Heterocyclic Building Blocks-quinoxaline

Luo, Shuai; Zhou, Hong-Yan; Wang, Le; Yu, Ai-Nong; Yang, Xiao-Hong published an article in 2012, the title of the article was Effects of urea on the formation of perfume compounds by ascorbic acid-methionine model reaction.Name: 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

By the headspace-solid phase micro-extraction – gas chromatog. – mass spectrometry (Headspace-SPME-GC-MS) technol., this article identifies products from the model reaction between ascorbic acid and methionine (ASA-Met), and studies the impacts of urea on the formation of perfume compounds from the model reaction. 17 Perfume compounds have been identified, including pyrazine, sulfur compounds, thiophene, pyrrole and compounds containing benzene rings, of which sulfur compounds, such as alicyclic sulfides, thioether and pyrazine, are the main flavor components. For urea being added to the model system, one the one hand, the yields of some sulfur compounds will be significantly reduced; on the other hand, it promotes the production of several nitrogen compounds such as Me pyrazine, Et pyrazine and 2,6-di-Me pyrazine, and other alkyl pyrazine. This indicates that urea inhibits the thermal degradation of Met in the model reaction, and also implies that as the nitrogen source during the thermal degradation of urea NH3 may be generated. After a competing reaction occurs between NH3 and the degradation products of H2S and ASA, nitrogen compounds are formed, such as alkyl pyrazine, so as to cause the lower production of sulfur compounds The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Name: 5,6,7,8-Tetrahydroquinoxaline

The Article related to perfume compound urea ascorbic acid methionine thermal degradation, Food and Feed Chemistry: Physical, Organic, and Inorganic Chemistry and Model Systems and other aspects.Name: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On June 30, 1987, Baltes, Werner; Bochmann, Gloria published an article.Quality Control of 5,6,7,8-Tetrahydroquinoxaline The title of the article was Model reactions on roast aroma formation. IV. Mass spectrometric identification of pyrazines from the reaction of serine and threonine with sucrose under the conditions of coffee roasting. And the article contained the following:

From the volatiles of model roastings, where serine, threonine, and sucrose (in different ratios) were treated under the conditions of coffee roasting, 123 mono- and bicyclic pyrazines were separated and identified by capillary gas chromatog. and mass spectrometry. The spectra obtained were compared with the spectra of roast coffee volatiles. Numerous compounds unknown up to now were identified, among them 12 products which, according to their behavior, were postulated to be furfurylpyrazines. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Quality Control of 5,6,7,8-Tetrahydroquinoxaline

The Article related to pyrazine aroma coffee roasting model, serine threonine sucrose pyrazine, Food and Feed Chemistry: Physical, Organic, and Inorganic Chemistry and Model Systems and other aspects.Quality Control of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ji, Hong; Bernhard, Richard A. published an article in 1992, the title of the article was Effect of microwave heating on pyrazine formation in a model system.Quality Control of 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

The effect of microwave heating was contrasted with that of conventional heating in pyrazine formation in a model food Maillard system containing glucose, glycine, and base. The heating system, and the time and temperature of heating, greatly influenced pyrazine formation and pyrazine distribution. Kinetic studies indicated that pyrazine formation follows pseudo-zero order reaction rates, and this order is the same regardless of the heating method used. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Quality Control of 5,6,7,8-Tetrahydroquinoxaline

The Article related to pyrazine food flavor cooking, maillard glucose glycine pyrazine, microwave pyrazine food flavor, Food and Feed Chemistry: Physical, Organic, and Inorganic Chemistry and Model Systems and other aspects.Quality Control of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On December 31, 1989, Huang, Tzou Chi; Bruechert, Linda J.; Ho, Chi Tang published an article.Formula: C8H10N2 The title of the article was Kinetics of pyrazine formation in amino acid-glucose systems. And the article contained the following:

The chem. and kinetics of pyrazine formation were studied in 4 amino acid-glucose model systems. Different amounts of the same alkylpyrazines were produced in the 4 systems. The most abundant alkylpyrazine generated in a glycine-glucose system was 2,3,5-trimethylpyrazine, while 2-methylpyrazine was most abundant in an arginine-glucose system and 2,5-dimethylpyrazine predominated in a histidine-glucose system. 2-Methylpyrazine and 2,5-dimethylpyrazine were the 2 most abundant alkylpyrazines in a lysine-glucose system. Kinetic data from the arginine-glucose system indicated that each of 4 selected pyrazines was formed by a pseudo-zero-order reaction. Activation energies in the same system were 19.5 ± 4.1 kcal/mol for pyrazine, 24.8 ± 8.7 for 2-methylpyrazine, 20.8 ± 4.7 for 2,6-dimethylpyrazine and 29.0 ± 3.8 for 2-methyl-6,7-dihydro-5H-cyclopentapyrazine. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to pyrazine formation kinetics maillard reaction, alkylpyrazine formation kinetics maillard reaction, amino acid glucose maillard reaction pyrazine, Food and Feed Chemistry: Physical, Organic, and Inorganic Chemistry and Model Systems and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Baltes, Werner; Knoch, Eberhard published an article in 1993, the title of the article was Model reactions on roast aroma formation. XIII. The formation of some uncommon N-heterocyclic compounds and furans after roasting of tryptophan with reducing sugars and sugar degradation products.COA of Formula: C8H10N2 And the article contains the following content:

After treatment of D-glucose and D-xylose with tryptophan under the conditions of coffee roasting, 311 volatile compounds were identified. Among others, quinolines, quinoxalines and carbazoles were formed. Their formation is assumed to proceed via alkylated indoles by ring enlargement reactions of intramol. cyclizations. Another group of compounds formed are bicyclic furans, furfurylamines and N-2-furfuryl-pyrroles, the mass spectra of which are listed. The pathway of tryptophan degradation, as well as the formation of the described products, is discussed. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).COA of Formula: C8H10N2

The Article related to coffee roast aroma compound model, tryptophan reducing sugar roasting aroma compound, furan aroma coffee roasting model, heterocycle aroma coffee roasting model, Food and Feed Chemistry: Physical, Organic, and Inorganic Chemistry and Model Systems and other aspects.COA of Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On March 31, 1984, McNab, Hamish published an article.Electric Literature of 62163-09-1 The title of the article was The thermolysis of polyazapentadienes. Part 4. Formation of indoles and quinoxalines from 5-(2,6-disubstituted phenyl)-1,2,5-triazapentadienes and related compounds. And the article contained the following:

7-Methylindole and 5-substituted quinoxalines are the main cyclized products from the gas-phase thermolysis of PhNHN:CRCH:NC6H3Me2-2,6 (R = H, Me) and MeON:CHCMe:NC6H3Me2-2,6. Both heterocyclic systems arise by competitive decomposition of a spirodienyl radical intermediate, the indole by loss of MeCN and an H atom, and the quinoxalines by loss of Me•. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Electric Literature of 62163-09-1

The Article related to pyrolysis cyclization aryltriazapentadiene mechanism, triazapentadiene aryl pyrolysis cyclization mechanism, quinoxaline, methylindole, indole methyl, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.Electric Literature of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 21, 1995, Ellis, Michael J.; Lloyd, Douglas; McNab, Hamish; Walker, Marion J. published an article.Formula: C8H10N2 The title of the article was Gas-phase pyrolysis of 2,3-dihydro-1,4-diazepines: involvement of the saturated portion of the ring in chemical reactions and novel cis-trans isomerization of a fused ring system. And the article contained the following:

Flash vacuum pyrolysis of 2,3-dihydro-1,4-diazepines in the range 450-550 °C involves interaction of the saturated portion of the mol. with the vinamidine system and causes 1,5-hydrogen shifts which have been established by deuterium labeling experiments; at higher temperatures, ring contraction occurs to give pyrazines as major products. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to isomerization pyrolysis dihydrodiazepine, ring contraction pyrolysis dihydrodiazepine, hydrogen shift pyrolysis dihydrodiazepine, mechanism pyrolysis dihydrodiazepine, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On June 30, 2000, Wei, Shuping; Zhang, Hua; Xu, Xiaobin; Yang, Yayan published an article.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline The title of the article was Natural-existed pyrazine derivatives and their application to flavors. And the article contained the following:

A series of natural-existed pyrazine derivatives were studied in relation to regularities between their aroma and structure, and also showed some application as flavorant. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

The Article related to pyrazine derivative flavor application, Food and Feed Chemistry: Additives, Sweeteners, Flavorings, Condiments, and Confectionery and other aspects.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On April 30, 2011, Khanafari, A.; Olia, M. Seyed Jafari; Sharifnia, F. published an article.SDS of cas: 34413-35-9 The title of the article was Bioconversion of essential oil from plants with eugenol bases to vanillin by Serratia marcescens. And the article contained the following:

Essential oils extraction from native or collective plants with eugenol basses such as Eugenia caryophyllata and Ocimum basilicum and bio-transformation to vanillin by Serratia marcescens (ATCC 13880) was investigated. The oils were obtained by steam distillation and were analyzed by UV and GC-MS. Essential oils with eugenol bases was added to resting phase of bacterium growth curve with final concentration of 20 gL-1 and incubated at 27°C and 150 rpm, for 24 h to bioconversion to vanillin. Crystalline structure of vanillin was isolated and confirmed by GC-MS. Forthy-three and one hundred and fifteen compounds were identified in essential oil of Eugenia caryopyllata by using first and second methods and eugenol was determined as the major component with 88.205 % and 54.628 % resp. Eugenol in essential oil of Ocimum basilicum was rare. The highest vanillin concentration, 0.6 gL-1, was obtained with 46 % purity from flower buds of Eugenia caryopyllata. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).SDS of cas: 34413-35-9

The Article related to eugenia ocimum essential oil eugenol vanillin serratia bioconversion, Food and Feed Chemistry: Additives, Sweeteners, Flavorings, Condiments, and Confectionery and other aspects.SDS of cas: 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On October 14, 2010, Jiang, Huanfeng; Chen, Huoji; Wang, Azhong; Liu, Xiaohang published an article.Synthetic Route of 34413-35-9 The title of the article was Palladium-catalyzed acetoxylation of sp3 C-H bonds using molecular oxygen. And the article contained the following:

Mol. oxygen as oxidant to promote palladium-catalyzed acetoxylation of sp3 C-H bonds to afford α-oxygenated products is reported. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Synthetic Route of 34413-35-9

The Article related to palladium catalyzed acetoxylation mol oxygen, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Synthetic Route of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider