Category: quinoxaline

Kawasaki, M.; Goto, M.; Kawabata, S.; Kometani, T. published an article about the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6,SMILESS:CCC1=CC=C(CBr)C=C1 ).COA of Formula: C9H11Br. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:57825-30-6) through the article.

The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol (I) was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alc. was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, resp. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalyzed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of I was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-I and then the enantioselective hydrolysis of the resultant ester to afford (S)-I.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-ethylbenzene(SMILESS: CCC1=CC=C(CBr)C=C1,cas:57825-30-6) is researched.COA of Formula: C9H11Br. The article 《Incorporation of Cobalt-Cyclen Complexes into Templated Nanogels Results in Enhanced Activity》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:57825-30-6).

Recent advances in nanomaterials have identified nanogels as an excellent matrix for novel biomimetic catalysts using the mol. imprinting approach. Polymerisable Co-cyclen complexes with phosphonate and carbonate templates were prepared, fully characterized and used to obtain nanogels that show high activity and turnover with low catalytic load, compared to the free complex, in the hydrolysis of 4-nitrophenyl phosphate, a nerve agent simulant. The chem. structure of the template has an impact on the coordination geometry and oxidation state of the metal center in the polymerisable complex resulting in very significant changes in the catalytic properties of the polymeric matrix. Both pseudo-octahedral Co(III) and trigonal-bipyramidal Co(II) structures were used for the synthesis of imprinted nanogels, and the catalytic data demonstrate that: (i) the imprinted nanogels can be used in 15% load and show turnover; (ii) the structural differences in the polymeric matrixes resulting from the imprinting approach with different templates are responsible for the mol. recognition capabilities and the catalytic activity. Nanogel P1, imprinted with the carbonate template, shows > 50% higher catalytic activity than P2 imprinted with the phosphonate.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Science called An N-heterocyclic carbene ligand promotes highly selective alkyne semihydrogenation with copper nanoparticles supported on passivated silica, Author is Kaeffer, Nicolas; Liu, Hsueh-Ju; Lo, Hung-Kun; Fedorov, Alexey; Coperet, Christophe, which mentions a compound: 32717-95-6, SMILESS is C12=C(CCC3=C4CC2)[Cu+]1534[Cl-][Cu+]678(C9=C6CCC7=C8CC9)[Cl-]5, Molecular C16H16Cl2Cu2, Application In Synthesis of Chloro(1,5-cyclooctadiene)copper(I) dimer.

A surface organometallic route that generates copper nanoparticles (NPs) on a silica support while simultaneously passivating the silica surface with trimethylsiloxy groups is reported. The material was active for the catalytic semihydrogenation of phenylalkyl, dialkyl and diaryl alkynes and displayed high chemo- and stereoselectivity at full alkyne conversion to corresponding (Z)-olefins in the presence of an N-heterocyclic carbene (NHC) ligand. Solid-state NMR spectroscopy using the NHC ligand 13C-labeled at the carbenic carbon revealed a genuine coordination of the carbene to Cu NPs. The presence of distinct Cu surface environments and the coordination of the NHC to specific Cu sites likely accounted for the increased selectivity.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 221012-82-4, is researched, Molecular C38H34N2O4P2, about Ru-catalyzed highly enantioselective hydrogenation of β-alkyl-substituted β-(acylamino)acrylates, the main research direction is beta amino acid enantioselective preparation; bipyridyldiphosphine ruthenium complex enantioselective hydrogenation beta amino acrylate; enantioselective hydrogenation beta amino acrylate bipyridyldiphosphine ruthenium rhodium complex; rhodium bipyridyldiphosphine complex enantioselective hydrogenation Z beta aminoacrylate; ruthenium bipyridyldiphosphine complex enantioselective hydrogenation E beta aminoacrylate.Computed Properties of C38H34N2O4P2.

β-Alkyl-substituted (E)-β-(acylamino)-acrylates R1C(AcNH):CHCO2R2 (R1 = Me, Et, EtCH2, Me2CH, Me3C; R2 = Me, Et) undergo enantioselective hydrogenation in the presence of the nonracemic bipyridyldiphosphine I (R = 3,5-Me2C6H3) and [RuCl2(benzene)]2 to provide β-aminoesters R1CH(NHAc)CH2CO2R2 in up to 99.7% ee. (Z)-β-(acylamino)-acrylates R1C(AcNH):CHCO2R2 (R1 = Me, Et, EtCH2, Me2CH, Me3C; R2 = Me, Et) undergo enantioselective hydrogenation in the presence of nonracemic bipyridyldiphosphine I (R = 3,5-Me2C6H3) and Rh(COD)2BF4 to provide β-aminoesters R1CH(NHAc)CH2CO2R2 in 57-82% ee. Hydrogenation does not occur in the presence of ruthenium or rhodium complexes of I (R = Ph, 4-MeC6H4, 3,5-Me2C6H3) in aprotic solvents; methanol is found to be the optimal solvent. Decreasing the hydrogen pressure increases the enantioselectivity marginally, with 4 atm. of hydrogen pressure being optimal. Ruthenium complexes of I give higher enantioselectivities for hydrogenation of (E)-β-aminoacrylates than the corresponding rhodium complexes; for the hydrogenation of (Z)-β-aminoacrylates, rhodium complexes of I give higher enantioselectivities than the corresponding ruthenium complexes. Variations in the electronic and steric properties of the dipyridylphosphine ligand, variation of the transition metal used, and variations in the enamine stereochem. influence the rate and enantioselectivity of the hydrogenation of β-(acylamino)acrylates.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ramaiah, Kommineni; Srinivasan, Vankipuram R. researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Name: 8-Hydroxyquinoline 1-oxide.They published the article 《Heterocyclic N-oxides. V. Substitution reactions on 8-hydroxyquinoline 1-oxide》 about this compound( cas:1127-45-3 ) in Indian Journal of Chemistry. Keywords: quinoline substitution reaction. We’ll tell you more about this compound (cas:1127-45-3).

Nitration and halogenation of 8-hydroxyquinoline 1-oxide (I) having N-oxide and phenolic OH groups, each capable of orienting electrophilic substitution in the different rings, was studied with a view to knowing the relative directive influence of these groups and to screen the compounds obtained for bacteriostatic and fungistatic activity. Halogenation afforded under usual conditions products by substitution only in the benzene ring. Thus, 1.5 ml. SO2Cl2 in 10 ml. CHCl3 was added dropwise to a stirred solution of 0.8 g. I in 10 ml. CHCl3 at <5° to yield 0.92 g. 5,7-dichloro-8-hydroxyquinoline 1-oxide (II) as H2O-insoluble fraction (aqueous solution A), m. 203-4° (HOAc). Deoxygenation of II with PCl3 afforded 5,7-dichloro-8-hydroxyquinoline, m. 176°. The aqueous solution (A) on cooling yielded 0.07 g. 5-chloro-8-hydroxyquinoline 1-oxide, m. 169-70°. Similarly, bromination of 0.8 g. I in 10 ml. HOAc with 1 ml. Br in 10 ml. HOAc yielded 1.42 g. of the dibromo compound, m. 198-200° (HOAc), which on deoxygenation yielded 5,7-dibromo-8-hydroxyquinoline, m. 195°. Nitration of 0.8 g. I in 10 ml. HOAc with 2 ml. fuming HNO3 (d. 1.5) initially at room temperature and then 1 hr. at 70-80° (water-bath) yielded 0.8 g. 5,7-dinitro-8-hydroxyquinoline 1-oxide (III), m. 213-14° (HOAc). Nitration of 0.8 g. I in 10 ml. HOAc with 0.7 ml. concentrated HNO3 (d. 1.42) at <20° for 1 hr. yielded 0.75 g. 5-nitro-8-hydroxyquinoline 1-oxide (IV), m. 191-3° (EtOH). The structure of III and IV were established through deoxygenation and comparison with the known 5-nitro and 5,7-dinitro-8-hydroxyquinolines. The phenolic hydroxyl exerts greater influence than the N-oxide function. The usual 5,7-disubstituted derivatives of 8-hydroxyquinoline, 5,7-dihalo- or the 5,7-dinitro compounds were resistant to N-oxidation either by 30% H2O2-HOAc or BzO2H. As far as I know, this compound(1127-45-3)Name: 8-Hydroxyquinoline 1-oxide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Cuihua Xuebao called One-step synthesis of chiral dimethyl 2-oxo-3-phenyl-glutarate in the asymmetric triple-carbonylation of styrene, Author is Wang, Lailai; Zhang, Qinsheng; Cui, Yuming, which mentions a compound: 221012-82-4, SMILESS is COC(C=C1P(C2=CC=CC=C2)C3=CC=CC=C3)=NC(OC)=C1C4=C(OC)N=C(OC)C=C4P(C5=CC=CC=C5)C6=CC=CC=C6, Molecular C38H34N2O4P2, Electric Literature of C38H34N2O4P2.

One-step synthesis of chiral di-Me 2-oxo-3-phenyl-glutarate via asym. triple-carbonylation of styrene catalyzed by palladium complex with chiral 2,2′,6,6′-tetramethoxy-4,4′-bis(diphenylphosphine)-3,3′-bipyridine is reported.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.Name: 8-Hydroxyquinoline 1-oxide.Kacens, J.; Cebure, A.; Neilands, O. published the article 《8-Hydroxyquinophthalone derivatives》 about this compound( cas:1127-45-3 ) in Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija. Keywords: hydroxyquinonaphthalone; quinophthalone hydroxy. Let’s learn more about this compound (cas:1127-45-3).

8-Acetoxyquinophthalone (I, R = Ac, X = H) (II) was prepared in 62% yield by reaction of 8-quinolinol oxide with 1,3-indandione in Ac2O. Analogously prepared was I (R = Ac, X = Cl) in 62% yield. Hydrolysis of the acetate gave the corresponding alcs. (I, R = H, (Cl). Treatment of II with SO2Cl2 gave indandione (III, X = H). Analogously III (X = C) was obtained.

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Related Products of 19777-66-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains. Author is Hay, Duncan A.; Fedorov, Oleg; Martin, Sarah; Singleton, Dean C.; Tallant, Cynthia; Wells, Christopher; Picaud, Sarah; Philpott, Martin; Monteiro, Octovia P.; Rogers, Catherine M.; Conway, Stuart J.; Rooney, Timothy P. C.; Tumber, Anthony; Yapp, Clarence; Filippakopoulos, Panagis; Bunnage, Mark E.; Muller, Susanne; Knapp, Stefan; Schofield, Christopher J.; Brennan, Paul E..

Small-mol. inhibitors that target bromodomains outside of the bromodomain and extra-terminal (BET) sub-family are lacking. Here, the authors describe highly potent and selective ligands for the bromodomain module of the human lysine acetyl transferase CBP/p300, developed from a series of 5-isoxazolyl-benzimidazoles. The starting point was a fragment hit, which was optimized into a more potent and selective lead using parallel synthesis employing Suzuki couplings, benzimidazole-forming reactions, and reductive aminations. The selectivity of the lead compound against other bromodomain family members was investigated using a thermal stability assay, which revealed some inhibition of the structurally related BET family members. To address the BET selectivity issue, x-ray crystal structures of the lead compound bound to the CREB binding protein (CBP) and the first bromodomain of BRD4 (BRD4(1)) were used to guide the design of more selective compounds The crystal structures obtained revealed two distinct binding modes. By varying the aryl substitution pattern and developing conformationally constrained analogs, selectivity for CBP over BRD4(1) was increased. The optimized compound is highly potent (Kd = 21 nM) and selective, displaying 40-fold selectivity over BRD4(1). Cellular activity was demonstrated using fluorescence recovery after photo-bleaching (FRAP) and a p53 reporter assay. The optimized compounds are cell-active and have nanomolar affinity for CBP/p300; therefore, they should be useful in studies investigating the biol. roles of CBP and p300 and to validate the CBP and p300 bromodomains as therapeutic targets.

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COA of Formula: F2H8NiO4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Nickel(ii)fluoridetetrahydrate, is researched, Molecular F2H8NiO4, CAS is 13940-83-5, about Thermal decomposition of nickel and zinc fluoride tetrahydrates.

NiF2.4H2O decomposes in 3 steps when heated. In dry air or Ar atm. NiF2.H2O is formed at ∼125°, but H2O and HF are lost and NiOHF.3NiF2 is formed at ∼225°. NiOHF.3NiF2 loses another mol. of HF at ∼430° and the final product is a mixture of NiF2 and NiO in 3:1 mole ratio. In the presence of H2O, the final product is NiO, the other steps being the same. ZnF2.4H2O loses H2O at >75° to give anhydrous ZnF2.

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Leedham, T. J.; Powell, D. B.; Scott, J. G. V. published an article about the compound: Chloro(1,5-cyclooctadiene)copper(I) dimer( cas:32717-95-6,SMILESS:C12=C(CCC3=C4CC2)[Cu+]1534[Cl-][Cu+]678(C9=C6CCC7=C8CC9)[Cl-]5 ).Category: quinoxaline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:32717-95-6) through the article.

There have been several recent reports on the spectra of C2H4 and 1,5-cyclooctadiene complexes of d8 metallic ions which have shown that 2 bands in the vibrational spectrum of the olefin are sensitive to the coordinated metal. A series of d10 ions were complexed to 1,5-cyclooctadiene and a shift was found having the order Au(I) ∼ Cu(I) > Ag(I). Three distinct compounds were also formed between 1,5-cyclooctadiene and Au(III) or Au(I) and their ir spectra and suggested structures are reported.

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