 h. It was then concentrated, diluted with DCM (80 mL), washed with water (20 mL), dried over Na2SO4 and concentrated. The crude product was taken for next step without further purification. Yield: 75% (600 mg, dark brown liquid). 1H NMR (400 MHz, DMSO-d6): delta 8.91 -8.89 (m, 2H), 8.03 (t, J = 11.6 Hz, 2H), 7.87-7.86 (m, 1 H), 5.49 (d, J = 5.9 Hz, 1 H), 4.97 (t, J = 6.2 Hz, 1 H), 1.42 (d, J = 8.6 Hz, 3H). LCMS: (Method A) 175.0 (M+H), Rt. 1.89 min, 95.0% (Max).

The synthetic route of 83570-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

83570-42-7, To a stirred solution of 1-(quinoxalin-6-yl)ethan-1-one (0.8 g,4.65mmol) in dry MeOH (20 mL), sodium borohydride (0.36 g, 9.3 mmol) was added portion wise at 0 C and the resulting mixture was stirred for 1 h. It was then concentrated, diluted with DCM (80 mL), washed with water (20 mL), dried over Na2SO4 and concentrated. The crude product was taken for next step without further purification. Yield: 75% (600 mg, dark brown liquid). 1H NMR (400 MHz, DMSO-d6): delta 8.91-8.89 (m, 2H), 8.03 (t, J = 11.6 Hz, 2H), 7.87-7.86 (m, 1H), 5.49 (d, J = 5.9 Hz, 1H), 4.97 (t, J = 6.2 Hz, 1H), 1.42 (d, J = 8.6 Hz, 3H). LCMS: (Method A) 175.0 (M+H), Rt. 1 .89 min, 95.0% (Max).

83570-42-7 1-(Quinoxalin-6-yl)ethanone 22631249, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider