Tag: 100-200

Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids was written by Wang, Xiu-Zhi;Zeng, Cheng-Chu. And the article was included in Tetrahedron in 2019.Product Details of 6639-82-3 This article mentions the following:

An efficient and mild protocol was developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with α-keto acids to afford acyl-pyrazine derivatives e.g., I. Distinct from the conventional Minisci acylation conditions, the chem. was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt as catalyst. A wide range of substrates, including aliphatic or aromatic α-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Product Details of 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Product Details of 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Measurement of the relative values of oscillator strengths in the spectrum of the iron atom by the total absorption method was written by Valters, A. K.;Nikonova, E. I.;Startsev, G. P.. And the article was included in Optika i Spektroskopiya in 1964.HPLC of Formula: 6639-82-3 This article mentions the following:

The total absorption method was applied to the multiplets in the 3950-2750-A. region, beginning from the a⁶D and a⁵F levels. A King vacuum furnace with spherical mirrors allowed the light to pass through the vapor up to 16 times, a flat diffraction grating spectrograph, and suitable filters to eliminate spurious spectra and diffused light were used. The tabulated results are in good agreement with those of King (K. and King. CA 32, 2427⁷) in the 3950-3550-A. region, but diverge considerably in the shorter wave region. The total absorption method can be successfully applied to investigations of the gf values in the far ultraviolet region. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3HPLC of Formula: 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.HPLC of Formula: 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Regioselectivity in the reaction of nitroquinoxaline N-oxides with phosphoryl chloride was written by Nasielski-Hinkens, R.;Vande Vyver, E.;Nasielski, J.. And the article was included in Bulletin des Societes Chimiques Belges in 1986.Safety of 6-Chloroquinoxaline This article mentions the following:

Oxidation of nitroquinoxalines I (n = 0; R, R¹ = H, Me) by m-ClC₆H₄CO₂OH gave their N-oxides; the NO₂ group orients the O atom preferentially to N-1, but the N-4:N-1 selectivity is diminished in the methylated derivatives Meisenheimer reaction of I (n = 1, R = R¹ = H) with POCl₃ gave I (n = 0, R = Cl, R¹ = H). The orientation of the entering Cl is discussed on the basis of electronic effects induced by the N-oxide and NO₂ groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Safety of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Phototransformations of 6-X-5-Nitroquinoxalines was written by Rtishchev, N. I.;Selitrennikov, A. V.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 2004.SDS of cas: 5448-43-1 This article mentions the following:

Photophys. properties and photochem. activity of 6-X-5-nitroquinoxalines with electron-donor substituents (X = H, CH₃, Cl, OC₂H₅, NH₂) ortho to the nitro group were studied. The quantum yield of the formation of 5-hydroxyquinoxaline from the corresponding nitro derivative depends on the nature of the substituent and irradiation conditions. Phototransformations can go through nitro-nitrite rearrangement with the participation of two alternative T(nπ*) levels, depending on the size and electronic effects of the substituent. The latter factor is largely determined by the population on excitation of different charge-transfer states involving the nitro group. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1SDS of cas: 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.SDS of cas: 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

A novel near-infrared fluorescent probe for rapid detection of peroxynitrite with large stokes shift and imaging in living cells was written by Parthiban, C.;Manivannan, R.;Son, Young-A.. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Name: 6-Methoxyquinoxaline This article mentions the following:

Peroxynitrite (ONOO^–) plays an essential role in pathol. and physiol. processes like signal transduction, antibacterial activity, etc. Imagining ONOO- in the living system is more important to monitor their function. We have analyzed various coumarin derivatives using DFT computations. We have designed and synthesized a coumarin chalcone-hybrid (Coumn-pHP-ONOO^–) based turn-on NIR fluorescent probe for the rapid detection of ONOO^– based on oxidative hydrolysis of aryl boronate group in a living system. Our probe Coumn-pHP-ONOO^– shows sensitive and selective detection of ONOO^– in the presence of various reactive species with a large stokes shift (149 nm) in THF/Water (6/4, volume/volume, pH = 7.4) solution and rapid response (<5s). The detection limit of the probe is 53.8 nM level and has a reasonable specificity in the presence of other reactive oxygen species. Moreover, our probe Coumn-pHP-ONOO^– displays low toxicity, good biocompatibility, excellent permeability, and it successfully detects the ONOO^– in HeLa cell. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Name: 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Name: 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates was written by Park, Nathaniel H.;Teverovskiy, Georgiy;Buchwald, Stephen L.. And the article was included in Organic Letters in 2014.Computed Properties of C8H5ClN2 This article mentions the following:

A new air-stable nickel precatalyst for C-N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C-N bond formation to include both a wide range of aryl and heteroaryl electrophiles and aryl, heteroaryl, and alkylamines. The catalyst system is also compatible with a weak base, allowing the amination of substrates containing base-sensitive functional groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Computed Properties of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Computed Properties of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis and application of novel styryl dyes derived from 1,4-diethyl-1,2,3,4-tetrahydro-6-methoxyquinoxaline was written by Satam, Vijay;Rajule, Rajkumar;Bendre, Samir;Bineesh, Purushotthaman;Kanetkar, Vinod. And the article was included in Journal of Heterocyclic Chemistry in 2009.Category: quinoxaline This article mentions the following:

1,4-Diethyl-1,2,3,4-tetrahydro-7-methoxyquinoxaline-6-carboxaldehyde was synthesized, characterized, and condensed with suitably substituted active methylene compounds by classical Knoevenagel condensation to obtain five monostyryl dyes and a bis-styryl dye. These novel styryl dyes have hues varying from orange to violet. The dyes were applied to polyester fibers. The spectral and thermal characteristics of the dyes and fastness properties of the dyed polyester fabric were investigated. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Category: quinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

CuI/Oxalamide Catalyzed Couplings of (Hetero)aryl Chlorides and Phenols for Diaryl Ether Formation was written by Fan, Mengyang;Zhou, Wei;Jiang, Yongwen;Ma, Dawei. And the article was included in Angewandte Chemie, International Edition in 2016.Quality Control of 6-Chloroquinoxaline This article mentions the following:

Couplings between (hetero)aryl chlorides and phenols can be effectively promoted by CuI in combination with an N-aryl-N’-alkyl-substituted oxalamide ligand to proceed smoothly at 120 °C. For this process, N-aryl-N’-alkyl-substituted oxalamides are more effective ligands than bis(N-aryl)-substituted oxalamides. A wide range of electron-rich and electron-poor aryl and heteroaryl chlorides gave the corresponding coupling products in good yields. Satisfactory conversions were achieved with electron-rich phenols as well as a limited range of electron-poor phenols. Catalyst and ligand loadings as low as 1.5 mol % are sufficient for the scaled-up variants of some of these reactions. Thus, e.g., coupling of 4-chlorotoluene with phenol in presence of CuI and oxalamide I afforded 4-methylphenyl Ph ether (96%). In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Quality Control of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Quality Control of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease was written by Le Douaron, Gael;Ferrie, Laurent;Sepulveda-Diaz, Julia E.;Seon-Meniel, Blandine;Raisman-Vozari, Rita;Michel, Patrick P.;Figadere, Bruno. And the article was included in ACS Chemical Neuroscience in 2017.Related Products of 166402-16-0 This article mentions the following:

Parkinson’s disease is a chronic degenerative disease characterized by motor symptoms, which result from the death of midbrain dopamine neurons and concomitant disruption of dopamine mediated neurotransmission. No curative treatment is currently available for this disorder in clin. practice. In the search for druggable neuroprotective compounds for dopamine neurons, the authors have synthesized new 1,4,8-triazaphenanthrenes by combination of 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reaction. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a Parkinson’s disease cellular model has led to the selection of hit compound I. In vitro characterization of I showed that this compound operates via a direct effect on DA neurons with no impact on astroglial cells. Most interestingly, I was able to counteract neurodegeneration in a MPTP lesioned mouse model of Parkinson’s disease, making this compound a promising drug candidate for the treatment of this disorder. In the experiment, the researchers used many compounds, for example, 3-Chloroquinoxalin-6-amine (cas: 166402-16-0Related Products of 166402-16-0).

3-Chloroquinoxalin-6-amine (cas: 166402-16-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Related Products of 166402-16-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia was written by Fan, Mengyang;Zhou, Wei;Jiang, Yongwen;Ma, Dawei. And the article was included in Organic Letters in 2015.Recommanded Product: 6-Chloroquinoxaline This article mentions the following:

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120 °C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Recommanded Product: 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Recommanded Product: 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider