Tag: 108229-82-9

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and thiophenol (1.10 g, 0.01 mol) was added. The reaction mixture was heated under reflux for 4 h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of acetonitrile was evaporated under reduced pressure and the residue obtained was dried and purified by a silica gel column chromatography (petroleum ether (60-80C)/ethyl acetate 5 : 0.1, v/v ) to give the product. Yield: 48%; (yellow powder): m.p. 139-141 C; IR (KBr, cm -1 ): 1593 (C=N). 1 H NMR (DMSO-d 6 , delta ,ppm): 7.52-7.77 (m, 8H, Ar-H). 13 C NMR (DMSO-d 6 , delta , ppm): 121.74-140.20 (12Ar-C), 153.83, 154.51(2C=N). MS (m/z), 350 (M + ; 32%), 351 (M + + 1;100%), 352 (M + + 2; 46%), 353 (M + + 3; 37%), 354(M + + 4; 13%). Analysis: calcd. for C 14 H 8 BrClN 2 S(351.65): C, 47.82; H, 2.29; N, 7.97; S, 9.12%;found: C, 48.04; H, 2.47; N, 8.13; S, 9.35%., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), sodium azide(0.12 g, 2 mmol) was added and the reaction mixture was refluxed for two days. After completionof the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, washedwith a little amount of ethanol, dried and crystallized from methanol to give the product; yield: 85%.(Brown powder): mp 229-231 C; IR (KBr) max in cm1: 2155 (N3), 1608 (C=N); 1H-NMR(DMSO-d6): 8.26-9.01 (m, 3H, Ar-H); 13C-NMR (DMSO-d6): 119.61, 120.27, 122.00, 123.33, 123.59,133.93 (6Ar-C), 140.37, 140.59 (2C=N); MS (m/z), 103 (M+ C6H3N8, 100%), 290 (M+; 7%), 291(M+ + 1; 1%), 292 (M+ + 2; 7%). Anal. Calcd. for C8H3BrN8 (291.07): C, 33.01; H, 1.04; N, 38.50%.Found: C, 32.87; H, 1.23; N, 38.69%.

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of substituted 2-chloro-6,7-dimethoxy-4-aminoquinazoline (0.01 mol) 1 and 2,3-dichloroquiaxolines (0.01 mol) 2a-e in glacial acetic acid 10 mL containing 0.2 mL of DMF as a catalyst wa refluxed for 10 hr (monitored by TLC). The reaction mixture was cooled and the deposited solid was filtered, dried and re-crystallized from DMF/MeOH 1:4 furnish compounds 3a-e.

108229-82-9, As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Article; Srinivas; Prasanna; Ravinder; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 53; 2; (2014); p. 238 – 242;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.,108229-82-9

To a solution of compound 1 (2.78 g, 0.01 mol)in acetonitrile (50 mL), DMF (10 mL), anhydrouspotassium carbonate (2.0 g) and 2-thiouracil (1.54 g,0.012 mol) were added. The reaction mixture washeated under reflux for 16 h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the solution was allowed to stand overnight at room temperature. The separated solid was filtered, dried and purified by column chromatography using an elution system chloroform : methanol (5 : 0.1, v/v) to give the product. Yield: 50%; (brown powder): m.p. 237-239 C;IR (KBr, cm -1 ): 1712 (C=O), 1594 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 6.54 (d, 1H, J = 7 Hz, CH-C=O-pyrimidine), 8.02-8.08 (m, 3H, Ar-H),8.41 (d, 1H, J = 7 Hz, CH-N-pyrimidine). 13 C NMR(DMSO-d 6 , delta , ppm): 112.09 (CH-C=O-pyrimidine),123.19-138.74 (6Ar-C), 144.47, 146.33 (3C=N),151.25 (CH-N=C-pyrimidine), 159.60 (C=O). MS(m/z), 64 (M + – C 8 H 3 BrN 3 OS; 100%), 332 (M + ;69%), 333 (M + + 1; 12%), 334 (M + + 2; 67%).Analysis: calcd. for C 12 H 5 BrN 4 OS (333.16): C,43.26; H, 1.51; N, 16.82; S, 9.62%; found: C, 43.39;H, 1.43; N, 16.98; S, 9.84%.

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 1 (2.78 g, 0.01 mol)and arylthiosemicarbazone (0.01 mol) in absolute ethanol (50 mL) was refluxed for 4-5 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried and crystallized from benzene to produce the corresponding compounds.

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

2-Aminophenol (2.73 g, 0.025 mol) was dissolved in a mixture of benzene (50 mL) and DMF (2mL) containing anhydrous potassium carbonate (2.0g) and compound 1 (2.78 g, 0.01 mol) was added. The mixture was refluxed for 12 h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of benzene was evaporated under reduced pressure and the separated solid was dried. The product was amixture of compounds 14 and 15 which were separated by column chromatography using an elutionsystem chloroform : methanol (10 : 0.1, v/v).

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider