quinoxaline| Page 61 of 643 | Heterocyclic Building Blocks-quinoxaline

He, Yuqin et al. published their research in Journal of the Science of Food and Agriculture in 2018 |CAS: 34413-35-9

The Article related to coffee aroma maltose lysine flash gas chromatog electronic nose, maillard reaction, coffee, electronic nose, lysine, solid-phase microextraction-gas chromatography-mass spectrometry (spme-gc-ms) and other aspects.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

He, Yuqin; Zhang, Haide; Wen, Nana; Hu, Rongsuo; Wu, Guiping; Zeng, Ying; Li, Xiong; Miao, Xiaodan published an article in 2018, the title of the article was Effects of maltose and lysine treatment on coffee aroma by flash gas chromatography electronic nose and gas chromatography-mass spectrometry.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

BACKGROUND : Arabica coffee is a sub-tropical agricultural product in China. Coffee undergoes a series of thermal reactions to form abundant volatile profiles after roasting, so it loses a lot of reducing sugars and amino acids. Adding carbonyl compounds with amino acids before roasting could ensure the nutrition and flavor of coffee. The technol. is versatile for the development of coffee roasting process. This investigation evaluates the effects of combining maltose and lysine (Lys) to modify coffee aroma and the possibly related mechanisms. Arabica coffee was pretreated with a series of solvent ratios of maltose and Lys with an identical concentration (0.25 mol L-1) before microwave heating. RESULTS : It was found that the combination of maltose and Lys significantly (P ≤ 0.05) influenced quality indexes of coffee (pH and browning degree). Ninety-six aromatic volatiles have been isolated and identified. Twelve volatile profiles revealed the relationship between fragrance difference and compound content in coffee. Moreover, coffee aroma was modified by a large number of volatiles with different chem. classes and character. CONCLUSION : Thus, our results suggest that the combination of reagents changed overall aroma quality through a series of complex thermal reactions, especially the ratio of Lys/maltose over 2:1. © 2017 Society of Chem. Industry. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

McNab, Hamish et al. published their research in Journal of the Chemical Society in 1982 |CAS: 62163-09-1

The Article related to quinoxaline preparation carbon 13 nmr, glyoxal cyclocondensation aminotoluene, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Application In Synthesis of 5-Chloroquinoxaline

On February 28, 1982, McNab, Hamish published an article.Application In Synthesis of 5-Chloroquinoxaline The title of the article was Carbon-13 nuclear magnetic resonance spectra of quinoxaline derivatives. And the article contained the following:

I (R = H, 5-Me, 5-Cl, 5-OMe, 6-Me; 5,6-Me2; R1 = H, 2-Me, 2-Cl, 2-OMe; 2,3-Me2) are prepared by the cyclocondensation of a phenylenediamine with an α-oxoaldehyde or an α,β-diketone; their 13C NMR are assigned by a first order anal. 2,3-(H2N)2C6H3Me was treated with OHCCHO and NaHSO3 in H2O to give I (R = 5-Me, R1 = H). The 13C-H coupling constants are reported for some I. Acceptable additivity of substituent effects is found within the quinoxaline series. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application In Synthesis of 5-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Verbeek, J. et al. published their research in Recueil des Travaux Chimiques des Pays-Bas in 1976 |CAS: 62163-09-1

The Article related to photochem hydroxylation quinoxaline, esr dihydroquinoxaline radial cation, Physical Organic Chemistry: Photo- and Irradiation-Induced Reactions, Free Radical-Induced Reactions, Free Radical Reactions and other aspects.Category: quinoxaline

Verbeek, J.; Berends, W.; Van Beek, H. C. A. published an article in 1976, the title of the article was Photochemical hydroxylation of quinoxalines.Category: quinoxaline And the article contains the following content:

Irradiation of quinoxaline (I) in acidic aqueous solution under anaerobic conditions gave 5-hydroxyquinoxaline (II) and the 1,4-dihydroquinoxaline radical cation (III). III was characterized by ESR spectroscopy. Under aerobic conditions II is the only irradiation product formed. The effect of substituents attached to the benzene nucleus of I is analyzed. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Mohajeri, Afshan et al. published their research in Journal of Physical Organic Chemistry in 2010 |CAS: 62163-09-1

The Article related to substituent effect local aromaticity substituted heterocyclic naphthalene analog, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Name: 5-Chloroquinoxaline

On May 31, 2010, Mohajeri, Afshan; Shahamirian, Mozhgan published an article.Name: 5-Chloroquinoxaline The title of the article was Substituent effect on local aromaticity in mono and di-substituted heterocyclic analogs of naphthalene. And the article contained the following:

A quant. study on local aromaticity has been performed on a series of mono- and di-substituted biheterocycles (quinoline, isoquinoline, quinoxaline, quinazoline). Three electronically based indexes (PDI, ATI, and FLU) have been employed to investigate the substituent effect on the π-electron delocalization in both heterocycle and benzenoid rings. Three typical substituents (Cl, OCH3, and CN) with different inductive and resonance power have been selected. Generally, substituent causes a reduction in aromaticity irresp. of whether it is electron attracting or electron donating. It is shown that the maximum aromaticity exhibits a similar trend of Cl > CN > OCH3 for all the studied rings. Moreover, it is found that the substituent situation with respect to the heteroatom has a significant influence on the aromaticity. It results from our study that in di-substituted derivatives, irresp. of whether the two substituents form a meta or para isomer, they preferably choose the position which leads to the maximum aromaticity character. Copyright © 2009 John Wiley & Sons, Ltd. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Name: 5-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Manoharan, Mariappan et al. published their research in Journal of Organic Chemistry in 2000 |CAS: 34413-35-9

The Article related to aromaticity transition state diels alder quinodimethane ab initio dft, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Electric Literature of 34413-35-9

On November 17, 2000, Manoharan, Mariappan; De Proft, Frank; Geerlings, Paul published an article.Electric Literature of 34413-35-9 The title of the article was Enhanced Aromaticity of the Transition Structures for the Diels-Alder Reactions of Quinodimethanes: Evidence from ab Initio and DFT Computations. And the article contained the following:

The Diels-Alder reactions of various quinodimethanes with ethylene are studied by means of ab initio MO and d. functional theory (DFT) to show the effect of aromaticity on the reaction path. The calculations reveal that these reactions are both kinetically and thermodynamically much more favored than the prototype butadiene-ethylene Diels-Alder reaction due to the aromatization process in the transition state (TS) and product. A progressive aromaticity gain is noticed during the reaction, and hence the partial π-delocalized peripheral diene ring function is coupled with the six-electron σ,π-delocalized cyclic unit resulting in an enhanced aromaticity of the TS. The magnetic criteria such as magnetic susceptibility exaltation and nucleus independent chem. shift provide definitive evidence for and fully support the aromatization process and the aromaticity of the TS. The extent of σ-π delocalization and the bond make-break at the TS are consistent with each other, and this is strongly influenced by the adjacent π-aromatization process. Moreover, the aromaticity trends in the resulting TSs and products parallel the activation and reaction energies; the extent of aromatization increases with increasing reaction rate and exothermicity. This confirms that aromaticity is the driving factor governing cycloadditions involving quinodimethanes. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Electric Literature of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Shahin, Mai I’s team published research in Bioorganic Chemistry in 2014-10-31 | 6272-25-9

Bioorganic Chemistry published new progress about Biological permeation. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, COA of Formula: C8H4ClN3O2.

Shahin, Mai I.; Abou El Ella, Dalal A.; Ismail, Nasser S. M.; Abouzid, Khaled A. M. published the artcile< Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold>, COA of Formula: C8H4ClN3O2, the main research area is arylaminoquinoxalinone arylaminoquinoxaline ureidoarylaminoquinoxaline preparation VEGFR2 inhibitor; structure arylaminoquinoxalinone arylaminoquinoxaline ureidoarylaminoquinoxaline inhibition VEGFR2 kinase; mol docking arylaminoquinoxalinone arylaminoquinoxaline ATP binding site VEGFR2; calculated lipophilicity solubility absorption CYP 2D6 inhibition arylaminoquinoxalinone arylaminoquinoxaline; Docking study; Kinase; Quinoxaline; Type-II; VEGFR-2.

Arylaminoquinoxalinones I [R = HO; R1 = 4-MeOC6H4NH; R2 = R3NHC(:X)NH, 4-R4C6H4SO2NH, 2-HO2CC6H4CONH, MeCONH; R3 = Ph, 3-ClC6H4, 3-MeC6H4, cyclohexyl; R4 = H, Me; X = O, S], arylaminoquinoxalines I [R = H; R1 = 4-R5C6H4NH; R2 = R3NHC(:X)NH, 4-R4C6H4SO2NH, MeCONH; R3 = Ph, 3-MeC6H4, cyclohexyl; R4 = H, Me; R5 = MeO, Cl; X = O, S] and ureidoarylaminoquinoxalines I [R = H; R1 = 4-(3-R6C6H4NHCONH)C6H4NH; R2 = O2N; R6 = H, Cl] were prepared as ATP-competitive VEGFR-2 inhibitors for potential use as antitumor agents. I (R = HO; R1 = 4-MeOC6H4; R2 = PhNHCONH) was the most effective VEGFR-2 inhibitor of the compounds prepared at a concentration of 10 μM. Mol. docking calculations were performed to rationalize the selectivities of quinoxalines for VEGFR-2; calculated physicochem. properties, absorption, and probabilities of CYP 2D6 inhibition were determined for the compounds

Bioorganic Chemistry published new progress about Biological permeation. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, COA of Formula: C8H4ClN3O2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Rangnekar, D W’s team published research in Dyes and Pigments in 1986 | 6272-25-9

Dyes and Pigments published new progress about Disperse dyeing. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Application In Synthesis of 6272-25-9.

Rangnekar, D. W.; Tagdiwala, P. V. published the artcile< Synthesis of 6-acetamido-2-substituted quinoxaline derivatives and their use as fluorescent whiteners for polyester fibers>, Application In Synthesis of 6272-25-9, the main research area is quinoxaline acetamido dye polyester; acetamidoquinoxaline fluorescent brightener; polyester disperse dye acetamidoquinoxaline.

6-Nitro-2-chloroquinoxaline [6272-25-9] was condensed with amines, alcs. and phenols to give 6-nitro-2-substituted quinoxalines. The nitro compounds were reduced to the corresponding amino compounds and then acetylated to yield 6-acetamido-2-substituted quinoxalines. 6-Nitro-2-substituted amino quinoxalines and 6-acetamido-2-substituted quinoxalines were evaluated as disperse dyes and fluorescent brighteners, resp., on polyester fibers.

Dyes and Pigments published new progress about Disperse dyeing. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Application In Synthesis of 6272-25-9.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Rao, Koppaka V’s team published research in Journal of Heterocyclic Chemistry in 1973 | 23088-24-6

Journal of Heterocyclic Chemistry published new progress about Reduction. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Related Products of 23088-24-6.

Rao, Koppaka V.; Jackman, Dennis published the artcile< Reaction of sodium borohydride with heteroaromatic nitro compounds>, Related Products of 23088-24-6, the main research area is quinoxaline nitro reduction; quinoline nitro reduction; tetrahydronitroquinoxaline; dihydronitroquinoline.

Quinoxalines (I, R = 5-, 6-NO2, 6-CN, 6-CO2Et, 6-CF3) and 5-, 6-, 7-, 8-nitroquinoline (II) were reduced selectively by NaBH4 in HOAc at 5° to give 1,2,3,4-tetrahydro-derivatives of I and 1,2-dihydro-derivatives of II resp. 5-Nitroisoquinoline was reduced to the 1,2,3,4-tetrahydro derivative in HOAc at 5° but yielded the 1,2-dihydro derivative in aqueous MeOH.

Journal of Heterocyclic Chemistry published new progress about Reduction. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Related Products of 23088-24-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Deng, Jing’s team published research in Journal of Medicinal Chemistry in 2011-07-14 | 6272-25-9

Journal of Medicinal Chemistry published new progress about Amination. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Category: quinoxaline.

Deng, Jing; Feng, Enguang; Ma, Sheng; Zhang, Yan; Liu, Xiaofeng; Li, Honglin; Huang, Huang; Zhu, Jin; Zhu, Weiliang; Shen, Xu; Miao, Liyan; Liu, Hong; Jiang, Hualiang; Li, Jian published the artcile< Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?>, Category: quinoxaline, the main research area is quinoxaline derivative preparation SAR drug screen RhoA inhibitory; cardiovascular disease.

RhoA is a member of Rho GTPases, a subgroup of the Ras superfamily of small GTP-binding proteins. RhoA, as an important regulator of diverse cellular signaling pathways, plays significant roles in cytoskeletal organization, transcription, and cell-cycle progression. The RhoA/ROCK inhibitors have emerged as a new promising treatment for cardiovascular diseases. However, to date, RhoA inhibitors are macromols., and to our knowledge, small mol.-based inhibitors have not been reported. In this study, a series of first-in-class small mol. RhoA inhibitors have been discovered by using structure-based virtual screening in conjunction with chem. synthesis and bioassay. Virtual screening of ∼200,000 compounds, followed by SPR-based binding affinity assays resulted in three compounds with binding affinities to RhoA at the micromolar level. Compound I was selected for further structure modifications in considering binding activity and synthesis ease. Forty-one new compounds were designed and synthesized accordingly. It was found that eight showed high RhoA inhibition activities with IC50 values of 1.24 to 3.00 μM. A pharmacol. assay indicated that two compounds II and III demonstrated noticeable vasorelaxation effects against PE-induced contraction in thoracic aorta artery rings and served as good leads for developing more potent cardiovascular agents.

Journal of Medicinal Chemistry published new progress about Amination. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Category: quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Marques-Gallego, Patricia’s team published research in Dalton Transactions in 2010-06-07 | 5182-90-1

Dalton Transactions published new progress about Antitumor agents. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Computed Properties of 5182-90-1.

Marques-Gallego, Patricia; Gamiz-Gonzalez, M. Amparo; Fortea-Perez, Francisco R.; Lutz, Martin; Spek, Anthony L.; Pevec, Andrej; Kozlevcar, Bojan; Reedijk, Jan published the artcile< Quinoxaline-2-carboxamide as a carrier ligand in two new platinum(II) compounds: Synthesis, crystal structure, cytotoxic activity and DNA interaction>, Computed Properties of 5182-90-1, the main research area is crystal structure platinum quinoxalinecarboxamide chloro solvent complex; platinum quinoxalinecarboxamide chloro solvent preparation DNA binding unwinding cytotoxicity; ethylguanine substitution platinum quinoxalinecarboxamide chloro solvent DNA model; antitumor platinum quinoxalinecarboxamide chloro solvent complex.

The search for platinum compounds structurally different from cisplatin has led to two new platinum(II) compounds containing quinoxaline-2-carboxamide as a carrier ligand, i.e. cis-[Pt(qnxca)(MeCN)Cl2] (1) and the [Pt(qnxca-H)(DMSO)Cl] (2). Both compounds have been synthesized and characterized using different spectroscopic methods. In addition, single-crystal structures have been determined by X-Ray diffraction for both compounds In each case a square planar Pt(II) is present; in (1) the qnxca is monodentate and neutral, whereas in (2) the ligand has lost a hydrogen, to form the anionic chelating ligand abbreviated as qnxca-H. The biol. activity of both compounds has been investigated in a panel of seven human tumor cells, displaying poor cytotoxic activity, compared to cisplatin. The interaction of the new compounds with 1 or 2 equivalent of 9-ethylguanine has been studied using 1H NMR, 195Pt NMR and ESI-MS spectroscopy, finding poor reactivity of 1 towards the model base, forming only the monosubstituted adduct. Surprisingly, compound 2, which is more sterically crowded, interacts more efficiently with the 9-EtG, forming a bifunctional adduct with two 9-EtG with substitution of the DMSO and the chloride ligand. Unwinding studies of pUC19 plasmid DNA by compound 1 show similar unwinding properties to cisplatin.

Dalton Transactions published new progress about Antitumor agents. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Computed Properties of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider