Category: quinoxaline

Tomoda, Haruhiko published the artcileSynthesis and physical properties of pyrido[1′,2′:1,2]imidazo[4,5-b]quinoxalines, Product Details of C8H2Cl4N2, the main research area is pyridoimidazoquinoxaline preparation; fluorescence substituent effect pyridoimidazoquinoxaline preparation.

A series of 2-, 3-, or 4-substituted pyrido[1′,2′:1,2]imidazo[4,5-b]quinoxalines (PIQs) were synthesized in moderate-to-good yields by the reactions of 2-amino-3-chloroquinoxalines (ACQs) with substituted pyridines, and the structures were established. The reactions of ACQs with 3-phenoxycarbonyl and 3-benzoylpyridines gave the corresponding 2-substituted PIQs, while those with 3-Me, 3-Et, 3-benzyl, 3-Ph, 3-ethoxycarbonyl, and 3-acetylpyridines gave the corresponding 4-substituted PIQs. PIQ derivatives having substituents at the 2,4,8- and/or 9-positions were also studied. The spectroscopic and electrochem. properties of a series of PIQs derivatives were studied. PIQ showed a strong green fluorescence at 481.5 and 505 nm (F = 0.40) in ethanol. The introduction of substituents at the 3 position of PIQ altered the color of the fluorescence from blue to green without deteriorating the high quantum yield of PIQ. All of the derivatives showed strong (blue to orange) fluorescence in both solution and the solid state.

Bulletin of the Chemical Society of Japan published new progress about Fluorescence. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Product Details of C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Romer, Duane R. published the artcileSynthesis and fungicidal activity of 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline, the main research area is quinoxaline derivative fungicide structure activity.

A series of 11 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles (I, R1 = H, Cl, CF3, MeO, CN, Ac, NO2; R2 = H, Cl Me, NO2) was prepared by reaction of 2,3-dichloroquinoxalines with disodium (Z)-2,3-dimercapto-2-butenedinitrile in N,N-dimethylformamide. These products were tested for in-vitro fungicidal activity by a Min. Inhibitory Concentration method. Several of these compounds showed broad-spectrum fungicidal activity. The activity exhibited by these compounds was greatly dependent upon the substituents of the quinoxaline ring, with the nitro-substituted derivatives showing the highest levels of antifungal activity. None of the compounds prepared, however, showed fungicidal activity comparable to that of the com. fungicides screened.

Pesticide Science published new progress about Fungicides. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Kolli, Sunder Kumar published the artcileLigand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: An unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis, Related Products of quinoxaline, the main research area is thienyl pyrroloquinoxaline preparation PDE4 inhibitor apoptosis hepatotoxicity; Apoptosis; PDE4; Palladium; Pyrroloquinoxaline; Zebrafish.

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacol. properties when tested in vitro and in zebrafish embryos.

European Journal of Medicinal Chemistry published new progress about Apoptosis. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lee, Sujin published the artcileNanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1, SDS of cas: 25983-14-6, the main research area is triazolo quinoxaline analog preparation renal urea transporter inhibitor diuretic.

Urea transporter A (UT-A) isoforms encoded by the Slc14a2 gene are expressed in kidney tubule epithelial cells, where they facilitate urinary concentration UT-A1 inhibition is predicted to produce a unique salt-sparing diuretic action in edema and hyponatremia. Here we report the discovery of 1,2,4-triazoloquinoxalines and the anal. of 37 synthesized analogs. The most potent compound, 8ay, containing 1,2,4-triazolo[4,3-a]quinoxaline-substituted benzenesulfonamide linked by an aryl ether, rapidly and reversibly inhibited UT-A1 urea transport by a noncompetitive mechanism with IC50 ≈ 150 nM; the IC50 was ∼2 μM for the related urea transporter UT-B encoded by the Slc14a1 gene. Mol. modeling suggested a putative binding site on the UT-A1 cytoplasmic domain. In vitro metabolism showing quinoxaline ring oxidation prompted the synthesis of metabolically stable 7,8-difluoroquinoxaline analog 8bl, which when administered to rats produced marked diuresis and reduced urinary osmolality. 8bl has substantially improved UT-A1 inhibition potency and metabolic stability compared with prior compounds

Journal of Medicinal Chemistry published new progress about Diuretics. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, SDS of cas: 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Obafemi, Craig A. published the artcilePermanganate oxidation of quinoxaline and its derivatives, Application In Synthesis of 39267-05-5, the main research area is permanganate oxidation quinoxaline; chloroquinoxaline permanganate oxidation; quinoxalinone permanganate oxidation; quinoxalinedione permanganate oxidation.

The oxidation reactions of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described. Neutral oxidation of 2-chloro- and 2,3-dichloroquinoxalines afforded the corresponding chloro- and dichloropyrazinedicarboxylic acids in good yield. On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alk. medium gave different products, with the quinoxalin-2(1H)-one forming 1,4-dihydroquinoxaline-2,3-dione, while various substituted quinoxalin-2,3-dione derivatives gave dimeric products.

Helvetica Chimica Acta published new progress about Oxidation. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Application In Synthesis of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Carmeli, Mira published the artcileA new efficient route for the formation of quinoxaline N-oxides and N,N’-dioxides using HOFCH3CN, COA of Formula: C8H2Cl4N2, the main research area is quinoxaline oxide dioxide preparation acetonitrile hydrofluoride oxygen transfer.

HOFCH3CN, a very efficient oxygen-transfer agent made readily from fluorine and aqueous acetonitrile, was reacted with various quinoxaline derivatives to give the corresponding mono N-oxides and especially the N,N’-dioxides in very good yields under mild conditions and short reaction times.

Journal of Organic Chemistry published new progress about Oxidation. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, COA of Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ammar, Y. A. published the artcileSynthesis of some newer thiazolo and thiadiazino derivatives from 6-methyl- or 6-nitro-2,3-dichloroquinoxalines, HPLC of Formula: 39267-05-5, the main research area is chloroquinoxaline cyclocondensation thiourea; quinoxaline dichloro cyclocondensation thiourea; diquinoxalinodithiin; aminoiminodihydrothiazoloquinoxaline preparation cyclization carbon disulfide; thiazoloquinoxaline preparation reaction.

Interaction of 6-methyl- or 6-nitro-2,3-dichloroquinoxaline with thiourea in EtOH led to the formation of diquinoxalinodithiin derivatives I (R = Me, NO2) together with 2-imino-2,3-dihdyrothiazolo[4,5-b]quinoxalines II (R1 = H). 7-Methyl- or 7-nitro-3-amino-2-imino-2,3-dihydrothiazolo[4,5-b]quinoxalines II (R1 = NH2) were also prepared Reaction of II (R1 = NH2) with CS2 gave the corresponding 2-mercaptothiadiazine[5,6-b]quinoxaline derivatives III. Other reactions are also described.

Journal of the Indian Chemical Society published new progress about chloroquinoxaline cyclocondensation thiourea; quinoxaline dichloro cyclocondensation thiourea; diquinoxalinodithiin; aminoiminodihydrothiazoloquinoxaline preparation cyclization carbon disulfide; thiazoloquinoxaline preparation reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Morais, Victor M. F. published the artcileThermochemical study of chloropyrazines and chloroquinoxalines, Formula: C8H2Cl4N2, the main research area is enthalpy formation combustion vaporization sublimation chloropyrazine chloroquinoxaline; mol structure chloropyrazine chloroquinoxaline DFT.

The standard (p° = 0.1 MPa) molar enthalpies of formation for liquid 2-chloropyrazine and crystalline 2,6-dichloropyrazine, 2,3-dichloroquinoxaline and 2,3,6,7-tetrachloroquinoxaline were derived from the standard molar enthalpies of combustion, in oxygen, to yield CO2(g), N2(g), and HCl·600H2O(l), at the temperature T = 298.15 K, measured by rotating-bomb combustion calorimetry. The standard molar enthalpies of vaporization or of sublimation, at T = 298.15 K, were measured by Calvet microcalorimetry. D. functional theory with the B3LYP functional and two different basis sets, 6-31G* and 6-311G*, was used to optimize the geometries of all chloro-substituted pyrazines and some chloro-substituted quinoxalines. The calculation of the energy of isodesmic reactions allowed the estimation of the standard molar enthalpies of formation in the gas phase for all compounds, including some not studied exptl.

Journal of Chemical Thermodynamics published new progress about Combustion enthalpy. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sastry, C. V. Reddy published the artcileSynthesis and biological activities of some 1,5-dihydro[1,2,4]ditriazolo[4,3-a:3′,4′-c]quinoxaline-1,6-diones, HPLC of Formula: 39267-05-5, the main research area is ditriazoloquinoxalinedione preparation pharmacol; antiallergic ditriazoloquinoxalinedione preparation; antimicrobial ditriazoloquinoxalinedione preparation; antiprotozoal ditriazoloquinoxalinedione preparation; anthelmintic ditriazoloquinoxalinedione preparation; nitrodihydroditriazoloquinoxalinedione preparation antiallergic.

Title compounds I (R = H, R1 = H, Cl, Me, NO2; R = NO2, Cl, Me, OMe, R1 = NO2) were prepared and tested for their antiallergic, antimicrobial, antiprotozoal and anthelmintic activities. I (R = H, NO2, Cl, R1 = NO2) had egg albumin-induced rat passive cutaneous anaphylaxis (PCA) activity >90% at 50 mg/kg.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Allergy inhibitors. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Wang, Zhaolin published the artcileDiscovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction, HPLC of Formula: 25983-14-6, the main research area is quinoxaline preparation hIgG hFcRn protein interaction antagonist autoimmune disease.

The neonatal Fc receptor, FcRn, prolongs the half-life of IgG in the serum and represents a potential therapeutic target for the treatment of autoimmune disease. Small mols. that block the protein-protein interactions of human IgG-human FcRn may lower pathogenic autoantibodies and provide effective treatment. A novel class of quinoxalines has been discovered as antagonists of the IgG:FcRn protein-protein interaction through optimization of a hit derived from a virtual ligand-based screen. Compound I was found to be the most potent with IC50 = 2 μM.

Bioorganic & Medicinal Chemistry Letters published new progress about Autoimmune disease. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, HPLC of Formula: 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider