Heterocyclic Building Blocks-quinoxaline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

0.6 g Iridium (III) chloride hydrate (2 mmol), 0.79 g 5-methyl-5H-benzo[c][1,5]naphthyridin-6-one (4.4 mmol), 24 mL 2-ethoxy ethanol, and 7 mL water were added and reacted for 24 hr under nitrogen. After cooling, filtration, and washing by small amount of methanol, a chlorine-bridged dimer complex was obtained. The complex, 1.06 g sodium carbonate (Na2CO3) (10 mmol), 25 mL 2-ethoxyanol, and 0.7 g quinoxaline-2-carboxylic acid (4 mmol) were then mixed and reacted for 9 hr under nitrogen. After cooling, solid was precipitated and washed by small amount of water. After purification by silicon-gel column, 0.63 g yellow solid was obtained, with a yield of 40%.1H NMR (CDCl3, 400 MHz) spectrum data9.85 (s, 1 H), 8.58 (d, J=5.5 Hz, 1 H), 8.20 (d, J=8.4 Hz, 1 H), 7.93-7.75 (m, 4 H), 7.68 (d, J=8.5 Hz, 1 H), 7.64 (d, J=8.5 Hz, 1 H), 7.47-7.43 (m, 2 H), 7.31-7.15 (m, 3 H), 7.05 (t, J=7.6 Hz, 1 H), 6.76 (d, J=7.4 Hz, 1 H), 6.22 (d, J=7.4 Hz, 1 H), 3.80 (s, 3 H), 3.77 (s, 3 H)., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE; US2008/214818; (2008); A1;,
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7712-28-9, 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7712-28-9, General procedure: In a typical reaction, AMA 2:3 (10mmol), the corresponding carboxylic acid (1mmol) and the alcohol (2ml) were mixed in the provided reaction glass tube equipped with a screw cap and magnetic agitation until a wet mixture was achieved. The reaction mixture was irradiated with microwaves (Anton Parr Monowave 300 reactor) at 120C for 10-25min. On cooling, the mixture was diluted with DCM (41mL), and filtered over celite. Then the filtrate was washed with Na2CO3 (ss) and water. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to give the ester.

As the paragraph descriping shows that 7712-28-9 is playing an increasingly important role.

Reference£º
Article; Estrin, Dario; Fabian, Lucas; Gomez, Natalia; Moglioni, Albertina; Salvatori, Melina; Taverna Porro, Marisa; Turk, Gabriela; European Journal of Medicinal Chemistry; vol. 188; (2020);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

A suspension of 2,3,6-trichloroquinoxaline (J. Med. Chem. 33, 2240-54,1990) (5.84 g, 25 mmol) in dry methanol (70 ml) was stirred at 50 C. while methanolic sodium methoxide (30 mmol) (prepared from 0.7 g of sodium and 70 ml of dry methanol) was added over 5 hours. After the addition was complete, heating and stirring was continued for a further 16 hours. The mixture was cooled in an ice bath, the precipitate filtered off, washed with a small amount of methanol and dried to afford 4.28 g of a mixture consisting of 2,3-dimethoxy-6-chloroquinoxaline, 2,6-dichloro-3-methoxyquinoxaline and 3,6-dichloro-2-methoxy-quinoxaline, respectively., 2958-87-4

The synthetic route of 2958-87-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novo Nordisk A/S; US6927214; (2005); B1;,
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen atmosphere, the compound of formula (F) (1.34 g, 7.26 mmol) 5,8-dibromoquinoxanline (0.951 g, 3.30 mmol), sodium tert-butoxide (0.952 g, 9.90 mmol), Bis (dibenzylideneacetone) palladium (0) (0.114 g), (¡À) -2,2 ‘- (¡À) -2,2′-bis (diphenylphosphino ) -1,1′-binaphthalene [(¡À) -2,2′-Bis (diphenylphosphino) -1,1’-binaphthalene] (0.185 g, 0.297 mmol) was refluxed for 12 hours. After the temperature was lowered to room temperature, the mixture was washed with water, the residue was removed with MgSO 4, hydrazine monohydrate was added thereto, and the mixture was stirred at room temperature for 30 minutes. Precipitated in hexane, filtered off the solid and dried under vacuum to obtain the compound P-1.

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; LG Chem, Ltd.; Kim Jin-seok; Bae Jae-sun; Lee Jae-cheol; Shin Hyeon-a; Hwang Min-ho; Ryu So-yeong; Jeong Se-jin; (36 pag.)KR2019/5591; (2019); A;,
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1865-11-8, Methyl quinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of freshly prepared saturated aqueous ammonia (20mL) and 2-quinoxalinecarboxylate (115mg, 0.612 mmol) was stirred at room temperature for 18 hours. The solution was then evaporated under reduced pressure to yield the product as an off-white solid in quantitative yield. Elemental analysis calcd (%) for C9H7N3O (173.06): Calc. C 62.40 H 4.07 N 24.26; found: C 62.40 H 4.11 N 23.94. 1H NMR (400 MHz, d6-DMSO): delta (ppm) 9.439 (s, 1H, H5), 8.237 (dd, J1-2 = 8 Hz, J1-3 = 2 Hz, 1H, H1), 8.194 (dd, J4-3 = 8 Hz, J4-2 = 0.8 Hz, 1H, H4), 7.997 (q-br, J2/3-3/2/1/4 = 10 Hz, 2H, H2/3).

1865-11-8, The synthetic route of 1865-11-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cowan, Matthew G.; Miller, Reece G.; Brooker, Sally; Supramolecular Chemistry; vol. 27; 11-12; (2015); p. 780 – 786;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 148231-12-3, The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 5 N,N’-Dibutylcarbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride 2-Chloro-3-methylquinoxaline (3.572 g., 0.02 mole) was dissolved in 50 ml. of methanol, treated with Norit and filtered. The filtrate was added to 3.767 g. (0.02 mole) of 1,3-dibutylthiourea dissolved in 25 ml. of methanol. The resulting solution was stirred at room temperature for 1 hour and evaporated on a rotary evaporator. The residual oil was triturated successively with several portions of ether, 2:1 pentane-ether and acetone, and was filtered and washed with pentane, to give 2.60 g. (38.6%) of product as a tan solid, m.p. 97-99. Analysis for: C18 H27 ClN4 S Calculated: C, 58.92; H, 7.41; N, 15.27; Cl, 9.66; S, 8.74. Found: C, 58.93; H, 7.50; N, 15.31; Cl, 9.71; S, 9.01.

32601-86-8, 32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
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879-65-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (32 mg, 0.101 mmol) obtained in Example 1, (3), quinoxaline-2-carboxylic acid (35 mg, 0.202 mmol), and O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (42 mg, 0.111 mmol) were dissolved in DMF (2.0 mL), then the solution was added with triethylamine (20 mg, 0.202 mmol), and the mixture was stirred over night. The reaction mixture was treated in a conventional manner to obtain the title compound (10 mg, yield 21%) as yellow crystals. 1H NMR (CDCl3, 400MHz) delta: 3.63 (2H, s), 7.07 (1H, d, J=9Hz), 7.33 (2H, d, J=9Hz), 7.62 (2H, d, J=8Hz), 7.71 (1H, t, J=8Hz), 7.8-8.0 (5H, m), 8.09 (1H, d, J=8Hz), 8.1-8.3 (2H, m), 8.50 (1H, s), 9.75 (1H, s), 9.91 (1H, s)

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Nippon Chemiphar Co., Ltd.; USHIODA, Masatoshi; KOBAYASHI, Kunio; SAITO, Daisuke; SAKUMA, Shogo; IMAI, Toshiyasu; INOUE, Kazuhide; EP2803662; (2014); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 10 ml solution of 3-hydroxy-2-quinoxalinecarboxylic acid in methanol at a concentration of 0. lmol ¡¤ I / 1 was added dropwise to a solution of 5 ml of Co (Cl0) at a concentration of 0.05 mol / 4) 2.6H20 aqueous solution, shake to get a red clear solution, standing at room temperature8 days for self-assembly reaction, to obtain red lumpy crystals, and then followed by anhydrous ethanol, ether washing, drying, that is,A cobalt complex of the formula [Co (qc) 2 (H20) 2] ¡¤ 2H20, wherein qc represents a 3-hydroxy-2-quinoxaline carboxylate represented by the formula(I), yield 54%. The cobalt complex prepared in this example was a mononuclear complex with X-single crystal diffractometer analysis. elementAnalysis: According to the theoretical structure of C18H18CoN4iiq, the calculated value

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing university of information science and technology; Xiao, bo; Chen, MinDong; Liu, qi; (9 pag.)CN103709204; (2016); B;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, General procedure: To a solution of S7 (502.3 mg, 1.4 mmol) in THF (10 mL) containing 10 muL DMF was added oxalylchloride (360.0 muL, 0.3 mmol) at room temperature. The solution was stirred for 2 h andconcentrated. The resulting acid chloride S8 (37.0 mg, 0.1 mmol) was reacted with thecorresponding amine (0.2 mmol) and N,N-Diisopropylethylamine (52.3 muL, 0.3 mmol) overnight.The solution was extracted with ethyl acetate (3 mL), washed with citric acid solution, saturatedNaHCO3, and concentrated. The residue was then purified by preparative TLC.

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Lee, Hsin-Yu; Suciu, Radu M.; Horning, Benjamin D.; Vinogradova, Ekaterina V.; Ulanovskaya, Olesya A.; Cravatt, Benjamin F.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 16; (2018); p. 2682 – 2687;,
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