Heterocyclic Building Blocks-quinoxaline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-63-0,2,3-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of sodium (1 mmol, 0.023 g) and alcohol (3 mL) was stirred for 15 min at room temperature. Then 2,3-dichloroquinoxaline (1 mmol, 0.199 g) was added to the mixture until the complete consumption of the starting materials, monitored by TLC. After evaporation of the solvent, the resulting precipitate was washed with H2O; it did not require any further purification., 2213-63-0

As the paragraph descriping shows that 2213-63-0 is playing an increasingly important role.

Reference£º
Article; Keivanloo, Ali; Kazemi, Shaghayegh Sadat; Nasr-Isfahani, Hossein; Bamoniri, Abdolhamid; Tetrahedron; vol. 72; 41; (2016); p. 6536 – 6542;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Hqc (9.5 mg, 0.05 mmol) in 5 ml MeOH was slowly added into a 2 ml H2O solution of Zn(ClO4)2¡¤6H2O (18.7 mg, 0.05 mmol) resulting in the formation of a clear yellow solution. Colorless crystals suitable for X-ray analysis were obtained after the solution was allowed to stand for several days (Yield 53%). Anal. Calc. for C19H20N4O10Zn: C, 43.08; H, 3.81; N, 10.58. Found: C, 43.15; H, 3.69, N, 10.67%. IR (KBr)/cm-1: 3446(m), 2809(s), 1697(s), 1493(m), 1221(m), 1019(w), 954(w), 880(w),747(w), 593(m), 509(w), 483(w).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xiao, Bo; Xiao, Hai-Yang; Yang, Li-Jun; Inorganica Chimica Acta; vol. 407; (2013); p. 274 – 280;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

55687-02-0,55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-chloro-6-bromo quinoxaline (1 .6 g, 6.6 mmol) was dissolved in DMSO (30 mL) at room temperature. (R)-1-(3-chlorophenyl)ethanamine (1.0 g, 6.4 mmol) and TEA (2.75 mL, 9.7 mmol) were added and the reaction mixture was stirred at RT for 18 hours. After completion of the reaction as judged by TLC, water (50 mL) was added to the reaction mixture and the aqueous was extracted with ethyl acetate (25 mL x 3). The organic layer was separated off, washed with water (15mL), brine (15 mL) and was dried over Na2SC>4. The solvent was evaporated off in vacuo at 40C to afford crude title compound. The crude title compound was adsorbed onto silica and was purified by flash column chromatography on silica eluting with a gradient of 0-1 % methanol in DCM to afford the title product (1.28 g, 54%).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; WALKER, David Winter; (166 pag.)WO2016/170163; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

Step A diethyl N-(6-quinoxalyl)aminomethylenemalonate A mixture of 6-aminoquinoxaline(19.2 g) and diethyl ethoxymethylenemalonate(34.8 g) was heated for an hour at 110 C. After filtration, the crystals thus obtained were crystallized from ethanol to give diethyl N-(6-quinoxalyl)aminomethylenemalonate (37.5 g) as pale yellow needles, m.p. 112-114 C., 6298-37-9

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Taisho Pharmaceutical Co., Ltd.; US4190581; (1980); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 22 (4S)-3-Fluoro-4-hydroxy-4-({4-[(2-quinoxalinylmethyl)amino]-l- piperidinyl}methyl)-4,5-dihydro-7Hr-pyrrolo[3,2,l-^]-l|>5-naplithyridin-7-one (Enantiomer El) dihydrochlorideA mixture of (4S)-4-[(4-amino-l-piperidinyl)methyl]-3-fluoro-4-hydroxy-4,5- dihydro-7H-pyrrolo[3,2,l-Je]-l,5-naphthyridin-7-one (El enantiomer) (80 mg, 0.25 mmol) and 2-quinoxalinecarbaldehyde (30mg, 0.20 mmol) in dichloromethane/methanol (0.5 mL/0.1 mL) was treated with sodium triacetoxyborohydride (127mg, 06 mL). After one hour, the reaction mixture was treated with a saturated aqueous solution of sodium bicarbonate (2 mL) and chloroform (1 mL). The mixture was shaken for 5 minutes. The aqueous layer was further extracted with dichloromethane/methanol (lmL/0.2mL). The combined organic extracts were added to the top of a column and and chromatographed eluting with a 0-30% gradient of methanol/dichloromethane affording the free base of the title compound as a clear oil (30 mg, 33%). deltaH (CDCl3, 250MHz)1.45-1.73 (2H, m), 1.90-2.10 (2H, m), 2.40 (IH, t), 2.55 (IH, t), 2.70 (IH, m), 2.90 (IH, d), 2.95-3.07 (2H, m), 3.27 (IH, d), 4.25 (2H, s), 4.35 (IH, d), 4.45 (IH, d), 6.85 (IH, d), 7.25-7.32 (2H, m), 7.88 (IH, d), 8.05-8.15 (2H, m), 8.38 (IH, s), 8.90 (IH, s). MS (+ve ion electrospray) m/z 461 (MH+).

1593-08-4, The synthetic route of 1593-08-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/71936; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50998-17-9, Known quinoxaline xvi (CAS 50998-17-9, 1.0 g, 4.78 mmol) is dissolved in acetonitrile (20 mL) under inert atmosphere. Triethylamine (6.6 mL, 47.8 mmol) is added, followed by known pyrazole xvii (CAS 1354706-26-5, 850 mg, 5.26 mmol) and palladium tetrakis (665 mg, 0.478 mmol). The reaction is heated to 70 C and stirred for 18 horns. The solvent is removed by distillation under vacuum at 55 C, and the resultant product is purified by flash chromatography (30% ethyl acetate in petroleum ether) to give xviii in 80% yield.

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; CLAVIUS PHARMACEUTICALS, LLC; SAWYER, J., Scott; (109 pag.)WO2019/5241; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13708-12-8,5-Methylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: N-heteroarene (1 mmoL, 80 mg), alpha-keto acid (3 mmol), Formic acid (1 mmol, 38 muL), ammonium persulfate (3 mmoL, 685 mg), ferrous sulfate heptahydrate (0.08 mmoL, 22 mg) and 20 mL of mixed solvent (DCM: H2O = 3: 1) , 0.1 mL DMSO was added into a 25 mL round-bottomed flask. The mixture was stirred at 40 oC until TLC analysis indicating that the reaction was complete (witnessed by the disappearance of the N-heteroarene). After separation of organic phase, the residue was neutralized by 0.1 M sodium hydroxide solution, then extracted with DCM (3¡Á20 mL), combined the organic phases, dried over Na2SO4, and concentrated in vacuo. The residue was N-heteroarene (1 mmoL, 80 mg), alpha-keto acid (3 mmol), Formic acid (1 mmol, 38 muL), ammonium persulfate (3 mmoL, 685 mg), ferrous sulfate heptahydrate (0.08 mmoL, 22 mg) and 20 mL of mixed solvent (DCM: H2O = 3: 1) , 0.1 mL DMSO was added into a 25 mL round-bottomed flask. The mixture was stirred at 40 oC until TLC analysis indicating that the reaction was complete (witnessed by the disappearance of the N-heteroarene). After separation of organic phase, the residue was neutralized by 0.1 M sodium hydroxide solution, then extracted with DCM (3¡Á20 mL), combined the organic phases, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel using a mixture of petroleum ether/EtOAc (v : v = 20 : 1) as eluent to afford the desired pure product.

13708-12-8, The synthetic route of 13708-12-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Xiu-Zhi; Zeng, Cheng-Chu; Tetrahedron; vol. 75; 10; (2019); p. 1425 – 1430;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89891-65-6,7-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

89891-65-6, a) 7-bromoquinoxaline-2-amine 7-bromo-2-chloroquinoxaline (1.0 g, 4.13 mmol) and ammonia (7 mL) were added to 1,4-dioxane (7 mL). After reaction under agitation at 70 C for 5 h, the reaction mixture was cooled to rt. Water (10 mL) was added, and EA (30 mL*2) was used for extraction. The organic phases were combined, washed with a saturated saline solution (50 mL), dried with anhydrous sodium sulfate, filtered, and concentrated at reduced pressure to obtain a crude compound. Isolation and purification by column chromatography (silica gel, PE: EA = 3:1 as an eluant) were performed to obtain the targeted compound (500 mg, 54.2% yield, yellow solid). LC-MS (ESI): m/z (M+1) 223.99.

As the paragraph descriping shows that 89891-65-6 is playing an increasingly important role.

Reference£º
Patent; Impact Therapeutics, Inc; CAI, Suixiong; TIAN, Ye Edward; (74 pag.)EP3567041; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6639-87-8,6639-87-8, 6-Nitroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b. Quinoxalin-6-amine To a solution of 6-nitroquinoxaline (17.0 g, 0.097 mol) in MeOH (500 mL) was added hydrazine hydrate (19.4 g, 0.39 mol) and Raney Ni (2.0 g). The mixture was stirred at room temperature for 1 h. The mixture was then filtered, and the filtrate was concentrated under reduce pressure to give quinoxalin-6-amine as a yellow solid (14.0 g, yield 99%). ESI MS: m/z 146.1 [M+H]+.

6639-87-8 6-Nitroquinoxaline 96029, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Sunovion Pharmaceuticals Inc.; US2012/178748; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50998-17-9, 6-Bromo quinoxaline (2.0 g, 9.5 mmcl) in toluene (20 mL) was degassed for 30 mm. To thissolution, 1-ethoxy vinyl tributyltin (3.8 g, 10.5 mmol) and bis(triphenylphosphine)palladium dichloride (0.67 g, 0.95 mmol) were added at rt and stirred for 16 hours at 90 C. The reaction mixture was cooled to rt and filtered through celite. After evaporation of the solvent, 6 N HCI solution in water (20 mL) was added and the mixture was stirred for I hour at rt. It was concentrated and neutralized with sat. NaHCO3. The desired product wasextracted with DCM (100 mL), dried over Na2SO4 and concentrated. The crude productwas purified by column chromatography to afford the title compound (brown solid). 1H NMR(400 MHz, DMSO-d6): 6 9.06-9.04 (m, 2H), 8.70 (d, J=2.4 Hz, I H), 8.28 (t, J = 2.8 Hz, I H),8.16 (d, J = 11.6 Hz, IH), 2.97 (5, 3H). LCMS: (Method A) 173 (M+H), Rt. 2.25 mm,99.06% (Max).

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider