Category: quinoxaline

Synthesis of N-(Hetero)aryl Carbamates via CuI/MNAO Catalyzed Cross-Coupling of (Hetero)aryl Halides with Potassium Cyanate in Alcohols was written by Kumar, S. Vijay;Ma, Dawei. And the article was included in Journal of Organic Chemistry in 2018.Safety of 6-Chloroquinoxaline This article mentions the following:

An efficient route to N-(hetero)aryl carbamates, e.g. I, was developed through CuI/MNAO [2-((2-methylnaphthalen-1-yl)amino)-2-oxoacetic acid] catalyzed cross-coupling of (hetero)aryl chlorides with potassium cyanate in alcs. at 120-130 °C. This method utilizes broadly available substrates to afford various N-(hetero)aryl carbamates in good to excellent yields. Moreover, (hetero)aryl bromides and (hetero)aryl iodides were also reacted at low catalyst loadings and relatively low temperatures to provide N-(hetero)aryl carbamates. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Safety of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)₂: Key Roles of DMAP was written by Zhang, Xingjie;Xia, Aiyou;Chen, Haoyi;Liu, Yuanhong. And the article was included in Organic Letters in 2017.Recommanded Product: 6-Chloroquinoxaline This article mentions the following:

A new and general nickel-catalyzed cyanation of hetero(aryl) chlorides using less toxic Zn(CN)₂ as the cyanide source has been developed. The reaction relies on the use of inexpensive NiCl₂·6H₂O/dppf/Zn as the catalytic system and DMAP as the additive, allowing the cyanation to occur under mild reaction conditions (50-80 °C) with wide functional group tolerance. DMAP was found to be crucial for successful transformation, and the reaction likely proceeds via a Ni(0)/Ni(II) catalysis based on mechanistic studies. The method was also successfully extended to aryl bromides and aryl iodides. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Recommanded Product: 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Recommanded Product: 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Application of the AMYR calculating method on quinoxaline, 3-chloroquinoxaline, and 3-methylquinoxaline in the interaction with n water molecules (n varies from 1 to 6) was written by El Assyry, A.;Benali, B.;Boucetta, A.;Lakhrissi, B.. And the article was included in Journal of Structural Chemistry in 2014.Computed Properties of C8H5ClN2 This article mentions the following:

AMYR is a computer program for the calculation of mol. associations using Fraga’s pairwise atom-atom potential. The interaction energy is evaluated through a 1/R expansion. A pairwise dispersion energy term is included in the potential and corrected by a damping function. The program carries out energy minimizations through variable metric methods. The new version allows for the stationary point anal. of the intermol. potential by means of the Hessian eigenvalues. AMYR model is used for the first time in a calculation of quinoxaline, 3-chloroquinoxaline, and 3-methylquinoxaline mols. interacting with some water mols. Intermol. interaction energies are obtained and the stable conformation is determined in each case. The change conformation was considered at α ≈ (CNC) angle when the solute mols. are surrounded by n water mols. (1 ≤ n ≤ 6). In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Computed Properties of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Computed Properties of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Challenging nickel-catalysed amine arylations enabled by tailored ancillary ligand design was written by Lavoie, Christopher M.;MacQueen, Preston M.;Rotta-Loria, Nicolas L.;Sawatzky, Ryan S.;Borzenko, Andrey;Chisholm, Alicia J.;Hargreaves, Breanna K. V.;McDonald, Robert;Ferguson, Michael J.;Stradiotto, Mark. And the article was included in Nature Communications in 2016.Name: 6-Chloroquinoxaline This article mentions the following:

An operationally simple and air-stable ligand/nickel(II) pre-catalyst that accommodated the broadest combination of C(sp²)-N coupling partners reported to date for any single nickel catalyst, without the need for a precious-metal co-catalyst was reported. Key to the unprecedented performance of this pre-catalyst was the application of the new, sterically demanding yet electron-poor bisphosphine PAd-DalPhos. Featured were the first reports of nickel-catalyzed room temperature reactions involving challenging primary alkylamine and ammonia reaction partners employing an unprecedented scope of electrophiles, including transformations involving sought-after (hetero)aryl mesylates for which no capable catalyst system was known. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Name: 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Name: 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines was written by Elumalai, Vijayaragavan;Hansen, Joern H.. And the article was included in SynOpen in 2021.Safety of 6-Chloroquinoxaline This article mentions the following:

A highly efficient and catalyst-free protocol was reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds Remarkably simple and green reaction conditions employed methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature The conditions allow at least 10 g scale synthesis of quinoxalines and preferred starting point for optimization and method of choice for applications in the synthetic community. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Safety of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Direct C-2 arylation of quinoxaline with arylhydrazine salts as arylation reagents was written by Wang, Xing;Wang, Bing;Miao, Jing;Chen, Yi;Zhu, Gaofeng;Zhang, Jiquan;Wang, Jianta;Wang, Haibo;Tang, Lei;Wang, Cong. And the article was included in Journal of Heterocyclic Chemistry in 2022.Application of 5448-43-1 This article mentions the following:

A transition metal-free synthesis of 2-arylquinoxalines I (R = H, Me; R¹ = H, Me, Cl; R² = H, Me; R³ = Ph, 3-methylphenyl, 3-chloro-4-methylphenyl, pyridin-2-yl, etc.) is achieved by using arylhydrazine salt R³NHNH₂.HCl as an aryl radical arylation reagent and air as an oxidant in the presence of K₂CO₃. This protocol is metal-free and environment friendly, has no additives, and mild reaction conditions, and can be used to construct biol. active mols. containing 2-phenylquinoxaline structure. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Application of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Application of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Bistrifluoromethylated organocuprate [Ph₄P]⁺[Cu(CF₃)₂]^–: synthesis, characterization and its application for trifluoromethylation of activated heteroaryl bromides, chlorides and iodides was written by Liu, He;Shen, Qilong. And the article was included in Organic Chemistry Frontiers in 2019.Name: Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:

The synthesis and characterization of a bistrifluoromethylated organocuprate [Ph₄P]⁺[Cu(CF₃)₂]^– and its reactions with a variety of activated heteroaryl bromides, chlorides and iodides were described. These results showed that complex [Ph₄P]⁺[Cu(CF₃)₂]^– can serve as a trifluoromethylating reagent. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Name: Ethyl 3-chloroquinoxaline-2-carboxylate).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Name: Ethyl 3-chloroquinoxaline-2-carboxylate

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis of cyano-substituted heterocycles by tetraethylammonium cyanide was written by Hermann, Klaus;Simchen, Gerhard. And the article was included in Liebigs Annalen der Chemie in 1981.Computed Properties of C11H9ClN2O2 This article mentions the following:

RCN (R = optionally substituted 2-pyridinyl, 4-pyrimidinyl, 4-quinazolinyl, 2-quinazolinyl, 2-quinoxalinyl) were prepared by treating RCl with NMe₃ and treating RN⁺Me₃ Cl^– with Et₄N⁺ CN^– to give RCN. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Computed Properties of C11H9ClN2O2).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Computed Properties of C11H9ClN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Infrared spectra of unsaturated N-heterocyclic compounds. I. Quinoxaline and derivatives was written by Perkampus, H. H.;Roders, A.. And the article was included in Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie in 1960.Reference of 5448-43-1 This article mentions the following:

The regularities within the range of the nonplanar C-H deforming vibrations depending on the number of substituents of the benzene nucleus are applied on quinoxaline and 17 of its derivative Also this class of compound can be joined to the known schedule. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Reference of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Reference of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider