Tag: 146.15

Yuan, Jin-Wei et al. published their research in Organic Chemistry Frontiers in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Recommanded Product: 2-Quinoxalinol

Site-specific C-H chalcogenation of quinoxalin-2(1H)-ones enabled by Selectfluor reagent was written by Yuan, Jin-Wei;Zhang, Yang;Huang, Guang-Chao;Ma, Meng-Yao;Yang, Teng-Yu;Yang, Liang-Ru;Zhang, Shou-Ren;Mao, Pu;Qu, Ling-Bo. And the article was included in Organic Chemistry Frontiers in 2021.Recommanded Product: 2-Quinoxalinol This article mentions the following:

A site-specific oxidative C-H chalcogenation of quinoxalin-2(1H)-ones I (R = H, Et, n-Pr, Bn, etc.) with various diaryl diselenides/disulfides Ar(Z)2Ar (Z = S, Se; Ar = Ph, 4-fluorophenyl, 2-nitrophenyl, etc.) is presented by employing Selectfluor reagent as an oxidant. The reaction proceeds selectively at the C6 position of quinoxalin-2(1H)-ones I, and enables access to a wide array of chalcogenyl quinoxalin-2(1H)-ones II. The merits of the transformation involve excellent substrate and functional compatibility, operational simplicity, and the use of a mild oxidant. The present work offers a fundamental basis for the selective synthesis of functional quinoxalin-2(1H)-ones II from readily available feedstocks. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Recommanded Product: 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Recommanded Product: 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Dai, Peng et al. published their research in Tetrahedron in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Category: quinoxaline

Direct Csp2-H difluoromethylation of heterocycle by K2S2O8 was written by Dai, Peng;Jiao, Jian;Wang, Qingqing;Yu, Xiang;Teng, Peng;Zhu, Yuchuan;Gu, Yu-Cheng;Zhang, Wei-Hua. And the article was included in Tetrahedron in 2021.Category: quinoxaline This article mentions the following:

A novel and efficient transition-metal-free C(sp2)-H oxidative difluoromethylation of heterocycles such as 2H-chromen-2-one, quinoxalin-2(1H)-one, quinolin-2(1H)-one, etc. has been reported. It uses stable and nontoxic NaSO2CF2H as difluoromethyl source and potassium persulfate as oxidant without the need for metal catalyst. Significantly, the reaction affords difluoromethyl heterocycles RCF2H (R = 2-oxo-2H-chromen-3-yl, 2-oxo-quinoxalin-3-yl, 2-oxo-quinolin-3-yl, etc.) in moderate to good yields with a broad substrate tolerance. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Category: quinoxaline).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Sharma, Suraj et al. published their research in ChemistrySelect in 2022 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application In Synthesis of 2-Quinoxalinol

K2S2O8 Mediated Three-component Radical Cascade C3 Alkylation of Quinoxalin-2(1H)-ones with Vinylarenes and 4-Hydroxycoumarins/4-Hydroxy-6-methyl-2-pyrone was written by Sharma, Suraj;Bhuyan, Mayurakhi;Baishya, Gakul. And the article was included in ChemistrySelect in 2022.Application In Synthesis of 2-Quinoxalinol This article mentions the following:

Quinoxalin-2(1H)-ones I (R = H, Cl, NO2, Me; R1 = H, Me, 4-chlorophenyl, Bn, etc.; R2 = H, Cl, Me) undergo a three-component radical cascade C3 alkylation reaction with 4-hydroxycoumarins II (R3 = H, OMe; R4 = H, Cl, Br, Me)/4-hydroxy-6-methyl-2-pyrone by using vinyl arenes 2-R5-4-R6-C6H3CH=CH2 (R5 = H, Me; R6 = H, Cl, Br, OMe) as intermediary radical acceptors. K2S2O8 in dimethylsulfoxide (DMSO) works as the best reagent-solvent combination, which promotes the reaction under metal-, photocatalyst- and light-free conditions producing the three-component products III and IV in moderate yields. The involvement of radicals in the course of the reaction by performing several radical scavenging experiments with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), di-Ph ethylene, and butylated hydroxytoluene (BHT) was also proved. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Application In Synthesis of 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application In Synthesis of 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Yuan, Jin-Wei et al. published their research in Organic Chemistry Frontiers in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Recommanded Product: 2-Quinoxalinol

Site-specific C-H chalcogenation of quinoxalin-2(1H)-ones enabled by Selectfluor reagent was written by Yuan, Jin-Wei;Zhang, Yang;Huang, Guang-Chao;Ma, Meng-Yao;Yang, Teng-Yu;Yang, Liang-Ru;Zhang, Shou-Ren;Mao, Pu;Qu, Ling-Bo. And the article was included in Organic Chemistry Frontiers in 2021.Recommanded Product: 2-Quinoxalinol This article mentions the following:

A site-specific oxidative C-H chalcogenation of quinoxalin-2(1H)-ones I (R = H, Et, n-Pr, Bn, etc.) with various diaryl diselenides/disulfides Ar(Z)2Ar (Z = S, Se; Ar = Ph, 4-fluorophenyl, 2-nitrophenyl, etc.) is presented by employing Selectfluor reagent as an oxidant. The reaction proceeds selectively at the C6 position of quinoxalin-2(1H)-ones I, and enables access to a wide array of chalcogenyl quinoxalin-2(1H)-ones II. The merits of the transformation involve excellent substrate and functional compatibility, operational simplicity, and the use of a mild oxidant. The present work offers a fundamental basis for the selective synthesis of functional quinoxalin-2(1H)-ones II from readily available feedstocks. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Recommanded Product: 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Recommanded Product: 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Dai, Peng et al. published their research in Tetrahedron in 2021 | CAS: 1196-57-2

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Category: quinoxaline

Direct Csp2-H difluoromethylation of heterocycle by K2S2O8 was written by Dai, Peng;Jiao, Jian;Wang, Qingqing;Yu, Xiang;Teng, Peng;Zhu, Yuchuan;Gu, Yu-Cheng;Zhang, Wei-Hua. And the article was included in Tetrahedron in 2021.Category: quinoxaline This article mentions the following:

A novel and efficient transition-metal-free C(sp2)-H oxidative difluoromethylation of heterocycles such as 2H-chromen-2-one, quinoxalin-2(1H)-one, quinolin-2(1H)-one, etc. has been reported. It uses stable and nontoxic NaSO2CF2H as difluoromethyl source and potassium persulfate as oxidant without the need for metal catalyst. Significantly, the reaction affords difluoromethyl heterocycles RCF2H (R = 2-oxo-2H-chromen-3-yl, 2-oxo-quinoxalin-3-yl, 2-oxo-quinolin-3-yl, etc.) in moderate to good yields with a broad substrate tolerance. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Category: quinoxaline).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider