Category: quinoxaline

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.COA of Formula: C9H7NO2.Kacens, J.; Cebure, A.; Neilands, O. published the article 《8-Hydroxyquinophthalone derivatives》 about this compound( cas:1127-45-3 ) in Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija. Keywords: hydroxyquinonaphthalone; quinophthalone hydroxy. Let’s learn more about this compound (cas:1127-45-3).

8-Acetoxyquinophthalone (I, R = Ac, X = H) (II) was prepared in 62% yield by reaction of 8-quinolinol oxide with 1,3-indandione in Ac2O. Analogously prepared was I (R = Ac, X = Cl) in 62% yield. Hydrolysis of the acetate gave the corresponding alcs. (I, R = H, (Cl). Treatment of II with SO2Cl2 gave indandione (III, X = H). Analogously III (X = C) was obtained.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Propane-1,2-diamine dihydrochloride(SMILESS: C[C@H](N)CN.[H]Cl.[H]Cl,cas:19777-66-3) is researched.COA of Formula: C9H7NO2. The article 《Enantiomeric impurities in chiral catalysts, auxiliaries, synthons and resolving agents. Part 2》 in relation to this compound, is published in Tetrahedron: Asymmetry. Let’s take a look at the latest research on this compound (cas:19777-66-3).

The enantiomeric purity of reagents used in asym. synthesis is of fundamental importance when evaluating the selectivity of a reaction and the product purity. In this work, 109 chiral reagents (many recently introduced) are assayed. Approx. 64% of these reagents had moderate to high levels of enantiomeric impurities (i.e. from >0.1% to <16%). The type of chiral reagents assayed and used in enantioselective synthesis include metal-ligand catalysts for allylic substitutions, catalysts for addition of Grignard reagents and other additions, epoxidations and reduction of ketones and aldehydes; Ru-complex auxiliaries for asym. cyclopropanation, as well as amine, diamine, alc., diol, amino alc., carboxylic acid and oxazolidinone auxiliaries; epoxide, lactone, furanone, pyrrolidinone, nitrile, sulfoximine and carboxylic acid synthons (including malic acid, mandelic acid, lactic acid and tartaric acid); and a variety of chiral resolving agents. Accurate, efficient assays for all compounds are given. This literature about this compound(19777-66-3)Category: quinoxalinehas given us a lot of inspiration, and I hope that the research on this compound((S)-Propane-1,2-diamine dihydrochloride) can be further advanced. Maybe we can get more compounds in a similar way.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Hai-jun; Li, Cheng; Wang, Lai-lai researched the compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ).COA of Formula: C38H34N2O4P2.They published the article 《Stereoselective alternating copolymerization of propene and carbon monoxide catalyzed by Pd(II) -chiral ligands treated with BF3 · Et2O》 about this compound( cas:221012-82-4 ) in Fenzi Cuihua. Keywords: stereoselective alternating polymerization propylene carbon monoxide; palladium phosphine complex boron compound catalyst stereoselective alternating polymerization. We’ll tell you more about this compound (cas:221012-82-4).

The use of BF3·Et2O as a co-catalyst in the alternating copolymerization of propene and carbon monoxide catalyzed by [L2]Pd (OAC)2 (L2 = chiral diphosphine ligand) in CH2Cl2/CH3OH was reported. High yields of chiral polyketone were obtained. 13C NMR, 1H NMR and molar optical rotation confirmed that the copolymers have an alternating structure and high streroregularity. The IR spectra of the copolymers showed that both spiroketal and pure ketone structures were present at the same time. Low mol. weight and wide polydispersity of the chiral polyketones were achieved.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Propane-1,2-diamine dihydrochloride(SMILESS: C[C@H](N)CN.[H]Cl.[H]Cl,cas:19777-66-3) is researched.COA of Formula: C38H34N2O4P2. The article 《Metal Complexes with Cis α Topology from Stereoselective Quadridentate Ligands with Amine, Pyridine, and Quinoline Donor Groups》 in relation to this compound, is published in Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:19777-66-3).

Though the principles governing quadridentate topol. and metal stereochem. were known for some time, the cis α topol. was little exploited in designing catalysts for asym. reactions. Study of the inorganic chem. of labile metal cis α complexes was undertaken as a prelude to exploring their potential to serve as catalysts for a variety of different reactions. The synthesis of 1st row transition metal complexes of quadridentate ligands with ethylenediamine (en) and S-propylenediamine (S-pn) backbones that were alkylated at N with either pyridine (py) or quinoline (qn) donor groups as well as with noncoordinating benzyl (Bn) or pentafluorobenzyl (F5Bn) groups was undertaken. The steric and electronic properties vary throughout the ligand series, en(Bn)py, 1, en(F5Bn)py, 2, S-pn(F5Bn)py, 3, and S-pn(F5Bn)qn, 4. These ligands were reacted with MCln salts (n = 2, M = Mn, Fe, Co, Ni, Cu, Zn; n = 3, M = Fe) to generate, in most cases, octahedral complexes with the targeted cis α topol. UV/visible, NMR, IR, cyclic voltammetry (CV), and conductivity anal. are described for the metal compounds x-ray structural anal. of [Cu{en(F5Bn)py}Cl]Cl reveals a five coordinate square pyramidal geometry. Single or major diastereomers were obtained for all diamagnetic Zn(II) complexes as well as for Co(III) analogs that were prepared by oxidation of Co(II) species using Br2 as the oxidant. Electronic differences among ligands are reflected in the oxidation potentials of the resp. metal complexes as determined by CV, with fluorinated systems showing greater resistance to oxidation, as expected.

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Formula: C38H34N2O4P2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Application of Copper(II)-Dipyridylphosphine Catalyst in the Asymmetric Hydrosilylation of Simple Ketones in Air. Author is Zhang, Xi-Chang; Wu, Yan; Yu, Feng; Wu, Fei-Fei; Wu, Jing; Chan, Albert S. C..

A copper(II) salt/chiral dipyridylphosphine/PhSiH3 system (see scheme) acts as a very effective and practical catalyst for the asym. reduction of heteroaromatic and other types of ketones in air with good-to-excellent enantioselectivities (up to 94 %), giving many chiral alcs. that are intermediates for physiol. active compounds Remarkable temperature effects were observed for some heteroaromatic ketones.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Quality Control of (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine, is researched, Molecular C38H34N2O4P2, CAS is 221012-82-4, about Iridium-catalyzed asymmetric hydrogenation of pyridinium salts. Author is Ye, Zhi-Shi; Chen, Mu-Wang; Chen, Qing-An; Shi, Lei; Duan, Ying; Zhou, Yong-Gui.

A highly efficient iridium-catalyzed asym. hydrogenation of 2-substituted pyridinium salts is developed. A series of chiral 2-substituted piperidines were obtained in good to excellent yields and up to 93% ee.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Obshchei Khimii called Synthesis and study of N-oxides of heterocyclic compounds. I. N-Oxides of derivatives of morphine, tetra-hydroisoquinoline, and quinoline, Author is Khaletskii, A. M.; Pesin, V. G.; Tsin, Chshou, which mentions a compound: 1127-45-3, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2, Quality Control of 8-Hydroxyquinoline 1-oxide.

cf. Ochiai, C.A. 48, 3359i. Heating 8.4 g. codeine with 45 ml. 3% H2O2 at 50-60° gave after evaporation 8 g. codeine N-oxide, m. 206-8° (H2O); HCl salt, m. 214-17° (EtOH). To 5 g. dihydrohydroxycodeinone-HCl was added 10 ml. 10% NaOH yielding 93% dihydrohydroxycodeinone, m. 213-16°, which with 3% H2O2 as above gave 46.2% dihydrohydroxycodeinone N-oxide, decompose 152-3°, which gives a red color with Ac2O; picrate, m. 190-2°; HCl salt, m. 167-8°. The oxide treated with SO2 in warm EtOH gave 62.5% C18H23O8NS, decompose 169-70°, which was evidently an isomer of dihydrohydroxycodeinone sulfate; with BaCl2 solution it readily gave BaSO4; hydrolysis with 10% NaOH gave the original dihydrohydroxycodeinone, m. 207-9° (sulfate, m. 138-9°). Salsolidine (3 g.) in 20 ml. Me2CO and 30 ml. H2O treated with 2.5 ml. 30% H2O2 after several days at room temperature gave 15.48% N-hydroxysalsolidine, m. 100-1° (aqueous EtOH), which reduced Fehling and Tollens reagents. Similarly, N-methylsalsolidine gave N-methylsalsolidine N-oxide picrate, m. 133-4° (aqueous EtOH); HCl salt analog, decompose 162-3°. Oxidation of salsoline with 3% H2O2 in AcOH or with BzO2H in CHCl3 either gave no reaction or failed to yield any definite products. N-Methylsalsoline with aqueous H2O2 at room temperature in 3 days gave N-methylsalsoline N-oxide, m. 183° (EtOH); HCl salt, m. 186°. Oxidation of 8-hydroxyquinoline in CHCl3 with BzO2H with cooling gave yellow 8-hydroxyquinoline N-oxide, m. 137-8° (H2O); the same formed on oxidation with 30% H2O2 in AcOH-Ac2O at 40-5° in 3 hrs., but with 30% H2O2-AcOH in 2 hrs. only the starting material was recovered. 8-Hydroxyquinoline N-oxide treated with alc. KOH and Etl at reflux gave 8-ethoxyquinoline N-oxide, isolated as picrate, m. 135-8°; the same formed on treatment of 8-ethoxyquinoline with AcOH-Ac2O-30% H2O2 at 45-50°; HCl salt, m. 158°; free oxide, m. 61-2°. Similarly 2-phenylquinoline-4-carboxylic acid and AcOH-H2O2 gave 76% N-oxide, m. 244°, and 15% benzoylanthranilic acid, m. 170-2°. Oxidation of 2-phenylquinoline-4-carboxylic acid with BzO2H in CHCl3 in 2 days gave no evident reaction, the same being true of oxidation with 25% H2O2 in EtOH-Me2CO at 50°. Reduction of 2-phenylquinoline-4-carboxylic acid N-oxide with Na hydrosulfite in aqueous EtOH gave the original 2-phenylquinoline-4-carboxylic acid, m. 205-7°.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Nickel(ii)fluoridetetrahydrate, is researched, Molecular F2H8NiO4, CAS is 13940-83-5, about Parameters of dosimetric interest of some vanadium and nickel compounds.Category: quinoxaline.

Mass attenuation coefficients (μm), effective at. numbers (Zeff) and electron densities (Nel) of some V compounds V2O3, VO2, VF3, VF4, NH4VO3 and Ni compounds NiF2, NiCl2, NiCl2.6H2O, Ni(ClO4)2.6H2O, NiF2.4H2O have been computed over a wide energy region from 10 keV to 100 GeV. In all the parameters, a similar trend is observed All the parameters initially possesses maximum values, which decreases very rapidly upto 100 keV, then becomes almost constant upto 3 MeV and with the further increase in the incident photon energy beyond 3 MeV, values of all the parameters also increase which may be due to dominance of different partial photon interaction process in different energy regions.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Syntheses of 8-hydroxyquinoline N-oxide and its metallic complex salts》. Authors are Murase, Ichiro.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).SDS of cas: 1127-45-3. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

8-Hydroxyquinoline N-oxide (IH) was obtained by the direct oxidation of 8-hydroxyquinoline with AcOH + 30% H2O2 or phthalic monoperacid as yellow crystals m. 138°. Greenish yellow CuI2.H2O, greenish black (MnI)2O.H2O and brownish black FeI3 were obtained. Fe(II), Ni, Co, and Zn do not form complexes.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 221012-82-4, is researched, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2Journal, Tetrahedron called First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates, Author is Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine, the main research direction is iridium chiral ligand hydrogenation quinoxaline.Computed Properties of C38H34N2O4P2.

For the first time, the asym. hydrogenation of quinoxaline-2-carboxylates was performed successfully. The best catalysts are based on iridium complexes modified by chiral phosphorous ligands. Accelerated examination of ligands and catalysts has been undertaken by using a Chemspeed workstation (automated instrument) workstation enables carrying out, in parallel, eight independent catalytic reactions at the laboratory scale. Tetrahydroquinoxaline-2-carboxylates could be obtained with high yields and up to 74% ee. The synthesis of the target compounds was achieved using chiral ligands, such as (11aR)-10,11,12,13-tetrahydro-N,N-dimethyldiindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin-5-amine [i/e/. (R)-siphos], 1,1′-[(1S)-6,6′-dimethoxy[1,1′-biphenyl]-2,2′-diyl]bis[1,1-diphenylphosphine] [i.e., (S)-MeO-BIPHEP], (R)-Cl-MeO-BIPHEP, (R)-difluorphos, (R)-GARPHOS, (R)-P-PHOS, (S)-C3-TUNEPHOS [i.e., 1,1′-[(13aS)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin-1,13-diyl]bis[1,1-diphenylphosphine]], (S)-SEGPHOS, (S)-Xyl-SolPhos, CATASium T3, N-[(1R)-2-[(11bR)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yloxy]-1-methylethyl]-N’-phenylurea [i.e., ureaphos], SL-J404-1, SL-J006-1, SL-J002-1, SL-J003-1, SL-J009-1, SL-T002-1, SL-W006-1. Pre-catalysts included bis(acetato-κO,κO’)[(4R)-1,1′-[4,4′-bi-1,3-benzodioxole]-5,5′-diylbis[1,1-diphenylphosphine-κP]]ruthenium [i.e., Ru(OAc)2[(R)-segphos]], [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium [i.e., RuCl[(R,R)-TsDPEN][p-cymene]] and [1,1′-(1S)-[4,4′-bi-1,3-benzodioxole]-5,5′-diylbis[1,1-diphenylphosphine-κP]][4-cyano-3-nitrobenzenecarboxylato(2-)-κC6,κO1](η3-2-propen-1-yl)iridium.

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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider