Category: 945400-80-6

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Goya-Jorge, Elizabeth; Abdmouleh, Fatma; Carpio, Laureano E.; Giner, Rosa M.; Sylla-Iyarreta Veitia, Maite researched the compound: 2-Bromobenzo[d]thiazol-6-amine( cas:945400-80-6 ).Product Details of 945400-80-6.They published the article 《Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities》 about this compound( cas:945400-80-6 ) in European Journal of Pharmaceutical Sciences. Keywords: aryl pyridinylbenzothiazole hydrocarbon receptor antimicrobial agonistic activity; Agonism; Ah receptor; Antibacterial; Antibiofilm; Antifungal; Benzothiazole. We’ll tell you more about this compound (cas:945400-80-6).

Benzothiazole is a privileged scaffold in medicinal chem. present in diverse bioactive compounds with multiple pharmacol. applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl and 2-pyridinylbenzothiazoles as antimicrobial agents and as aryl hydrocarbon receptor (AhR) modulators. The antimicrobial activity against Gram-pos. (S. aureus and M. luteus) and Gram-neg. (P. aeruginosa, S. enterica and E. coli) pathogens yielded MIC ranging from 3.13 to 50μg/mL and against the yeast C. albicans, the benzothiazoles displayed MIC from 12.5 to 100μg/mL. All compounds showed promising antibiofilm activity against S. aureus and P. aeruginosa. The arylbenzothiazole 12 displayed the greatest biofilm eradication in S. aureus (74%) subsequently verified by fluorescence microscopy. The ability of benzothiazoles to modulate AhR expression was evaluated in a cell-based reporter gene assay. Six benzothiazoles (7, 8-10, 12, 13) induced a significant AhR-mediated transcription and interestingly compound 12 was also the strongest AhR-agonist identified. Structure-activity relationships are suggested herein for the AhR-agonism and antibiofilm activities. Furthermore, in silico predictions revealed a good ADMET profile and druglikeness for the arylbenzothiazole 12 as well as binding similarities to AhR compared with the endogenous agonist FICZ.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki-Miyaura cross-coupling reactions, published in 2013-09-02, which mentions a compound: 945400-80-6, Name is 2-Bromobenzo[d]thiazol-6-amine, Molecular C7H5BrN2S, Name: 2-Bromobenzo[d]thiazol-6-amine.

In positron emission tomog. [11C]PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer’s disease. Synthetic routes for the preparation of the precursor of [11C]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple 1-step synthesis of the precursor of [11C]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [18F] precursor derivatives of PIB containing a nitro function.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

COA of Formula: C7H5BrN2S. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Bromobenzo[d]thiazol-6-amine, is researched, Molecular C7H5BrN2S, CAS is 945400-80-6, about Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki-Miyaura cross-coupling reactions. Author is Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde.

In positron emission tomog. [11C]PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer’s disease. Synthetic routes for the preparation of the precursor of [11C]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple 1-step synthesis of the precursor of [11C]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [18F] precursor derivatives of PIB containing a nitro function.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities, published in 2020-08-01, which mentions a compound: 945400-80-6, Name is 2-Bromobenzo[d]thiazol-6-amine, Molecular C7H5BrN2S, Reference of 2-Bromobenzo[d]thiazol-6-amine.

Benzothiazole is a privileged scaffold in medicinal chem. present in diverse bioactive compounds with multiple pharmacol. applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl and 2-pyridinylbenzothiazoles as antimicrobial agents and as aryl hydrocarbon receptor (AhR) modulators. The antimicrobial activity against Gram-pos. (S. aureus and M. luteus) and Gram-neg. (P. aeruginosa, S. enterica and E. coli) pathogens yielded MIC ranging from 3.13 to 50μg/mL and against the yeast C. albicans, the benzothiazoles displayed MIC from 12.5 to 100μg/mL. All compounds showed promising antibiofilm activity against S. aureus and P. aeruginosa. The arylbenzothiazole 12 displayed the greatest biofilm eradication in S. aureus (74%) subsequently verified by fluorescence microscopy. The ability of benzothiazoles to modulate AhR expression was evaluated in a cell-based reporter gene assay. Six benzothiazoles (7, 8-10, 12, 13) induced a significant AhR-mediated transcription and interestingly compound 12 was also the strongest AhR-agonist identified. Structure-activity relationships are suggested herein for the AhR-agonism and antibiofilm activities. Furthermore, in silico predictions revealed a good ADMET profile and druglikeness for the arylbenzothiazole 12 as well as binding similarities to AhR compared with the endogenous agonist FICZ.

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Reference:
Quinoxaline – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 945400-80-6, is researched, Molecular C7H5BrN2S, about Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities, the main research direction is aryl pyridinylbenzothiazole hydrocarbon receptor antimicrobial agonistic activity; Agonism; Ah receptor; Antibacterial; Antibiofilm; Antifungal; Benzothiazole.Quality Control of 2-Bromobenzo[d]thiazol-6-amine.

Benzothiazole is a privileged scaffold in medicinal chem. present in diverse bioactive compounds with multiple pharmacol. applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl and 2-pyridinylbenzothiazoles as antimicrobial agents and as aryl hydrocarbon receptor (AhR) modulators. The antimicrobial activity against Gram-pos. (S. aureus and M. luteus) and Gram-neg. (P. aeruginosa, S. enterica and E. coli) pathogens yielded MIC ranging from 3.13 to 50μg/mL and against the yeast C. albicans, the benzothiazoles displayed MIC from 12.5 to 100μg/mL. All compounds showed promising antibiofilm activity against S. aureus and P. aeruginosa. The arylbenzothiazole 12 displayed the greatest biofilm eradication in S. aureus (74%) subsequently verified by fluorescence microscopy. The ability of benzothiazoles to modulate AhR expression was evaluated in a cell-based reporter gene assay. Six benzothiazoles (7, 8-10, 12, 13) induced a significant AhR-mediated transcription and interestingly compound 12 was also the strongest AhR-agonist identified. Structure-activity relationships are suggested herein for the AhR-agonism and antibiofilm activities. Furthermore, in silico predictions revealed a good ADMET profile and druglikeness for the arylbenzothiazole 12 as well as binding similarities to AhR compared with the endogenous agonist FICZ.

There is still a lot of research devoted to this compound(SMILES：NC1=CC=C2N=C(Br)SC2=C1)Quality Control of 2-Bromobenzo[d]thiazol-6-amine, and with the development of science, more effects of this compound(945400-80-6) can be discovered.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider