Tag: 100-200

Rhodium-catalyzed transfer hydrogenation of quinoxalines with water as a hydrogen source was written by Zhang, Xia;Chen, Jingchao;Khan, Ruhima;Shen, Guoli;He, Zhenxiu;Zhou, Yongyun;Fan, Baomin. And the article was included in Organic & Biomolecular Chemistry.Safety of 6-Methoxyquinoxaline This article mentions the following:

Rhodium-catalyzed transfer hydrogenation of quinoxalines with water as a hydrogen source is reported. The reaction allows the simple preparation of 1,2,3,4-tetrahydroquinoxalines under mild conditions. The deuterium-labeling experiment confirmed that water is the sole hydrogen source in the transfer hydrogenation reaction. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Safety of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson閳ユ獨, and Alzheimer閳ユ獨 diseases. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Safety of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The mass spectra of halo derivatives of quinoxaline was written by Poradowska, Henryka;Kaniewska, Alicja. And the article was included in Organic Mass Spectrometry in 1981.Safety of 6-Chloroquinoxaline This article mentions the following:

The mass spectra of 17 haloquinoxalines I (R-R³ = H, Br, Cl, Me) were recorded. All I gave mol.-ion peaks with typical isotopic ratios. The fragmentation path depended on the position of the halo atom: pyrazine-bound halo derivatives fragmented primarily via elimination of a halogen radical with insignificant cyanogen halide elimination, whereas benzene-bound halo derivatives fragmented via successive elimination of 2 RCN mols. (R = H, Me). In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Safety of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Observed n 閳?锜? bands in the ultraviolet absorption solution spectra of the biazanaphthalenes was written by Hirt, R. C.;King, F. T.;Cavagnol, J. C.. And the article was included in Journal of Chemical Physics in 1956.Application of 5448-43-1 This article mentions the following:

Weak bands were observed in the ultraviolet absorption solution spectra of phthalazine, quinoxaline, 6-chloroquinoxaline, and 6-bromoquinoxaline, which show “blue-shifts” in a more polar solvent sequence. These bands, along with those reported for cinnoline, were assigned as n 閳?锜? bands analogous to those of the diazines and triazines. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Application of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Application of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ag-Catalyzed Minisci C-H difluoromethylarylation of N-heteroarenes was written by Xie, Xiaojuan;Zhang, Yifang;Hao, Jian;Wan, Wen. And the article was included in Organic & Biomolecular Chemistry in 2020.Safety of 6-Methoxyquinoxaline This article mentions the following:

A mild silver-catalyzed decarboxylative difluoromethylarylation of electron-deficient N-heteroarenes e.g., I has been developed by using aryldifluoro acetic acids RC(F₂)C(O)OH [R = 4-methoxyphenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-1-yl, etc.] as difluoromethyl sources. This protocol provides an efficient and straightforward access to difluoromethylated heteroarenes e.g., II in moderate to excellent yields with good selectivities. Furthermore, this reaction was applicable to bioactive heteroarenes, providing a straightforward approach for the late-stage C-H difluoromethylation of pharmacophores. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Safety of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Safety of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nickel Phosphite/Phosphine-Catalyzed C-S Cross-Coupling of Aryl Chlorides and Thiols was written by Jones, Kieran D.;Power, Dennis J.;Bierer, Donald;Gericke, Kersten M.;Stewart, Scott G.. And the article was included in Organic Letters in 2018.Electric Literature of C8H5ClN2 This article mentions the following:

A method for the coupling of aryl chlorides and thiophenols using an air-stable nickel(0) catalyst is described. This thioetherification procedure can be effectively applied to a range of electronically diverse aryl/heteroaryl chlorides without more expensive metal catalysts such as palladium, iridium, or ruthenium. This investigation also illustrates both, a variety of thiol coupling partners and, in certain cases, the use of Cs₂CO₃. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Electric Literature of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Electric Literature of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Direct C-H arylation of heterocycles with heteroaryl chlorides using a bis(alkoxo)palladium complex was written by Li, Yabo;Wang, Jingran;Yan, Beiqi;Huang, Mengmeng;Zhu, Yu;Wu, Yusheng;Wu, Yangjie. And the article was included in Tetrahedron in 2015.Synthetic Route of C8H5ClN2 This article mentions the following:

An efficient and practical bis(alkoxo)palladium complex Cat.I catalyzed C-H arylation of heterocycles with heteroaryl chlorides has been developed. With 1 mol % of Cat.I, the direct arylation of a series of heterocycles with various heteroaryl chlorides could proceed smoothly affording desired products in moderate to excellent yields. The catalytic system allows one-pot synthesis of 2,5-diheteroaryled thiophenes via twofold direct C-H arylation. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Synthetic Route of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Synthetic Route of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

A General, Practical Palladium-Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides was written by Senecal, Todd D.;Shu, Wei;Buchwald, Stephen L.. And the article was included in Angewandte Chemie, International Edition in 2013.SDS of cas: 5448-43-1 This article mentions the following:

The authors have disclosed a general method for the cyanation of (hetero)aryl chlorides and bromides. The authors use a palladium-catalyzed cyanation system that (1) is applicable to aryl chlorides at low to moderate catalyst loadings; (2) works well with a wide range of heterocyclic halides, including in many cases five-membered heterocycles bearing free NH groups; and (3) is complete in one hour at 閳?100鎺? The use of a nontoxic cyanide source in conjunction with wide functional-group tolerance and fast reaction times make this method particularly convenient to synthetic chemists. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1SDS of cas: 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.SDS of cas: 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ruthenium(II) 鐣?sup>6-arene complexes containing a dinucleating ligand based on 1,8-naphthyridine was written by Tang, Wei-Hung;Liu, Yi-Hung;Peng, Shie-Ming;Liu, Shiuh-Tzung. And the article was included in Journal of Organometallic Chemistry in 2015.Recommanded Product: 6639-82-3 This article mentions the following:

Ruthenium arene half-sandwich complexes, [(鐣?sup>6-p-cymene)₂Ru₂(娓?L)Cl₂](PF₆)₂ (3b, L = N,N,N’,N’-tetra-2-pyridinyl-1,8-naphthyridine-2,7-diamine) and [(鐣?sup>6-p-cymene)Ru(L’)Cl](PF₆) [4, L’ = tri-2-pyridinylamine], were synthesized and characterized by spectroscopic and anal. techniques. The mol. structure of [(鐣?sup>6-p-cymene)₂Ru₂(娓?L)Cl₂]Cl₂ (3a) was further determined by single-crystal x-ray anal. The use of these ruthenium complexes as pre-catalysts for oxidative coupling of 1,2-diols/1,2-aminoalc. with o-phenylenediamines leading to quinoxalines was investigated. Complex 3b appeared to be a good catalyst for this transformation. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Recommanded Product: 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Recommanded Product: 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

A “Pool and Split” Approach to the Optimization of Challenging Pd-Catalyzed C-N Cross-Coupling Reactions was written by Fordham, James M.;Kollmus, Philipp;Cavegn, Monika;Schneider, Regina;Santagostino, Marco. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 5448-43-1 This article mentions the following:

A screening method for the rapid identification of catalytic conditions for Pd-catalyzed C-N cross-coupling reactions was reported. The strategy evaluates mixtures of precatalysts, ligands and bases to identify productive conditions that are subsequently optimized through two deconvolution steps, which uncover the active catalyst and identify the optimal solvent and base for the catalytic system. The efficacy of this approach was demonstrated through application to a previously reported reaction, whereby both the literature conditions and addnl. solutions were retrieved. The same approach to Ni-catalyzed C-N cross-coupling was investigated in parallel but was found to be less successful due to limited activity of the evaluated reagent combinations. Finally, the utility of this method was showcased by identifying effective conditions for the Pd-catalyzed cross-coupling of complex mols., which not only revealed nonobvious solutions for the processes under evaluation, but also resulted in the discovery of new chem. reactions. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Product Details of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Product Details of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nickel-catalyzed electrochemical Minisci acylation of aromatic N-heterocycles with α-keto acids via ligand-to-metal electron transfer pathway was written by Ding, Hang;Xu, Kun;Zeng, Cheng-Chu. And the article was included in Journal of Catalysis in 2020.Reference of 6639-82-3 This article mentions the following:

A nickel-catalyzed electrochem. methodol. for the Minisci acylation of aromatic electron-deficient heterocycles with α-keto acids had been developed. The reaction was performed in an undivided cell under constant current conditions, featuring broad scope of substrates and avoiding the conventional utilization of silver-based catalysts in conjunction with excess amount of oxidants. Cyclic voltammetric anal. disclosed that a ligand-to-metal electron transfer process may be involved in the generation of the key acyl radicals. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Reference of 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Reference of 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider