Heterocyclic Building Blocks-quinoxaline

Electric Literature of 2213-63-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article£¬once mentioned of 2213-63-0

An efficient synthesis of tetraazapentacenes

Organic electronics on demand? The palladium-catalyzed coupling of aromatic ortho-diamines with substituted dichloroquinoxalines furnishes N,N-dihydrotetraazaacenes, which were oxidized by MnO2 into the corresponding tetraazapentacenes (see structures; N blue, Cl green, Si yellow). The modular synthesis of these acenes allows the introduction of any substituent by choice of the proper quinoxaline derivative. Copyright

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Quinoxaline | C8H6N1583 | ChemSpider

Application of 7712-28-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.7712-28-9, Name is 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid, molecular formula is C11H10N2O3. In a Patent£¬once mentioned of 7712-28-9

Has a matrix metalloproteinase inhibiting activity of the quinoxaline derivative and its preparation method and application (by machine translation)

The invention discloses a matrix metalloprotease inhibiting activity of the quinoxaline derivative and its preparation method and application, the invention synthesizes a series of specific matrix metalloproteinase – 9 and/or matrix metalloprotease – 13 inhibiting activity of the quinoxaline derivatives, such compounds can be used as MMP – 9 and/or matrix metalloprotease – 13 specific inhibitor, and then can become a therapeutic index higher can be used for clinical drug, solved in the prior art in the treatment of osteoarthritis, osteoporosis, periodontal disease drug type less, curative effect is not sufficiently precise and the like. (by machine translation)

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Application of 1448-87-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer?s disease

Multitarget molecules are considered as an effective way for the treatment of AD, instead of the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety of studies indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (AchE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO). Various substituted quinoxaline-hydrazone derivatives were synthesized, and their activity in vitro were investigated, including AChE/BuChE inhibitory activity and MAOA/B inhibitory activity. Based on the experimental results, compound 5l exhibited good inhibitory potency on both AchE (IC50 = 0.028 ¡À 0.001 muM) and monoamine oxidase B (IC50 = 0.046 ¡À 0.002 muM). Molecular modeling studies showed that 5l could bind to the active site of AChE and MAO-B. Taken together, these results suggested that compound 5l might be a potential multifunctional agent for the treatment of AD.

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Quinoxaline | C8H6N543 | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 15804-19-0, name is Quinoxaline-2,3(1H,4H)-dione, introducing its new discovery. SDS of cas: 15804-19-0

Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors

In continuation of our previous work on the design and synthesis of topoisomerase II (Topo II) inhibitors and DNA intercalators, a new series of quinoxaline derivatives were designed and synthesized. The synthesized compounds were evaluated for their cytotoxic activities against a panel of three cancer cell lines (Hep G-2, Hep-2, and Caco-2). Compounds 18b, 19b, 23, 25b, and 26 showed strong potencies against all tested cell lines with IC50 values ranging from 0.26 ¡À 0.1 to 2.91 ¡À 0.1 muM, comparable with those of doxorubicin (IC50 values ranging from 0.65 ¡À 0.1 to 0.81 ¡À 0.1 muM). The most active compounds were further evaluated for their Topo II inhibitory activities and DNA intercalating affinities. Compounds 19b and 19c exhibited high activities against Topo II (IC50 = 0.97 ¡À 0.1 and 1.10 ¡À 0.1 muM, respectively) and bound the DNA at concentrations of 43.51 ¡À 2.0 and 49.11 ¡À 1.8 muM, respectively, whereas compound 28b exhibited a significant affinity to bind the DNA with an IC50 value of 37.06 ¡À 1.8 muM. Moreover, apoptosis and cell-cycle tests of the most promising compound 19b were carried out. It was found that 19b can significantly induce apoptosis in Hep G-2 cells. It has revealed cell-cycle arrest at the G2/M phase. Moreover, compound 19b downregulated the Bcl-2 levels, indicating its potential to enhance apoptosis. Furthermore, molecular docking studies were carried out against the DNA?Topo II complex to examine the binding patterns of the synthesized compounds.

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Quinoxaline | C8H6N314 | ChemSpider

Electric Literature of 82019-32-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.82019-32-7, Name is 7-Bromo-1-methyl-1H-quinoxalin-2-one, molecular formula is C9H7BrN2O. In a Patent£¬once mentioned of 82019-32-7

A 3 – trifluoro methyl quinoxaline compound preparation method (by machine translation)

The invention is a 3 – trifluoromethyl quinoxaline compound preparation method. The method comprises the following steps: in the inert gas atmosphere, the quinoxaline compound, three fluorine methyl asia sodium sulfonate and oxidizing agent is added to the solvent, in the 0 – 75 temperature reaction 6 – 18 hours, separation and purification by column chromatography, to obtain the 3 bit trifluoromethyl substituted quinoxaline compound. The reagent used in this invention is low cost, mild reaction conditions, after treatment is simple, is applicable to industrial production. (by machine translation)

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Electric Literature of 2213-63-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 2213-63-0, 2,3-Dichloroquinoxaline, introducing its new discovery.

SYNTHESIS, STRUCTURE, AND CHEMICAL PROPERTIES OF SOME N-(3-CHLORO-2-QUINOXALYL)ARYLSULFONAMIDES

We have developed a method for synthesis of N-(3-chloro-2-quinoxalyl)sulfonamides by reaction of 2,3-dichloroquinoxaline with substituted arylsulfonamides.Based on the IR spectra, we have established that in the solid state, the synthesized compounds exist in the form of amide tautomers.Alkylation of these compounds leads to N-methyl-N-(3-chloro-2-quinoxalyl)arylsulfonamides.We demonstrate the possibility of nucleophilic substitution of the halogen upon treatment with O- and N-nucleophiles.The use of bifunctional nucleophiles leads to condensed quinoxalines.

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Quinoxaline | C8H6N1431 | ChemSpider

Electric Literature of 1448-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

Novel gas-phase cyclisation reactions of 2-(1-pyrazolyl)phenylnitrenes

Flash vacuum pyrolysis of the azide 3 gives a mixture of pyrazolobenzotriazole 2, quinoxaline 5 and pyrazolobenzimidazole 4 derived from the corresponding nitrene.

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Quinoxaline | C8H6N556 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 6-Methylquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 6344-72-5

Nano-TiO2: An eco-friendly alternative for the synthesis of quinoxalines

Nano-TiO2 as an eco-friendly and efficient nanocatalyst was applied for quinoxaline preparation with improved yield. In this protocol, diketones and 1,2-diamines were condensed in the presence of catalyst at room temperature.

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Synthetic Route of 2213-63-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article£¬once mentioned of 2213-63-0

Stable hexacenes through nitrogen substitution

Give me an N: Tetraazahexacenes (see picture, N blue, Si brown) are easily prepared in high yields. Their modular synthesis allows the introduction of any substituent by the choice of suitable quinoxaline derivatives. Copyright

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Quinoxaline | C8H6N1429 | ChemSpider

Related Products of 6298-37-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6298-37-9, Name is Quinoxalin-6-amine, molecular formula is C8H7N3. In a Article£¬once mentioned of 6298-37-9

Synthesis and antimalarial activity of pyrido<3,2-f>quinoxalines and their N-oxides

Unsubstituted, 2,3-dimethyl, and 2,3-diphenyl 10-chloro pyrido<3,2-f>quinoxalines have been prepared and converted to 10-substituted amino and Mannich base derivatives.Pyrido<3,2-f>quinoxaline undergoes oxidation in the presence of m-CPBA to give the corresponding mono and bis N-oxides.The mono N-oxide reacts with POCl3 to give the dichloro derivative and with trimethyl silyl cyanide to give the 8-cyano-10-chloro derivative.The dichloro pyrido<3,2-f>quinoxaline further undergoes oxidation with m-CPBA to give dichloro mono N-oxide.All the compounds have beeen testedin the Plasmodium berghei infected mice by oral route.Compounds 9, and 12 displayed 100percent activity in K-173 infected mice at 25 mg/kg.

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