Heterocyclic Building Blocks-quinoxaline

Phototransformations of 6-X-5-Nitroquinoxalines was written by Rtishchev, N. I.;Selitrennikov, A. V.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 2004.SDS of cas: 5448-43-1 This article mentions the following:

Photophys. properties and photochem. activity of 6-X-5-nitroquinoxalines with electron-donor substituents (X = H, CH₃, Cl, OC₂H₅, NH₂) ortho to the nitro group were studied. The quantum yield of the formation of 5-hydroxyquinoxaline from the corresponding nitro derivative depends on the nature of the substituent and irradiation conditions. Phototransformations can go through nitro-nitrite rearrangement with the participation of two alternative T(nπ*) levels, depending on the size and electronic effects of the substituent. The latter factor is largely determined by the population on excitation of different charge-transfer states involving the nitro group. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1SDS of cas: 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.SDS of cas: 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Regioselectivity in the reaction of nitroquinoxaline N-oxides with phosphoryl chloride was written by Nasielski-Hinkens, R.;Vande Vyver, E.;Nasielski, J.. And the article was included in Bulletin des Societes Chimiques Belges in 1986.Safety of 6-Chloroquinoxaline This article mentions the following:

Oxidation of nitroquinoxalines I (n = 0; R, R¹ = H, Me) by m-ClC₆H₄CO₂OH gave their N-oxides; the NO₂ group orients the O atom preferentially to N-1, but the N-4:N-1 selectivity is diminished in the methylated derivatives Meisenheimer reaction of I (n = 1, R = R¹ = H) with POCl₃ gave I (n = 0, R = Cl, R¹ = H). The orientation of the entering Cl is discussed on the basis of electronic effects induced by the N-oxide and NO₂ groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Safety of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Measurement of the relative values of oscillator strengths in the spectrum of the iron atom by the total absorption method was written by Valters, A. K.;Nikonova, E. I.;Startsev, G. P.. And the article was included in Optika i Spektroskopiya in 1964.HPLC of Formula: 6639-82-3 This article mentions the following:

The total absorption method was applied to the multiplets in the 3950-2750-A. region, beginning from the a⁶D and a⁵F levels. A King vacuum furnace with spherical mirrors allowed the light to pass through the vapor up to 16 times, a flat diffraction grating spectrograph, and suitable filters to eliminate spurious spectra and diffused light were used. The tabulated results are in good agreement with those of King (K. and King. CA 32, 2427⁷) in the 3950-3550-A. region, but diverge considerably in the shorter wave region. The total absorption method can be successfully applied to investigations of the gf values in the far ultraviolet region. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3HPLC of Formula: 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.HPLC of Formula: 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Infrared spectra of unsaturated N-heterocyclic compounds. I. Quinoxaline and derivatives was written by Perkampus, H. H.;Roders, A.. And the article was included in Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie in 1960.Reference of 5448-43-1 This article mentions the following:

The regularities within the range of the nonplanar C-H deforming vibrations depending on the number of substituents of the benzene nucleus are applied on quinoxaline and 17 of its derivative Also this class of compound can be joined to the known schedule. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Reference of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Reference of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis of cyano-substituted heterocycles by tetraethylammonium cyanide was written by Hermann, Klaus;Simchen, Gerhard. And the article was included in Liebigs Annalen der Chemie in 1981.Computed Properties of C11H9ClN2O2 This article mentions the following:

RCN (R = optionally substituted 2-pyridinyl, 4-pyrimidinyl, 4-quinazolinyl, 2-quinazolinyl, 2-quinoxalinyl) were prepared by treating RCl with NMe₃ and treating RN⁺Me₃ Cl^– with Et₄N⁺ CN^– to give RCN. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Computed Properties of C11H9ClN2O2).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Computed Properties of C11H9ClN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Bistrifluoromethylated organocuprate [Ph₄P]⁺[Cu(CF₃)₂]^–: synthesis, characterization and its application for trifluoromethylation of activated heteroaryl bromides, chlorides and iodides was written by Liu, He;Shen, Qilong. And the article was included in Organic Chemistry Frontiers in 2019.Name: Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:

The synthesis and characterization of a bistrifluoromethylated organocuprate [Ph₄P]⁺[Cu(CF₃)₂]^– and its reactions with a variety of activated heteroaryl bromides, chlorides and iodides were described. These results showed that complex [Ph₄P]⁺[Cu(CF₃)₂]^– can serve as a trifluoromethylating reagent. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Name: Ethyl 3-chloroquinoxaline-2-carboxylate).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Name: Ethyl 3-chloroquinoxaline-2-carboxylate

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Direct C-2 arylation of quinoxaline with arylhydrazine salts as arylation reagents was written by Wang, Xing;Wang, Bing;Miao, Jing;Chen, Yi;Zhu, Gaofeng;Zhang, Jiquan;Wang, Jianta;Wang, Haibo;Tang, Lei;Wang, Cong. And the article was included in Journal of Heterocyclic Chemistry in 2022.Application of 5448-43-1 This article mentions the following:

A transition metal-free synthesis of 2-arylquinoxalines I (R = H, Me; R¹ = H, Me, Cl; R² = H, Me; R³ = Ph, 3-methylphenyl, 3-chloro-4-methylphenyl, pyridin-2-yl, etc.) is achieved by using arylhydrazine salt R³NHNH₂.HCl as an aryl radical arylation reagent and air as an oxidant in the presence of K₂CO₃. This protocol is metal-free and environment friendly, has no additives, and mild reaction conditions, and can be used to construct biol. active mols. containing 2-phenylquinoxaline structure. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Application of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Application of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines was written by Elumalai, Vijayaragavan;Hansen, Joern H.. And the article was included in SynOpen in 2021.Safety of 6-Chloroquinoxaline This article mentions the following:

A highly efficient and catalyst-free protocol was reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds Remarkably simple and green reaction conditions employed methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature The conditions allow at least 10 g scale synthesis of quinoxalines and preferred starting point for optimization and method of choice for applications in the synthetic community. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Safety of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Challenging nickel-catalysed amine arylations enabled by tailored ancillary ligand design was written by Lavoie, Christopher M.;MacQueen, Preston M.;Rotta-Loria, Nicolas L.;Sawatzky, Ryan S.;Borzenko, Andrey;Chisholm, Alicia J.;Hargreaves, Breanna K. V.;McDonald, Robert;Ferguson, Michael J.;Stradiotto, Mark. And the article was included in Nature Communications in 2016.Name: 6-Chloroquinoxaline This article mentions the following:

An operationally simple and air-stable ligand/nickel(II) pre-catalyst that accommodated the broadest combination of C(sp²)-N coupling partners reported to date for any single nickel catalyst, without the need for a precious-metal co-catalyst was reported. Key to the unprecedented performance of this pre-catalyst was the application of the new, sterically demanding yet electron-poor bisphosphine PAd-DalPhos. Featured were the first reports of nickel-catalyzed room temperature reactions involving challenging primary alkylamine and ammonia reaction partners employing an unprecedented scope of electrophiles, including transformations involving sought-after (hetero)aryl mesylates for which no capable catalyst system was known. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Name: 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Name: 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Application of the AMYR calculating method on quinoxaline, 3-chloroquinoxaline, and 3-methylquinoxaline in the interaction with n water molecules (n varies from 1 to 6) was written by El Assyry, A.;Benali, B.;Boucetta, A.;Lakhrissi, B.. And the article was included in Journal of Structural Chemistry in 2014.Computed Properties of C8H5ClN2 This article mentions the following:

AMYR is a computer program for the calculation of mol. associations using Fraga’s pairwise atom-atom potential. The interaction energy is evaluated through a 1/R expansion. A pairwise dispersion energy term is included in the potential and corrected by a damping function. The program carries out energy minimizations through variable metric methods. The new version allows for the stationary point anal. of the intermol. potential by means of the Hessian eigenvalues. AMYR model is used for the first time in a calculation of quinoxaline, 3-chloroquinoxaline, and 3-methylquinoxaline mols. interacting with some water mols. Intermol. interaction energies are obtained and the stable conformation is determined in each case. The change conformation was considered at α ≈ (CNC) angle when the solute mols. are surrounded by n water mols. (1 ≤ n ≤ 6). In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Computed Properties of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Computed Properties of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider