Heterocyclic Building Blocks-quinoxaline

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, 59564-59-9, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Mickelson, John W., mentioned the application of 59564-59-9, Name is 3,4-Dihydroquinoxalin-2(1H)-one, molecular formula is C8H8N2O

High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: Synthesis and structure – Activity relationship studies of a new series of tetracyclic imidazoquinoxalines

A series of tetracyclic imidazoquinoxaline analogs was developed which constrain the carbonyl group of the partial agonist 3-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-5-[(dimethylamino)carbonyl]4,5-dihydroimidazo[1,5- a]quinoxaline (2, U-91571) away from the benzene ring. These analogs orient the carbonyl group in the opposite direction of the previously reported full agonist 1-(5-cyclopropyl- 1,2,4-oxadiazol-3-yl)- 12,12a-dihydroimidazo[1,5- a]pyrrolo[2,1-c]quinoxalin- 10(11H)one (3, U-89267). A number of approaches were utilized to form the ‘bottom’ ring of this tetracyclic ring system including intramolecular cyclizations promoted by Lewis acids or base, as well as metal-carbenoid conditions. The size and substitution pattern of the additional ring was widely varied. Analogs within this series had high affinity for the benzodiazepine receptor on the alpha-aminobutyric acid A chloride ion channel complex. From TBPS shift and Cl- current assays, the in vitro efficacy of compounds within this class ranged from antagonists to partial agonists with only 18a identified as a full agonist. Additionally, several analogs were quite potent at antagonizing metrazole-induced seizures indicating possible anticonvulsant or anxiolytic activity. Unlike 3, analogs in this series did not have high affinity for the diazepam insensitive alpha6beta2delta2 subtype. These results suggest that either constraining the carbonyl group away from the benzene ring or the greater planarity that results from the additional cyclic structure provides analogs with partial agonist properties and prevents effective interaction with the alpha6beta2delta2 subtype.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 59564-59-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 59564-59-9, in my other articles.

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Quinoxaline | C8H6N173 | ChemSpider

2213-63-0, Name is 2,3-Dichloroquinoxaline, belongs to quinoxaline compound, is a common compound. 2213-63-0In an article, authors is Abulkhair, Hamada S., once mentioned the new application about 2213-63-0.

Design, synthesis, and molecular docking studies of new [1,2,4]triazolo[4,3-a]quinoxaline derivatives as potential A2B receptor antagonists

Abstract: Many shreds of evidence have recently correlated A2B receptor antagonism with anticancer activity. Hence, the search for an efficient A2B antagonist may help in the development of a new chemotherapeutic agent. In this article, 23 new derivatives of [1,2,4]triazolo[4,3-a]quinoxaline were designed and synthesized and its structures were confirmed by different spectral data and elemental analyses. The results of cytotoxic evaluation of these compounds showed six promising active derivatives with IC50 values ranging from 1.9 to 6.4 muM on MDA-MB 231 cell line. Additionally, molecular docking for all synthesized compounds was performed to predict their binding affinity toward the homology model of A2B receptor as a proposed mode of their cytotoxic activity. Results of molecular docking were strongly correlated with those of the cytotoxic study. Finally, structure activity relationship analyses of the new compounds were explored. Graphic abstract: [Figure not available: see fulltext.].

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Quinoxaline | C8H6N1235 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. 18671-97-1, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 18671-97-1

Quinoxalinyloxy phenoxy proprionic acid derivatives as selective herbicides

The invention concerns novel compounds of the formula I STR1 wherein: D and U are independently chosen from halogen, methyl and halomethyl; G is chosen from hydroxy, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, cycloalkoxy and the group OM wherein M is an alkali metal or alkaline earth metal ion; and k and l are independently chosen from 0 and 1. The compounds are herbicides and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of compounds of formula I, herbicidal compositions containing as active ingredient a compound of formula I, and processes for severely damaging or killing unwanted plants by applying to the plants or to the growth medium of the plants and effective amount of a compound of formula I.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. 18671-97-1

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Quinoxaline | C8H6N1639 | ChemSpider

55687-34-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.55687-34-8, Name is 6-Bromoquinoxalin-2(1H)-one, molecular formula is C8H5BrN2O. In a Article, authors is Sakata, Gozyo£¬once mentioned of 55687-34-8

The facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones

Facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones and these reaction mechanisms are described.The intramolecular cyclization reaction of 4′-substituted 2′-nitroacetoacetanilides in aqueous basic medium and the reduction of 6-substituted 2(1H)-quinoxalinone-4-oxide wit sodium borohydride or sodium hydrogensulfite were studied in detail

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Quinoxaline | C8H6N1812 | ChemSpider

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 6640-47-7, C8H8N4. A document type is Article, introducing its new discovery., 6640-47-7

On the Amination of Azaheterocycles. A New Procedure for the Introduction of an Amino Group

A new method of amination of diazines and triazines, using potassium amide, liquid ammonia and potassium permanganate, has been described.

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Quinoxaline | C8H6N256 | ChemSpider

Let¡¯s face it, organic chemistry can seem difficult to learn. 59564-59-9. Especially from a beginner¡¯s point of view. Like 59564-59-9, Name is 3,4-Dihydroquinoxalin-2(1H)-one. In a document type is Article, introducing its new discovery.

High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex

A series of imidazo[1,5-a]quinoxaline amides, carbamates, and ureas which have high affinity for the gamma-aminobutyric acid A/benzodiazepine receptor complex was developed. Compounds within this class have varying efficacies ranging from antagonists to full agonists. However, most analogs were found to be partial agonists as indicated by [35S]TBPS and Cl- current ratios. Many of these compounds were also effective in antagonizing metrazole-induced seizures in accordance with anticonvulsant and possible anxiolytic activity. Selected quinoxalines displayed limited benzodiazepine-type side effects such as ethanol potentiation and physical dependence in animal models. Dimethylamino urea 41 emerged as the most interesting analog, having a partial agonist profile in vitro while possessing useful activity in animal models of anxiety such as the Vogel and Geller assays. In accordance with its partial agonist profile, 41 was devoid of typical benzodiazepine side effects.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 1910-90-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1910-90-3, name is 6-Bromoquinoxaline-2,3(1H,4H)-dione. In an article£¬Which mentioned a new discovery about 1910-90-3

A One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives 3a?n. The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamine and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines have been obtained in good to excellent overall yields. Eight known compounds 3a?3h were characterized by IR, 1H-NMR, and mass spectroscopies. Compounds 3i?3n without spectroscopic data were characterized by IR, 1H-NMR, 13C-NMR, and mass spectroscopies.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1910-90-3 is helpful to your research. 1910-90-3

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2213-63-0, Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2213-63-0, Name is 2,3-Dichloroquinoxaline

Synthesis of tetrazolo[1,5-a]quinoxaline based azetidinones & thiazolidinones as potent antibacterial & antifungal agents

4-Chlorotetrazolo[1,5-a]quinoxaline (III) was synthesized by azide (2+3) cycloaddition of 2,3-dichloroquinoxaline (II). Compound (III) on further refluxing with hydrazine hydrate furnished 4-hydrazinotetrazolo[1,5- a]quinoxaline (IV). Further refluxing of (IV) with different aromatic aldehydes in methanol yielded corresponding Schiff’s bases V(a-j). Various 4-aminotetrazolo[1,5-a]quinoxaline based azetidinones VII(a-j) were synthesized by stirring the compounds V(a-j), at low temperature, with equimolar mixture of chloroacetylchloride & triethylamine in dry benzene, while 4-aminotetrazolo[1,5-a]quinoxaline based thiazolidinones VIII(a-j) were synthesized by refluxing Schiff’s bases V(a-j) with thioglycolic acid in oil-bath. The structures of all the compounds were confirmed on the basis of 1H-NMR & FT-IR spectral data. All the newly synthesized compounds were screened for in-vitro antimicrobial activity against E. coli, S. aureus, K. pneumoniae & P. aeruginosa & antifungal activity against C. albicans. Few of them have exhibited the promising activity.

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Quinoxaline | C8H6N1419 | ChemSpider

49679-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.49679-45-0, Name is Ethyl 3-chloroquinoxaline-2-carboxylate, molecular formula is C11H9ClN2O2. In a article£¬once mentioned of 49679-45-0

Quinoxaline chemistry. Part 12. 3-Carboxy-2[phenoxyl-6(7)substituted quinoxalines and N-[4-(6(7) substituted-3-carboxyquinoxalin- 2-yl)hydroxy]-benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity

Thirty quinoxalines bearing a substituted phenoxy or hydroxybenzoylglutamate group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate the in vitro anticancer activity. Screening over 21 compounds selected at the National Cancer Institute (Bethesda, MD) showed that only few derivatives exhibited a moderate growth inhibition activity on various tumor panel cell lines at 10-4 molar concentration. The acid derivatives showed no growth inhibition activity. The results obtained in this series seem to indicate that in general carboxy or carboethoxy groups close to O-link with phenyl or benzoyl glutamates on position 2 are detrimental for anticancer activity.

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Quinoxaline | C8H6N1910 | ChemSpider

Because a catalyst decreases the height of the energy barrier, 25594-62-1, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.25594-62-1, Name is 2-Acetylquinoxaline, molecular formula is C10H8N2O. In a article£¬once mentioned of 25594-62-1

Asymmetric Michael Addition of 2-Acetyl Azaarenes to beta-CF3-beta-(3-indolyl)nitroalkenes Catalyzed by a Cobalt(II)/(imidazoline-oxazoline) Complex

The first enantioselective Michael addition of 2-acetyl azaarenes to beta-CF3-beta-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst. The reaction affords a series of CF3- A nd 3-indole-containing adducts featuring a trifluoromethylated all-carbon quaternary stereocenter in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee). Furthermore, the functional groups in the adducts including Ca?O, NO2, and the azaarene provide a large variety of useful transformations, leading to the formation of valuable intermediates such as optically active secondary alcohol, pyrroline, ester, and pyrrolidinone which all contain a 3-substituted indole and a trifluoromethylated all-carbon quaternary stereocenter.

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