Category: quinoxaline

Vadagaonkar, Kamlesh S. published the artcileI2 catalyzed tandem protocol for synthesis of quinoxalines via sp3, sp2 and sp C-H functionalization, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is ethylenearene phenylenediamine iodine tandem reaction quinoxaline preparation green chem; ethylarene phenylenediamine iodine tandem reaction quinoxaline preparation green chem; ethynearene phenylenediamine iodine tandem reaction quinoxaline preparation green chem.

One-pot, atom-economic synthesis of quinoxalines was achieved through generation of arylglyoxal from easily available ethylarenes, ethylenearenes and ethynearenes, and subsequent condensation with o-phenylenediamines. Catalytic I2 with tert-Bu hydroperoxide (TBHP) as an oxidant in DMSO was the system of choice for the domino reaction involving C-H functionalization/oxidative cyclization. The metal-free, mechanistically distinct and functional group tolerant tandem approach could be a powerful complement to traditional approaches for the synthesis of quinoxalines.

RSC Advances published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Kumar, Sonu published the artcileRegioselective 6-endo-dig iodocyclization: an accessible approach for iodo-benzo[a]phenazines, Computed Properties of 39267-05-5, the main research area is aryl alkynyl quinoxaline regioselective iodocyclization; iodobenzophenazine preparation.

A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C-H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallog. studies of the compound

Organic & Biomolecular Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Computed Properties of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nakhi, Ali published the artcilePyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay, Name: 2,3-Dichloro-6-methylquinoxaline, the main research area is luciferase reporter gene assay false pos result; pyrroloquinoxaline preparation inhibitor firefly luciferase.

2-Substituted pyrrolo[2,3-b]quinoxalines having free NH were prepared directly from 3-alkynyl-2-chloroquinoxalines in a single pot by using readily available and inexpensive methanesulfonamide (or p-toluenesulfonamide) as an ammonia surrogate. The reaction proceeded in the presence of Cu(OAc)2 affording the desired product in moderate yield. The crystal structure anal. of a representative compound and its supramol. interactions are presented. Some of the compounds synthesized exhibited inhibitory activities against luciferase that was supported by the predictive binding mode of these compounds with luciferase enzyme through mol. docking studies. The key observations disclosed here can alert users of luciferase reporter gene assays for possible false pos. results due to the direct inhibition of luciferase.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Name: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Yaohong published the artcileFacile, eco-friendly, catalyst-free synthesis of polyfunctionalized quinoxalines, HPLC of Formula: 40353-41-1, the main research area is quinoxaline green chem azido ketone diamine; 1, 2-Diamines; Catalyst-free; Eco-friendly; Quinoxalines; Water.

A novel, facile and eco-friendly synthesis of quinoxalines from α-azido ketones and 1,2-diamines was developed. An attractive feature of this protocol is that the desired products could be generated efficiently in water and without any catalyst, which is in accordance with the aim of green chem. A plausible mechanism has been proposed.

Molecular Diversity published new progress about Diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, HPLC of Formula: 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Peter, Matthias published the artcileA cyclic vicinal bis(tetraketone) and structural investigations of formoins, SDS of cas: 40353-41-1, the main research area is cyclic vicinal tetraketone structural investigation formoins.

Investigations of simple formoins such as 2,5-bis(1,1-dimethyl-2-phenylethyl)-2,4-dihydroxyfuran-3(2H)-one (17), benzoylformoin (18), p-toluoylformoin (19), pivaloylformoin (20), and the 2,4-dihydroxy-2,5-bis(heterocycl-2-yl)furan-3-ones 21-23 (heterocycle = furan, thiophene, selenophene) by NMR spectroscopy in DMSO showed the dihydroxyfuranone skeleton and not an enediol structure. The formoin 17 was oxidized to the corresponding tetraketone 10. The intermol. double benzoin condensation of 1,4-bis(2,2-dimethyl-3,4-dioxobutyl)benzene (27) affords, in low yield, the bis(formoin) 29, and this could be oxidized to provide 2,2,2′,2′,7,7,7′,7′-octamethyl[8,8]paracyclophan-3,3′,4,4’5,5’6,6′-octaone (9). The mol. structures of 17 and 29, the monohydrate of 10 (30), and also the dihydrate of 9 (31) are reported.

European Journal of Organic Chemistry published new progress about Benzoin condensation reaction (intermol. double benzoin). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, SDS of cas: 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sarkis, George Y. published the artcileSynthesis and spectral data for quinoxaline derivatives, Related Products of quinoxaline, the main research area is quinoxaline derivative; phenylenediamine ketone reaction.

Quinoxalines (I; R = 2-fluorenyl, p-HOC6H4, p-O2NC6H4, Me, 3-indolyl, 5-indanyl, 2-thienyl, 2-, 3-, 4-pyridyl, 2-furyl; II; R1 = H, NO2) were prepared by treating o-phenylenediamine with either RCOCH2Br, RCOCHO or the corresponding 2-bromo-1-tetralones. The uv, ir, and NMR spectral data for the quinoxalines are given.

Journal of Chemical and Engineering Data published new progress about Ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ghosh, Subhendu published the artcileAccess to Multifunctional AEEgens via Ru(II)-Catalyzed Quinoxaline-Directed Oxidative Annulation, Safety of 2-(Thiophen-2-yl)quinoxaline, the main research area is ruthenium catalyzed quinoxaline oxidative annulation aggregation induced emission.

Multifaceted application potential of AEEgens in bio-imaging, theranostic, chemo/bio sensors, mechanochromic, solar cells and organic photoelectronic opens up a new research paradigm to develop and design more such compounds Herein, quinoxaline N-directed Ru(II)-catalyzed oxidative annulation of 2-arylquinoxalines with internal alkynes leads to the formation of highly luminescent annulated quaternary ammonium salts in the presence of Cu(OAc)2.H2O oxidant. While the synthesized compounds exhibit emissions in green to yellow region with large Stoke shifts and reasonable quantum yields, their DFT calculation display 3D twisted conformation bearing donor-π-acceptor (D-π-A) configuration, where the two Ph moieties could serve as the donors and the extended quinoxaline core as the acceptor. Single crystal anal. of quaternary salt 3aa, depicts the presence of multiple intermol. non-covalent and weak π-π interactions that are possibly responsible for the luminescent behavior in crystalline as well as solid state. Advent of AEE in quinoxalinium salt 3aa in DMF/water is due to the restriction of intramol. motion (RIM) and suppression of intermol. charge transfer in aggregated state. AEEgen 3aa unveils reversible mechanochromism on changing from crystalline to amorphous state upon grinding and returned back to the crystalline state upon DCM fuming, where a few of such compounds are utilized for development of latent fingerprints on an adhesive tape. Furthermore, a representative group of synthesized luminescent quinoxalinium salts portray dose dependent cell growth inhibition of HeLa cells with concomitant cell arrest in G1 phases. Hence, these AEE luminogens are not only attractive as luminescent “”light-up”” probes for cell imaging, but also important as anticancer agents.

ACS Omega published new progress about Aggregation-induced emission enhancement. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Safety of 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lippa, K. A. published the artcileNucleophilic Aromatic Substitution Reactions of Chloroazines with Bisulfide (HS-) and Polysulfides (Sn2-), Quality Control of 25983-14-6, the main research area is chloroazine nucleophilic aromatic substitution reaction bisulfide polysulfide; seawater pollution chloroazine natural remediation nucleophilic reaction bisulfide polysulfide.

Reactions of bisulfide and polysulfides with chloroazines (important constituents of agrochems. and textile dyes) were examined in aqueous solution at 25°. For atrazine, rates are first-order in polysulfide concentration, and polysulfide dianions are the principal reactive nucleophiles; no measurable reaction occurs with HS-. Second-order rate constants for reactions of an array of chloroazines with polysulfides are several orders of magnitude greater than for reactions with HS-. Transformation products indicate the substitution of halogen(s) by sulfur. Ring aza nitrogens substantially enhance reactivity through a combination of inductive and mesomeric effects, and electron-withdrawing or electron-donating substituents markedly enhance or diminish reactivity, resp. The overall second-order nature of the reaction, the products observed, and reactivity trends are all consistent with a nucleophilic aromatic substitution (SNAr) mechanism. Rate constants for reactions with HS- and Sn2- (n = 2-5) correlate only weakly with LUMO (LUMO) energies, suggesting that the electrophilicity of a chloroazine is not the sole determinant of its reactivity. When second-order rate constants are extrapolated to HS- and Sn2- concentrations reported in salt marsh pore waters, half-lives of minutes to years are obtained. Polysulfides in particular could play an important role in effecting abiotic transformations of chloroazines in hypoxic marine waters.

Environmental Science and Technology published new progress about Aquatic sediment pore water (salt marsh). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Quality Control of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Laru, Sudip published the artcileRu(II)-Catalyzed Switchable C-H Alkylation and Spirocyclization of 2-Arylquinoxalines with Maleimides via ortho-C-H Activation, Application of 2-(Thiophen-2-yl)quinoxaline, the main research area is arylquinoxaline maleimide ruthenium catalyst regioselective alkylation; quinoxalinylaryl succinimide preparation; maleimide arylquinoxaline ruthenium catalyst regioselective oxidative spirocyclization; spiro indenoquinoxaline pyrrolidinedione preparation.

A Ru(II)-catalyzed facile and controllable protocol for C-H alkylation and spirocyclization of 2-arylquinoxalines with maleimides were achieved under ambient air in high yields. Sequential ortho-C-H activation and C-annulation resulted in the formation of diverse polyheterocycles containing spiro[indeno[1,2-b]quinoxaline-11,3′-pyrrolidine]-2′,5′-diones, which is of potent interest in medicinal chem. Mechanistic investigations suggested a reversible cleavage of the ortho-C-H bond in the turnover-limiting step.

Journal of Organic Chemistry published new progress about Alkylation catalysts, regioselective. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Application of 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Podsiadly, Radoslaw published the artcileSynthesis and photochemical reaction of novel, visible-wavelength oxidizable polymerization sensitizer based on the 12H-quinoxalino[2,3-b][1,4]benzothiazine skeleton, Recommanded Product: 2,3,6,7-Tetrachloroquinoxaline, the main research area is quinoxalinobenzothiazine dye sensitized alkoxypyridinium photodecomposition initiator visible light photopolym; photolysis quinoxalinobenzothiazine visible light sensitizer alkoxypyridinium polymerization photoinitiator.

Novel dyes based on the 12H-quinoxalino[2,3-b] [1,4]benzothiazine skeleton were synthesized and subsequently characterized using 1H NMR. Their electrochem. and spectral properties, such as absorption and emission spectra, quantum yield of fluorescence, and quantum yield of singlet oxygen formation, were measured. These compounds were evaluated as sensitizers for alkoxypyridinium salt photodecomposition, and the results are discussed on the basis of the free energy change for electron transfer from benzothiazine dyes to alkoxypyridinium compounds Benzothiazine dyes are useful oxidizable sensitizers for N-alkoxypyridinium photoinitiators. The mechanism of the dye photobleaching is supported by time-dependent d. functional theory (TD-DFT) calculations and the quantum yields of sensitized proton formation. Photoredox pairs consisting of benzothiazine dyes and alkoxypyridinium salt were found to be effective initiation systems for free radical polymerization of Me acrylate and trimethylolpropane triacrylate (TMPTA) using visible light.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Absorption spectra (photobleaching). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Recommanded Product: 2,3,6,7-Tetrachloroquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider