Heterocyclic Building Blocks-quinoxaline

98416-72-9, 6-Bromo-2-chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Aminophenol (0.01 mol) was dissolved in a mixture of acetonitrile(50 mL) and DMF (5 mL) containing anhydrous potassium carbonate(2.0 g). The mixture was refluxed for 1 h, then (5, 0.01 mol)was added and the mixture was further refluxed for 6 h (monitoredby TLC). After completion of the reaction, the mixture was filteredand the excess of acetonitrile was evaporated under reduced pressureand crystallized from ethanol to give the correspondingcompounds, 98416-72-9

As the paragraph descriping shows that 98416-72-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
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6924-66-9,6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PyBOP (100 mg, 193 muiotaetaomicronIota) was added to a mixture of 8-amino-2-(3,5-difluorophenyl)-2- azaspiro[4.5]decan-1-one (isomer 1; Intermediate I28) (50.0 mg, 161 muiotaetaomicronIota), quinoxaline-5- carboxylic acid (30.8 mg, 177 muiotaetaomicronIota) and N,N-diisopropylethylamine (140 muIota, 800 muiotaetaomicronIota) in DMF (1.8 ml) and the mixture was stirred over night at room temperature. For work-up, the reaction mixture was concentrated and the residue was stirred with methanol. The precipitate was collected by filtration, washed with water and methanol and then dried to give the title compound 53.5 mg (76 % yield).LC-MS (Method 1): Rt= 1.23 min; MS (ESIpos): m/z = 437 [M+H]+1H-NMR (400 MHz, DMSO-d6): delta [ppm] = 9.78 (d, 1H), 9.10-9.05 (m, 2H), 8.44 (dd, 1H), 8.27 (dd, 1H), 7.98 (dd, 1H), 7.56-7.48 (m, 2H), 7.02 (tt, 1H), 3.96-3.78 (m, 3H), 2.14-2.00 (m, 4H), 1.75-1.62 (m, 4H),

6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-02-0, Preparation of tert-butyl 2-(4-(6-bromoquinoxalin-2-yl)phenyl)-2-oxoethylcarbamate A suspension of tert-butyl 2-oxo-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate (1.5 g, 4.15 mmol, Eq: 1.00), 6-bromo-2-chloroquinoxaline (1.01 g, 4.15 mmol, Eq: 1.00), cesium carbonate (2.71 g, 8.3 mmol, Eq: 2) and tetrakis(triphenylphosphine)palladium (0) (480 mg, 415 mumol, Eq: 0.1) in Dioxane (20 ml) and Water (2 ml) was purged with nitrogen for 10 min. then r*n. Mixture was heated at 80 C. for 16 hrs. Solvent removed in vacuo, the black residue filtered through a pad of Celite, washed with EtOAc, concentrated, triturated with ether, light yellow solid filtered, dried to obtain tert-butyl 2-(4-(6-bromoquinoxalin-2-yl)phenyl)-2-oxoethylcarbamate (1.7 g, 3.84 mmol, 92.6% yield) as a light yellow powder. LC/MS (M++H)=443

As the paragraph descriping shows that 55687-02-0 is playing an increasingly important role.

Reference£º
Patent; Alam, Muzaffar; Berthel, Steven Joseph; Brinkman, John A.; Hawley, Ronald Charles; Li, Hongju; Palmer, Wylie Solang; Pietranico-Cole, Sherrie; Sarabu, Ramakanth; Smith, Mark; So, Sung-Sau; Yi, Lin; Zhai, Yansheng; Zhang, Qiang; Zhao, Shu-Hai; US2012/230951; (2012); A1;,
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212327-10-1, 7-Bromo-2-methoxyquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0211] To a solution of 7-bromo-2-methoxyquinoxaline (26.7 g, 0.11 mol, 1.0 eq.) in DMF (1100 mL) were added TEA (77.7 mL, 0.56 mol, 5.0 eq.), Et3SiH (71.2 mL, 0.45 mol, 4.0 eq.) and Pd(dppf)Cl2CH2Cl2 (4.56 g, 5.6 mmol, 0.05 eq.). The resulting mixture was stirred at 90 C in an autoclave for 12 h under CO (1 MPa), then cooled and concentrated. The resulting residue was purified via flash column chromatography (EA/PE=l/4, v/v) to afford 3-methoxyquinoxaline-6-carbaldehyde as a white solid (8.5 g, 40.5%yield).

212327-10-1, 212327-10-1 7-Bromo-2-methoxyquinoxaline 1237168, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2014/75077; (2014); A1;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

To a mixture of ethyl 3-chloroquinoxaline-2-carboxylate (1 g,4.22 mmol) and 2-bromophenylboronic acid (0.93 g, 4.64mmol) in MeCN (30 mL), was added Pd(PPh3)4 (0.097 g, 0.084mmol) and 2 M aq Na2CO3 solution (10 mL). The resultingmixture was stirred at 100 C for 5 h. After cooling the mixturewas diluted with CH2Cl2 and washed three times with H2O anddried over MgSO4. After filtration and evaporation of the solvent,the crude product was purified by silica gel chromatographywith CH2Cl2 as eluent to furnish the product 3 as a yellowsolid; yield 1.1 g (73%); mp 100 C. 1H NMR (250 MHz, CDCl3): delta= 1.19 (t, J = 7.1 Hz, 3 H, CH3), 4.33 (q, J = 7.1 Hz, 2 H, CH2), 7.33-7.40 (m, 1 H, HAr), 7.45-7.85 (m, 2 H, HAr), 7.67 (d, J = 8.0 Hz, 1 H,HAr), 7.89-7.93 (m, 2 H, HAr), 8.19-8.23 (m, 1 H, HAr), 8.31-8.35(m, 1 H, HAr). 13C NMR (62.5 MHz, CDCl3): delta = 13.7, 62.3, 122.1,127.6, 129.3, 130.0, 130.3, 130.5, 131.0, 132.1, 132.3, 139.8,140.4, 142.0, 144.4, 153.2, 164.7. Anal. Calcd for C17H13BrN2O2:C, 57.16; H, 3.67; N, 7.84. Found: C, 57.61; H, 3.61; N, 7.86.

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khoumeri, Omar; Vanelle, Francois-Xavier; Crozet, Maxime D.; Terme, Thierry; Vanelle, Patrice; Synlett; vol. 27; 10; (2016); p. 1547 – 1550;,
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50998-17-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

6-Bromo quinoxaline (2.0 g, 9.5 mmol) in toluene (20 mL) was degassed for 30 min. To this solution, 1-ethoxy vinyl tributyltin (3.8 g, 10.5 mmol) and bis(triphenylphosphine)palladium dichloride (0.67 g, 0.95 mmol) were added at rt and stirred for 16 hours at 90 C. The reaction mixture was cooled to rt and filtered through celite. After evaporation of the solvent, 6 N HCI solution in water (20 mL) was added and the mixture was stirred for 1 hour at rt. It was concentrated and neutralized with sat. NaHCO3. The desired product was extracted with DCM (100 mL), dried over Na2SO4 and concentrated. The crude product was purified by column chromatography to afford the title compound (brown solid). 1H NMR (400 MHz, DMSO-de): delta 9.06-9.04 (m, 2H), 8.70 (d, J=2.4 Hz, 1 H), 8.28 (t, J = 2.8 Hz, 1 H), 8.16 (d, J = 11.6 Hz, 1 H), 2.97 (s, 3H). LCMS: (Method A) 173 (M+H), Rt. 2.25 min, 99.06% (Max).

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.,879-65-2

Method III N,N’-Carbonyldiimidazole (13.95 g) and 2-quinoxalinecarboxylic acid (15 g) in tetrahydrofuran (600 ml) were heated under reflux for 2 hours. 5-Amino-1H-tetrazole (7.32 g) in tetrahydrofuran (36 ml) and dimethylformamide (24 ml) was added and the mixture was heated under reflux for 50 minutes. The solvent was distilled off under reduced pressure and the residue was dissolved in water (300 ml). The solution was acidified to pH2 with dilute hydrochloric acid and the solid was collected and crystallized from dimethylformamide. It had m.p. 284-285 (d) (70%).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Allen & Hanburys Limited; US3997535; (1976); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, Example 44 {(S)-3-[3-(4-Fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}-quinoxalin-6-yl- methanone The compound was prepared following the procedure described in the Example 36, using 6-quinoxalinecarboxylic acid as the acid of choice and S-3- [3- (4-fluoro-phenyl)- [1, 2,4] oxadiazol-5-yl]-piperidine hydrochloride (prepared as described in the Example 12). {(S)-3-[3-(4-Fluoro-phenyl)-1, 2, 4-oxadiazol-5-yl]-piperidin-1-yl}-quinoxalin-6- yl-methanone was obtained pure after purification through a silica gel cartridge (eluent: DCM/MeOH/NH40H 98/2/0. 2). Yield: 83% (white solid); [a] o= +120 (c=1.0, CHC13) ; LCMS (Tr): 7.0 min (method A); MS (ES+) gave m/z : 404.0. 1H-NMR (CDC13, 330 K, 300 MHz), 8 (ppm): 8. 88 (s, 2H); 8. 18 (dd, 2H); 8. 06 (m, 2H); 7.82 (dd, 1H) ; 7.15 (dd, 2H); 4.47 (mbr, 1H); 4.02 (mbr, 1H) ; 3.65 (dd, 1H); 3.44-3. 23 (m, 2H) ; 2.36 (m, 1H) ; 2.14-1. 88 (m, 2H); 1.74 (m, 1H).

As the paragraph descriping shows that 6925-00-4 is playing an increasingly important role.

Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
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879-65-2,879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation X. Preparation of 2-quinoxalyl isocyanate Diphenylphosphoryl azide (1.23 mL) was added to a solution of triethylamine (800 ul) and 2-quinoxaline carboxylic acid 1 g (5.74 mmol) stirring in 10 mL of dry dimethylformamide in an icewater cooling bath (2). The reaction was stirred for 2.33 h during which time the reaction was allowed to warm to 25. The reaction was poured into ice water and extracted three times with diethyl ether. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and then concentrated in vacuo. The crude azide was dissolved in 15 mL of benzene and heated at reflux for 1.5 h. The solvent was removed in vacuo to provide the desired solid isocyanate. FT IR indicated a strong isocyanate absorption.

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; US5198560; (1993); A;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step J (Compound 10): [00150] Compound 6 (77.7 mg./0. 33 mmol. ) was dissolved in ethanol. Added was 3,5- Dimethyl aniline and the reaction mixture (in a sealed tube) was heated to 85 degrees. After stirring overnight, the reaction was allowed to cool to room temperature. The precipitated solid was diluted with ethanol and collected by filtration. Yield: 33.7 mg. approximately 30%. LC Data-retention time: 7.166 min. , >95% pure, MS+ (FIA) Data: 322.1., 49679-45-0

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2005/56547; (2005); A2;,
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