Heterocyclic Building Blocks-quinoxaline

Visible-Light Organophotoredox-Mediated [3 + 2] Cycloaddition of Arylcyclopropylamine with Structurally Diverse Olefins for the Construction of Cyclopentylamines and Spiro[4.n] Skeletons was written by Luo, Zhengshan;Cao, Bowen;Song, Tianhang;Xing, Zequn;Ren, Jun;Wang, Zhongwen. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C8H4Cl2N2 This article mentions the following:

A visible-light-mediated [3 + 2] cycloaddition of arylcyclopropylamine with structurally diverse olefins was developed using QXPT-NPh I as a highly efficient organic photoredox catalyst. The use of various alkyl-substituted alkenes in intermol. [3 + 2] cycloadditions with cyclopropylamine was first achieved. A general and efficient strategy for the construction of compounds containing structurally diverse cyclopentane-based spiro[4.n] skeletons such as II with 1,3-difunctional groups was also developed, which broadly exist in natural products and synthetic mols. Furthermore, a hydrogen-bond mode between the arylcyclopropylamine and the photocatalyst QXPT-NPh was proposed. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Computed Properties of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Computed Properties of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa was written by Fernandez, Maria C.;O’flaherty, Cristian. And the article was included in Human Reproduction in 2018.Synthetic Route of C10H8Br2N2O2 This article mentions the following:

Are all components of the peroxiredoxins (PRDXs) system important to control the levels of reactive oxygen species (ROS) to maintain viability and DNA integrity in spermatozoa. The answer is PRDX6 is the primary player of the PRDXs system for maintaining viability and DNA integrity in human spermatozoa. It is known that mammalian spermatozoa are sensitive to high levels of ROS and PRDXs are antioxidant enzymes proven to control the levels of ROS generated during sperm capacitation to avoid oxidative damage in the spermatozoon. Low amounts of PRDXs are associated with male infertility. The absence of PRDX6 promotes sperm oxidative damage and infertility in mice. Semen samples were obtained over a period of one year from a cohort of 20 healthy nonsmoking volunteers aged 22-30 years old. Sperm from healthy donors was incubated for 2 h in the absence or presence of inhibitors for the 2-Cys PRDXs system (peroxidase, reactivation system and NADPH-enzymes suppliers) or the 1-Cys PRDX system (peroxidase and calcium independent-phospholipase A2 (Ca2+-iPLA2) activity). Sperm viability, DNA oxidation, ROS levels, mitochondrial membrane potential and 4-hydroxynonenal production were determined by flow cytometry. We observed a significant decrease in viable cells due to inhibitors of the 2-Cys PRDXs, PRDX6 Ca2+-iPLA2 activity or the PRDX reactivation system compared to controls (P 鈮?0.05). PRDX6 Ca2+-iPLA2 activity inhibition had the strongest detrimental effect on sperm viability and DNA oxidation compared to controls (P 鈮?0.05). The 2-Cys PRDXs did not compensate for the inhibition of PRDX6 peroxidase and Ca2+-iPLA2 activities. LARGE SCALE DATA: Not applicable. LIMITATIONS, REASONS FOR CAUTION: Players of the reactivation systems may differ among mammalian species. The wider implications and findings are that the Ca2+-iPLA2 activity of PRDX6 is the most important and first line of defense against oxidative stress in human spermatozoa. Peroxynitrite is scavenged mainly by the PRDX6 peroxidase activity. These findings can help to design new diagnostic tools and therapies for male infertility. In the experiment, the researchers used many compounds, for example, 2,3-Bis(bromomethyl)quinoxaline 1,4-dioxide (cas: 18080-67-6Synthetic Route of C10H8Br2N2O2).

2,3-Bis(bromomethyl)quinoxaline 1,4-dioxide (cas: 18080-67-6) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson鈥檚, and Alzheimer鈥檚 diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Synthetic Route of C10H8Br2N2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Dual role of novel hole-transporting and deep-blue emitting materials based on twisted binaphthyl was written by Huang, Haifang;Kong, Yafen;Gao, Jian;Fan, Heliang;Lin, Qifu. And the article was included in Optical Materials (Amsterdam, Netherlands) in 2022.Quality Control of Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile This article mentions the following:

Three novel deep blue-emitting materials from binaphthyl derivatives, namely BFS, BNS and BNF, were designed and synthesized. Due to their rigid structure, all the materials exhibit high thermal stability with Td exceed 440 掳C and Tg as high as 153 掳C, 149 掳C and 140 掳C, resp. They also show appropriate HOMO and LUMO energy level, excellent amorphous stability and outstanding solubility in common organic solvents. These novel materials are highly emissive in both solution and solid states, with deep blue emissions peaked at 鈭?50 nm. Deep-blue OLEDs using the novel materials as emitter resulted in efficient CE, EQE and luminance. The BFS, BNS and BNF based devices show good EL performances with the Lmax of 857 cd/m2 (CEmax of 0.3 cd/A), Lmax of 1038 cd/m2 (CEmax of 0.5 cd/A), and Lmax of 3717 cd/m2 (CEmax of 0.5 cd/A), resp. They should be promising hole-transport and deep blue-emitting materials for OLED devices. In the experiment, the researchers used many compounds, for example, Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4Quality Control of Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile).

Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when 伪-ketonic acids, 伪-chlorketones, 伪-aldehyde alcohols and 伪-ketone alcohols are used in place of diketones.Quality Control of Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Influence of timolol, benzalkonium-preserved timolol, and benzalkonium-preserved brimonidine on oxidative stress biomarkers in the tear film was written by Sedlak, Lech;Wojnar, Weronika;Zych, Maria;Wygledowska-Promienska, Dorota. And the article was included in Cutaneous and Ocular Toxicology in 2020.HPLC of Formula: 70359-46-5 This article mentions the following:

PurposeThe objective of this study was to investigate the influence of topical preservative-free timolol, benzalkonium chloride(BAC)-preserved timolol, BAC-preserved timolol, and BAC-preserved brimonidine on total protein concentration, advanced oxidation protein products (AOPP) content, total sulfhydryl groups content, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as Total Oxidant Status (TOS), Total Antioxidant Response, and Oxidative Stress Index (OSI) in the tear film. MethodsThe patients were divided into four groups: group C (n = 25)-control group-subjects who did not use topical antiglaucoma medications, group T (n = 17)-patients using topical preservative-free timolol, group T + BAC (n = 24)-patients using topical BAC-preserved timolol, and group BR + BAC (n = 19)-patients using topical BAC-preserved brimonidine. ResultsThe SOD, CAT, and GPx activities as well as AOPP, TOS, and OSI were found to be higher in the tear film of patients treated with BAC-preserved topical timolol or brimonidine in comparison with patients treated with preservative-free timolol or patients who did not use antiglaucoma topical medications. ConclusionsThis indicates that using BAC-preserved topical medications increases oxidative stress in the tear film and may, in the long-term, contribute to the clin. presentation of dry eye disease. In the experiment, the researchers used many compounds, for example, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine (2R,3R)-2,3-dihydroxysuccinate (cas: 70359-46-5HPLC of Formula: 70359-46-5).

5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine (2R,3R)-2,3-dihydroxysuccinate (cas: 70359-46-5) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.HPLC of Formula: 70359-46-5

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects was written by Ye, Qing;Zhang, Yinan;Cao, Yanan;Wang, Xiachang;Guo, Yubin;Chen, Jing;Horn, Jamie;Ponomareva, Larissa V.;Chaiswing, Luksana;Shaaban, Khaled A.;Wei, Qiou;Anderson, Bradley D.;St, Clair Daret K.;Zhu, Haining;Leggas, Markos;Thorson, Jon S.;She, Qing-Bai. And the article was included in Cell Chemical Biology in 2019.Product Details of 18080-67-6 This article mentions the following:

Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor progression. Here, we identify the prototypical pyranonaphthoquinone natural product frenolicin B (FB) as a selective inhibitor of Prx1 and Grx3 through covalent modification of active-site cysteines. FB-targeted inhibition of Prx1 and Grx3 results in a decrease in cellular glutathione levels, an increase of reactive oxygen species (ROS), and concomitant inhibition of cancer cell growth, largely by activating the peroxisome-bound tuberous sclerosis complex to inhibit mTORC1/4E-BP1 signaling axis. FB structure-activity relationship studies reveal a pos. correlation between inhibition of 4E-BP1 phosphorylation, ROS-mediated cancer cell cytotoxicity, and suppression of tumor growth in vivo. These findings establish FB as the most potent Prx1/Grx3 inhibitor reported to date and also notably highlight 4E-BP1 phosphorylation status as a potential predictive marker in response to ROS-based therapies in cancer. In the experiment, the researchers used many compounds, for example, 2,3-Bis(bromomethyl)quinoxaline 1,4-dioxide (cas: 18080-67-6Product Details of 18080-67-6).

2,3-Bis(bromomethyl)quinoxaline 1,4-dioxide (cas: 18080-67-6) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Product Details of 18080-67-6

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

N-Oxides of the quinoxaline series. VI. N-Oxides of amino and hydroxy derivatives of quinoxaline was written by Elina, A. S.;Tsirul’nikova, L. G.. And the article was included in Zhurnal Obshchei Khimii in 1963.HPLC of Formula: 5424-05-5 This article mentions the following:

2-Acetamidoquinoxaline in 10.3% AcO₂H in the presence of NaOAc (22 h. at 45-8掳) gave 50% 1,4-di-N-oxide, decomposed 233掳, and 4.5% more soluble 2-amino-3-hydroxyquinoxaline 1,4-di-N-oxide (Ia), decomposed 300掳. Reaction with AcO₂H (48 h. at 20-5掳) gave 20% 2-acetamidoquinoxaline 1-N-oxide, m. 193-4掳, and 6% corresponding 4-N-oxide, m. 239-40掳, insoluble in CHCl₃; the residue contained a mixture of these oxides. Heating 2-acetamidoquinoxaline in AcOH with 30% H₂O₂ in the presence of Na₄P₂O₇ 22 h. at 55-60掳 gave 20% Ia and mixed mono-N-oxides. 2-Amino-3-methylquinoxaline refluxed with Ac₂O 0.5 h. gave 65% diacetyl derivative (I), m. 87.5-8掳; similar reaction in MePh in 2 h. gave 85% 2-acetamido-3-methylquinoxaline, m. 145-6掳. I and 10% AcO₂H in the presence of H₂SO₄ (22 h. at 50掳) gave on evaporation and treatment with MeOH-Et₂O 25% 4-N-oxide, m. 208-9掳, identified as that of 2-acetamido-3-methylquinoxaline; the residue gave some mono-N-oxide of I, m. 144.5-6掳. 2-Acetamido-3-methylquinoxaline heated 22.5 h. in AcOH with 30% H₂O₂ at 60掳 gave 62.7% 2-amino-3-methylquinoxaline 1,4-di-N-oxide, decomposed 215-16掳. Heating the N-oxides of 2-acetamidoquinoxalines with 2.5N HCl 10-12 min. at 100掳 gave: 2-aminoquinoxaline 1,4-di-N-oxide (II), decomposed 242掳, 89.5%, which gave a green color with FeCl₃; 2-aminoquinoxaline 1-N-oxide (IIa), m. 191-2掳, 75.9%, bluegreen color with FeCl₃; 2-aminoquinoxaline 4-N-oxide (IIb), decomposed 276掳, 70.3%, gave no color with FeCl₃; 2-aminoquinoxaline 4-N-oxide (IIb) decomposed 276掳, 70.3%, gave no color with FeCl₃; 2-amino-3-methylquinoxaline 4-N-oxide, m. 208-9掳, 80.2%, gave no color with FeCl₃. Longer heating with 2.5N HCl resulted in isomerization of N oxides into o-hydroxy compounds and 2-10 h. heating gave the following from the above oxides: II gave in 0.5 h. mainly 2-amino-3-hydroxyquinoxaline 1-N-oxide (III), decomposed 300掳, and 10% 2,3-dihydroxyquinoxaline, did not m. <360掳; the former gave green color with FeCl₃; similar reaction in 10 h. gave 2,3-dihydroxyquinoxaline 1-N-oxide (IV), decomposed 279-80掳, which gave red color with FeCl₃. III in 4 h. gave IV. IIa in 13.5 h. gave 30% IIa.HCl, decomposed 241.5掳, and unchanged IIa. IIb in 2 h. gave mainly 2-amino-3-hydroxyquinoxaline, did not m. <360掳, and 20% 2,3-dihydroxyquinoxaline, did not m. <360掳, 2-amino-3-hydroxy-quinoxaline 1,4-di-N-oxide in 4 h. gave 65% 2,3-dihydroxyquinoxaline 1,4-di-N-oxide, decomposed 261-2.5掳. The R_f values for paper chromatog. of the oxides in BuOH-5% AcOH system are tabulated. II refluxed 0.5 h. in N NaOH gave (on acidification to pH 5) 55% III; IIa in 4 h. gave 65% 2-hydroxyquinoxaline 1-N-oxide (V), m. 207-8掳; mixed 1- and 4-N-oxides of 2-acetamidoquinoxaline in 0.5 h. gave mainly V and IIa, with some IIb; similarly, 2-amino-3-methylquinoxaline 1,4-di-N-oxide gave in 5.5 h. 30% 2-hydroxy-3-methylquinoxaline 1,4- di-N-oxide, decomposed 216-17掳, and unchanged starting material. Shaking the N-oxides in H over Raney Ni at room temperature in aqueous MeOH or aqueous NaOH or EtOH-AcOH gave the following results: II gave 2-aminoquinoxaline, m. 150-1掳; 2-amino-3-hydroxyquinoxaline 1,4-di-N-oxide gave the 4-N-oxide, decomposed 282掳, and 2-amino-3-hydroxyquinoxaline. IV gave 2,3-dihydroxyquinoxaline, while IIa was largely unchanged and gave some unidentified product (undescribed). In the experiment, the researchers used many compounds, for example, Quinoxalin-2-amine (cas: 5424-05-5HPLC of Formula: 5424-05-5).

Quinoxalin-2-amine (cas: 5424-05-5) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.HPLC of Formula: 5424-05-5

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Positive Modulation of 伪-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid-Type Glutamate Receptors Elicits Neuroprotection after Trimethyltin Exposure in Hippocampus was written by Munirathinam, Subramani;Rogers, Gary;Bahr, Ben A.. And the article was included in Toxicology and Applied Pharmacology in 2002.Category: quinoxaline This article mentions the following:

The 伪-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamatergic receptors have been linked to survival signaling, especially when the receptors are allosterically modulated by members of the Ampakine family. While increased glutamatergic communication through AMPA receptors has been shown to protect against toxic conditions that target hippocampal subfield CA1, protection in other subfields has not been shown. Accordingly, pos. modulation of AMPA receptors by Ampakine compounds CX727 and CX516 was tested for effects on trimethyltin (TMT) neurotoxicity in rat hippocampal slice cultures. TMT was applied for 4 h followed by a rapid washout and antagonistic quenching of AMPA and N-methyl-d-aspartate (NMDA) receptors. After a 24-h period, the TMT-exposed slices exhibited increased levels of calpain-mediated spectrin breakdown as well as synaptic deterioration. TMT selectively targeted CA3 pyramidal neurons and dentate gyrus (DG) granule cells as evidenced by degeneration and neuronal loss. The cytoskeletal and synaptic damage was reduced when Ampakine modulation was initiated during the postinsult period. Furthermore, the extent of protection was comparable to that produced by the NMDA receptor antagonist AP5. The above results were substantiated by histol. experiments, revealing that Ampakine treatment prevented TMT-induced cell loss in CA3 and DG. These results indicate that AMPA receptor signals are part of cellular repair responses following exposure to an environmental toxin. In the experiment, the researchers used many compounds, for example, Piperidin-1-yl(quinoxalin-6-yl)methanone (cas: 154235-83-3Category: quinoxaline).

Piperidin-1-yl(quinoxalin-6-yl)methanone (cas: 154235-83-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

K₂S₂O₈ Mediated Three-component Radical Cascade C3 Alkylation of Quinoxalin-2(1H)-ones with Vinylarenes and 4-Hydroxycoumarins/4-Hydroxy-6-methyl-2-pyrone was written by Sharma, Suraj;Bhuyan, Mayurakhi;Baishya, Gakul. And the article was included in ChemistrySelect in 2022.Application In Synthesis of 2-Quinoxalinol This article mentions the following:

Quinoxalin-2(1H)-ones I (R = H, Cl, NO₂, Me; R¹ = H, Me, 4-chlorophenyl, Bn, etc.; R² = H, Cl, Me) undergo a three-component radical cascade C3 alkylation reaction with 4-hydroxycoumarins II (R³ = H, OMe; R⁴ = H, Cl, Br, Me)/4-hydroxy-6-methyl-2-pyrone by using vinyl arenes 2-R⁵-4-R⁶-C₆H₃CH=CH₂ (R⁵ = H, Me; R⁶ = H, Cl, Br, OMe) as intermediary radical acceptors. K₂S₂O₈ in dimethylsulfoxide (DMSO) works as the best reagent-solvent combination, which promotes the reaction under metal-, photocatalyst- and light-free conditions producing the three-component products III and IV in moderate yields. The involvement of radicals in the course of the reaction by performing several radical scavenging experiments with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), di-Ph ethylene, and butylated hydroxytoluene (BHT) was also proved. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Application In Synthesis of 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application In Synthesis of 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach was written by Kaneko, Daiki;Ninomiya, Masayuki;Yoshikawa, Rina;Ono, Yukari;Sonawane, Amol D.;Tanaka, Kaori;Nishina, Atsuyoshi;Koketsu, Mamoru. And the article was included in Bioorganic Chemistry in 2020.Electric Literature of C8H4Cl2N2 This article mentions the following:

A series of [1,2,4]triazolo[4,3-a]quinoxalines I [R¹ = benzyl, anilino, styryl, etc.], EAPB0203 (N-methyl-1-(2-phenethyl)imidazo[1,2-a]quinoxalin-4-amine) incorporated with 1,3,4-oxadiazole/thiadiazoles II [X = O, S; R² = H, Me, Cl, etc.] and imiquimod incorporated with 1,3,4-oxadiazole/thiadiazoles III [Y = O, S; R³ = Me, OH, NH₂] were synthesized and assessed their antiproliferative effects against various cancer cell lines. The 1,3,4-oxadiazole derivatives demonstrated the superior effectiveness compared to imiquimod and EAPB0203. These findings highlight the excellent potential of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as anticancer agents. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Electric Literature of C8H4Cl2N2).

2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Electric Literature of C8H4Cl2N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

2,3-Disubstituted Fluorene Scaffold for Efficient Green Phosphorescent Organic Light-Emitting Diodes was written by Wei, Jia-Jia;Yang, Yong-Jian;Liu, Xiang-Yang;Li, Runlai;Li, Shu-an. And the article was included in Chemistry – A European Journal in 2022.Related Products of 105598-27-4 This article mentions the following:

A simple and efficient strategy for the derivatization at the 2- and 3- positions in fluorene unit was explored. By introducing different types of substituents, 2 pairs of 2,3-disubstituted fluorene isomers were designed and used as host materials for phosphorescent organic light-emitting diodes (PHOLEDs). The green PHOLEDs hosted by these fluorene derivatives realize high external quantum efficiencies (EQE) >20% with low efficiency roll-off. The devices hosted by 2TRz3TPA and 2TPA3TRz achieve nearly 24% EQE and 104 lm W^-1 power efficiency. The 2,3-disubstituted fluorene platforms are potentially useful for constructing host materials. In the experiment, the researchers used many compounds, for example, Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4Related Products of 105598-27-4).

Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Related Products of 105598-27-4

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider