Tag: 148231-12-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

2-ethylhexylmagnesium bromide in THF (0.89 M, 17.5 mL, 15.6 mmol), and zinc chloride solution (1.00 M, 15.7 mL, 15.7 mmol) was added to the flask of 0 , and the mixture was stirred at room temperature for 1 hour. 4,7-Dibromoquinoxaline 4 (2.71 g, 9.41 mmol) and tetrakis (triphenylphosphine) palladium (0) (0.54 g, 0.47 mmol) was added and the mixture was 1.5 hours refluxing. Added saturated ammonium chloride solution to the reaction mixture, the reaction mixture was extracted with dichloromethane. The organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (dichloromethane) to give Compound 2 of red liquid (1.74 g, 58%).

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; THE UNIVERSITY OF TOKYO; NAKAMURA, EIICHI; FURUKAWA, SHUNSUKE; NAKAMURA, TOMOYA; (20 pag.)JP2016/56126; (2016); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

Flask in 50mL flask 5,8-Dibromoquinoxaline utilizing our after infusion (compound j-1) 2.00 g, it makes the vacuum. After injecting THFanhydous 30mL and slowly inject 5.8 mL tert-butyllithium at -78 C, was stirred at the same temperature for 15 minutes, then it reacted at room temperature for 2 hours. Under the conditions of -78 C then slowly inject 2.0 mL lane 2- isopropoxy -4,4,5,5- tetramethyl 1-1,3,2- Sabo dioxane, and the mixture was stirred for 12 hours. After 12 hours, after the completion of the reaction through the water, after extraction via the ethylacetate and the aqueous solution of NaCl, one can obtain a product of the organic layer extracted lower sides yellow liquid, and injecting the obtained liquid phase in 250mL round bottom flask, methanol 70mL after the injection, the injection was diluted to 20.2 mL of distilled water 10mL KHF2 a stirring. When stirred for 30 minutes when it is generated the filter through the ether to give a yellow solid product of potassium di [5,8-quinoxaline] 4,7-bis (triple as a borate) (Compound J) (yield: 47%)

148231-12-3, As the paragraph descriping shows that 148231-12-3 is playing an increasingly important role.

Reference£º
Patent; Pusan National University Industry-Academic Cooperation Foundation; Hwang, Do Hun; Kim, Ji Hun; Kim, Hee Woon; Im, Jong Min; (52 pag.)KR101495152; (2015); B1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 C. Then, the respective terminal arylacetylene (4aeg) (2.5 mmol) dissolved in tetrahydrofuran (10 mL) was added dropwise. The reaction mixture was stirred under reflux for 20min under a nitrogen atmosphere. Cooled down to room temperature, the solution was evaporated, and the crude product was purified by a silica gel chromatography column using hexane/dichloromethane (70:30) as the eluent to afford the respective final compound 5a-g.

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

Under nitrogen atmosphere, The compound of formula A (2 g, 7.26 mmol), 5,8-dibromoquinoxanline (0.951 g, 3.30 mmol), sodium tert-butoxide (0.952 g, 9.90 mmol), Bis (dibenzylideneacetone) palladium (0) (0.114 g), bis (diphenylphosphino) – 1,1′-binaphthalene (0) 100 mL of toluene was added to [(¡À) -2,2′-Bis (diphenylphosphino) -1,1′-binaphthalene] (0.185 g, 0.297 mmol) and refluxed for 12 hours. After the temperature was lowered to room temperature, the mixture was washed with water, the residue was removed with MgSO 4, hydrazine monohydrate was added thereto, and the mixture was stirred at room temperature for 30 minutes. Precipitated in hexane, filtered off the solid and dried under vacuum to obtain Compound 1.

148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; LG Chem, Ltd.; Kim Jin-seok; Bae Jae-sun; Lee Jae-cheol; Shin Hyeon-a; Hwang Min-ho; Ryu So-yeong; Jeong Se-jin; (36 pag.)KR2019/5591; (2019); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider