Heterocyclic Building Blocks-quinoxaline

23088-23-5, Methyl 6-Quinoxalinecarboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of quinoxaline-6-carboxylic acid methyl ester (2084mg, 11.07mmol) in ethanol (25mL) was added an aqueous solution of 1 N sodium hydroxide (25mL), and the solution was stirred for 4 hours under reflux. 1 N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, then, the precipitated solid was collected by filtration, washed with water and isopropanol, then dried to obtain the title compound (1477mg, 8.479mmol, 76.6%) as a solid. 1H-NMR Spectrum (DMSO-d6) delta(ppm) : 8.18 (1H, d, J=8.4Hz), 8.29 (1H, dd, J=8.4, 1.2Hz), 8.61 (1 H, d, J=1.2Hz), 9.00-9.07 (2H, m).

23088-23-5, As the paragraph descriping shows that 23088-23-5 is playing an increasingly important role.

Reference£º
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, To 6-bromo-quinoxaline (1 g) in acetonitrile (25 mL) was added propargyl alcohol (0.285 mL) and triethylamine (1.334 mL) followed by copper(I) iodide (10 mg) and bis(triphenylphosphine)palladium chloride (34 mg). The reaction mixture was stirred under nitrogen and then heated at 800C for 18h. The mixture was allowed to cool and then filtered. The filtrate was evaporated and then purified by chromatography on silica eluting with ethylacetate / isohexane (1 : 1 to 1 : 0) to afford the sub-titled compound as a solid (0.7 g).1H NMR (400 MHz, DMSO) I’ 8.97 (2H, dd), 8.13 (IH, d), 8.10 (IH, d), 7.84 (IH, dd), 5.45 (IH, t), 4.39 (2H, d).

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB; WO2009/153536; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3476-89-9,1,2,3,4-Tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: Bromine was added dropwise to a magnetically stirred refluxing solution of quinoxaline (1) or tetrahydroquinoxaline 15 or 19 in the relevant solvent. The resulting reaction mixture was heated at reflux temperature. The reaction was monitored by TLC or 1H NMR spectroscopy. After the desired time, the resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. The crude was purified appropriate method described in below.

3476-89-9, 3476-89-9 1,2,3,4-Tetrahydroquinoxaline 77028, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, After adding 6-bromoquinoxaline (3.8 g, 18.2 mmol), n-butyl vinyl ether (12.3 mL, 95.2 mmol), potassium carbonate (3.1 g, 22.8 mmol), 1,3-bis(diphenylphosphino)propane (504 mg, 1.3 mmol) and palladium(II) acetate (124 mg, 0.5 mmol) to N,N-dimethylformamide (47 mL) and water (6 mL), the result was stirred and refluxed for 6 hours. After terminating the reaction, the result was cooled to room temperature, 2 N hydrochloric acid was added thereto, and the result was stirred for 0.5 hours. Ethyl acetate was added thereto, the organic layer was washed with water and sodium bicarbonate, dried using anhydrous magnesium sulfate, and filtered. The filtrate was concentrated and purified using column chromatography to obtain a target compound (2.4 g). 1H NMR spectrum (300 MHz, DMSO-d6) delta 10.05(d, 1H), 9.73(t, 1H), 8.71(s, 1H), 7.97(d, 1H), 3.16(s, 3H).

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Hanmi Pharmaceutical Co., Ltd.; LEE, Kyung Ik; JUNG, Young Hee; SONG, Ji Young; JUN, Seung Ah; (89 pag.)EP3480193; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (137 mg, 0.717 mmol) was added to a methylene chloride solution (4.8 ml) of (2S)-3-methyl-1-oxo-1-(4-{[6-(trifluoromethyl)pyridin-3-yl]oxy}piperidin-1-yl)butan-2-amine dihydrochloride (200 mg, 0.478 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (93.7 mg, 0.478 mmol), 1-hydroxybenzotriazole monohydrate (77.5 mg, 0. 574 mmol) and N-methylmorpholine (0.263 ml, 2.39 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride, and the extract was washed sequentially with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the resulting residue was suspended in a mixed solvent of ethanol-diethyl ether, and then the solid substance was collected by filtration to afford the desired title compound (145 mg, yield 59%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.08 (1H, brs), 10.15 (1H, brs), 8.41 (1H, dd, J=10.6 Hz, 2.7 Hz), 8.02 (1H, brs), 7.66-7.30 (5H, m), 5.09-5.04 (1H, m), 4.78-4.70 (1H, m), 4.10-3.64 (4H, m), 2.35-1.95 (5H, m), 1.14-1.09 (6H, m). IR (KBr) cm-1: 2965, 1685, 1640, 1530, 1340. MS (ESI, m/z): 518 (M+H)+. HRMS (ESI, m/z): 518.2016 (Calcd for C25H27F3N5O4: 518.2015). Anal. Calcd for C25H26F3N5O4¡¤0.5H2O: C, 57.03; H, 5.17; N, 13.30; F, 10.83. Found: C, 56.82; H, 4.98; N, 13.03; F, 10.89., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

EXAMPLE 183 N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo [4,5-c]quinolin-1-yl]butyl}quinoxaline-2-carboxamide Using the general method of Example 181 1-(4-aminobutyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.5 g, 4.78 mmol) was reacted with 2-quinoxalinecarboxylic acid (1.0 g, 5.74 mmol) to provide 270 mg of N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}quinoxaline-2-carboxamide as a yellow crystalline solid, m.p. 85-87 C. Analysis: Calculated for C26H27N7O2: %C, 66.51; %H, 5.80; %N, 20.88; Found: %C, 66.12; %H, 5.70; %N, 20.62.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Coleman, Patrick L.; Crooks, Stephen L.; Griesgraber, George W.; Lindstrom, Kyle J.; Merrill, Bryon A.; Rice, Michael J.; US2003/144283; (2003); A1;,
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2427-71-6, 6-Chloro-2(1H)-quinoxalinone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-chloroquinoxalin-2(1H)-one (1.0 g, 5.5 mmol) and phosphorus tribromide (PBr3; 3.5 mL, 36.1 mmol) was heated at 120 C. for 4 h. The reaction mass was cooled to RT, diluted with cold H2O and extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, filtered and concentrated under vacuum to get crude product. The crude compound was purified by silica gel column chromatography (eluting with EtOAc/hexane) to afford 2-bromo-6-chloroquinoxaline (550 mg, 2.26 mmol, 42%) as a solid. 1H NMR (200 MHz, CDCl3): delta 8.86 (s, 1H), 8.11 (s, 1H), 7.99 (d, J=8.8 Hz, 1H), 7.75 (dd, J=9.0, 2.4 Hz, H). MS (ESI): m/z 243 [M+]., 2427-71-6

2427-71-6 6-Chloro-2(1H)-quinoxalinone 75507, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; US2012/329802; (2012); A1;,
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Quinoxaline | C8H6N2 | ChemSpider

2379-60-4, 2 3-Dichloro-6-nitroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 3-Chloro-2-hydrazino-6-nitroquinoxaline A mixture of 6.1 g (25 mmol) of 2,3-dichloro-6-nitroquinoxaline and 2.75 g (55 mmol) of hydrazine hydrate in 150 ml of ethanol was stirred at room temperature over night. The precipitate was isolated and washed with water, cold ethanol and ether to give 5.67 g (95%) of crude product., 2379-60-4

The synthetic route of 2379-60-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novo Nordisk A/S; US5504085; (1996); A;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

H2S04 (0673 ml, 1263 mmol) was added to a solution of quinoxaline-2-carhoxylic acid (1.1 g, 6.32 mmol) in Methanol (20 nil) at 0 O( The reaction mixture was refluxed for 3h. After completion of reaction, methanol was evaporated under reduced pressure and the residue was diluted withdichlorornethane. The organic portion was washed with saturated sodium bicarbonate solution, brine and evaporated under reduced pressure to give methyl quinoxaline-2-carboxylate (1.1 g, 5.85 rnmol,93%)

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PI INDUSTRIES LTD.; SAXENA, Rohit; PANMAND, Deepak Shankar; JENA, Lalit Kumar; SRIVASTAVA, Khushboo; RAJU, Jella Rama; MANJUNATHA, Sulur G; SAMANTA, Jatin; GARG, Ruchi; AUTKAR, Santosh Shridhar; VENKATESHA, Hagalavadi M; GADAKH, Ramdas Balu; KLAUSENER, Alexander G. M.; POSCHARNY, Konstantin; (219 pag.)WO2018/116072; (2018); A1;,
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Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (220 mg, 0.580 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (110 mg, 0.580 mmol) to afford the desired title compound (132 mg, yield 45%) as a white solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.57 and 10.15 (1H, brs), 7.98 (1H, d, J=4.6 Hz), 7.65-7.53 (4H, m), 7.37 (1H, brs), 6.99 (2H, d, J=8.6 Hz), 5.07 (1H, t, J=7.3 Hz), 4.72-4.65 (1H, m), 4.03-3.62 (5H, m), 2.36-2.10 (2H, m), 2.02-1.80 (3H, m), 1.12 (3H, d, J=6.8 Hz), 1.11 (3H, d, J=6.8 Hz). IR (ATR) cm-1: 1685, 1630, 1610, 1515, 1445, 1320, 1250. MS (ESI, m/z): 517 (M+H)+. Anal. Calcd for C26H27F3N4O4: C, 60.46; H, 5.27; N, 10.85. Found: C, 60.23; H, 5.23; N, 10.82., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider