Category: quinoxaline

On October 31, 1980, Hollstein, Ulrich; Krisov, Galen E. published an article.Category: quinoxaline The title of the article was Carbon-13 NMR studies on some 5-substituted quinoxalines. And the article contained the following:

The 11 quinoxalines I (R = NO2, NH2, CO2H, OMe, Me, OH, F, Cl, Br, I, CN) were prepared and their 13C NMR were recorded in (D3C)2SO and assigned. The observed chem. shifts agree with those calculated from C6H6 substituent parameters and are close to those of corresponding carbons in 1-substituted phenazines and naphthalenes, except for the quinoxaline C-4a and C-8a which, due to their proximity to N, are downfield relative to those of the naphthalenes. The spectrum of I (R = F) was recorded in a range of solvents: in each case there was a low 2J(CF) for C-4a and no C-F spin-spin splitting for the 3-bond coupling of C-8a. Linear relationships exist between the Q parameter of the substituent and the chem. shift of C-4a, -5, and -6 and between the chem. shift of C-8 and the Hammet σp parameter of the substituent. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Category: quinoxaline

The Article related to nmr carbon quinoxaline substituent effect, Physical Organic Chemistry: Spectral and Related Studies and other aspects.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 1, 2006, Johnson, Brett A.; Xu, Zhe; Pancoast, Paige; Kwok, Jennifer; Ong, Joan; Leon, Michael published an article.Category: quinoxaline The title of the article was Differential specificity in the glomerular response profiles for alicyclic, bicyclic, and heterocyclic odorants. And the article contained the following:

As part of our ongoing effort to relate stimulus to response in the olfactory system, we tested the hypothesis that the unique chem. structures and odors of various cyclic odorants would be associated with unique spatial response patterns in the glomerular layer of the rat olfactory bulb. To this end, rats were exposed to sets of odorants, including monocyclic hydrocarbons, bicyclic compounds, and various heterocyclic structures containing oxygen or nitrogen in the ring. Relative activity across the entire layer was assessed by mapping uptake of 2-deoxyglucose into anatomically standardized data matrixes. Whereas monocyclic hydrocarbons evoked patterns similar to those evoked by open-chained hydrocarbon odorants, a set of bicyclic compounds with structures and odors similar to camphor evoked uptake in paired ventral domains not previously associated with any other odorant chem. structures. Despite their unique odors as judged by humans, heterocyclic odorants either evoked uptake in previously characterized areas corresponding to their functional groups or stimulated weak or patchy patterns involving isolated glomeruli. Although the patchiness of the patterns may be partially related to the rigidity of the compounds, which would be expected to restrict their interactions to only a few receptors, the weakness of the patterns suggests the possibility of species-specific odorant representations. We conclude that, whereas some of the novel cyclic structures indeed were represented by unique patterns in the rat bulb, other unique structures were poorly represented, even when they evoked intense and unique odors in humans. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Category: quinoxaline

The Article related to alicyclic bicyclic heterocyclic odorant olfactory bulb glomerulus olfaction, hydrocarbon lactone furan pyridine pyrazine olfactory glomerulus, Mammalian Biochemistry: General Physiological Chemistry and other aspects.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Houminer, Yoram; Sanders, Edward B. published an article in 1980, the title of the article was The reaction of alkylpyrazine anions with some electrophiles. Synthesis of 1,2-bis(2-pyrazyl)ethanes.Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

The coupling of pyrazines I (R-R2 = Me, H; R = R1 = H, R2 = Me; R = Me, R1 = R2 = H) using LiN(CHMe)2(LDA)-iodine gave II (31-43%). The treatment of I (R-R2 = Me) with LDA and O gave 21% I (R = CH2OH, R1 = R2 = Me), which was coupled with I (R = Me, R1 = R2 = H) to yield 49% III. (±)- And meso-IV were prepared by the treatment of 5,6,7,8-tetrahydroquinoxaline with LDA and O. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline

The Article related to dipyrazinylethane, ethane dipyrazinyl, pyrazinylethane, bisquinoxalyl, coupling quinoxaline methylpyrazine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Poradowska, Henryka; Grzechowska, Alicja published an article in 1980, the title of the article was The investigations on synthesis and properties of halogenoquinoxalines.Application of 62163-09-1 And the article contains the following content:

Haloquinoxalines I and II (R = Cl, Br; R1, R2 = H, Me) were obtained in 10-34% yield by diazotization and halogenation of I and II (R = NH2), prepared by cyclizing phenylenetriamines with R1COCOR2. Spectra of I and II are discussed. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application of 62163-09-1

The Article related to haloquinoxaline, quinoxaline halo, spectra haloquinoxaline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Application of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On January 28, 2021, Pan, Shiow-Lin; Yang, Chia-Ron; Huang, Han-Li; Tu, Huang-Ju; Liou, Jing-Ping; Teng, Che-Ming published a patent.Electric Literature of 62163-09-1 The title of the patent was Preparation of hydroxamic acid compounds as histone deacetylase 6 inhibitors and method for treating neuropathic pain. And the patent contained the following:

Disclosed herein are hydroxamic acid compounds of formula I. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6. Compounds of formula I wherein A is absent and CR1R2; E is absent and CR3R4; W is bicyclic aryl and bicyclic heteroaryl; X is CR5R6, O, S and NH and derivatives; Y is arylene and heteroarylene; Z is a bond, methylene and ethylene; R1, R2, R3 and R4 are independently H, halo, CN, amino, OH, etc.; R5 and R6 are independently H, (un)substituted C1-5 alkyl, (un)substituted C1-5 alkenyl, (un)substituted aryl, etc.; are claimed. Example compound II was prepared by reductive amination of Me 4-formylbenzoate with 3-quinolinamine followed by amidation with hydroxylamine hydrochloride. The invention compounds were evaluated for their HDAC6 inhibitory activity.y. From the assay, it was determined that compound II exhibited IC50 values of 19.11 nM and 0.78μM towards HDAC6 and HDAC1, resp. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Electric Literature of 62163-09-1

The Article related to hydroxamic acid preparation hdac6 inhibitor treatment neuropathic pain, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Electric Literature of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On June 3, 2016, Luo, Kai; Chen, Yao-Zhong; Chen, Li-Xian; Wu, Lei published an article.Computed Properties of 34413-35-9 The title of the article was Autoxidative C(sp2)-P Formation: Direct Phosphorylation of Heteroarenes under Oxygen, Metal-Free, and Solvent-Free Conditions. And the article contained the following:

The authors reveal here a direct autoxidative phosphorylation of heteroarenes induced by O under metal-free and solvent-free conditions. This new methodol. provides an economical, operationally simple, and environmentally friendly approach toward (Het)C(sp2)-P formation with medium to excellent yields. Heteroarenes including thiazole and quinoxaline derivatives are applicable under standard conditions, which is testified via a radical mechanism. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Computed Properties of 34413-35-9

The Article related to phosphorylation heteroarene arylphosphine oxide, heteroaryl phosphine oxide preparation, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Computed Properties of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On December 29, 2020, Xiong, Yunkui; Wang, Tao; Zhang, Yu; Qi, Liping published a patent.Application of 62163-09-1 The title of the patent was Phosphorus-containing quinoxaline compounds, its preparation method and application. And the patent contained the following:

A phosphorus-containing quinoxaline compounds, its preparation method and application having economical, easy operation, high yield, and suitable for large-scale production is provided. The phosphorus-containing quinoxaline compounds having following structure shown in formula I or formula II. The preparation method of phosphorus-containing quinoxaline compounds comprises the following steps: under the condition of participation of peroxide, mixing quinoxaline compound and diphenylphosphonium oxide compound react to obtain phosphorus-containing quinoxaline compound The application of phosphorus-containing quinoxaline compound was used to prepare medicines, optoelectronic materials, flame retardant materials or as phosphine ligands. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application of 62163-09-1

The Article related to quinoxaline phosphine oxide preparation, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Frost, Scott C.; Walker, Paige; Orians, Colin M.; Robbat, Jr. Albert published an article in 2022, the title of the article was The Chemistry of Green and Roasted Coffee by Selectable 1D/2D Gas Chromatography Mass Spectrometry with Spectral Deconvolution.COA of Formula: C8H10N2 And the article contains the following content:

Gas chromatog./mass spectrometry (GC/MS) is a long-standing technique for the anal. of volatile organic compounds (VOCs). When coupled with the Ion Analytics software, GC/MS provides unmatched selectivity in the anal. of complex mixtures and it reduces the reliance on high-resolution chromatog. to obtain clean mass spectra. Here, we present an application of spectral deconvolution, with mass spectral subtraction, to identify a wide array of VOCs in green and roasted coffees. Automated sequential, two-dimensional GC-GC/MS of a roasted coffee sample produced the retention index and spectrum of 750 compounds These initial analytes served as targets for subsequent coffee anal. by GC/MS. The workflow resulted in the quantitation of 511 compounds detected in two different green and roasted coffees. Of these, over 100 compounds serve as candidate differentiators of coffee quality, AAA vs. AA, as designated by the Coopedota cooperative in Costa Rica. Of these, 72 compounds survive the roasting process and can be used to discriminate green coffee quality after roasting. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).COA of Formula: C8H10N2

The Article related to roasted coffee spectral deconvolution gas chromatog mass spectrometry, 2d–gc/ms, gc/ms, coffee, coffee quality, deconvolution, green coffee, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.COA of Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Domeno, Celia; Aznar, Margarita; Nerin, Cristina; Isella, Francesca; Fedeli, Mauro; Bosetti, Osvaldo published an article in 2017, the title of the article was Safety by design of printed multilayer materials intended for food packaging.Name: 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

Printing inks are commonly used in multilayer plastics materials used for food packaging, and compounds present in inks can migrate to the food either by diffusion through the multilayers or because of set-off phenomena. To avoid this problem, the right design of the packaging is crucial. This paper studies the safety by design of multilayer materials. First, the migration from four different multilayers manufactured using polyethylene terephthalate (PET), aluminum (Al) and polyethylene (PE) was determined The structural differences among materials such as the presence of inks or lacquer coatings as well as the differences in layers position allowed the study of a safety-by-design approach. Sixty-nine different compounds were detected and identified; 49 of them were not included in the pos. list of Regulation EU/10/2011 or in Swiss legislation and 15 belong to Cramer class III, which means that they have a theor. high toxicity. Some of the compounds related to ink composition were pyrene, a compound com. used to make dyes and dye precursors and the antioxidant Irganox 1300. The application of external lacquers decreased the concentration of some migrants but also brought the potential for new migrants coming from its composition A final risk assessment of the material allowed evaluating food safety for different food simulants and confirm it. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Name: 5,6,7,8-Tetrahydroquinoxaline

The Article related to printed multilayer material food packaging safety regulation, gc-ms, inks, food packaging, lacquer, risk assessment, safety by design, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Name: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On September 25, 2011, Zhu, Xinpeng; Yao, Min published an article.Product Details of 34413-35-9 The title of the article was Optimization of preparation of coffee flavor by thermal reaction. And the article contained the following:

In this study, orthogonal array design was employed to optimize thermal reaction conditions for the preparation of coffee flavor. This was followed by reaction product anal. by gas chromatog.-mass spectrometry (GC-MS). When the reaction system was composed of 5 g of amino acids, 4 g of reducing sugar, 100 g of propylene glycol, 10 g of 95% ethanol and 40 g of deionized water at pH 6-8, the optimal reaction conditions were glucose/fructose ratio of 1: 1.5, arginine/lysine ratio of 2.5: 1, reaction temperature of 115°C, and reaction time of 4.5 h. The reaction resulted in the generation of 25 volatile flavor compounds such as furfuryl alc., maltol, di-Me pyrazine, acetyl pyrrole and mercaptans. Moreover, pyrazine, pyrrodine, furan, phenol and their substitutes were the major volatile flavor compounds The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Product Details of 34413-35-9

The Article related to coffee flavor maillard reaction gc ms, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Product Details of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider