Heterocyclic Building Blocks-quinoxaline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 1 (2.78 g, 0.01 mol)and arylthiosemicarbazone (0.01 mol) in absolute ethanol (50 mL) was refluxed for 4-5 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried and crystallized from benzene to produce the corresponding compounds.

108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

[0195] To a solution of quinoxaline-6-carboxylic acid (5.1 g, 29.3 mmol, 1.0 eq) in DMF (100 mL) were added HATU (13.3 g, 35 mmol. 1.2 eq), DIEA (20 mL, 117.2 mmol, 4.0 eq) and Omicron,Nu- Dimethyl-hydroxylamine hydrochloride salt (3.38 g, 35 mmol, 1.2 eq). The mixture was stirred at rt overnight, then concentrated. The resulting residue was purified via flash column chromatography (PE/EA = 2/1, v/v) to afford N-methoxy-N-methylquinoxaline-6-carboxamide as yellow solid (5.1 g, 80 %).

6925-00-4, The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/40515; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

H2S04 (0673 ml, 1263 mmol) was added to a solution of quinoxaline-2-carhoxylic acid (1.1 g, 6.32 mmol) in Methanol (20 nil) at 0 O( The reaction mixture was refluxed for 3h. After completion of reaction, methanol was evaporated under reduced pressure and the residue was diluted withdichlorornethane. The organic portion was washed with saturated sodium bicarbonate solution, brine and evaporated under reduced pressure to give methyl quinoxaline-2-carboxylate (1.1 g, 5.85 rnmol,93percent), 879-65-2

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; PI INDUSTRIES LTD.; SAXENA, Rohit; PANMAND, Deepak Shankar; JENA, Lalit Kumar; SRIVASTAVA, Khushboo; RAJU, Jella Rama; MANJUNATHA, Sulur G; SAMANTA, Jatin; GARG, Ruchi; AUTKAR, Santosh Shridhar; VENKATESHA, Hagalavadi M; GADAKH, Ramdas Balu; KLAUSENER, Alexander G. M.; POSCHARNY, Konstantin; (219 pag.)WO2018/116072; (2018); A1;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 2 Preparation of 5-(3-(4-fluoro-2-methoxyphenoxy)quinoxaline-2-carboxamido)picolinic [00621] A mixture of ethyl 3-chloroquinoxaline-2-carboxylate (300 mg, 1.27 mmol), 4-fluoro- 2-methoxy-phenol (289.0 mu, 2.54 mmol) and Cs2C03 (826.3 mg, 2.54 mmol) in NMP (3.0 mL) was stirred at 100 C for 3 hours. The reaction mixture was poured into water, the pH was adjusted to pH 6 with IN HCl and the mixture was extracted with ethyl acetate (3x). The organics were combined, washed with brine, dried over Na2S04 and evaporated to dryness. Purification by column chromatography using a gradient of MeOH in dichloromethane (0 -10%) gave 3-(4-fluoro-2-methoxy- phenoxy)quinoxaline-2-carboxylic acid (360 mg, 90%) as a red oil. ESI-MS m/z calc. 314.07, found 315.1 (M+l)+; Retention time: 1.35 minutes (3 minutes run).

49679-45-0, 49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ANDERSON, Corey; ARUMUGAM, Vijayalaksmi; ASGIAN, Iuliana, Luci; BEAR, Brian, Richard; TERMIN, Andreas, P.; JOHNSON, James, Philip; WO2014/120815; (2014); A1;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

General procedure: Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder.

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, Method A: To a solution of thiophenol (2.20 g,0.02 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and compound 1 (2.78 g,0.01 mol) were added. The reaction mixture washeated under reflux for 3 h. After completion of thereaction, the reaction mixture was filtered to removethe potassium carbonate, then the excess of acetoni-trile was evaporated under reduced pressure and theresidue obtained was dried and purified by a silicagel column chromatography (petroleum ether (60-80 O C)/ethyl acetate 5 : 0.1, v/v) to give the product;yield: 68%.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.887590-25-2,tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate,as a common compound, the synthetic route is as follows.

887590-25-2, To a round bottom flask charged with compound 14-2 (90mg, 0.38 mmol) and methyl 4-(bromomethyl)benzoate (87 mg, 0.38 mmol) in DMF (5 mL) was added K2CO3 (105 mg, 0.76 mmol). The resulting mixture was allowed to stir for 2 h at 80 C. The mixture was cooled to room temperature and after addition of water (15 mL) extracted with EtOAc (3 x 15 mL). The combined organic extracts were washed with brine (20 mL), dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 5% MeOH/DCM), and the title compound was obtained as an off- white waxy solid (90 mg, 60%).1H NMR (CDCI3) delta 7.99, 7.32 (AlphaAlpha’ChiChi’ multiplet, AX + /AX’ = 8.2 Hz, 4H), 7.48 (br d, / = 7.4 Hz, 1H), 7.32 (d, / = 7.9 Hz, 2H), 6.90 (incompletely resolved ddd approaching dt, average of two larger / = 7.8 Hz, additional / = 1.1 Hz, 1H), 6.66 (incompletely resolved ddd approaching dt, average of two larger / = 7.6 Hz, additional / = 1.2 Hz, 1H), 6.55 (dd, / = 8.2 Hz, 0.9 Hz, 1H), 4.56 (s, 2H), 3.90 (s, 3H), 3.86, 3.44 (AA’XX’ multiplet, AX + /AX’ = 10.2 Hz, 4H), 1.53 (s, 9H). 13C NMR (DMSO- 6) delta 166.9, 153.3, 143.7, 138.2, 130.1 (2C), 129.1, 126.5 (2C), 125.1, 124.7, 116.3, 111.6, 100.0, 81.1, 54.9, 52.1, 49.5, 41.6, 28.4 (3C). ESI LRMS: [M+H]+, mlz 383.3.

As the paragraph descriping shows that 887590-25-2 is playing an increasingly important role.

Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; KOZIKOWSKI, Alan; SHEN, Sida; BERGMAN, Joel; (100 pag.)WO2017/142883; (2017); A1;,
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6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6344-72-5, A mixture of 6-methylquinoxaline (2.0 g, 13.9 mmol), N-bromosuccinimide (3.0 g, 16.9 mmol), and benzoyl peroxide (411 mg, 1.7 mmol) in anhydrous carbon tetrachloride (50 mL) was stirred at reflux for 2 days. Dichloromethane (50 mL) was added after cooling to room temperature. The mixture was extracted with 1 N NaOH (1 x 100 mL) and brine (1 x 100 mL). The organic extract was recovered, dried over MgSO4, filtered, evaporated, and dried in vacuo. The crude product was purified by flash chromatography (0-30% EtOAc/hexanes), affording 6- (bromomethyl)quinoxaline (1.10 g, 35% yield).

6344-72-5 6-Methylquinoxaline 242567, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita; WO2010/132999; (2010); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, Examples 16-18:O-(1H-Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (112 mg, 0.30 mmol), triethylamine (207 mul, 1.49 mmol) and the product of preparation 24 (80 mg, 0.25 mmol) were added to a solution of the appropriate carboxylic acid (RCOOH, 0.28 mmol) in acetonitrile (1 ml), and the reaction mixture was stirred at room temperature for 18 hours. It was then heated under reflux for a further 18 hours before being concentrated in vacuo. The residues were diluted with dichloromethane (20 ml), washed with saturated sodium carbonate (20 ml), passed through a hydrophobic membrane and concentrated in vacuo. Purification of the residue by HPLC using a Phenomenex Luna C18 system, eluting with water/acetonitrile/trifluoroacetic acid (5:95:0.5):acetonitrile, 95:5 to 5:95, afforded the title compounds.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER LIMITED; WO2006/123242; (2006); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, General procedure: General Synthesis Procedure for Nuepsilon-modified Na-tertbutoxycarbonyl-L-lysine-tert- butylesters 3a – 8a. Na-tertbutoxycarbonyl-L-lysine-tert-butyiester (0.5 g, 1.65 mmol) and the carboxylic acid of the respective chromophore (1.65 mmol, 1 eq) were placed in a 50 ml two-necked round bottom flask and were dissolved in an- hydrous dichloromethane (25 ml) under argon atmosphere. The solution was cooled to 0 C in an ice bath and N-methyl-morpholine (0.4 ml, 3.64 mmol, 2.2 eq) and PyBOP (0.95 g, 1.82 mmol, 1.1 eq) were added. The reaction mixture was stirred for 16 h at room temperature. The solution was washed with 30 ml Na- HC03, the phases were separated and dried with MgS04. The solvent was re- moved under reduced pressure and the obtained oil was purified using flash column chromatography with ethyl acetate / petrol ether mixtures. The pure product was obtained as a foam..

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITAET KONSTANZ; SUMMERER, Daniel; SCHMIDT, Moritz Johannes; WO2015/11081; (2015); A2;,
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