Category: quinoxaline

Srinivas, B. published the artcileSynthesis of some new tetrazolo[1,5-a]quinazolino[2,3-c]imidazo[4,5-b]quinoxaline derivatives as antimicrobial agents, HPLC of Formula: 39267-05-5, the main research area is quinoxalinoimidazoquinazoline preparation antibacterial antifungal activity; tetrazoloquinazolinoimidazoquinoxaline preparation antibacterial antifungal activity.

A series of 6,7-dimethoxy-2-chloroquinazolo-[3,4-c]-imidazo-[4,5-6]-quinoxalines I [R = H, Me, Cl, Br, O2N] and 7,8-dimethoxytetrazolo-[1,5-a]-quinazolo-[2,3-c]-imidazo-[4,5-b]-quninoxalines II were synthesized by the reaction of 6,7-dimethoxy-2-chloroquinazolin-4-amine and 7,8-dimethoxytetrazolo-[1,5-a]-quinazolin-5-amine in acetic acid/DMF. The chem. structures of the newly synthesized compounds were characterized by IR, NMR, mass spectral and CHN anal. All the title compounds were subjected to in-vitro antibacterial testing against two pathogenic strains and antifungal screening against two fungi. Among the tested compounds, II [R = Me,Cl] showed significant antibacterial and antifungal activities. Also the compound I [R = Me] showed significant antifungal activity against Candida albicans.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Antibacterial agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Srinivas, B. published the artcileSynthesis and anti-microbial activity of novel series of Substituted 2-(Tetrazolo[1,5-a]quinoxalin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives, Formula: C9H6Cl2N2, the main research area is tetrazoloquinoxalinyl dihydrophthalazine dione preparation antibacterial antifungal.

A novel and efficient synthesis of 2-(substituted tetrazolo[1,5-a]quinoxalin-4-yl)-2,3-dihydrophthalazine-1,4-diones I (R1 = H, CH3, Cl, Br, NO2, OCH3; R2 = H, CH3) has been carried out. The substituted 4-hydrazinyl tetrazoloquinoxalines were treated with phthalic anhydride. All the synthesized compounds were screened for anti-microbial activity. Among all the synthesized compounds I (R1 = R2 = H, CH3) and I (R1 = Cl, Br, NO2, OCH3; R2 = H) showed moderate activity against gram-pos. bacterial strains S. aureus and gram-neg. bacterial strains E. coli. Compound I (R1 = NO2; R2 = H) showed appreciable activity against C. albicans and A. niger fungal strains.

Pharma Chemica published new progress about Antibacterial agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Dasari, Gouthami published the artcileSynthesis and anti microbial activity of tetrazolo quinoxaline containing pyrazole analogues, Safety of 2,3-Dichloro-6-methylquinoxaline, the main research area is tetrazoloquinoxalinyl dihydropyrazolone preparation antibacterial antifungal; tetrazoloquinoxalinylpyrazolidinedione preparation antibacterial antifungal.

In the present work some novel substituted 5-methyl-2-(tetrazolo[1,5-a]quinoxalin-4-yl)-2,4-dihydro-3H-pyrazol- 3-ones and substituted 1-(tetrazolo[1,5-a] quinoxalin-4-yl) pyrazolidin-3,5- diones were synthesized. These derivatives were synthesized by treating 4- hydrazinyl tetrazolo[1,5-a]quinoxalines with ethylaceto acetate and di-Et malonate in acetic acid solution All the synthesized compounds were characterized by IR, 1H-NMR and Elemental Anal. All the newly synthesized derivatives were evaluated for anti-microbial activity on different micro-organisms (E.coli, S. aureus, A.niger, C.albicans) at the concentration of 10μg/mL and 20μg/mL by using agar disk-diffusion method. The activity was measured in terms of zone of inhibition and compared with standard drug ciprofloxacin for antibacterial and Flucanazole for antifungal activity.

Heterocyclic Letters published new progress about Antibacterial agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Safety of 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Revathi, T. published the artcileSynthesis of novel tetrazolo and triazolo [1,2-e] imidazolo [4,5-b] quinoxaline derivatives as antimicrobial agents, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline, the main research area is quinoxaline imidazolo preparation antibacterial antifungal activity; dichloroquinoxaline amine heterocyclization potassium carbonate catalyst.

An efficient general method has been described for the synthesis of novel tetrazolo and triazolo[1,2-e]imidazolo[4,5-b]quinoxaline derivatives I (R1 = R2 = H, CH3; R1 = NO2, Br, Cl) and II by the reaction of (1H)-tetrazol-5-amine and (3H)-1,2,3-triazol-4-amine with substituted 2,3-dichloroquinoxaline in DMF solvent and added a catalytic amount of K2CO3. The synthesized compounds I and II were evaluated for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus (Gram pos. bacteria), Escherichia coli (Gram Neg. bacteria) and Aspergillus niger, Candida albicans (fungi). The quinoxalines I [R1 = NO2, Cl; R2 = H] and II [R1 = NO2, Cl; R2 = H] were identified as potent antimicrobial agents.

World Journal of Pharmaceutical Research published new progress about Antibacterial agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lian, Xu published the artcileAnti-MRSA drug discovery by ligand-based virtual screening and biological evaluation, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline, the main research area is virtual screening biol evaluation Staphylococous aureus resistant methicillin ligand; Antibacterial agent; Antibiotic resistance; DNA Gyrase inhibitors; MRSA; Virtual screening.

S. aureus resistant to methicillin (MRSA) is one of the most-concerned multidrug resistant bacteria, due to its role in life-threatening infections. There is an urgent need to develop new antibiotics against MRSA. In this study, we firstly compiled a data set of 2,3-diaminoquinoxalines by chem. synthesis and antibacterial screening against S. aureus, and then performed cheminformatics modeling and virtual screening. The compound with the Specs ID of AG-205/33156020 was discovered as a new antibacterial agent, and was further identified as a Gyrase B (GyrB) inhibitor. In light of the common features, we hypothesized that the 6c as the representative of 2,3-diaminoquinoxalines also inhibited GyrB and eventually proved it. Via mol. docking and mol. dynamics simulations, we identified binding modes of AG-205/33156020 and 6c to the ATPase domain of GyrB. Importantly, these GyrB inhibitors inhibited the MRSA strains and showed selectivity to HepG2 and HUVEC. Taken together, this research work provides an effective ligand-based computational workflow for scaffold hopping in anti-MRSA drug discovery, and discovers two new GyrB inhibitors that are worthy of further development.

Bioorganic Chemistry published new progress about Antibacterial agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Li, Xiaoqing published the artcileAn iodobenzene-catalysed domino route toward quinoxaline derivatives from simple ketones and o-phenylenediamines in one pot, SDS of cas: 40353-41-1, the main research area is quinoxaline derivative preparation iodobenzene catalyst.

An iodobenzene-catalyzed domino route to quinoxalines from ketones and o-phenylenediamines in one pot was developed. This transformation consisted of the generation of Koser’s generation, α-tosyloxylation of ketones, nucleophilic substitution and intramol. dehydration with o-phenylenediamines, and dehydrogenation.

Journal of Chemical Research published new progress about Dehydration reaction. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, SDS of cas: 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ceccarelli, Stefano published the artcileImidazo[1,2-a]quinoxalin-4-amines: a novel class of nonxanthine A1-adenosine receptor antagonists, Synthetic Route of 25983-14-6, the main research area is imidazoquinoxalinamine preparation A1 adenosine receptor binding.

The syntheses and A1 adenosine receptor affinities of a number of imidazo[1,2-a]quinoxalin-4-amines, e.g., I, are reported. Structure-activity relationships within the series and in comparison with other similar tricyclic nonxanthine adenosine antagonists are discussed, leading to a putative common binding mode of these nitrogen-containing heterocycles to A1 adenosine receptors. Secondary amino compounds displayed the best affinities toward A1 receptors, while the tertiary amines were almost devoid of activity, thus suggesting a crucial role for the hydrogen bond-forming 4-NH group. Remarkably higher potencies for 1-Me and N-cyclopentyl derivatives were also found. I (IRFI 165) is the most potent compound in this series, having Ki(A1) = 7.9 nM. It is also provided with a good A1 selectivity both vs. A2a and A3 subtypes and was selected for further pharmacol. studies.

European Journal of Medicinal Chemistry published new progress about Adenosine A1 receptor antagonists. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Synthetic Route of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Borjigin, Naraso published the artcilen- and p-Channel field-effect transistors based on diquinoxalino TTF derivatives, SDS of cas: 39267-05-5, the main research area is diquinoxalino TTF derivative field effect transistor structure optical property.

Three new quinoxalinoTTF derivatives with Me, trifluoromethyl and fluoro groups were synthesized and characterized by UV-visible absorption spectroscopy, DSC, x-ray single crystal anal., x-ray diffraction, and field-effect transistor (FET) characteristics. All of them have π-stacking structures in the single crystals. The quinoxalinoTTF derivative with trifluoromethyl groups exhibited an n-type FET, which is a rare example of n-channel FETs based on TTF derivatives The highest electron mobility is 0.01 cm2 V-1 s. The FET polarity was converted to p-channel from n-channel by replacing the trifluoromethyl groups with Me groups. The hole mobility is ≤0.2 cm2 V-1 s. In contrast, the fluoro substituted derivative did not show FET properties due to the poorly ordered mol. arrangement.

Synthetic Metals published new progress about Differential scanning calorimetry. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, SDS of cas: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lou, Shao-Jie published the artcilePd(OAc)2-catalyzed regioselective aromatic C-H bond fluorination, Name: 2-(Thiophen-2-yl)quinoxaline, the main research area is palladium acetate catalyzed regioselective aromatic carbon hydrogen bond fluorination.

A novel Pd(OAc)2-NFSI-TFA system was developed for the highly selective ortho-monofluorination directed by diverse aryl-N-heterocyclic directing groups e.g., quinoxaline, pyrazole, benzo[d]oxazole, and pyrazine derivatives A Pd(ii/iv) catalytic cycle was proposed based on the ESI-MS/MS studies.

Chemical Communications (Cambridge, United Kingdom) published new progress about C-H bond activation (aromatic). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Name: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Satish, Gandhesiri published the artcileI2Cu-mediated self-sorting domino reaction of aryl β-ketoesters into symmetrical 2-carboalkoxy-1,4-enediones: application to synthesis of pyrazine, β-carboline and quinoxalines, Category: quinoxaline, the main research area is enedione preparation stereoselective; ketoester domino reaction iodine copper acetate catalyst; quinoxaline carboline pyrazine preparation; diamine aryl enedione preparation nucleophilic addition iodine catalyst.

A self-sorting domino reaction of aryl β-ketoesters RC6H4C(O)CH2C(O)OCH2CH3 into sym. E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R was reported by an I2/Cu system. The reaction proceeds through tandem iodination, self-dimerization and Krapcho dealkoxycarbonylation in one pot under open air condition. Further, E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R were successfully employed for the synthesis of bioactive pyrazine, β-carboline and quinoxalines I via aza-Michael addition, intramol. cyclization and C-C bond cleavage of 1,3-dicarbonyl unit under mild reaction condition.

RSC Advances published new progress about Diastereoselective synthesis. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Category: quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider