Heterocyclic Building Blocks-quinoxaline

6344-72-5,6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 292 Synthesis of 6-(bromomethyl)quinoxaline. To a solution of 6-methylquinoxaline (5 g, 34.7 mmol) in DCE (100 mL) was added NBS (7.12 g, 40 mmol) and benzoyl peroxide (840 mg, 3.47 mmol). The reaction mixture was stirred at 85 C. for 16 h under nitrogen. H2O (100 mL) was added, and the mixture was extracted with DCM (150 mL*3). The combine organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo to give the crude product which was purified by silica gel chromatography (PE/EtOAc=1/1) to give 6-(bromomethyl)quinoxaline as a yellow solid. (5.5 g, 71%). ESI-MS [M+H]+: 224.1.

The synthetic route of 6344-72-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shire Human Genetic Therapies, Inc.; Papaioannou, Nikolaos; Fink, Sarah Jocelyn; Miller, Thomas Allen; Shipps, JR., Gerald Wayne; Travins, Jeremy Mark; Ehmann, David Edward; Rae, Alastair; Ellard, John Mark; (352 pag.)US2019/284182; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

Flask in 50mL flask 5,8-Dibromoquinoxaline utilizing our after infusion (compound j-1) 2.00 g, it makes the vacuum. After injecting THFanhydous 30mL and slowly inject 5.8 mL tert-butyllithium at -78 C, was stirred at the same temperature for 15 minutes, then it reacted at room temperature for 2 hours. Under the conditions of -78 C then slowly inject 2.0 mL lane 2- isopropoxy -4,4,5,5- tetramethyl 1-1,3,2- Sabo dioxane, and the mixture was stirred for 12 hours. After 12 hours, after the completion of the reaction through the water, after extraction via the ethylacetate and the aqueous solution of NaCl, one can obtain a product of the organic layer extracted lower sides yellow liquid, and injecting the obtained liquid phase in 250mL round bottom flask, methanol 70mL after the injection, the injection was diluted to 20.2 mL of distilled water 10mL KHF2 a stirring. When stirred for 30 minutes when it is generated the filter through the ether to give a yellow solid product of potassium di [5,8-quinoxaline] 4,7-bis (triple as a borate) (Compound J) (yield: 47%)

148231-12-3, As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; Pusan National University Industry-Academic Cooperation Foundation; Hwang, Do Hun; Kim, Ji Hun; Kim, Hee Woon; Im, Jong Min; (52 pag.)KR101495152; (2015); B1;,
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6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

METHOD B To a stirred solution of 6-aminoquinoxaline (3 g.) in glacial acetic acid at room temperature was added dropwise over a period of one minute a solution of iodine monochloride (4.5 g.) in glacial acetic acid (15 ml.). Stirring at room temperature was continued for a further 30 minutes, after which the precipitated solid was collected by filtration and washed with diethyl ether to afford 6.5 g. of 6-amino-5-iodoquinoxaline hydrochloride, as a complex with iodine, m.p. 167-169 with decomposition. Analysis: Found: C, 21.79; H, 1.58; N, 9.66%. Required for C8 H6 IN3.I.HCl: C, 22.11; H, 1.63; N, 9.67%.

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US4029792; (1977); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.,91-19-0

General procedure: Bromine was added dropwise to a magnetically stirred refluxing solution of quinoxaline (1) or tetrahydroquinoxaline 15 or 19 in the relevant solvent. The resulting reaction mixture was heated at reflux temperature. The reaction was monitored by TLC or 1H NMR spectroscopy. After the desired time, the resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2¡Á25mL). Combined organic layers were washed with water, dried over Na2SO4 and concentrated. The crude was purified appropriate method described in below.

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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13708-12-8, 5-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a typical run, a 50 mL stainless steel autoclave equipped with a transducer for online pressure monitoring was charged, under air, of Pd-pol (23.2 mg, Pd: 0.5 mol%), the substrate (1.0 mmol), and water (5.0 mL) or water (4.0 mL) and CH3OH (1.0 mL). The autoclave was then purged three times with hydrogen, then pressurized with 10 bar H2, set on a magnetic stirrer and heated to 80 C. After the minimum time needed to reach reaction completion, the autoclave was let to reach room temperature, the hydrogen was vented and the autoclave opened. The catalyst was recovered by filtration while the organic product was extracted with ethyl acetate (3 mL), the water phase was washed with ethyl acetate (2 ¡Á 5 mL) and the organic layers were collected. The yields were assessed by GLC analysis of the ethyl acetate solution with the internal standard (biphenyl) method., 13708-12-8

13708-12-8 5-Methylquinoxaline 61670, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Dell’Anna, Maria Michela; Capodiferro, Vito Filippo; Mali, Matilda; Manno, Daniela; Cotugno, Pietro; Monopoli, Antonio; Mastrorilli, Piero; Applied Catalysis A: General; vol. 481; (2014); p. 89 – 95;,
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108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of substituted 2-chloro-6,7-dimethoxy-4-aminoquinazoline (0.01 mol) 1 and 2,3-dichloroquiaxolines (0.01 mol) 2a-e in glacial acetic acid 10 mL containing 0.2 mL of DMF as a catalyst wa refluxed for 10 hr (monitored by TLC). The reaction mixture was cooled and the deposited solid was filtered, dried and re-crystallized from DMF/MeOH 1:4 furnish compounds 3a-e.

108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Srinivas; Prasanna; Ravinder; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 53; 2; (2014); p. 238 – 242;,
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55687-34-8, 6-Bromoquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55687-34-8

6-bromoquinoxalin-2(1 H)-one (9.0 g, 40 mmol) was dissolved in POCI3 (50 mL) and DMF (2 mL) was added at RT. The mixture was heated at 50C for 2 hours. After completion of the reaction it was cooled to RT and was poured slowly into ice cold water. The mixture was stirred for 30 minutes and then filtered to afford crude product.The crude product was purified by column chromatography using neutral silica gel of 60- 120 mesh size. A gradient of 8-9 % DCM in hexane was used to elute the title compound (5.O g, 51%).1H NMR (d6-DMSO) D 9.03 (s, 1 H), 8.42 (d, 1H), 8.08 (dd, 1 H), 7.98 (d, 1H).

55687-34-8 6-Bromoquinoxalin-2(1H)-one 12686394, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), sodium azide(0.12 g, 2 mmol) was added and the reaction mixture was refluxed for two days. After completionof the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, washedwith a little amount of ethanol, dried and crystallized from methanol to give the product; yield: 85%.(Brown powder): mp 229-231 C; IR (KBr) max in cm1: 2155 (N3), 1608 (C=N); 1H-NMR(DMSO-d6): 8.26-9.01 (m, 3H, Ar-H); 13C-NMR (DMSO-d6): 119.61, 120.27, 122.00, 123.33, 123.59,133.93 (6Ar-C), 140.37, 140.59 (2C=N); MS (m/z), 103 (M+ C6H3N8, 100%), 290 (M+; 7%), 291(M+ + 1; 1%), 292 (M+ + 2; 7%). Anal. Calcd. for C8H3BrN8 (291.07): C, 33.01; H, 1.04; N, 38.50%.Found: C, 32.87; H, 1.23; N, 38.69%.

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1392413-56-7,6-Bromo-3-chloro-2-methylquinoxaline,as a common compound, the synthetic route is as follows.

1392413-56-7, INTERMEDIATE: (7-Bromo-3-methyl-quinoxalin-2-yl)-hydrazine (Iln). A mixture of 4-bromo-l- fluoro-2-nitn benzene (99 g), racemic alanine (120 g), and CS2CO3 (440 g) were refluxed for 5h in a mixture of in ethanol (1.2 L) and water (400 mL). After cooling to ambient temperature the mixture was diluted with water (600 mL) and acidified to pH 3. The solid was filtered off and dried to afford 2-(4-bromo-2-nitro-phenylamino)-propionic acid (110 g) as yellow solid. A portion of this material (10 g) was dissolved in AcOH (35 mL), and iron powder (5.8 g) was added. The mixture was stirred at 90 C for 2h, cooled to ambient temperature, and filtered. Most of the volatiles in the filtrate were removed in vacuo. The remaining slurry was diluted in DCM. The organic layer was dried over Na2S04, filtered, and concentrated in vacuo to afford 7-bromo-3-methyl-3,4-dihydro H-qumoxalin- 2-one (6.4 g) as a yellow solid. A larger portion of this material prepared in a similar manner (45 g) was mixed with water (180 mL) and 30% aq hydrogen peroxide (140 mL). The mixture was stirred at 60 C for 6h, cooled and the solid was filtered off, washed with water, and dried to afford 7- bromo-3-methyl-lH-quinoxalin-2-one (36 g) as a yellow solid. A portion of this material (12 g) was stirred in PI1POCI2 (80 mL) at 150 C for 4h. After cooling to ambient temperature, water was added and pH was adjusted to 7 with aqueous ammonia. The precipitated solid was filtered off, washed with water, and dried to afford 6-bromo-3-chloro-2-methyl-quinoxaline (8.0 g) as a yellow solid. A larger portion of this material prepared in a similar manner (16 g) was dissolved in ethanol (250 mL). Hydrazine hydrate (160 mL) was added, and the mixture was refluxed for 3h, cooled to ambient temperature, and most of the volatiles were removed in vacuo. The residue was suspended in water, the solid was filtered off, washed with water, and dried to afford Iln (13 g) as a yellow solid pure for the next step.

1392413-56-7 6-Bromo-3-chloro-2-methylquinoxaline 71520791, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; H. LUNDBECK A/S; J?RGENSEN, Morten; BRUUN, Anne, Techau; RASMUSSEN, Lars, Kyhn; LARSEN, Mogens; WO2013/34755; (2013); A1;,
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6639-87-8,6639-87-8, 6-Nitroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) Quinoxaline-6-ylamine. To a round-bottomed flask equipped with magnetic stirring was added 4-nitro-1,2-phenylenediamine (1.0 g, 6.5 mmol, Aldrich), acetonitrile (10 mL) and glyoxal (2.2 mL, 19 mmol, 40 wt. % in water, Aldrich). The reaction mixture was allowed to stir at 50 C. for 12 h, then concentrated in vacuo to yield 1.1 g crude 6-nitro-quinoxaline. The crude product was dissolved in methanol, treated with 10% Pd/C (10 mg, Aldrich) and stirred under H2 (1 atm) at 25 C. overnight. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to provide the title product. MS (ESI, pos. ion) m/z: 146 (M+1).

The synthetic route of 6639-87-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang; US2003/195201; (2003); A1;,
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