Brief introduction of 1204-75-7

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (157 mg, 0.821 mmol) was added to a methylene chloride solution (5.5 ml) of (2S)-3-methyl-1-{4-[(3-methylpyrazin-2-yl)oxy]piperidin-1-yl}-1-oxobutan-2-amine dihydrochloride (200 mg, 0.547 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (107 mg, 0.547 mmol), 1-hydroxybenzotriazole monohydrate (88.8 mg, 0.657 mmol) and N-methylmorpholine (0.301 ml, 2.74 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride, and the extract was washed sequentially with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the resulting residue was suspended in a mixed solvent of ethanol-diethyl ether, and subsequently the solid substance was collected by filtration to afford the desired title compound (181 mg, yield 71%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.64 (1H, brs), 10.17 (1H, brs), 8.02-8.00 (2H, m), 7.91 (1H, dd, J=6.3 Hz, 2.7 Hz), 7.63-7.38 (3H, m), 5.41-5.34 (1H, m), 5.13-5.08 (1H, m), 4.06-3.68 (4H, m), 2.51 and 2.47 (3H, s), 2.36-1.92 (5H, m), 1.16-1.11 (6H, m). IR (KBr) cm-1: 2960, 1690, 1640, 1540, 1415. MS (ESI, m/z): 465 (M+H)+. HRMS (ESI, m/z): 465.2251 (Calcd for C24H29N6O4: 465.2250). Anal. Calcd for C24H28N6O4: C, 62.06; H, 6.08; N, 18.09. Found: C, 61.70; H, 6.05; N, 17.90.

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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Analyzing the synthesis route of 1593-08-4

1593-08-4, As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 18 (3.2 g, 0.02 mol) was dissolved in 250 mL ethanol. To the solution was added freshly prepared N-tert-butyl-hydroxylamine (2.67 g, 0.03 mol). The reaction was allowed to proceed for 4 h. After the workup, solvent was removed in vacuo and the crude product was purified by column chromatography (petroleum ether/ethyl acetate 4:1) to afford compound 19 as a red solid, (3.49 g, 75.2% yield), mp: 88-89 C. 1H NMR (CDCl3): 1.70 (s, 9H), 7.77 (m, 2H), 8.03 (m, 2H), 8.14 (s, 1H), 10.49 (s, 1H). ESI-MS: 230 [M+H]+. Anal. (C13H15N3O) C, H, N.

1593-08-4, As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Conference Paper; Sun, Yewei; Zhang, Gaoxiao; Zhang, Zaijun; Yu, Pei; Zhong, Haijing; Du, Jing; Wang, Yuqiang; Bioorganic and Medicinal Chemistry; vol. 20; 12; (2012); p. 3939 – 3945;,
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New learning discoveries about 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various.

32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Methyl 4-hydroxybenzoate (42.1mmol, 6.4g) and K2CO3 (50.5mmol, 5.3g) were dissolved in DMF (150mL), the resulting solution was allowed to react at 85C for 12h. Compound 2a (23.5mmol, 5.0g) was added in batches, and the resulting mixture was allowed to react for additional 12hat the same condition. After completion of reaction, the reaction was quenched with cooled water (150mL) and extracted with EtOAc (2¡Á100mL). The combined organic phase was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuum to afford the crude product, which was purified by silica gel flash chromatography (PE: EA=50:1, v:v) to afford 6.6g of 3a as oily semi-solid, yield 80%. ESI-MS m/z: 295.4 [M+H]+., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Xia, Qiao-Hong; Hu, Wei; Li, Chen; Wu, Ji-Feng; Yang, Liang; Han, Xue-Mei; Shen, Yue-Mao; Li, Zhi-Yu; Li, Xun; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 311 – 325;,
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Some tips on 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, To a solution of quinoxaline-2-carboxylic acid 5 (0.2 g, 1.14 mmol) in dichloromethane was cooled to 0 C followed by addition of triethylamine (0.18 ml, 1.2 equiv) and ethylchloroformate (0.14 ml, 1.2 equiv) into it and stirred for 30 min. This reaction mixture was then transferred to a solution in another flask containing 5-(4-aminophenyl)-10,15,20-tripyridylporphyrin 7 (0.1 g, 0.158) dissolved in dichloromethane and triethylamine (0.18 ml, 1.2 equiv) at 0 C. Stirring continued for 1 h at the same temperature and allowed to reach at room temperature for another 1 h. After completion of the reaction, water (5 mL) was added into the reaction mixture and basified to pH ~ 8 with sodium carbonate and extracted with chloroform (3 ¡Á 25 mL). The solvent was evaporated and purified on a silica gel (100-200) column chromatography by using 5% methanol/chloroform to produce porphyrin 8 in good yield. (0.095 g, 76%). 1H NMR (400 MHz, DMSO-d6) delta: 10.20 (s, 1H), 9.85 (s, 1H), 9.00-8.90 (m, 8H), 8.79-8.78 (m, 5H), 8.32-8.21 (m, 5H), 8.13-8.07 (m, 6H), 7.99-7.77 (m, 3H), -2.93 (s, 2H). ESIMS m/z: calcd for C50H33N10O: 788 (M+), found: 789 (M+H).

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Kumar, Dalip; Chandra Shekar; Mishra, Bhupendra; Kurihara, Ryohsuke; Ogura, Maiko; Ito, Takeo; Bioorganic and Medicinal Chemistry Letters; vol. 23; 11; (2013); p. 3221 – 3224;,
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Analyzing the synthesis route of 879-65-2

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

879-65-2, General procedure: The tail group containing monomer, dimer ortrimer (0.266 mmol) was dissolved in methanol (25 mL), to which Pd/C-10% (60mg) was added at 0oC under nitrogen with stirring. The reactionmixture was hydrogenated at room temperature and atmospheric pressure for 4 h.The catalyst was removed over Kieselguhr and the solvent was removed underreduced pressure to give the amine, which was dissolved in DMF (1 mL, dry). Theappropriate head group carboxylic acid (0.266 mmol) was dissolved in DMF (1 mL,dry) to which HBTU (260 mg, 0.685 mmol) and triethylamine (50 muL) were added tothe reaction mixture at room temperature with stirring and the reaction mixturewas left standing at room temperature overnight. The product was purified byHPLC (no work up required). Fractions containing the product were collected andfreeze dried to give the required product.

The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Scott, Fraser J.; Puig-Sellart, Mireia; Khalaf, Abedawn I.; Henderson, Catherine J.; Westrop, Gareth; Watson, David G.; Carter, Katharine; Grant, M. Helen; Suckling, Colin J.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3478 – 3486;,
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Simple exploration of 55687-05-3

As the paragraph descriping shows that 55687-05-3 is playing an increasingly important role.

55687-05-3, 2,5-Dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55687-05-3, EXAMPLE 5 Preparation of N-(5-chloro-2-quinoxalinyl)benzofuran-5-sulfonamide In a manner similar to Example 4, the reaction mixture from benzofuran-5-sulfonamide (397 mg, 2.01 mmol), sodium hydride (60%, 315 mg, 7.9 mmol) and 2,5-dichloroquinoxaline (600 mg, 3.01 mmol) was poured carefully into water and washed with hexanes. The hexane-free aqueous was acidified to a pH of 1-2 by the addition of 5N hydrochloric acid solution and the resulting precipitate was collected and dried. This precipitate was washed with methylene chloride and the solid obtained by evaporation of the filtrate was purified by radial silica gel chromatography (EtOAc/hexanes) followed by silica gel flash chromatography (diethyl ether/hexanes). The resulting foam which was broken up in hexanes, collected and dried, finally under vacuum at 80 C. to yield the title product (110 mg, 15%) as a solid. Analysis of the title compound gave the following results: 1 H NMR (300 MHz, d6 -DMSO) delta7.15 (d, 1H, J=2.0 Hz, Ar-H), 7.64-8.0 (overlapping multuplets, 4H, Ar-H), 8.03 (d, 1H, J=7.3 Hz, Ar-H), 8.13 (d, 1H, J=2.0 Hz, Ar-H), 8.51 (s, 1H, Ar-H), 8.67 (s, 1H, Ar-H), 12.21 (s, 1H, exchanges with D2 O, NH); IR(KBr) 1617, 1581, 1453, 1263 and 1153 cm-1; FDMS (DMSO) m/e=359, 361 (M+). Analysis of C16 H10 ClN3 O3 S: Theory: C, 53.41; H, 2.80; N, 11.68. Found: C, 52.95; H, 2.99; N, 11.47.

As the paragraph descriping shows that 55687-05-3 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly and Company; US5529999; (1996); A;,
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Simple exploration of 148231-12-3

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various.

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 C. Then, the respective terminal arylacetylene (4aeg) (2.5 mmol) dissolved in tetrahydrofuran (10 mL) was added dropwise. The reaction mixture was stirred under reflux for 20min under a nitrogen atmosphere. Cooled down to room temperature, the solution was evaporated, and the crude product was purified by a silica gel chromatography column using hexane/dichloromethane (70:30) as the eluent to afford the respective final compound 5a-g.

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
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Some tips on 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various.

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (126 mg, 0.657 mmol) and 1-hydroxybenzotriazole monohydrate (89.0 mg, 0.657 mmol) were added to a methylene chloride solution (5.0 ml) of the resulting compound (165 mg, 0.438 mmol) and 3-hydroxyquinoxaline-2-carboxylic acid (125 mg, 0.657 mmol), at room temperature, and stirring was carried out at room temperature overnight. The reaction solution was poured into a 2N aqueous hydrochloric acid solution, followed by extraction with ethyl acetate, the extract was washed sequentially with water, a saturated aqueous sodium hydrogencarbonate solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. The organic layer was concentrated, the resulting residue was purified by a medium-pressure preparative liquid chromatograph (manufactured by Biotage, Inc., 25+M), the residue resulting from concentration was suspended in a mixed solvent of methylene chloride-dimethylether, and the solid substance was collected by filtration to afford the desired title compound (217 mg, yield 90%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.82 (1H, brs), 9.50 (1H, d, J=9.0 Hz), 7.86 (1H, t, J=7.0 Hz), 7.65-7.63 (2H, m), 7.49-7.36 (4H, m), 4.94-4.85 (2H, m), 3.71-3.61 (4H, m), 2.55 (3H, d, J=12.9 Hz), 1.96-1.84 (5H, m), 0.97-0.93 (6H, m). IR (KBr) cm-1: 2965, 1685, 1640, 1540, 1480, 1265. MS (ESI, m/z): 571 (M+Na)+. HRMS (ESI, m/z): 571.2075 (Calcd for C28H29FN6NaO5: 571.2081)., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

Downstream synthetic route of 212327-11-2

212327-11-2, 212327-11-2 7-Bromoquinoxalin-2-amine 15322531, aquinoxaline compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.212327-11-2,7-Bromoquinoxalin-2-amine,as a common compound, the synthetic route is as follows.

7-bromoquinoxaline-2-amine (500 mg, 2.24 mmol) and 2-bromo-1-(tetrahydro-2H-pyran-4-yl)ethan-1-one (462 mg, 2.24 mmol) were added to N-methylpyrrolidone (1 mL). After reaction under agitation at 150 C for 1 h under the protection of nitrogen, the reaction mixture was cooled to rt. Water (10 mL) was added, and EA (20 mL*2) was used for extraction. The organic phases were combined, washed with a saturated saline solution (20 mL*2), dried with anhydrous sodium sulfate, filtered, and concentrated at reduced pressure to obtain a crude compound. Isolation and purification by column chromatography (silica gel, DCM: MeOH = 30:1 as an eluant) was performed to obtain the targeted compound (120 mg, 16.2% yield, yellow solid). LC-MS (ESI): m/z (M+1) 332.14.

212327-11-2, 212327-11-2 7-Bromoquinoxalin-2-amine 15322531, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Impact Therapeutics, Inc; CAI, Suixiong; TIAN, Ye Edward; (74 pag.)EP3567041; (2019); A1;,
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Simple exploration of 1865-11-8

The synthetic route of 1865-11-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1865-11-8,Methyl quinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: All the solids and liquids were introduced on the platform whichis inertized under argon. [Ir(cod)Cl]2 (3.4 mg; 0.005 mmol), the ligands (0.011 mmol for the bisphosphines and 0.022 mmol for the monophosphines) were automatically weighted into vials and solubilized into the chosen solvents (5 mL). Iodine solution (0.025 mmol, 12.7 mg in 2 mL of solvent) was prepared in a separated vial. The catalytic solutions were introduced into the autoclaves and the mixtures were stirred for 30 min for preparing the precatalysts. The substrate (1 mmol) was then added in each autoclave. Then, iodine in solution (0.1 mmol) was introduced. The reactors were then purged with molecular hydrogen three times and pressurized at the desired pressure of dihydrogen. The stirring was started once the desired temperature was reached. At the end of the assays, the reactors were returned at ambient temperature and depressurized. The catalytic mixtures were filtered separately through pads of silica gel. Then, GC analysis and examination of 1HNMR spectra allowed determining the conversions. The enantiomeric excesses were determined by HPLC analysis., 1865-11-8

The synthetic route of 1865-11-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine; Tetrahedron; vol. 72; 10; (2016); p. 1375 – 1380;,
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