Category: quinoxaline

Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates was written by Park, Nathaniel H.;Teverovskiy, Georgiy;Buchwald, Stephen L.. And the article was included in Organic Letters in 2014.Computed Properties of C8H5ClN2 This article mentions the following:

A new air-stable nickel precatalyst for C-N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C-N bond formation to include both a wide range of aryl and heteroaryl electrophiles and aryl, heteroaryl, and alkylamines. The catalyst system is also compatible with a weak base, allowing the amination of substrates containing base-sensitive functional groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Computed Properties of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Computed Properties of C8H5ClN2

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis and application of novel styryl dyes derived from 1,4-diethyl-1,2,3,4-tetrahydro-6-methoxyquinoxaline was written by Satam, Vijay;Rajule, Rajkumar;Bendre, Samir;Bineesh, Purushotthaman;Kanetkar, Vinod. And the article was included in Journal of Heterocyclic Chemistry in 2009.Category: quinoxaline This article mentions the following:

1,4-Diethyl-1,2,3,4-tetrahydro-7-methoxyquinoxaline-6-carboxaldehyde was synthesized, characterized, and condensed with suitably substituted active methylene compounds by classical Knoevenagel condensation to obtain five monostyryl dyes and a bis-styryl dye. These novel styryl dyes have hues varying from orange to violet. The dyes were applied to polyester fibers. The spectral and thermal characteristics of the dyes and fastness properties of the dyed polyester fabric were investigated. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Category: quinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Category: quinoxaline

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

CuI/Oxalamide Catalyzed Couplings of (Hetero)aryl Chlorides and Phenols for Diaryl Ether Formation was written by Fan, Mengyang;Zhou, Wei;Jiang, Yongwen;Ma, Dawei. And the article was included in Angewandte Chemie, International Edition in 2016.Quality Control of 6-Chloroquinoxaline This article mentions the following:

Couplings between (hetero)aryl chlorides and phenols can be effectively promoted by CuI in combination with an N-aryl-N’-alkyl-substituted oxalamide ligand to proceed smoothly at 120 °C. For this process, N-aryl-N’-alkyl-substituted oxalamides are more effective ligands than bis(N-aryl)-substituted oxalamides. A wide range of electron-rich and electron-poor aryl and heteroaryl chlorides gave the corresponding coupling products in good yields. Satisfactory conversions were achieved with electron-rich phenols as well as a limited range of electron-poor phenols. Catalyst and ligand loadings as low as 1.5 mol % are sufficient for the scaled-up variants of some of these reactions. Thus, e.g., coupling of 4-chlorotoluene with phenol in presence of CuI and oxalamide I afforded 4-methylphenyl Ph ether (96%). In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Quality Control of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Quality Control of 6-Chloroquinoxaline

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease was written by Le Douaron, Gael;Ferrie, Laurent;Sepulveda-Diaz, Julia E.;Seon-Meniel, Blandine;Raisman-Vozari, Rita;Michel, Patrick P.;Figadere, Bruno. And the article was included in ACS Chemical Neuroscience in 2017.Related Products of 166402-16-0 This article mentions the following:

Parkinson’s disease is a chronic degenerative disease characterized by motor symptoms, which result from the death of midbrain dopamine neurons and concomitant disruption of dopamine mediated neurotransmission. No curative treatment is currently available for this disorder in clin. practice. In the search for druggable neuroprotective compounds for dopamine neurons, the authors have synthesized new 1,4,8-triazaphenanthrenes by combination of 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reaction. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a Parkinson’s disease cellular model has led to the selection of hit compound I. In vitro characterization of I showed that this compound operates via a direct effect on DA neurons with no impact on astroglial cells. Most interestingly, I was able to counteract neurodegeneration in a MPTP lesioned mouse model of Parkinson’s disease, making this compound a promising drug candidate for the treatment of this disorder. In the experiment, the researchers used many compounds, for example, 3-Chloroquinoxalin-6-amine (cas: 166402-16-0Related Products of 166402-16-0).

3-Chloroquinoxalin-6-amine (cas: 166402-16-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Related Products of 166402-16-0

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Novel antagonists of 5-HT₃ receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives was written by Monge, A.;Palop, J. A.;Del Castillo, J. C.;Caldero, J. M.;Roca, J.;Romero, G.;Del Rio, J.;Lasheras, B.. And the article was included in Journal of Medicinal Chemistry in 1993.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:

A series of piperazinylquinoxalines I (R = alkyl, Ph, substituted Ph, R¹ = H; R = H, Et, R¹ = NO₂) were synthesized and studied as 5-HT₃ receptor antagonists in different preparations Antagonism to 5-HT in the longitudinal muscle of the guinea pig ileum was particularly prominent in cyanoquinoxaline derivatives with an alkyl substituent on the piperazine moiety. The pA₂ of some selected compounds against the 5-HT₃ agonist 2-methyl-5HT in the guinea pig ileum was in the range of tropisetron or ondansetron, and one of them, I (R = allyl, R¹ = H), was more potent than these reference compounds by approx. 2 or 3 orders of magnitude. However, these compounds were markedly less potent than either tropisetron or ondansetron as displacers of ³H-BRL 43694 binding to rat cortical membranes or as antagonists of the Bezold-Jarisch reflex in rats. Piperazinylcyanoquinoxalines represent a new class of 5-HT₃ antagonists with a selective effect on guinea pig peripheral receptors. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Application In Synthesis of Ethyl 3-chloroquinoxaline-2-carboxylate

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia was written by Fan, Mengyang;Zhou, Wei;Jiang, Yongwen;Ma, Dawei. And the article was included in Organic Letters in 2015.Recommanded Product: 6-Chloroquinoxaline This article mentions the following:

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120 °C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Recommanded Product: 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Recommanded Product: 6-Chloroquinoxaline

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Hydrogen Auto-transfer Synthesis of Quinoxalines from o-Nitroanilines and Biomass-based Diols Catalyzed by MOF-derived N,P Co-doped Cobalt Catalysts was written by Sun, Kangkang;Li, Dandan;Lu, Guo-Ping;Cai, Chun. And the article was included in ChemCatChem in 2021.Formula: C8H5ClN2 This article mentions the following:

A Co-based heterogeneous catalyst supported on N,P co-doped porous carbon (Co@NCP) is prepared via a facile in-situ doping-carbonization method. The Co@NCP composite features a large surface area, high pore volume, high-d. and strong basic sites. Furthermore, doping of P atoms can regulate the electronic d. of Co. Therefore, Co@NCP exhibited good performance for the synthesis of quinoxalines from o-nitroanilines and biomass-derived diols under alkali-free conditions. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Formula: C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Formula: C8H5ClN2

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Theoretical investigation in the ground state of the energetic and structural properties of quinoxaline and two of its derivatives: 3-chloroquinoxaline and 3-methylquinoxaline was written by El Assyry, A.;Benali, B.;Lazar, Z.;Boucetta, A.;Elblidi, K.;Lakhrissi, B.;Massoui, M.. And the article was included in Physical & Chemical News in 2007.SDS of cas: 5448-43-1 This article mentions the following:

AM1 and MNDO semi – empirical methods of calculation are used to obtain information on the structural and energy properties for some quinoxaline derivatives Formation heat, at. charges and dipole moments permit qual. predictions about the substituent effects by a chlorine or Me group on the quinoxaline properties in the ground state. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1SDS of cas: 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.SDS of cas: 5448-43-1

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Halo o-phenylenediamines and derived heterocyles. Hydrodechlorination of chloroquinoxalines was written by Burton, D. E.;Hughes, D.;Newbold, G. T.;Elvidge, J. A.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1968.Name: 6-Chloroquinoxaline This article mentions the following:

Treatment of 5,6,8-trichloro-7-methylquinoxaline (I) with alkali in aqueous EtOH gives 5,8-dichloro-6-methylquinoxaline (II) cleanly in good yield. 5,6,7,8-Tetrachloroquinoxaline similarly, though less satisfactorily, yields 5,6,8-trichloroquinoxaline and 5,8-dichloroquinoxaline. Further experiments with a bearing on the course of these reactions are described and a possible mechanism is discussed. The preparation of 5,8-dichloro-6-ethoxy-7-methylquinoxaline, a possible product from the reaction I → II, and unambiguous syntheses of III and 5,7-dichloro-6-methylquinoxaline are described. Ir and 1H N.M.R. data for several quinoxalines and their intermediates are also given. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Name: 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Name: 6-Chloroquinoxaline

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Efficient synthesis of quinoxalines from 2-nitroanilines and vicinal diols via a ruthenium-catalyzed hydrogen transfer strategy was written by Xie, Feng;Zhang, Min;Jiang, Huanfeng;Chen, Mengmeng;Lv, Wan;Zheng, Aibin;Jian, Xiujuan. And the article was included in Green Chemistry in 2015.Synthetic Route of C9H8N2O This article mentions the following:

Via a ruthenium-catalyzed hydrogen transfer strategy, we have demonstrated a one-pot method for efficient synthesis of quinoxalines e. g., I, from 2-nitroanilines and biomass-derived vicinal diols for the first time. In such a synthetic protocol, the diols and the nitro group serve as the hydrogen suppliers and acceptors, resp. Hence, there is no need for the use of external reducing agents. Moreover, it has the advantages of operational simplicity, broad substrate scope and the use of renewable reactants, offering an important basis for accessing various quinoxaline derivatives In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Synthetic Route of C9H8N2O).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Synthetic Route of C9H8N2O

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider