Heterocyclic Building Blocks-quinoxaline

6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 36 iV-Methyl-iV-tetrahvdro-lH-pyran^-ylquinoxaline–carboxamide To a suspension of quinoxaline-6-carboxylic acid (0.7g, 4 mmol) and N-methyltetrahydro- 2H-pyran-4-amine (0.7 g, mmol), in DMF (6 ml) and dichloromethane (6 ml), were added DMAP (0.49 g, 4 mmol), etaOBT (0.54 g, 4 mmol), NEt3 (1.6 ml) and EDCI (1.26g). The reaction mixture was stirred at room temperature for 4h and then concentrated under vacuum. The crude product was purified on a silica gel column eluting with chloroform/methanol/ triethylamine (95:5:0.5) to give an oil (1.5g) which formed a beige solid upon trituration with dichloromethane/diethyl ether. Mp = 130-131C, LC-MS, MH+ = 272; 1H NMR (300 MHz, CDCl3) delta 8.91 (s, 2H); 8.18 (d, J = 8.4 Hz, IH); 8.11 (s, IH); 7.79 (d, J = 8.4 Hz, IH); 4.95- 3.50 (m, 5H); 3.07 and 2.91 (s + s, 3H); 2.02-1.65 ppm (m, 4H)., 6925-00-4

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/143963; (2008); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (184 mg, 0.530 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (104 mg, 0.530 mmol) to afford the desired title compound (134 mg, yield 49%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.84 (1H, brs), 9.56 (1H, m), 7.87 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.8 Hz), 7.30 (2H, d, J=8.6 Hz), 7.11 (2H, dd, J=8.6 Hz, 5.0 Hz), 5.00 (1H, m), 4.69 (1H, m), 4.08-3.79 (2H, m), 3.58-3.20 (2H, m), 2.10-1.46 (6H, m), 0.92 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2945, 1685, 1640, 1505, 1240. MS (ESI, m/z): 519 (M+H)+. HRMS (ESI, m/z): 519.1850 (Calcd for C25H26F3N4O5: 519.1855).

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

[0175] To a solution of quinoxaline-6-carboxylic acid (5.1 g, 29.3 mmol, 1.0 eq) in DMF (100 mL) was added HATU (13.3 g, 35 mmol. 1.2 eq), DIEA (20 mL, 117.2 mmol, 4.0 eq) and Omicron,Nu- Dimethyl-hydroxylamine hydrochloride salt (3.38 g, 35 mmol, 1.2 eq). The mixture was stirred at r.t. overnight, then the solvent was evaporated. The residue was purified via flash column (PE/EA = 2/1, v/v) to afford N-meth (5.1 g, 80 %).

6925-00-4, 6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/43935; (2013); A1;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50998-17-9, To a flask including 1 eq. of triphenylen-2-ylboronic acid and 1.2 eq. of 6-bromoquinoxaline, 0.03 eq. of Pd(dba)3, 0.06 eq. of (t-Bu)3P, and toluene (1 M) were added and refluxed with stirring for about 12 hours. Then, the reaction product was cooled to ambient temperature, extracted with methylene chloride and washed with distilled water. The product thus obtained was dried with MgSO4 and distilled under a reduced pressure, and the residue was separated by column chromatography to produce Compound B-1 (Yield 80.4%). The compound thus produced was identified using a high resolution mass spectrometer and 1H NMR. The mass of the synthesized compound thus identified was 355. [HRMS for C26H16N2 [M]+: calcd: 356.43, found: 355, Elemental Analysis for C26H16N2 calcd: C, 87.62; H, 4.52; N, 7.86].

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; SAMSUNG DISPLAY CO., LTD.; JEONG, Hyein; LEE, Jungsub; (58 pag.)US2017/162796; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

In N2in the gas purification system, the carbazole is dissolved in 1,4-dioxane solvent, and by adding CuI and K3PO4. Add another 5,8- […][…] (1.1 equivalent) and trans -1,2-diamino cyclohexane. In the solution 110 C and the temperature of the refluxing under stirring 24 hours. After the completion of reaction, to the room temperature and cooling the solution and distilled water extraction by ethyl acetate. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the remaining organic solvent. The material through the use of hexane and ethyl acetate to carry out wet refining column chromatography, thereby obtaining compound “l”. (Yield: 48%)

148231-12-3, The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of 2-chloro-3-methylquinoxaline L [45] (650mg, 3.6mmol) and 4-chlorophenol (0.37mL, 3.6mmol) in anhydrous DMF (15mL), Cs2CO3 (1.19 g, 3.6mmol) was added under inert atmosphere. The mixture was stirred at 70C overnight. After completion of the reaction, water was added, leading to a precipitate which was separated by filtration. The resulting precipitate was then thoroughly washed with water. The precipitate was dissolved in CH2Cl2 and dried with Na2SO4. After filtration and evaporation, the resulting solid was purified by silica gel column chromatography (eluent: Petroleum Ether/CH2Cl2 1/1) to afford 2-(4-chlorophenoxy)-3-methylquinoxaline. Yield 85%. Off-white powder. mp 108C. 1H NMR (250MHz, CDCl3) delta=7.69 (dd, J=6.1, 3.7 Hz, 1H), 7.57 (dd, J=6.3, 3.5 Hz, 2H), 7.46-7.38 (m, 2H), 7.28-7.19 (m, 2H), 2.81 (s, 3H). 13C NMR (63MHz, CDCl3) delta=155.8, 151.5, 147.9, 139.6, 139.4, 130.6, 129.7, 129.4, 128.1, 127.6, 127.4, 123.3, 20.7. LC-MS (ESI, 35 eV): tR=4.35min, m/z 271 [M+H]+., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desroches, Justine; Kieffer, Charline; Primas, Nicolas; Hutter, Sebastien; Gellis, Armand; El-Kashef, Hussein; Rathelot, Pascal; Verhaeghe, Pierre; Azas, Nadine; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 68 – 86;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, j. Quinoxaline-2-carboxylic Acid {(S)-3-methyl-1-[3-hydroxy-1-(1-oxy-pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}amide To a solution of the compound of Example 1i (320 mg, 0.73 mmol) in CH2Cl2 was added triethylamine (0.15 mL, 1.09 mmol), EDC (140 mg, 0.73 mmol), HOBt (99 mg, 0.73 mmol) and quinoxaline-2-carboxylic acid (127 mg, 0.73 mmol). The reaction was stirred until complete by TLC analysis. Workup and column chromatography of the residue gave the title compound: MS(EI) 556 (M+).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; SmithKline Beecham Corporation; US6583137; (2003); B1;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

49679-45-0, 49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

6924-66-9, To a solution of 8-amino-2-(2-chloro-4-fluorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 2 Intermediate 113), (75.0 mg, 253 mupiiotaomicronIota) in DMF (2.6 ml) was added PyBOP (145 mg, 278 muiotaetaomicronIota), N,N-diisopropylethylamine (180 muIota, 1.0 mmol) and quinoxaline-5-carboxylic acid (44.0 mg, 253 muiotaetaomicronIota) and the reaction was stirred for 16 h at room temperature. For work-up, brine (45 ml) was added and the resulting precipitate was filtrated. The residue was dissolved in DMSO and the crude product was purified by HPLC (Method 6) to give after trituration with water the title product (54 mg)LC-MS (Method 4): Rt = 1 .15 min; MS (ESIpos): m/z = 453 [M+H]+1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1 .548 (5.49), 1 .581 (5.92), 1 .788 (2.48), 1 .820 (5.92), 1 .848 (5.61 ), 1 .901 (6.65), 1 .992 (4.72), 2.001 (4.87), 2.026 (6.99), 2.052 (3.52), 2.124 (6.90), 2.142 (12.41 ), 2.158 (6.99), 2.327 (1 .99), 2.539 (3.37), 2.668 (1 .96), 3.628 (7.72), 3.645 (13.55), 3.662 (7.1 1 ), 4.224 (3.62), 7.293 (2.54), 7.299 (2.85), 7.314 (5.06), 7.321 (5.27), 7.335 (3.13), 7.343 (3.03), 7.485 (5.24), 7.499 (5.85), 7.507 (5.06), 7.521 (4.14), 7.579 (5.33), 7.586 (5.36), 7.600 (5.39), 7.607 (5.00), 7.975 (4.54), 7.995 (7.88), 8.014 (5.33), 8.270 (7.1 1 ), 8.274 (7.05), 8.291 (6.50), 8.295 (6.50), 8.300 (3.92), 8.522 (7.02), 8.526 (6.80), 8.541 (6.59), 9.079 (16.00), 9.087 (15.66), 10.452 (3.80), 10.471 (3.65)

The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6344-72-5, Example 3 Preparation of a Solid Sample of 6-bromomethyl-quinoxaline In a 100 ml flask, 6-methyl-quinoxaline (2.5 g, 17.4 mmol) was dissolved together with N-bromosuccinimide (4.63 g, 19 mmol) and benzoyl peroxide (0.3 g, 1.24 mmol) in 70 g of 1,2-dichloroethane. The solution was refluxed for 150 minutes and analyzed. The concentrations of the reactants and some of their molar ratios are shown below: The solution was cooled in the freezer overnight and the solid residue was separated by filtration. The solid was washed with pentane and the washings were combined with the liquid fraction. The clear reddish solution was then vacuum dried to give an orange solid that was used in the preparation of 6-hydroxymethyl-quinoxaline.

As the paragraph descriping shows that 6344-72-5 is playing an increasingly important role.

Reference£º
Patent; Air Products and Chemicals, Inc.; US6548670; (2003); B1;,
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