Category: 90272-84-7

New Advances in Chemical Research, May 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. Application of 90272-84-7, We’ll be discussing some of the latest developments in chemical about CAS: 90272-84-7, name is 2-Chloro-7-methylquinoxaline. In an article，Which mentioned a new discovery about 90272-84-7

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic alpha-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.

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Reference：
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1056 | ChemSpider

90272-84-7, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 90272-84-7, Name is 2-Chloro-7-methylquinoxaline, molecular formula is C9H7ClN2. In a article，once mentioned of 90272-84-7

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions – I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety – to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

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Quinoxaline – Wikipedia,
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COA of Formula: C9H7ClN2, New research progress on 90272-84-7 in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.90272-84-7, Name is 2-Chloro-7-methylquinoxaline, molecular formula is C9H7ClN2. In a article，once mentioned of 90272-84-7

The synthesis of a novel family of pentathiepino-pyrrolo[1,2-a]pyrazine derivatives is reported. These compounds are formed by the reaction of alkynyl-substituted heterocyclic precursors with elemental sulfur in the presence of molybdenum oxo bis-tetrasulfide under very mild conditions.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1059 | ChemSpider

90272-84-7, Name is 2-Chloro-7-methylquinoxaline, belongs to quinoxaline compound, is a common compound. Application In Synthesis of 2-Chloro-7-methylquinoxalineIn an article, once mentioned the new application about 90272-84-7.

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders

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Quinoxaline – Wikipedia,
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Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 2-Chloro-7-methylquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 90272-84-7

The unexpected and facile molybdenum mediated formation of tri- and tetracyclic pentathiepins from pyrazine-alkynes and sulfur

The synthesis of a novel family of pentathiepino-pyrrolo[1,2-a]pyrazine derivatives is reported. These compounds are formed by the reaction of alkynyl-substituted heterocyclic precursors with elemental sulfur in the presence of molybdenum oxo bis-tetrasulfide under very mild conditions.

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Quinoxaline – Wikipedia,
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Synthetic Route of 90272-84-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.90272-84-7, Name is 2-Chloro-7-methylquinoxaline, molecular formula is C9H7ClN2. In a Patent£¬once mentioned of 90272-84-7

Alpha 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd. (by machine translation)

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic alpha-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1056 | ChemSpider

Reference of 90272-84-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.90272-84-7, Name is 2-Chloro-7-methylquinoxaline, molecular formula is C9H7ClN2. In a Article£¬once mentioned of 90272-84-7

Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination

A rapid construction of enantioenriched benzo-fused quinolizidines, indolizidines, and their analogues by ruthenium-catalyzed asymmetric cascade hydrogenation/reductive amination of quinolinyl- and quinoxalinyl-containing ketones has been developed. This reaction proceeds under mild reaction conditions, affording chiral benzo-fused aliphatic N-heterocyclic compounds with structural diversity in good yields (up to 95 %) with excellent diastereoselectivity (up to >20:1 dr) and enantioselectivity (up to >99 % ee). Furthermore, this catalytic protocol is applicable to the formal synthesis of (+)-gephyrotoxin.

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Quinoxaline – Wikipedia,
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Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 90272-84-7, C9H7ClN2. A document type is Article, introducing its new discovery., 90272-84-7

Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469)

2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions – I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety – to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-{4-[(2-quinoxalinyl)oxy]phenoxy}propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1058 | ChemSpider