Heterocyclic Building Blocks-quinoxaline

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of compound 1 (2.78 g, 0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and an appropriate cyclic secondaryamine namely, piperidine or morpholine (0.01 mol) was added. The reaction mixture was refluxed for 4-h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of acetonitrile was evaporated under reduced pressure and the residue obtained was dried and crystallized from petroleum ether (60-80C) to afford the corresponding compounds.

108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 8-amino-2-(2-chlorophenyl)-2-azaspiro[4.5]decan-1-one (isomer 1 Intermediate I35), (80.0 mg, 287 muetaiotaomicronIota) in DMF (2.6 ml) was added PyBOP (149 mg, 287 muiotaetaomicronIota), N,N-diisopropylethylamine (180 muIota, 1.0 mmol) quinoxaline-5-carboxylic acid (45.4 mg, 261 muiotaetaomicronIota) and the reaction was stirred for 6 h at room temperature. For work-up, water (45 ml) and methanol (2 ml) were added and the mixture was stirred for 1 h. The resulting precipitate was collected by filtration, washed with water/methanol (4:1) and dried to give the title compound 88.0 mg.LC-MS (Method 1 ): Rt = 1.11 min; MS (ESIpos): m/z = 435 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.511 (1.32), 1.535 (1.90), 1.553 (1.86), 1.566 (1.15), 1.583 (0.94), 1.701 (6.81), 1.710 (7.70), 1.718 (4.21), 1.727 (4.89), 2.031 (2.37), 2.040 (2.45), 2.062 (2.30), 2.072 (2.09), 2.151 (3.91), 2.167 (7.46), 2.185 (4.20), 2.327 (0.71), 2.523 (2.11), 2.669 (0.74), 3.639 (4.24), 3.657 (7.45), 3.674 (4.09), 3.893 (0.95), 3.902 (1.18), 3.912 (0.99), 3.921 (1.16), 3.931 (0.92), 7.366 (0.91), 7.378 (2.34), 7.384 (0.94), 7.389 (2.78), 7.395 (1.80) 7.397 (1.97), 7.408 (5.72), 7.414 (9.89), 7.417 (11.90), 7.426 (4.60), 7.431 (1.87), 7.563 (2.52) 7.567 (4.20), 7.570 (2.67), 7.582 (2.11), 7.585 (3.42), 7.588 (2.18), 7.962 (3.09), 7.980 (3.80) 7.983 (4.01), 8.001 (3.67), 8.255 (4.10), 8.259 (4.31), 8.276 (3.62), 8.279 (3.59), 8.432 (3.87) 8.436 (3.99), 8.451 (3.77), 8.454 (3.48), 9.074 (3.30), 9.079 (16.00), 9.086 (3.50), 9.774 (2.94) 9.793 (2.89), 6924-66-9

As the paragraph descriping shows that 6924-66-9 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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53967-21-8, 6-(Bromomethyl)quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53967-21-8, A mixture of 6-(bromomethyl)quinoxaline (900 mg, 4.0 mmol), 6-methyl-2- sulfanylpyrimidin-4-ol (440 mg, 3.1 mmol), and triethylamine (1.1 mL, 7.8 mmol) in absolute ethanol (20 mL) was stirred at room temperature overnight. The reaction mixture was evaporated and then co-evaporated with EtOAc. The solid residue was treated with water (100 mL). The solid product was recovered by filtration, washed with water (2 x 20 mL), diethyl ether (3 x 20 mL), and hexanes (3 x 20 mL), and then dried in vacuo, affording 6-methyl-2-[(quinoxalin-6-ylmethyl)sulfanyl]pyrimidin-4-ol (658 mg, 75% yield). The product was used without further purification.

53967-21-8 6-(Bromomethyl)quinoxaline 10214510, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita; WO2010/132999; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34117-90-3,3-Chloroquinoxalin-2-amine,as a common compound, the synthetic route is as follows.

Step B – Synthesis of Int-21BInt-21 A (1.20 g, 6.7 mmol) was combined with 1-phenyl-3-bromopropane-1,2-dione (1.67 g, 7.4 mmol, prepared as a yellow oil by bromination in CHCl3 at 50 C, followed by chromatography) in THF (10 mL) and ether (15 mL). The mixture was stirred 18 h, concentrated, treated with ethanol (40 mL), heated at 90 C for 72 h, and allowed to cool.Concentration, addition of methanol (10 mL), and filtration gave Int-21B as a brown solid., 34117-90-3

As the paragraph descriping shows that 34117-90-3 is playing an increasingly important role.

Reference£º
Patent; SCHERING CORPORATION; HARRIS, Joel, M.; NEUSTADT, Bernard, R.; STAMFORD, Andrew, W.; WO2011/60207; (2011); A1;,
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98416-72-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98416-72-9,6-Bromo-2-chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: Method B: 4-[(4-substituted phenylimino)methyl]phenol(0.01 mol) was dissolved in acetonitrile (50 mL). Anhydrous potassiumcarbonate (2.0 g) was added to the mixture, which wasrefluxed for 1 h, then (5, 0.01 mol) was added and the mixturewas further refluxed for 8 h (monitored by TLC). After completionof the reaction, the mixture was filtered and the excess of acetonitrilewas evaporated under reduced pressure to produce the correspondingcompounds

The synthetic route of 98416-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
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1210048-05-7, 7-Bromo-5-fluoroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 365-Fluoro-7-[3-(piperidin-l-ylmethyl)phenyllquinoxalineGlyoxal (10 drops of a 40% solution in water) was added to a solution of 5- bromo-2,3-diaminofluorobenzene (82 mg, 0.4 mmol) in ethanol (3 mL). The mixture was stirred and left to stand at r.t. for 1 h. The mixture was partitioned between water and EtOAc (20 mL each), and the organic phase was dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DME (1.2 mL), and 3-(piperidin-l-ylmethyl)phenyl- boronic acid pinacol ester hydrochloride (135 mg, 0.4 mmol), 2M aqueous sodium carbonate solution (0.6 mL, 0.9 mmol) and Pd(PPh3)4 (14 mg, 0.012 mmol) were added. The mixture was heated to 12O0C in a sealed tube, under microwave irradiation, for 20 minutes. The mixture was partitioned between water and EtOAc (2 mL each), and the organic phase was concentrated in vacuo. The residue was purified by preparative HPLC to give the title compound (23 mg, 18% over the two steps) as a pale yellow-brown gum. deltaH (CDCl3) 8.94 (d, IH), 8.89 (d, IH), 8.17 (s, IH), 7.80 (d, IH), 7.72 (s, IH), 7.64 (d, IH), 7.48 (t, IH), 7.43 (d, IH), 3.64 (s, 2H), 2.40-2.60 (m, 4H), 1.55-1.70 (m, 4H), 1.39- 1.54 (m, 2H). LCMS (ES+) 322 (M+H)+, RT 2.25 minutes., 1210048-05-7

As the paragraph descriping shows that 1210048-05-7 is playing an increasingly important role.

Reference£º
Patent; UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; WO2010/52448; (2010); A2;,
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53967-21-8, 6-(Bromomethyl)quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(4-tert-butylphenyl)-4-{[4-(6-quinoxalyl)methyl]piperazin-1-yl}benzimidazole; To a suspension of 2-(4-t-butylphenyl)-4-piperazin-1-yl-1H-benzimidazole (49.5 g, 0.148 mol) and potassium carbonate (40.0 g, 0.29 mol) in acetone (0.800 L, EM) was added 6-bromomethylquinoxaline (33.0 g, 0.148 mol) as a solid in one portion at room temperature. The reaction mixture was stirred for 22 h at ambient temperature. The product precipitated out of solution was separated by filtration; the cake was washed with 30 mL of acetone, then triturated with 0.8 L of water and filtered again. The trituration procedure was repeated two more times. The resulting solid was dried in a stream of air first, then in a vacuum desiccator over CaSO4 to give 70 g (0.147 mol) of the desired product as a white amorphous solid. Purity 98% (HPLC at 254 nm)., 53967-21-8

As the paragraph descriping shows that 53967-21-8 is playing an increasingly important role.

Reference£º
Patent; Wyeth; US2005/282820; (2005); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

H2SO4 (16 mL) was added dropwise to a stirred solution of 3-hydroxy-2-quinoxalinecarboxylic acid (9.3 g, 49.0 mmol) in methanol (245 mL) at room temperature. After the mixture was stirred at room temperature overnight, the methanol was removed under vacuum. The residue thus obtained was dissolved in ethyl acetate and washed with water. The organic layer was separated, washed with brine, dried over anhydrous MgSO4, and concentrated in vacuo to afford 8.03 g of crude methyl 3-hydroxyquinoxaline-2-carboxylate as a light orange solid. LC-MS (M+H): 205.0., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; TaiGen Biotechnology Co., Ltd.; US2008/292626; (2008); A1;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 2-chloro-3-methylquinoxaline (89 mg, 0.50 mmol, 1 equiv), N-Boc-2- pyrroleboronic acid (158 mg, 0.75 mmol, 1.5 equiv), and K3P045H20 (0.45 g, 1.5 mmol, 3 equiv) was added THF (400 iL) then a THF stock solution of 3 and PAd3 (100 .iL, 0.25 imol of Pd/PAd3). The mixture was stirred at 70 C for 5 h. The reaction mixture was diluted with ethylacetate then extracted with water. The combine organic layers were evaporated and the crude product was purified by flash chromatography. After drying, 148 mg (96 %) of 30 was obtained as a white solid.1H NMR (501 MHz, CDC13) 8.09 – 7.98 (m, 2H), 7.74 – 7.63 (m, 2H), 7.43 (dd, J 3.4, 1.7 Hz, 1H), 6.44 (dd, J= 3.3, 1.7 Hz, 1H), 6.33 (t, J= 3.4 Hz, 1H), 2.56 (s, 3H), 1.17 (s, 9H).3C{1H} NMR (126 MHz, CDC13) oe 154.5, 149.6, 148.6, 141.2, 140.3, 130.7, 129.8, 129.1,129.0, 128.3, 122.5, 115.6, 111.4, 84.2, 27.4, 23.0.HRIVIS (ESI) mlz calculated for C18H19N302 (M+1) 310.1550, found 310.1552., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; THE TRUSTEES OF PRINCETON UNIVERSITY; CARROW, Brad P.; CHEN, Liye; (51 pag.)WO2017/75581; (2017); A1;,
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83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Titanium tetraisopropoxide (0.1 mL, 0.34 mmol) was added to a stirred suspension of Intermediate 3a (71 mg, 0.31 mmol) and l-(quinoxalin-6-yl)ethanone (CAS: 83570-42- 7; 63 mg, 0.37 mmol) in THF (1.5 mL) at rt and under N2 atmosphere. The mixture was stirred into a sealed tube at 80 C for 16 h. Then sodium cyanoborohydride (30 mg, 0.48 mmol) was added and the mixture was further stirred at 80 C for 16 h. Then, NaHC03 (aq. sat. soltn.) and DCM were added to the mixture. The solvent was evaporated in vacuo and the crude product was purified by flash column (0320) chromatography (silica gel, 7N solution of NH3 in MeOH in DCM, from 0/100 to 10/90) and then by RP HPLC (Stationary phase: CI 8 XBridge 30 x 100 mm 5 muetaiota; mobile phase: gradient from 81% lOmM NH4CO3H pH 9 solution in water, 19% CH3CN to 64% lOmM NH4CO3H pH 9 solution in water, 36% CH3CN). The desired fractions were collected and concentrated in vacuo to yield product 6 (15 mg, 13% yield) as yellow oil., 83570-42-7

83570-42-7 1-(Quinoxalin-6-yl)ethanone 22631249, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres Avelino; MARTINEZ VITURRO, Carlos Manuel; (116 pag.)WO2018/141984; (2018); A1;,
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