Tag: 146.15

Xiang, Panjie et al. published their research in Chinese Chemical Letters in 2022 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Product Details of 1196-57-2

Direct benzylation reactions from benzyl halides enabled by transition-metal-free photocatalysis was written by Xiang, Panjie;Sun, Kai;Wang, Shuang;Chen, Xiaolan;Qu, Lingbo;Yu, Bing. And the article was included in Chinese Chemical Letters in 2022.Product Details of 1196-57-2 This article mentions the following:

An SN2-based photochem. strategy using dithiocarbamate anion as catalyst was developed for the activation of benzyl halides, which are extremely challenging to be applied as radical precursors in visible light photocatalysis. With this transition-metal-free and oxidant-free protocol, the benzylation (or cyanomethylation) of various heterocycles including quinoxalin-2(1H)-ones, coumarin, 2-phenyl-2H-indazole, 1-methyl-5-phenylpyrazin-2(1H)-one, 1-(fluoromethyl)cinnolin-4(1H)-one, and 2,4-dibenzyl-1,2,4-triazine-3,5(2H,4H)-dione could be realized (46 examples, up to 98% yield). Importantly, some biol. relevant 3-benzylquinoxalin-2(1H)-ones were also be synthesized under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Product Details of 1196-57-2).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Product Details of 1196-57-2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Xie, Long-Yong et al. published their research in Green Chemistry in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Quality Control of 2-Quinoxalinol

Aryl acyl peroxides for visible-light induced decarboxylative arylation of quinoxalin-2(1H)-ones under additive-, metal catalyst-, and external photosensitizer-free and ambient conditions was written by Xie, Long-Yong;Peng, Sha;Yang, Li-Hua;Peng, Cun;Lin, Ying-Wu;Yu, Xianyong;Cao, Zhong;Peng, Yu-Yu;He, Wei-Min. And the article was included in Green Chemistry in 2021.Quality Control of 2-Quinoxalinol This article mentions the following:

Aryl radicals were generated for the first time from cheap and easily available aryl acyl peroxides in eco-friendly Et acetate under ambient conditions and visible-light illumination in the absence of any additive, metal catalyst, or external photosensitizer. The present arylation of quinoxalin-2(1H)-ones was chemo- and regioselective, and provided good access to various 3-arylquinoxalin-2(1H)-ones. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Quality Control of 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Quality Control of 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Yang, Le et al. published their research in Organic Letters in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Name: 2-Quinoxalinol

Molecular oxygen-mediated radical alkylation of C(sp3)-H bonds with boronic acids was written by Yang, Le;Qiu, Zhihong;Wu, Jintao;Zhao, Jianyou;Shen, Tong;Huang, Xuan;Liu, Zhong-Quan. And the article was included in Organic Letters in 2021.Name: 2-Quinoxalinol This article mentions the following:

A direct and site-specific alkylation of (sp3)C-H bond with aliphatic boronic acid was achieved. By simply heating glycinate and amines together with alkylboronic acids under an oxygen atm., a variety of unnatural α-amino acids and peptides could be obtained in good yields. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Name: 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Name: 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Ni, Hangcheng et al. published their research in New Journal of Chemistry in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Application of 1196-57-2

Visible-light-promoted/PIFA-mediated direct C-H acylation of quinoxalin-2(1H)-ones with aldehydes was written by Ni, Hangcheng;Li, Yu;Deng, Jieyi;Shi, Xingzi;Pan, Qinhai. And the article was included in New Journal of Chemistry in 2021.Application of 1196-57-2 This article mentions the following:

A simple and mild synthesis of 3-acylated quinoxalinones I [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, Me, allyl, etc.] had been achieved via C-H acylation reaction of quinoxalin-2(1H)-ones with aldehydes as the radical precursors under visible-light irradiation A wide variety of functional groups could be incorporated into the products by employing diverse aldehydes and quinoxalin-2(1H)-one derivatives Also, this method was applied to the modification of natural mols. and pharmaceutically relevant compounds A mechanistic study revealed that an HAT process occurred in the acylation reaction for the generation of acyl radicals, and that PIFA ([bis(trifluoroacetoxy)iodo]benzene) acted both as the photosensitizer and oxidant in this reaction. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Application of 1196-57-2).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Application of 1196-57-2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Li, Jing et al. published their research in Tetrahedron Letters in 2022 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Quality Control of 2-Quinoxalinol

Direct C3-H carbamoylation of quinoxalin-2(1H)-ones with isocyanides enabled by selectfluor II under mild conditions was written by Li, Jing;Hu, Jie;Xiao, Yao;Yin, Kun;Dan, Wenyan;Fan, Suhua;Jin, Feng;Wu, Hai;Zhang, Ronghua;Li, Jian. And the article was included in Tetrahedron Letters in 2022.Quality Control of 2-Quinoxalinol This article mentions the following:

A F reagent-mediated direct C-H carbamoylation of quinoxalin-2(1H)-ones had been developed. Under room temperature, a variety of isocyanides were employed to couple well with quinoxalin-2(1H)-ones affording alkyl-oxo-quinoxaline-carboxamide I [R1 = H, Me, Ph, etc.; R2 = t-Bu, Bn, 1-naphthyl, etc.; R3 = H, 7-Ph, 6,7-di-Me, etc.]. This metal-free mild strategy tolerated a wide range of functional groups and shows environmental friendliness and practicality. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Quality Control of 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Quality Control of 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Zhang, Hong-Yu et al. published their research in European Journal of Organic Chemistry in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Formula: C8H6N2O

The Cross-Dehydrogenative Coupling Reaction of 尾-Ketoesters with Quinoxalin-2(1H)-ones was written by Zhang, Hong-Yu;Yang, Zibing;Zhang, Huizhen;Han, Ya-Ping;Zhao, Jiquan;Zhang, Yuecheng. And the article was included in European Journal of Organic Chemistry in 2021.Formula: C8H6N2O This article mentions the following:

The cross-dehydrogenative coupling (CDC) reaction of 尾-ketoesters with quinoxalin-2(1H)-one derivatives has been successfully performed by using a readily available Cu salt as the catalyst in moderate to excellent yields under mild conditions [e.g, 1-methylquinoxalin-2(1H)-one + Et acetoacetate 鈫?I (80%, imine/enamine 鈮?1.46:1) in presence of Cu(OAc)2, TBHP and NaHCO3 in DMSO under Ar]. Owing to the characteristic of handy operation and good functional group tolerance, this protocol affords a convenient access to 伪-quinoxalinone-substituted 尾-ketoesters. Preliminary mechanistic investigations show this transformation possibly underwent an unusual ionic pathway. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Formula: C8H6N2O).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Formula: C8H6N2O

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Wan, Shuocheng et al. published their research in Tetrahedron Letters in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Recommanded Product: 2-Quinoxalinol

Copper catalyzed aerobic oxidative amination of 3,4-dihydroquinoxalin-2(1H)-ones was written by Wan, Shuocheng;Wang, Jie;Huo, Congde. And the article was included in Tetrahedron Letters in 2021.Recommanded Product: 2-Quinoxalinol This article mentions the following:

A copper catalyzed aerobic sp3 C-H amination of 3,4-dihydroquinoxalin-2(1H)-ones is developed. This protocol provides a concise method to access 3-aminoquinoxalinone derivatives with good functional-group tolerances, utilizing primary and secondary aliphatic amines as nitrogen sources under mild and simple reaction conditions. It provides a practical approach to the synthesis of pharmaceutical active 3-aminoquinoxalinones. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Recommanded Product: 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Recommanded Product: 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Nova-Fernandez, Jose Luis et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.HPLC of Formula: 1196-57-2

Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles was written by Nova-Fernandez, Jose Luis;Garcia, Montana J.;Mollari, Leonardo;Pascual-Coca, Gustavo;Cabrera, Silvia;Aleman, Jose. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.HPLC of Formula: 1196-57-2 This article mentions the following:

A sustainable strategy for the alkylation of heterocycles e.g., I is presented. The protocol relies on the in situ generation and further in-line use of alkyl zinc sulfinates through a continuous-flow system. The environment friendly character of the protocol is assured by the use of a green solvent mixture, the presence of a metal free oxidant and low waste generation. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2HPLC of Formula: 1196-57-2).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.HPLC of Formula: 1196-57-2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Li, Heng et al. published their research in Green Chemistry in 2022 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Safety of 2-Quinoxalinol

Electrochemical Minisci reaction via HAT-driven 伪-C(sp3)-H functionalization of alcohols was written by Li, Heng;Tong, Jinwen;Zhu, Yan;Jiang, Cong;Liu, Ping;Sun, Peipei. And the article was included in Green Chemistry in 2022.Safety of 2-Quinoxalinol This article mentions the following:

An efficient electrochem. Minisci reaction to access 3-hydroxyalkylquinoxalin-2(1H)-ones involving hydrogen-atom transfer (HAT) driven 伪-C(sp3)-H functionalization of alcs. was achieved. Transition metal- and chem. oxidant-free conditions were the attractive synthetic features. The hydrogen atom transfer agent was hydrazoic acid generated from TMSN3 in this transformation. Primary or secondary alcs. and a wide range of quinoxalinones were found to be compatible, providing the corresponding 3-hydroxyalkylquinoxalin-2(1H)-ones in good yields. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Safety of 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Safety of 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Li, Yi-Na et al. published their research in Organic & Biomolecular Chemistry in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Synthetic Route of C8H6N2O

Metal-free regioselective nitration of quinoxalin-2(1H)-ones with tert-butyl nitrite was written by Li, Yi-Na;Li, Xue-Lin;Wu, Jin-Bo;Jiang, Hong;Liu, Yunmei;Guo, Yu;Zeng, Yao-Fu;Wang, Zhen. And the article was included in Organic & Biomolecular Chemistry in 2021.Synthetic Route of C8H6N2O This article mentions the following:

A metal-free coupling of quinoxalin-2(1H)-ones with tert-Bu nitrite has been developed. Distinctly from the previous functionalization of quinoxalin-2(1H)-ones, this nitration reaction took place selectively at the C7 or C5 position of the Ph ring, affording a series of 7-nitro and 5-nitro quinoxalin-2(1H)-ones in moderate to good yields. Preliminary mechanistic studies revealed that the reaction may involve a radical process. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Synthetic Route of C8H6N2O).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Synthetic Route of C8H6N2O

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider