Category: 879-65-2

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

3. Take a 50 mL round bottom flask.To which quinoxaline-2-carboxylic acid (175 mg, 1 mmol) andEDCI (230mg, 1.2mmol) andHOBT (176mg, 1.3mmol)Soluble in 20mL DMF solution,The ratio of the amounts of the three raw materials is 1:1.2:1.3.Compound D (308 mg, 1.2 mmol) was added after half an hour.Stir at room temperature and monitor with TLC.After the reaction was completed, the reaction solution was washed with water, 5% HCl, 5% Na?The organic phase was dried over anhydrous Na 2 SO 4 and evaporated under reduced pressure.The crude product was separated and purified by thin layer chromatography (PE: EA = 2:1) to afford objective compound 1.Product 1 was a pale yellow solid with a yield of 40%.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Hefei University of Technology; Li Qingshan; Shen Bangnian; Li Yao; Ruan Banfeng; (19 pag.)CN109912574; (2019); A;,
Quinoxaline – Wikipedia
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

Example 108; 4-(4-Fluoro-benzyl)-1-(quinoxaline-2-carbonyl)-piperidine-4-carbonitrile To a stirred solution of Quinoxaline-2-carboxylic acid (100 mg, 0.57 mmol) in DMF was added DIPEA (0.3 ml, 0.72 mmol), EDCI (220 mg, 1.15 mmol), and HOBT (116 mg, 0.86 mmol) at 0 C. The reaction mixture was stirred for half an hour atroom temperature and was added 4-(4-Fluoro-benzyl)-piperidine-4-carbonitrile (125 mg, 0.57 mmol). The reaction mixture was stirred overnight atroom temperature, diluted with water and extracted with ethyl acetate. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated under reduced pressure. Thus obtained crude was purified with column chromatography (Si-gel, 0.5% MeOH-DCM) to afford 110 mg (51.4%) of 4-(4-Fluoro-benzyl)-1-(quinoxaline-2-carbonyl)-piperidine-4-carbonitrile. LC/MS [M+H]+: 375.4. 11H-NMR (400 MHz, DMSO-d6) delta (ppm): 9.1 (s, 1H), 8.17-7.94 (m, 4H), 7.36 (t, 2H), 7.17 (t, 2H), 4.64 (d, 1H), 4.0 (d, 1H), 3.27 (m, 1H), 2.99 (m, 3H), 1.93 (m, 1H), 1.79 (m, 3H). HPLC: 97.1%

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KHAMRAI, Uttam; Ronsheim, Matthew; Karak, Sumit Kumar; US2010/152160; (2010); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

Aniline 6 (3.70 g, 22.4 mmol) was added to a 250 mL round bottom flask with stir bar followed by quinoxaline-2-carboxylic acid (4.88 g, 28.0 mmol), EDC HCl (5.58 g, 29.1 mmol),and DMF (75 mL). DIPEA (11.5 mL) was added and the reaction was stirred for 16 h. A sample aliquot was taken from the reaction, dissolved in 1 mL HPLC grade MeCN, and analyzed with LC-MS to confirm the completion of the reaction.The reaction was diluted with DCM (500 mL) water (500 mL) and sat. aq. sodium bicarbonate (250 mL). The layers wereseparated and the aqueous was extracted with DCM (3 x 150 mL). The combined organic layers were washed with 0.1 NHCl (1 x 75 mL), then brine, dried over sodium sulfate, and condensed to give amide 7 as a tan solid (7.12 g, 99%).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Porter, Jacob D.; Lindeman, Sergey V.; Dockendorff, Chris; Tetrahedron Letters; vol. 61; 12; (2020);,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

In one embodiment, quinoxaline acid is combined with [GDI] in anhydrous tetrahydrofuran and heated to provide the acyl imidazole.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2004/14875; (2004); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred solution quinoxaline-2-carboxylic acid 5 (0.2 g, 1.14 mmol) in dichloromethane was added triethylamine (0.18 ml, 1.2 equiv) and ethylchloroformate (0.14 ml, 1.2 equiv) at 0 C and stirred for 30 min. Then, the above reaction mixture was transferred to a dropping funnel and added to a cooled solution of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin 3 (0.1 g, 0.158 mmol) in dichloromethane and triethylamine at 0 C. The contents were stirred at the same temperature for 1h and gradually allowed to warm at room temperature and stirring continued for another 1h. After completion, water (5 mL) was added into reaction mixture and basified to pH ~ 8 with sodium carbonate and extracted with chloroform (3 ¡Á 25 mL). The solvent was evaporated and purified on column chromatography with silica gel (100-200) with 90% chloroform/hexane to furnish compound 6 in good yield (0.111 g, 89%). 1H NMR (400 MHz, CDCl3) delta: 10.17 (s, 1H), 9.83 (s, 1H), 8.85-8.78 (m, 8H), 8.24-8.21 (m, 5H), 8.19-8.14 (m, 6H), 7.88-7.85 (m, 2H), 7.70-7.64 (m, 9H), -2.85 (s, 2H). ESIMS m/z: calcd for C53H36N7O: 786.3(M+H), found: 786.3 (M+H).

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kumar, Dalip; Chandra Shekar; Mishra, Bhupendra; Kurihara, Ryohsuke; Ogura, Maiko; Ito, Takeo; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3221 – 3224;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the product of Example 4A (25 mg, 0.088 mmol) in N,N- dimethylformamide (0.5 mL) was added quinoxaline-2-carboxylic acid (16.8 mg, 0.097 mmol), 1 – [bis(dimethylamino)methylene] – 1H- 1 ,2,3-triazolo[4,5-]pyridinium 3-oxid hexafluorophosphate (36.7 mg, 0.097 mmol, HATU), and N,N-diisopropylethylamine (0.046 mL, 0.26 mmol) at ambient temperature. The reaction mixture was stirred for 3 hours and then was purified by preparative HPLC [Waters XBridge C18 5 mupiiota OBD column, 30 x 100 mm, flow rate 40 mL/minute, 5-100% gradient of acetonitrile in buffer (0.1 % trifluoroacetic acid)] to give the title compound (30 mg, 0.068 mmol, 77% yield). JH NMR (400 MHz, DMSO-<) delta ppm 9.57 (s, 1H), 9.40 (s, 1H), 8.74 (s, 1H), 8.21 - 8.10 (m, 2H), 7.96 (ddd, J = 5.5, 4.6, 3.2 Hz, 2H), 7.47 (t, J = 8.9 Hz, 1H), 7.05 (dd, J = 11.4, 2.8 Hz, 1H), 6.84 (ddd, J = 8.9, 2.9, 1.2 Hz, 1H), 4.47 (s, 2H), 2.38 (s, 6H); MS (ESI+) m/z 440 (M+H)+. As the paragraph descriping shows that 879-65-2 is playing an increasingly important role. Reference£º
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; FROST, Jennifer, M.; PLIUSHCHEV, Marina, A.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; SWEIS, Ramzi, Farah; DART, Michael, J.; RANDOLPH, John, T.; MURAUSKI, Kathleen; (674 pag.)WO2019/90076; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of the product of Example 4A (25 mg, 0.088 mmol) in N,N- dimethylformamide (0.5 mL) was added quinoxaline-2-carboxylic acid (16.8 mg, 0.097 mmol), 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (36.7 mg, 0.097 mmol, HATU), and N,N-diisopropylethylamine (0.046 mL, 0.26 mmol) at ambient temperature. The reaction mixture was stirred for 3 hours and then was purified by preparative HPLC [Waters XBridge C185 mum OBD column, 30 ¡Á 100 mm, flow rate 40 mL/minute, 5-100% gradient of acetonitrile in buffer (0.1 % trifluoroacetic acid)] to give the title compound (30 mg, 0.068 mmol, 77% yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 9.57 (s, 1H), 9.40 (s, 1H), 8.74 (s, 1H), 8.21 – 8.10 (m, 2H), 7.96 (ddd, J = 5.5, 4.6, 3.2 Hz, 2H), 7.47 (t, J = 8.9 Hz, 1H), 7.05 (dd, J = 11.4, 2.8 Hz, 1H), 6.84 (ddd, J = 8.9, 2.9, 1.2 Hz, 1H), 4.47 (s, 2H), 2.38 (s, 6H); MS (ESI+) m/z 440 (M+H)+.

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; CALICO LIFE SCIENCES; ABBVIE, INC.; SIDRAUSKI, Carmela; PLIUSCHEV, Marina; FROST, Jennifer, M.; BLACK, Lawrence, A.; XU, Xiangdong; SWEIS, Ramzi, Farah; SHI, Lei; ZHANG, Qinwei, I.; TONG, Yunsong; HUTCHINS, Charles, W.; CHUNG, Seungwon; DART, Michael, J.; (661 pag.)WO2017/193063; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To the resin 13 (560 mg) in DMF (2.5 mL) were added a solutionof the appropriate Fmoc-protected amino acid (see Tables 1-3)(0.3 M), PyBOP (0.3 M) and HOBt (0.3 M) in dry DMF (4.2 mL). Thesuspensions were stirred for 3 min and then DIPEA (0.6 M) wasadded. The suspensions were stirred for 3 h under an argon atmosphereat rt. The resins were washed successively with DCM(150 mL), MeOH (120 mL), DCM (75 mL) and dried overnight undervacuum to give resins 14, each bearing an appropriate Fmoc-protectedamino acid. To the resins 14 (161 mg, 0.13 mmol) wereadded a solution of piperidine (20%, v/v) in DCM (2.1 mL) and themixtures were stirred for 1 h at rt. After filtration, the resins werewashed successively with DCM (50 mL), MeOH (45 mL), DCM(25 mL) and dried under vacuum to give resins 15. Portions(65 mg) of resins 15 were placed in reactor wells (12 mL) of anautomated synthesizer reaction block (40-well format) (AdvancedChemTech). To each well was added a solution of appropriate carboxylicacid (see Tables 1-3) (0.3 M), PyBOP (0.3 M) and HOBt 6-Cl(0.3 M) and DIPEA (0.6 M) in dry DMF (2 mL). The suspensionswere vortexed at 300 rpm over a period of 5 h under an argonatmosphere. The wells were then filtered to remove the reactivesolution from the resins 16 and washed successively with THF,DCM, MeOH and DCM.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Talbot, Amelie; Maltais, Rene; Kenmogne, Lucie Carolle; Roy, Jenny; Poirier, Donald; Steroids; vol. 107; (2016); p. 55 – 64;,
Quinoxaline – Wikipedia
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1.22: f4-(3-Chloro-phenvlethynvl)-4-hydroxv-piperidin-1-vll-quinoxalin-2-vl- methanone; MS (LC/MS): 392 [M+H]TLC Rf: 0.24 (EtOAc/cyclohex 1 :1)

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/89700; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

Thionyl chloride (1 mL) was added to a solution of 2-quinoxalinecarboxylic acid (125 mg, 0.718 mmol) in methanol (20 mL). The resulting solution was stirred for 3 hours and evaporated to dryness under reduced pressure. The resulting off-white solid was collected (115 mg, 85%). 1H NMR (400 MHz, CDCl3): delta (ppm) 9.567 (s, 1H, H5), 8.342 (dd, J1-2 = 8 Hz, J1-3 2 Hz, 1H, H1), 8.284 (dd, J4-3 = 8Hz, J4-2 = 0.8 Hz, 1H, H4), 7.938 (q-br, J2/3-3/2/1/4 = 8.4 Hz 2H, H2/3).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
Quinoxaline – Wikipedia
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