Heterocyclic Building Blocks-quinoxaline

98416-72-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98416-72-9,6-Bromo-2-chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

Method B: 4-(4-chlorobenzylideneamino)phenol (0.01 mol) wasdissolved in acetonitrile (50 mL). Anhydrous potassium carbonate(2.0 g) was added to the mixture, which was refluxed for 1 h, then(5, 0.01 mol) was added and the mixture was further refluxed for6 h (monitored by TLC). After completion of the reaction, the mixturewas filtered and the excess of acetonitrile was evaporatedunder reduced pressure to produce the compound, yield; 64%

The synthetic route of 98416-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
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6925-00-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

PyAOP 308 mg, 0.59 mml , 1.2 eq) was added to a suspension of quinoxaline-6-carboxylic acid (94 mg, 0.54 mmol, 1.1 eq) in DCM (2.0 mL).6-(4-isopropyl-4H-1,2,4- triazol-3-yl)pyridin-2-amine (100 mg, 0.49 mmol, 1.0 eq) and Et3N (0.16 mL, 1.13 mmol, 2.3 eq) were added and the reaction was stirred overnight. The reaction was partitioned between EtOAc and H2O. The layers were separated and the organic layer was washed with sat. NaHCO3, 10% citric acid, and brine. The organic layer was dried (MgSO4), filtered, and concentrated under reduced pressure. The resultant orange gum was purified by column chromatography eluting with DCM/MeOH (0% MeOH , 8% MeOH) to afford Example 1 (23.7 mg, 0.07 mmol, 13%) as a colorless amorphous solid: LCMS (ESI) m/z 360.15 (M+1).

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; WANG, Guoqiang; GRANGER, Brett; SHEN, Ruichao; HE, Yong; XING, Xuechao; MA, Jun; LONG, Jiang; HE, Jing; WANG, Bin; OR, Yat, Sun; (131 pag.)WO2018/218042; (2018); A1;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A sealable reaction tube equipped with a magnetic stirrer bar was charged with azaarenes (1.0 mmol), sodium benzenesulfinate (2 equiv), TBAI (0.2 equiv), tert-butyl peroxybenzoate (TBPB, 1 equiv), and water (1 ml). The reaction was carried out at 100 C. After completion, the result was diluted with diethyl ether, washed with water and brine, and dried with Mg2SO4. After solvent removal under reduced pressure, the residue was purified by column chromatography on silica gel to afford the corresponding product., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Dong, Dao-Qing; Gao, Xing; Li, Li-Xia; Hao, Shuang-Hong; Wang, Zu-Li; Research on Chemical Intermediates; vol. 44; 12; (2018); p. 7557 – 7567;,
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354793-04-7, Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

354793-04-7, Step B DMF (5 drops) was added to a suspension of 2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid methyl ester (650 mg) in thionyl chloride (6.7 ML) at 23 C. The reaction mixture was then heated to reflux for 18 hrs.After cooling to 23 C. and concentration, the residue was dissolved in chloroform and washed sequentially with portions of saturated aqueous sodium bicarbonate and brine.Drying over sodium sulfate and concentration afforded 2,3-dichloro-quinoxaline-6-carboxylic acid methyl ester as a white solid. MS (M+H)+=257.1.

354793-04-7 Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate 23847563, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US2004/192698; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59564-59-9,3,4-Dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

59564-59-9, 24b. 4-methyl-3,4-dihydroquinoxalin-2(1H)-one To a solution of 24a (500 mg, 3.378 mmol) in MeOH (3 mL) was added NaBH3CN (425 mg, 6.76 mmol), paraformaldehyde (102 mg), followed by HOAc (30 muL). The reaction mixture was stirred at rt for 4 h. Another portion of NaBH4CN (212 mg, 3.37 mmol) and parafornaldehyde (51 mg) were added to the reaction mixture along with conc. HCl (10 muL). The reaction mixture was stirred at 50 C. for 5 h and cooled to rt. The pH was adjusted to 8 and the solvent was evaporated under reduced pressure. The desired product was extracted into EtOAc and washed it with brine, dried over Na2SO4. The solvent was evaporated under reduced pressure to afford 24b (537 mg, 98%) as beige powder. LC-MS ESI m/z 163 [M+H]+.

The synthetic route of 59564-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

6-bromo-2-chloroquinoxaline (0.365 g 1.5 mmol) was dissolved in DMSO (10 mL) at room temperature and (R)-1-[3-(4-Methyl-piperazin-1-yl)-phenyl]-ethylamine (0.33 g, 1.5 mmol) and triethylamine (0.626 mL, 4.50mmol) were added to the solution. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, water (100 mL) was added and the product was extracted with ethyl acetate (3 x 50 mL). The organic layer was washed with water (10 mL) followed by brine solution (10 mL) and dried over Na2SO4. The organic layer was concentrated in vacuo to afford the crude product.The product was purified by column chromatography using neutral silica gel of 60-120 mesh size and was eluted by a gradient of 5-15 % ethyl acetate in hexane to afford the title compound as a solid (0.250 g, 47%)., 55687-02-0

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
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55687-23-5, 6-Fluoroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55687-23-5

Lithium hydride (57 mg, 7.3 mmol) was added to a solution of 6-fluoroquinoxalin-2(1 H)one (1 g, 6.0 mmol) in N,N-dimethylformamide (6 ml) under cooling on ice and the mixture was stirred at room temperature for 30 minutes. The mixture was cooled on ice again and a solution of 2-(2-bromoethyl)-1,3-dioxolane (0.88 ml, 7.3 mmol) in N,N-dimethylformamide (2 ml) was gradually added thereto and the mixture was stirred for 4 hours. Water was added thereto, the mixture was then extracted with ethyl acetate, and the extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to yield 0.5 g (32%) of the title compound. 1H-NMR(400MHz,DMSO-d6)delta:1.93-1.99(2H,m),3.76-3.80(2H,m),3.89-3.92(2H,m),4.23-4.27(2H,m),4.96-4.99(1H,m),7.17-7.28(1H,m),7.45-7.48(1H,m),7.88-7.90(1 H,m),8.18(1 H,s). MS(ESI)m/z:265(M+H)+.

The synthetic route of 55687-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; INAGAKI, Hiroaki; FUJISAWA, Tetsunori; ITOH, Masao; YOKOMIZO, Aki; TSUDA, Toshifumi; HIGUCHI, Saito; DAS, Biswajit; KATOCH, Rita; UPADHYAY, Dilip, J.; EP2674430; (2013); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

In a 250 mL round bottom flask,Add 2.1078g (2.0 mmol) of bis[tris(2-methyl-2-phenylpropyl)]tin oxide, 0.6975g (4.0 mmol) of quinoxaline-2-carboxylic acid, and 60 mL of toluene in order. Put on a Dean-Stark trap, heat and reflux at 112-120 for 12 h. After the reaction was completed, filter while hot, and the filtrate was removed with a rotary evaporator to obtain a white solid, which was recrystallized from ethanol, which was tri(2-methyl-2-phenylpropyl)tinquinoxaline-2-carboxylic acid Ester complex. Yield: 79%,

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Hengyang Normal University; Zhu Xiaoming; Yu Jiangxi; Jiang Wujiu; Feng Yonglan; Kuang Daizhi; Ou Yaping; Zhang Fuxing; (14 pag.)CN111116637; (2020); A;,
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34117-90-3, 3-Chloroquinoxalin-2-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthetic procedure for the preparation of (0): In a 5mL round bottom flask, aminopyrazine (250 mg, 1.3 mmol, 1 eq.), diazo compound (968 mg, 3.48 mmol, 2.5 eq.), Rh2(OAc)4 (61.52 mg, 0.139 mmol 10 mol %), and 3 mL of chlorobenzene were placed. The reaction mixture was heated at 100C for 24 hours. The progress of the reaction was monitored by LCMS. After 24 hours, the reaction reached 100% conversion. The mixture was adsorbed on celite and purified on silica column using 40% EtOAc in Heptane as eluent. Yield, 469 mg, 78.4%

34117-90-3, The synthetic route of 34117-90-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROMEGA CORPORATION; HALL, Mary; KIRLAND, Thomas; MACHLEIDT, Thomas; SHAKHMIN, Anton; WALKER, Joel, R.; (141 pag.)WO2018/22865; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, To a solution of 8-methyl-2-phenylquinoline-3-carboxaldehyde (80 mg, 0.32 mmol) in THF (5 mL) was added di-w-butyltin dichloride (10 mg, 0.032 mmol), phenylsilane (70 mg, 0.64 mmol) and 6-aminoquinoxaline (46 mg, 0.32 mmol). The mixture was heated in a microwave at 1000C for 3 h. Purification by preparative HPLC {Method 2) gave the title compound as an off-white solid (45 mg, 37%). deltaH (CDCl3) 8.61 (d, J2.1 Hz, IH), 8.51 (d, J 1.9 Hz, IH), 8.24 (s, IH), 7.84 (d, J9.0 Hz, IH), 7.71-7.76 (m, IH), 7.61-7.66 (m, IH), 7.40-7.58 (m, 6H), 7.10 (dd, J9.2, 2.6 Hz, IH), 6.88 (d, J2.6 Hz, IH), 4.64-4.69 (m, 2H), 4.52-4.60 (m, IH), 2.82 (s, 3H). LCMS (ES+) 377.2 (M+H)+, RT 4.23 minutes {Method 4).

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; WO2009/81105; (2009); A2;,
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