Heterocyclic Building Blocks-quinoxaline

Wozniak, Marian; Baranski, Andrzej; Nowak, Krystyna; Poradowska, Henryka published the artcile< Regioselectivity of the amination of some nitroquinoxalines by liquid ammonia/potassium permanganate>, Recommanded Product: 2-Chloro-6-nitroquinoxaline, the main research area is regioselective amination nitroquinoxaline; quinoxaline nitro regioselective amination.

5- And 6-nitroquinoxalines and some of their derivatives are aminated in a liquid NH3 solution of KMnO4 to yield the corresponding 2- and/or 3- and/or 5-amino compounds Quantum-chem. calculations are made to explain the regioselectivity of the amination reactions.

Liebigs Annalen der Chemie published new progress about Amination, regioselective. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Recommanded Product: 2-Chloro-6-nitroquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Takai, Hitoshi; Odani, Akira; Sasaki, Yoshio published the artcile< Studies on heterocyclic carbon-13 magnetic resonance spectroscopy. XI. Nitrogen heterocycles. (1). 6-Substituted quinoline and quinoxaline derivatives>, COA of Formula: C9H5N3, the main research area is carbon NMR quinoline quinoxaline; LFER NMR heterocycle.

The assignment of 13C NMR chem. shifts of 6-substituted quinoline and quinoxaline derivatives were confirmed, and the additivity rules of 13C chem. shifts of 2-substituted naphthalene derivatives were approved for both 6-substituted quinoline and quinoxaline derivatives The correlation coefficient of meta-like positions is promoted by the linear combinations of chem. shifts at the corresponding meta position of 2-substituted naphthalene derivatives and substituent constants σπ.

Chemical & Pharmaceutical Bulletin published new progress about Linear free energy relationship. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, COA of Formula: C9H5N3.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Wang, Jiayang; Sun, Bin; Zhang, Liang; Xu, Tengwei; Xie, Yuanyuan; Jin, Can published the artcile< Visible-light-induced trifluoromethylation of quinoxalin-2(1H)-ones under photocatalyst-free conditions>, Synthetic Route of 89898-96-4, the main research area is trifluoromethylquinoxalinone regioselective green preparation; quinoxalinone sodium trifluoromethanesulfinate trifluoromethylation.

C-H trifluoromethylation of quinoxalin-2(1H)-ones with com. available sodium trifluoromethanesulfinate (CF3SO2Na) under visible light irradiation without any external photocatalyst was developed, provided a variety of 3-trifluoromethylquinoxalin-2(1H)-ones I [R1 = H, 6-MeO, 7-Br, etc.; R2 = H, Me, Bn, etc.] in moderate to excellent yield. Predictably, the strategy would offer an environmentally friendly and simple operational access to pharmaceutically active 3-trifluoromethylquinoxalin-2(1H)-ones without any external photocatalyst.

Asian Journal of Organic Chemistry published new progress about Green chemistry. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Synthetic Route of 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Antczak, Christophe; Wee, Boyoung; Radu, Constantin; Bhinder, Bhavneet; Holland, Eric C.; Djaballah, Hakim published the artcile< A High-Content Assay Strategy for the Identification and Profiling of ABCG2 Modulators in Live Cells>, Name: YM-90709, the main research area is ABCG2 protein ABC transporter glioblastoma.

ABCG2 is a member of the ATP-binding cassette (ABC) family of transporters, the overexpression of which has been implicated in resistance to various chemotherapeutic agents. Though a number of cell-based assays to screen for inhibitors have been reported, they do not provide a content-rich platform to discriminate toxic and autofluorescent compounds To fill this gap, we developed a live high-content cell-based assay to identify inhibitors of ABCG2-mediated transport and, at the same time, assess their cytotoxic effect and potential optical interference. We used a pair of isogenic U87MG human glioblastoma cell lines, with one stably overexpressing the ABCG2 transporter. JC-1 (J-aggregate-forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol carbocyanine iodide) was selected as the optimal reporter substrate for ABCG2 activity, and the resulting assay was characterized by a Z’ value of 0.50 and a signal-to-noise (S/N) ratio of 14 in a pilot screen of ∼7,000 diverse chems. The screen led to the identification of 64 unique nontoxic positives, yielding an initial hit rate of 1%, with 58 of them being confirmed activity. In addition, treatment with two selected confirmed positives suppressed the side population of U87MG-ABCG2 cells that was able to efflux the Hoechst dye as measured by flow cytometry, confirming that they constitute potent new ABCG2 transporter inhibitors. Our results demonstrate that our live cell and content-rich platform enables the rapid identification and profiling of ABCG2 modulators, and this new strategy opens the door to the discovery of compounds targeting the expression and/or trafficking of ABC transporters as an alternative to functional inhibitors that failed in the clinic.

Assay and Drug Development Technologies published new progress about Antioxidants. 163769-88-8 belongs to class quinoxaline, and the molecular formula is C22H21N3O2, Name: YM-90709.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gobec, S.; Urleb, U. published the artcile< Product class 15: quinoxalines>, Electric Literature of 5182-90-1, the main research area is review quinoxaline preparation cyclization ring transformation aromatization.

A review. Methods for preparing quinoxalines are reviewed including cyclization, ring transformation, aromatization, and substituent modification.

Science of Synthesis published new progress about Aromatization. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Electric Literature of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

do Amaral, Daniel N.; Alves, Fernando R. de Sa; Barreiro, Eliezer J.; Laufer, Stefan A.; Lima, Lidia M. published the artcile< Multi-gram preparation of 7-nitroquinoxalin-2-amine>, SDS of cas: 89898-96-4, the main research area is nitro quinoxalinamine regioselective preparation.

Methodologies to obtain quinoxaline compounds regioselectively were rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives were desirable to explore the entire potential of these scaffolds for academic and/or com. application. A facile and multi-gram methodol. was described to obtain compound 7-nitroquinoxalin-2-amine I using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatog.

Journal of the Brazilian Chemical Society published new progress about Quinoxalines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, SDS of cas: 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Izzo, Francesca Caterina; Vitale, Valentina; Fabbro, Chiara; Van Keulen, Henk published the artcile< Multi-analytical investigation on felt-tip pen inks: Formulation and preliminary photo-degradation study>, COA of Formula: C9H7N3O, the main research area is photodegradation felt tip pen ink archaeol.

We present a multi-anal. study on the formulation of com. felt-tip pens, introduced in the second half of the 20th century and commonly used by modern and contemporary artists. These media of both drawing and writing have not yet been fully investigated, but the degradation processes they might undergo, such as fading, are well-known and rather apparent.Twelve water-based felt-tip pens were investigated by the joint use of complementary anal. techniques, such as Thin Layer Chromatog., NMR, Fourier transformed IR spectroscopy, X-ray fluorescence spectrometry and Pyrolysis-Gas Chromatog./Mass Spectrometry.The obtained results provided crucial, preliminary data for the identification of dyes, solvents and additives present in the inks’ formulations. Numerous synthetic food coloring agents and pigments were identified, such as Acid Yellow 23, Acid Red 18, Acid Blue 9, and Pigment Blue 15. In addition, glycols, fatty acids, 2-phenoxyethanol, colophony, benzotriazole derivatives and other solvents and additives were detected in the manufactured inks.Furthermore, the effects of photo-degradation on one emblematic ink sample were studied, highlighting in particular visual and aesthetical changes due to discoloration.This study demonstrates a methodol. based upon the use of an integrated anal. approach for the characterization of com. ink-based artistic media and their viable degradation patterns, which aims to develop suitable conservation treatments to assess modern and contemporary drawings and writings.

Microchemical Journal published new progress about Archaeology. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, COA of Formula: C9H7N3O.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Kato, Akira; Fujimoto, Takeshi; Okanda, Junko published the artcile< The ring-opening reaction of benzimidazoles with 2-chloro- or 2,3-dichloro-6-nitroquinoxaline>, Computed Properties of 6272-25-9, the main research area is ring opening benzimidazole chloronitroquinoxaline; quinoxaline chloronitro ring opening benzimidazole.

1-Methylbenzimidazole underwent ring-opening reaction with 2,3-dichloro-6-nitroquinoxaline in the presence of a few drops of water in benzene under reflux to give a mixture of structural isomers, 2-[2′-(N-formyl-N-methyl)amino]anilino-3-chloro- and 2-chloro-3-[2′-(N-formyl-N-methyl)amino]anilino-6-nitroquinoxaline. Similarly, other benzimidazoles afforded ring-opening products. On the reaction of benzimidazoles with 2-chloro-6-nitroquinoxaline, the ring-opening products were obtained as single isomers.

Seikei Daigaku Kogaku Kenkyu Hokoku published new progress about Ring opening. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Computed Properties of 6272-25-9.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Tagdiwala, P. V.; Rangnekar, D. W. published the artcile< Studies on novel pigments>, Formula: C8H4ClN3O2, the main research area is nitroquinoxaline derivative pigment ink; paint pigment nitroquinoxaline derivative.

The reaction of 2-chloro-6-nitroquinoxaline(I) with hydrazine gave 1,2-bis(6-nitroquinoxalin-2-yl)hydrazine (II) [95758-19-3] in 71.4% yield for use as red pigment in printing ink and paint. Similarly the reaction of I with piperazine yielded bright yellow 1,4-bis(6-nitroquinoxalin-2-yl)piperazine (III) [95758-20-6]. Fastness of the pigments to various agents was satisfactory; however, both pigments showed poor fastness when treated with DOP plasticizer. The oil absorption value of II and III was low compared to the com. standard pigments of similar shades.

Paintindia published new progress about Castor oil Role: PRP (Properties). 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Formula: C8H4ClN3O2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gobec, S.; Urleb, U. published the artcile< Product class 15: quinoxalines>, Formula: C8H5N3O3, the main research area is review quinoxaline preparation cyclization ring transformation aromatization.

A review. Methods for preparing quinoxalines are reviewed including cyclization, ring transformation, aromatization, and substituent modification.

Science of Synthesis published new progress about Aromatization. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Formula: C8H5N3O3.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider