Tag: 100-200

Houminer, Yoram; Sanders, Edward B. published an article in 1980, the title of the article was The reaction of alkylpyrazine anions with some electrophiles. Synthesis of 1,2-bis(2-pyrazyl)ethanes.Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

The coupling of pyrazines I (R-R2 = Me, H; R = R1 = H, R2 = Me; R = Me, R1 = R2 = H) using LiN(CHMe)2(LDA)-iodine gave II (31-43%). The treatment of I (R-R2 = Me) with LDA and O gave 21% I (R = CH2OH, R1 = R2 = Me), which was coupled with I (R = Me, R1 = R2 = H) to yield 49% III. (±)- And meso-IV were prepared by the treatment of 5,6,7,8-tetrahydroquinoxaline with LDA and O. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline

The Article related to dipyrazinylethane, ethane dipyrazinyl, pyrazinylethane, bisquinoxalyl, coupling quinoxaline methylpyrazine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Poradowska, Henryka; Grzechowska, Alicja published an article in 1980, the title of the article was The investigations on synthesis and properties of halogenoquinoxalines.Application of 62163-09-1 And the article contains the following content:

Haloquinoxalines I and II (R = Cl, Br; R1, R2 = H, Me) were obtained in 10-34% yield by diazotization and halogenation of I and II (R = NH2), prepared by cyclizing phenylenetriamines with R1COCOR2. Spectra of I and II are discussed. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application of 62163-09-1

The Article related to haloquinoxaline, quinoxaline halo, spectra haloquinoxaline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Application of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On January 28, 2021, Pan, Shiow-Lin; Yang, Chia-Ron; Huang, Han-Li; Tu, Huang-Ju; Liou, Jing-Ping; Teng, Che-Ming published a patent.Electric Literature of 62163-09-1 The title of the patent was Preparation of hydroxamic acid compounds as histone deacetylase 6 inhibitors and method for treating neuropathic pain. And the patent contained the following:

Disclosed herein are hydroxamic acid compounds of formula I. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6. Compounds of formula I wherein A is absent and CR1R2; E is absent and CR3R4; W is bicyclic aryl and bicyclic heteroaryl; X is CR5R6, O, S and NH and derivatives; Y is arylene and heteroarylene; Z is a bond, methylene and ethylene; R1, R2, R3 and R4 are independently H, halo, CN, amino, OH, etc.; R5 and R6 are independently H, (un)substituted C1-5 alkyl, (un)substituted C1-5 alkenyl, (un)substituted aryl, etc.; are claimed. Example compound II was prepared by reductive amination of Me 4-formylbenzoate with 3-quinolinamine followed by amidation with hydroxylamine hydrochloride. The invention compounds were evaluated for their HDAC6 inhibitory activity.y. From the assay, it was determined that compound II exhibited IC50 values of 19.11 nM and 0.78μM towards HDAC6 and HDAC1, resp. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Electric Literature of 62163-09-1

The Article related to hydroxamic acid preparation hdac6 inhibitor treatment neuropathic pain, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Electric Literature of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On June 3, 2016, Luo, Kai; Chen, Yao-Zhong; Chen, Li-Xian; Wu, Lei published an article.Computed Properties of 34413-35-9 The title of the article was Autoxidative C(sp2)-P Formation: Direct Phosphorylation of Heteroarenes under Oxygen, Metal-Free, and Solvent-Free Conditions. And the article contained the following:

The authors reveal here a direct autoxidative phosphorylation of heteroarenes induced by O under metal-free and solvent-free conditions. This new methodol. provides an economical, operationally simple, and environmentally friendly approach toward (Het)C(sp2)-P formation with medium to excellent yields. Heteroarenes including thiazole and quinoxaline derivatives are applicable under standard conditions, which is testified via a radical mechanism. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Computed Properties of 34413-35-9

The Article related to phosphorylation heteroarene arylphosphine oxide, heteroaryl phosphine oxide preparation, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Computed Properties of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On December 29, 2020, Xiong, Yunkui; Wang, Tao; Zhang, Yu; Qi, Liping published a patent.Application of 62163-09-1 The title of the patent was Phosphorus-containing quinoxaline compounds, its preparation method and application. And the patent contained the following:

A phosphorus-containing quinoxaline compounds, its preparation method and application having economical, easy operation, high yield, and suitable for large-scale production is provided. The phosphorus-containing quinoxaline compounds having following structure shown in formula I or formula II. The preparation method of phosphorus-containing quinoxaline compounds comprises the following steps: under the condition of participation of peroxide, mixing quinoxaline compound and diphenylphosphonium oxide compound react to obtain phosphorus-containing quinoxaline compound The application of phosphorus-containing quinoxaline compound was used to prepare medicines, optoelectronic materials, flame retardant materials or as phosphine ligands. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application of 62163-09-1

The Article related to quinoxaline phosphine oxide preparation, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Frost, Scott C.; Walker, Paige; Orians, Colin M.; Robbat, Jr. Albert published an article in 2022, the title of the article was The Chemistry of Green and Roasted Coffee by Selectable 1D/2D Gas Chromatography Mass Spectrometry with Spectral Deconvolution.COA of Formula: C8H10N2 And the article contains the following content:

Gas chromatog./mass spectrometry (GC/MS) is a long-standing technique for the anal. of volatile organic compounds (VOCs). When coupled with the Ion Analytics software, GC/MS provides unmatched selectivity in the anal. of complex mixtures and it reduces the reliance on high-resolution chromatog. to obtain clean mass spectra. Here, we present an application of spectral deconvolution, with mass spectral subtraction, to identify a wide array of VOCs in green and roasted coffees. Automated sequential, two-dimensional GC-GC/MS of a roasted coffee sample produced the retention index and spectrum of 750 compounds These initial analytes served as targets for subsequent coffee anal. by GC/MS. The workflow resulted in the quantitation of 511 compounds detected in two different green and roasted coffees. Of these, over 100 compounds serve as candidate differentiators of coffee quality, AAA vs. AA, as designated by the Coopedota cooperative in Costa Rica. Of these, 72 compounds survive the roasting process and can be used to discriminate green coffee quality after roasting. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).COA of Formula: C8H10N2

The Article related to roasted coffee spectral deconvolution gas chromatog mass spectrometry, 2d–gc/ms, gc/ms, coffee, coffee quality, deconvolution, green coffee, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.COA of Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Domeno, Celia; Aznar, Margarita; Nerin, Cristina; Isella, Francesca; Fedeli, Mauro; Bosetti, Osvaldo published an article in 2017, the title of the article was Safety by design of printed multilayer materials intended for food packaging.Name: 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

Printing inks are commonly used in multilayer plastics materials used for food packaging, and compounds present in inks can migrate to the food either by diffusion through the multilayers or because of set-off phenomena. To avoid this problem, the right design of the packaging is crucial. This paper studies the safety by design of multilayer materials. First, the migration from four different multilayers manufactured using polyethylene terephthalate (PET), aluminum (Al) and polyethylene (PE) was determined The structural differences among materials such as the presence of inks or lacquer coatings as well as the differences in layers position allowed the study of a safety-by-design approach. Sixty-nine different compounds were detected and identified; 49 of them were not included in the pos. list of Regulation EU/10/2011 or in Swiss legislation and 15 belong to Cramer class III, which means that they have a theor. high toxicity. Some of the compounds related to ink composition were pyrene, a compound com. used to make dyes and dye precursors and the antioxidant Irganox 1300. The application of external lacquers decreased the concentration of some migrants but also brought the potential for new migrants coming from its composition A final risk assessment of the material allowed evaluating food safety for different food simulants and confirm it. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Name: 5,6,7,8-Tetrahydroquinoxaline

The Article related to printed multilayer material food packaging safety regulation, gc-ms, inks, food packaging, lacquer, risk assessment, safety by design, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Name: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On September 25, 2011, Zhu, Xinpeng; Yao, Min published an article.Product Details of 34413-35-9 The title of the article was Optimization of preparation of coffee flavor by thermal reaction. And the article contained the following:

In this study, orthogonal array design was employed to optimize thermal reaction conditions for the preparation of coffee flavor. This was followed by reaction product anal. by gas chromatog.-mass spectrometry (GC-MS). When the reaction system was composed of 5 g of amino acids, 4 g of reducing sugar, 100 g of propylene glycol, 10 g of 95% ethanol and 40 g of deionized water at pH 6-8, the optimal reaction conditions were glucose/fructose ratio of 1: 1.5, arginine/lysine ratio of 2.5: 1, reaction temperature of 115°C, and reaction time of 4.5 h. The reaction resulted in the generation of 25 volatile flavor compounds such as furfuryl alc., maltol, di-Me pyrazine, acetyl pyrrole and mercaptans. Moreover, pyrazine, pyrrodine, furan, phenol and their substitutes were the major volatile flavor compounds The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Product Details of 34413-35-9

The Article related to coffee flavor maillard reaction gc ms, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Product Details of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On October 15, 2014, Tu, Bao-jun; Chen, Shang-long; Ma, Qing-yu; Ye, Li; Feng, Tan published an article.COA of Formula: C8H10N2 The title of the article was Effects of three drying processes on volatile compounds in Lentinus edodes. And the article contained the following:

The effects of hot air drying, electro-temperature vacuum drying and vacuum freeze-drying on volatile compounds in Lentinus edodes were investigated to find out the best drying process. The volatile compounds in Lentinus edodes and its dry products were extracted by simultaneous distillation extraction (SDE) using dichloromethane as the extractant and detected by gas chromatog.-mass spectrometry (GC-MS). Comprehensive evaluations of dried Lentinus edodes were conducted according to the relative contents and contributions of major volatile compounds The results indicated that 51 compounds were detected and the product dried by electro-temperature vacuum drying showed the highest score of 5.42, which was significantly higher than that of hot air drying (1.02) and vacuum freeze-drying (1.38). The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).COA of Formula: C8H10N2

The Article related to drying volatile compound lentinus, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.COA of Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Petkevicius, Vytautas; Vaitekunas, Justas; Tauraite, Daiva; Stankeviciute, Jonita; Sarlauskas, Jonas; Cenas, Narimantas; Meskys, Rolandas published an article in 2019, the title of the article was A biocatalytic synthesis of heteroaromatic N-oxides by whole cells of Escherichia coli expressing the multicomponent, soluble di-iron monooxygenase (SDIMO) PmlABCDEF.Computed Properties of 34413-35-9 And the article contains the following content:

Aromatic N-oxides (ArN-OX) are desirable biol. active compounds with a potential for application in pharmacy and agriculture industries. As biocatalysis is making a great impact in organic synthesis, there is still a lack of efficient and convenient enzyme-based techniques for the production of aromatic N-oxides. In this study, a recombinant soluble di-iron monooxygenase (SDIMO) PmlABCDEF overexpressed in Escherichia coli was showed to produce various aromatic N-oxides. Out of 98 tested N-heterocycles, seventy were converted to the corresponding N-oxides without any side oxidation products. This whole-cell biocatalyst showed a high activity towards pyridines, pyrazines, and pyrimidines. It was also capable of oxidizing bulky N-heterocycles with two or even three aromatic rings. Being entirely biocatalytic, our approach provides an environmentally friendly and mild method for the production of aromatic N-oxides avoiding the use of strong oxidants, organometallic catalysts, undesirable solvents, or other environment unfriendly reagents. The sequence of the p577A clone containing pmlABCDEF gene cluster was deposited in GenBank under the accession number MK037457. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Computed Properties of 34413-35-9

The Article related to sequence soluble di iron monooxygenase gene cluster pmlabcdef, heteroaromatic oxide biocatalytic synthesis monooxygenase pmlabcdef recombinant escherichia, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Computed Properties of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider