Heterocyclic Building Blocks-quinoxaline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.887590-25-2,tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate,as a common compound, the synthetic route is as follows.

887590-25-2, A partial solution of tert-butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate (100 mg, 0.467 mmol), 1,3-dibromobenzene (220 mg, 0.933 mmol), C52CO3 (608 mg, 1.867 mmol) in toluene (1 mL), was purged and degassed with N2, then 2,2?- bis(diphenylphosphino)-1,1?-binaphthalene (58.1 mg, 0.093 mmol) and palladium(II) acetate (20.95 mg, 0.093 mmol) were added, and the vessel was purged and degassedagain. The reaction flask was capped and stirred at 110 C overnight. The mixture was cooled, water (15 mL) was added and extracted with ethyl acetate (15 mL x 3). The combined organic layers were washed with brine, dried over Na2504, and concentrated. The residue was purified on silica gel with a gradient of 0-100% EtOAc in hexanes to give tert-butyl 4-(3 -bromophenyl)-3 ,4-dihydroquinoxaline- 1 (2H)-carboxylate (120 mg66.1% yield) as a white solid. LCMS M = 389.10/391.15. Method G. Retention time4.175 mm.

The synthetic route of 887590-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; BATT, Douglas G.; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; LIU, Qingjie; MARCOUX, David; NEELS, James; POSS, Michael A.; QIN, Lan-ying; RUAN, Zheming; SHI, Qing; SRIVASTAVA, Anurag S.; TINO, Joseph A.; WATTERSON, Scott Hunter; (532 pag.)WO2016/64957; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

EXAMPLE 17 By reaction of 2,3,6-trichloroquinoxaline with aminoacetaldehyde dimethyl acetal, according to a procedure that is similar to that followed in example 1, there is obtained 8-chloroimidazo[1,2-a]quinoxaline-4(5H)-one (m.p. >300 C.)., 2958-87-4

As the paragraph descriping shows that 2958-87-4 is playing an increasingly important role.

Reference£º
Patent; Biomedica Foscama Industria Chimicofarmaceutica S.p.A.; US6124287; (2000); A;,
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36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

36856-91-4, 2-bromoquinoxaline 100mmol, eight membered nitrogen (or sulfur) heterocyclic boride intermediate 220mmol were added to 1L three-necked flask and dissolved in 400mL of toluene, was added under nitrogen tetrakistriphenylphosphine palladium 1.5mmol, 250mmol potassium carbonate, distilled water 100mL, the reaction was stirred at reflux for 24 hours, cooled to room temperature, after the reaction liquid separation, silica gel funnel, washing, spin-dry, recrystallized, filtered, 71mmol obtain compound 17 as a gray solid, yield 71%.

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Ma, Xiaoyu; Song, Qiaohong; Zhao, He; (22 pag.)CN105315229; (2016); A;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6925-00-4, To a solution of quinoxaline-6-carboxylic acid (5.1 g, 29.3 mmol, 1.0 eq) in DMF (100 mL) were added HATU (13.3 g, 35 mmol 1.2 eq), DIEA (20 mL, 117.2 mmol, 4.0 eq) and O,N-dimethyl-hydroxylamine hydrochloride salt (3.38 g, 35 mmol, 1.2 eq). The mixture was stirred at rt overnight, then the solvent was evaporated. The resulting residue was purified by flash column chromatography (PE/EA=2/1, v/v) to afford N-methoxy-N-methylquinoxaline-6-carboxamide as yellow solid (5.1 g, 80%).

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NeuPharma, Inc.; Zhu, Yong-Liang; Qian, Xiangping; US2013/53384; (2013); A1;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of compound 1 (2.78 g, 0.01 mol)and arylthiosemicarbazone (0.01 mol) in absolute ethanol (50 mL) was refluxed for 4-5 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried and crystallized from benzene to produce the corresponding compounds.

108229-82-9, The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

N-(2-Adamantyl)-2-quinoxalinecarboxamide (144) Prepared from 1,1′-carbonyldiimidazole (161 mg, 1.00 mmol), 2-quinoxalinecarboxylic acid (174 mg, 1.00 mmol), 2-adamantanamine (136 mg, 0.90 mmol), and dichloromethane (3.5 mL) yielding 98 mg (35%) of (144): rt=11.79 min.; m/z (rel. int.) 307 (M+,33), 151 (12), 150 (100), 130 (24), 129 (35), 103 (11), 102 (20), 91 (13), 79 (11), 77 (8), 76 (6), 75 (5), 70 (6), 67 (5) 41 (6).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NPS Pharmaceuticals, Inc.; US6429207; (2002); B1;,
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83570-42-7,83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Titanium tetraisopropoxide (0.062 mL, 0.21 mmol) was added to a stirred solution of intermediate 17 (40 mg, 0.19 mmol), i-(6-quinoxalinyl)ethanone (CAS: 83570-42-7;45 mg, 0.26 mmol) in MeOH (1 mL) at rt and under N2 atmosphere. The mixture was stirred at 80C for 16 h. Then sodium cyanoborohydride (20 mg, 0.32 mmol) was added and the mixture was stirred at 80C for 5 h and then at rt for 60 h. The volatiles were evaporated in vacuo. The residue thus obtained was purified by flash column chromatography (silica, 7N solution of NH3 in MeOH in DCM, 0/100 to 10/90). Thedesired fractions were concentrated in vacuo to yield a fraction that was further purified by reverse phase HPLC (Stationary phase: C18 XBridge 30 x 100 mm 5 jim, mobile phase: gradient from 81% 10mM NH4CO3H pH 9 solution in water, 19% CH3CN to 64% 10mM NH4CO3H pH 9 solution in water, 36% CH3CN). The desired fractions were collected and extracted with EtOAc and DCM/2-PrOH (9/1). The desiredfractions were collected and concentrated in vacuo to yield product 11 as yellow oil (7.7 mg, 11% yield).

The synthetic route of 83570-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; ALCAZAR-VACA, Manuel, Jesus; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ZHANG, Wei; CHEN, Gang; (212 pag.)WO2018/109202; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89891-65-6,7-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

[0305] To a solution of 7-bromo-2-chloroquinoxaline (10 g, 41 mmol, 1 eq.) in CH3OH ( 200 mL) was added K2C03 ( 12.4 g, 91 mmol, 2 eq). The resulting mixture was stirred under reflux for 2h, then cooled to rt and concentrated. The resulting residue was dissolved in THF and filtered. The filtrate was concentrated to afford 7-bromo-2-methoxyquinoxaline as a white solid (9.88 g, 100%).

89891-65-6, 89891-65-6 7-Bromo-2-chloroquinoxaline 4913253, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/40515; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, EXAMPLE 183 N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo [4,5-c]quinolin-1-yl]butyl}quinoxaline-2-carboxamide Using the general method of Example 181 1-(4-aminobutyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.5 g, 4.78 mmol) was reacted with 2-quinoxalinecarboxylic acid (1.0 g, 5.74 mmol) to provide 270 mg of N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}quinoxaline-2-carboxamide as a yellow crystalline solid, m.p. 85-87 C. Analysis: Calculated for C26H27N7O2: % C, 66.51; % H, 5.80; % N, 20.88. Found: % C, 66.12; % H, 5.70; % N, 20.62.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; 3M Innovative Properties Company; US6756382; (2004); B2;,
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