Heterocyclic Building Blocks-quinoxaline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, To a solution of quinoxaline-6-carboxylic acid (60 g, 0.34 mol) in SOCl2 (300 mL) was added DMF (5 mL). The resulting mixture was heated under reflux overnight, then cooled and concentrated to afford crude mixture of 3-chloroquinoxaline-6-carbonyl chloride and 2-chloro-quinoxaline-6-carbonyl chloride (62 g, 94%).

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NeuPharma, Inc.; Zhu, Yong-Liang; Qian, Xiangping; US2013/53384; (2013); A1;,
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49679-45-0,49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of ethyl 3-chloroquinoxaline-2-carboxylate (500 mg, 2.12 mmol) in morpholine (5 mL was stirred for 1 hour at 100 C. It was diluted with water, extracted with EA (x3), washed with brine (x2). The organic layer was dried and concentrated to give 450 mg (cmde) of desired compound as yellow oil, which was used directly in the next step without further purification. ESI MS m/z = 287.5 [M+Hjt

49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; SHOOK, Brian, C.; KIM, In, Jong; BLAISDELL, Thomas, P.; YU, Jianming; PANARESE, Joseph; OR, Yat, Sun; (434 pag.)WO2017/15449; (2017); A1;,
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83570-42-7, 1-(Quinoxalin-6-yl)ethanone is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83570-42-7, To a stirred solution of 1-(quinoxalin-6-yl)ethan-1-one (0.8 g,4.6Smmol) in dry MeOH (20 mL), sodium borohydride (0.36 g, 9.3 mmol ) was added portion wise at 0 C and the resulting mixture was stirred for lh. It was then concentrated, diluted with DCM (80 mL), washed with water (20 mL), dried over Na2SO4 and concentrated. The crude product wastaken for next step without further purification. Yield: 75% (600 mg, dark brown liquid). 1H NMR (400 MHz, DMSO-d6): 6 8.91-8.89 (m, 2H), 8.03 (t, J = 11.6 Hz, 2H), 7.87-7.86 (m, IH), 5.49 (d, J = 5.9 Hz, IH), 4.97 (t, J = 6.2 Hz, IH), 1.42 (d, J = 8.6 Hz, 3H). LCMS:(Method A) 175.0 (M+H), Rt. 1.89 mm, 95.0% (Max).

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
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55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-02-0, Under nitrogen protection,Intermediate N1 (1 eq) was added to a three-neck flask equipped with a mechanical stirrer.Propylboronic acid (1eq),Potassium carbonate (5eq),Pd(Pph3)4(2%),Toluene 1000ml + ethanol 500ml + water 300ml,Stirring was turned on and heated to reflux for 8h.Organic phase silica gel column chromatography, concentrated,Recrystallization from toluene gave yellow powder N2 (9.0 g, 93.7%).

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Xing Qifeng; Li Zhiyang; Liu Shuyao; Ren Xueyan; (23 pag.)CN107954942; (2018); A;,
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25594-62-1, 2-Acetylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 22-bromo-1 -(quinoxalin-2-yl)ethanone (JS111 )Pyridinium tribromide (2.935 g, 9.18 mmol) was added to a stirred solution of JS1 10 (580 mg, 3.67 mmol) in 1 :1 CHCI3/EtOH (60 ml) and the mixture was heated at 50 C for 16 h. Removal of the solvent in vacuo was followed by addition of H20 and extraction with EtOAc (3x). The combined organic extracts were further washed with H20 and brine, dried (MgS04), filtered and concentrated in vacuo. Flash chromatography (CH2CI2 isocractic) afforded the title compound as a brown solid (656 mg, 2.61 mmol, 71 .2%). Mpt: Decomposed before melting [Lit. (Pharmazie 1983, 38(12), 829-32) 1 12-1 14 C]; Rf = 0.26 (CH2CI2); IR (vmax/crrf1, thin film): 1708 (CO stretch), 1392, 762 (C-Br Stretch); 1 H NMR (600 MHz, CDCI3): deltaEta = 4.96 (s, 2H, 12-H), 7.88-7.90 (m, 1 H, 8-H), 7.93-7.96 (m, 1 H, 7-H), 8.20-8.21 (m, 2H, 6,9-H), 9.53 (s, 1 H, 3-H); 13C NMR (150 MHz, CDCI3): 5C = 31.3 (C-12), 129.7 (C-6), 130.6 (C-9), 131 .3 (C- 8), 133.0 (C-7), 141.0 (C-10), 143.4 (C-3), 144.3 (C-5), 144.7 (C-2), 192.4 (C-11 ); LRMS m/z (El+): 252 [M(81Br)]+, 250 [M(79Br)]+, 142, 1 15 [(81Br)], 1 13 [(79Br)]; HRMS m/z (Epsilon ): Found 249.97396; Ci0H7BrN2O requires 249.97363; Anal. Calcd. for Ci0H7BrN2O: C, 47.84; H, 2.81 ; N, 1 1 .16. Found C, 47.70; H, 2.68; N, 10.86%., 25594-62-1

25594-62-1 2-Acetylquinoxaline 11105814, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin; WO2012/168733; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

General procedure: Method A: To a solution of compound 1 (2.78g, 0.01 mol) in DMF (50 mL), an appropriate cyclic secondary amine namely, piperidine or morpholine(0.01 mol) was added. The reaction mixture was refluxed for 10-14 h. After completion of the reaction, the reaction mixture was poured onto crushedice with stirring. The formed precipitate was filtered, dried and crystallized from petroleum ether(80-100C) to give the corresponding compounds.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

A mixture of 2-chloro-3-methylquinoxaline (100 mg, 0.56 mmol), 2-chlorophenol (144 mg, 1.12 mmol) and potassium carbonate (929 mg, 6.72 mmol) in DMSO (5.6 mL) was heated at 120C in a sealed tube for 18 h. The reaction mixture was partitioned between EtOAc (60 mL) and water (60 mL). The organic layer was separated and the aqueous layer was back-extracted with 10% propan-2-ol in chloroform (2 x 60 mL). The combined organic layers were dried (Na2S04) and concentrated in vacuo. The residue was purified by flash column chromatography (Si02, 0-100% EtO Ac/heptane, followed by 1-100%) MeOH/EtOAc), then repurified by preparative HPLC, yielding the title compound (37.5 mg, 24%) as an off-white solid. deltaEta (500 MHz, DMSO-d6) 8.03-7.99 (m, IH), 7.73-7.58 (m, 4H), 7.56-7.45 (m, 2H), 7.44-7.35 (m, IH), 2.80 (s, 3H). LCMS (ES+) 271.0/273.0 (M+H)+, RT 1.69 minutes., 32601-86-8

The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; FOULKES, Gregory; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; KROEPLIEN, Boris; REUBERSON, James Thomas; ROOK, Sarah Margaret; ZHU, Zhaoning; WO2015/86523; (2015); A1;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 (2.78 g, 0.01 mol) in DMF(50 mL), 2-aminopyridine (0.94 g, 0.01 mol) was added. The reaction mixture was refluxed for 17 h. After completion of the reaction, the reaction mixture was poured onto crushed ice with stirring. Then, the precipitate that formed was filtered, washed with water, dried and crystallized from petroleum ether(80-100C) to give the product. Yield: 40%; (yellow-brown powder): m.p.157-159 O C; IR (KBr, cm -1 ): 1610 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 7.27-7.77 (m, 7H, Ar-H). 13 CNMR (DMSO-d 6 , delta , ppm): 121.79-141.44 (10Ar-C),151.27, 151.56, 151.91 (3C=N). MS (m/z), 78 (M + -C 8 H 3 BrN 3 ; 100%), 298 (M + ; 46%), 299 (M + + 1;10%), 300 (M + + 2; 45%). Analysis: calcd. forC 13 H 7 BrN 4 (299.13): C, 52.20; H, 2.36; N, 18.73%;found: C, 52.43; H, 2.52; N, 18.92%., 108229-82-9

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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91-19-0, Quinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91-19-0, General procedure: A solution of quinoxaline (1) (390mg, 3.0mmol), NBS (390mg, 3.0mmol), and benzoyl peroxide (catalytic amount) in glacial acetic acid (10mL) was heated at reflux temperature for 20h. The reaction was monitored by TLC or 1H NMR spectroscopy. The resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. 6-Bromoquinoxaline (10) (315mg, 50%) was obtained as a sole product. The reaction was repeated using DMF as a solvent at the same reaction condition and monobromide 10 was obtained in 51% yield.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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