Heterocyclic Building Blocks-quinoxaline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A 25-mL round bottom flask equipped with a magnetic stirrer,a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline(100 mg, 0.48 mmol), 4-Fluorophenylboronic acid (80 mg, 0.57 mmol), water/dioxane(1.0 mL/4.0 ml), K2CO3 (132 mg, 0.96 mmol). The resulting solution was degassed for 15min, then Pd(PPh3)4 (27mg, 0.024 mmol) was added. Thereaction mixture was warmed to 100 oC and stirred for 1 h. After cooled to room temperature, thereaction mixture was diluted with EtOAc and washed with saturated NaHCO3,brine, dried over Na2SO4. The organic layer wasconcentrated in rotavapor and purified on silica gel. Elution with EtOAc/hexanes solvent systemafforded the desired compound (40 mg, 38% yield). 1H NMR (400 MHz, CDCl3)delta 9.34 (s, 1H), 8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25(m, 1H).

36856-91-4, 36856-91-4 2-Bromoquinoxaline 582225, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Parhi, Ajit K.; Zhang, Yongzheng; Saionz, Kurt W.; Pradhan, Padmanava; Kaul, Malvika; Trivedi, Kalkal; Pilch, Daniel S.; Lavoie, Edmond J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4968 – 4974;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6298-37-9

General procedure: To a solution of 6-aminoquinoxaline derivative 4a-m (1 equiv), K2CO3(2 equiv), and n-Bu4NI (0.2 equiv) in anhydrous DMF (2 mL/mmol of 4a-m) under inert atmosphere was added propargyl bromide (80% in toluene, 1.5 equiv) or 3-phenyl-propargyl bromide9 (1.5 equiv) and heated at 70 C for 24 h. The mixture was diluted with water, extracted with EtOAc, washed with brine, dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by silica gel flashchromatography (CH2Cl2-EtOAc, 90:10 to 80:20) to afford monopropargyl derivatives 5a-m as brownish yellow solids.

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Article; Vallerotto, Sara; Douaron, Gael Le; Bernadat, Guillaume; Ferrie, Laurent; Figadere, Bruno; Synthesis; vol. 48; 19; (2016); p. 3232 – 3240;,
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82031-32-1, 7-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7-Bromoquinoxalin-2(lH)-one (313.1 mg, 1.391 mmol) was dissolved in 0.15M DMF (9.2 mL) and treated with potassium carbonate (288.4 mg, 2.087 mmol) and iodomethane (95.5 mu,, 1.530 mmol). The reaction mixture was stirred at ambient temperature for 30 minutes. The reaction mixture was then diluted with water and extracted with EtOAc (2 X). The organics were washed with water (3 X) and brine (1 X), dried over Na2S04, filtered and concentrated. Biotage chromatography (hexanes/EtOAc) provided 7- bromo-l-methylquinoxalin-2(lH)-one (87.6 mg, 0.366 mmol, 26.3% yield). 1H NMR (400 MHz, (CD3)2SO) delta = 8.257 (s, 1H), 7.824 (s, 1H), 7.768-7.746 (d, 1H), 7.569-7.543 (dd, 1H), 3.591 (s, 3H)., 82031-32-1

As the paragraph descriping shows that 82031-32-1 is playing an increasingly important role.

Reference£º
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen; MATHIEU, Simon; MORENO, David; REN, Li; RUDOLPH, Joachim; WENGLOWSKY, Steven Mark; WO2012/118492; (2012); A1;,
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 148231-12-3

As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
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91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91-19-0, General procedure: A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the use of a compound “d” (0.3mol), 5,8-di bromo-Oxoquinoxaline (0.15mol), Pd (OAc)2(6.11mmol), P(t-Bu)3(50 wt %, 15 . 28mmol) sodium and tertiary butyl alcohol (0.61mol) is added to the toluene solvent and stirring. In the solution 120 C and the temperature of the refluxing under stirring 12 hours. After the completion of reaction, the solution is cooled to the room temperature and water and ethyl acetate extraction. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the solvent. The material through the use of hexane and ethyl acetate to carry out wet refining column chromatography, so as to obtain compound 22. (Yield: 79%), 148231-12-3

As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
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887590-25-2,887590-25-2, tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 3,4-dihydro-2H-quinoxaline-1-carboxylate (17 g, 72.6 mmol) in MeCN (150 mL) was added N-bromosuccinimide (12.3 g, 68.9 minol) by portionwise at 0 C. The mixture was stirred at 0 C for I h. The reaction was quenched with water (200 mE), extracted with EtOAc (200 mE x 3). The combined organic layers were dried over anhydrousNa2SO4, filtered and concentrated in vacuo. The crude residue was purified by silica gel chromatography (petroleum ether / EtOAc 20: 1 to 4: 1) to give the title compound (14.0 g, 62%) as a light yellow solid. ?H NMR (400 MHz, DMSO-d6) 8 7.50 (s, iH), 6.95 – 6.92 (m, 1H), 6.52 – 6.50 (m, IH), 6.29 (s, 1H), 3.58 – 3.56 (m, 2H), 3.24 – 3.23 (m, 2H), 1.45 (s, 9H).

887590-25-2 tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate 16740533, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ROMERO, F. Anthony; MAGNUSON, Steven; PASTOR, Richard; TSUI, Vickie Hsiao-Wei; MURRAY, Jeremy; CRAWFORD, Terry; ALBRECHT, Brian, K.; COTE, Alexandre; TAYLOR, Alexander, M.; LAI, Kwong Wah; CHEN, Kevin, X.; BRONNER, Sarah; ADLER, Marc; EGEN, Jackson; LIAO, Jiangpeng; WANG, Fei; CYR, Patrick; ZHU, Bing-Yan; KAUDER, Steven; (0 pag.)WO2016/86200; (2016); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (108 mg, 0.350 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (68.6 mg, 0.350 mmol) to afford the desired title compound (107 mg, yield 68%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.87 (1H, brs), 9.70 (1H, brs), 7.88 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.78 (2H, d, J=9.0 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.4 Hz), 7.19 (2H, dd, J=9.0 Hz, 2.6 Hz), 5.03 (1H, m), 4.83 (1H, m), 4.07-3.73 (2H, m), 3.57-3.17 (2H, m), 2.12-1.89 (2H, m), 1.78-1.47 (2H, m), 1.31 (3H, d, J=7.0 Hz). IR (KBr) cm-1: 2945, 2220, 1685, 1640, 1605, 1505, 1255. MS (ESI, m/z): 446 (M+H)+. HRMS (ESI, m/z): 446.1851 (Calcd for C24H24N5O4: 446.1828)., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, General procedure: To a solution of the intermediate acid compound 1a-f (1 equiv.)in anhydrous DMF was added EDCI (1.1 equiv) and HOBt (1.1equiv), respectively. The reaction mixture was stirred for 1 h at ambient temperature, and the L-serine ester (1.1 equiv.) and DIEA(3 equiv.) were added. The solution was heated to 70 C for 6 hand then cooled to room temperature. The reaction mixture was poured into ice water, and the resulting solid was filtered and dried to give the desired compound.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Article; Zhao, Shizhen; Wei, Peng; Wu, Mengya; Zhang, Xiangqian; Zhao, Liyu; Jiang, Xiaolin; Hao, Chenzhou; Su, Xin; Zhao, Dongmei; Cheng, Maosheng; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3242 – 3253;,
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In N2in the gas purification system, the 5,8- […][…] soluble in toluene solvent, and by adding 4 – (diphenyl amino) phenyl boronic acid (1.1 equivalent). The K2CO3 (4.4 equiv) dissolved in distilled water in and added to the mixed solution. By adding tetrahydrofuran solvent, and by adding palladium (0.05 equiv). The mixture at 80 C and the temperature of the refluxing under stirring. After the reaction is finished, by ethyl acetate extraction mixture. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the remaining organic solvent. The material through the use of methylene chloride and hexane to carry out wet refining column chromatography, thereby obtaining compound “m”. (Yield: 43%), 148231-12-3

148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
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