Tag: 1593-08-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: A 100-mL, round-bottom flask equipped with a magnetic stirring bar was charged with TZD (1 mmole) and rhodanine(1 mmol) in ionic liquid ChCl/urea was added aldehyde (1mmol). The reaction mixture was stirred for adequate amount of time under solvent-free conditions (Table 2). The progress of the reaction was monitored by TLC(Chloroform: Methanol (4:1). After completion of the reaction, H2O (3 ml) was added and ILs separated. Then, the obtained crude compound was collected by filtration and then washed with water and methanol. Finally, products were recrystallized from ethanol to afford (1-10) a, b in the excellent yield., 1593-08-4

As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Article; Akhavan, Malihe; Bekhradnia, Ahmadreza; Foroughifar, Naser; Pasdar, Hoda; Combinatorial chemistry and high throughput screening; vol. 22; 10; (2019); p. 716 – 727;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 68 This Example illustrates the preparation of 7-Methoxy-2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid [(2S,3aS,7aS)-1-(octahydro-indol-2-yl)methyl]-quinoxalin-2-ylmethyl-amide. Experimental conditions analogous to example 1, from with 80 mg (0.51 mmol) of quinoxaline-2-carbaldehyde, 0.15 g (0.61 mmol) of (2S,3aS,7aS)-2-aminomethyl-octahydro-indole-1-carboxylic acid tert-butyl ester, 5 mL dichloromethane, and 0.16 g (0.77 mmol) of sodium triacetoxyborohydride. The benzoylation step was performed using 0.21 mL (1.53 mmol) of triethylamine and 124 mg (0.51 mmol) of 7-methoxy-2,2-dimethyl-benzo[1,3]dioxole-5-carbonyl chloride. After 4 hours the reaction mixture was purified using flash chromatography (ethyl acetate in hexane). The residue was dissolved in 3 mL of 10% trifluoroacetic acid in dichloromethane, and after 4 hours neutralized with aqueous sodium bicarbonate and purified using reverse phase HPLC, mobile phase with a gradient 10-70% acetonitrile in 60 min. The residue was dissolved in dichloromethane, washed with aqueous sodium bicarbonate, dried with anhydrous magnesium sulfate and evaporated under vacuum to yield 60 mg of pale yellow solid as a free base. LC-MSD, m/z for C29H34N4O4 [M+H]+: 503.6. 1H NMR (400 MHz, CDCl3/HCl): delta 1.2-1.9 (m, 15H), 2.3-2.5 (m, 2H), 3.6-3.7 (m, 1H), 3.8 (s, 3H), 4.0-4.2 (m, 2H), 4.2-4.4 (m, 1H), 5.5-5.9 (m, 2H), 6.7 (s, 1H), 7.0 (s, 1H), 8.0-8.1 (m, 2H), 8.3-8.4 (ms, 1H), 8.5-8.6 (m, 1H), 9.0 (bs, 1H), 10.4 (bs, 1H), 10.6 (bs, 1H).

1593-08-4, As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Patent; ChemoCentryx, Inc.; US2006/74071; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 67 1-[(2S,3S)-3-(N2 -Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide 50 mul (0.36 mmol) of triethylamine and 27 mg (0.42 mmol) of sodium cyanoborohydride were added, whilst ice-cooling, to a solution of 300 mg (0.60 mmol) of 1-[3-(L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide hydrochloride and 115 mg (0.72 mmol) of 2-formylquinoxaline in 3 ml of methanol, and the resulting mixture was stirred at room temperature for 20 hours. The progress of reaction was then stopped by adding 0.60 ml of 1N aqueous hydrochloric acid, and the solvent was removed by distillation under reduced pressure. The resulting residue was extracted with ethyl acetate. The organic extract was then washed with a 5% w/v aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure, and the residue was purified by preparative thin layer chromatography, using a 16:4:1 by volume mixture of chloroform, methanol and 33% v/v aqueous acetic acid as the developing solvent, to give 76 mg of the title compound as a yellow powder, melting at 116-119 C. Elemental analysis: Calculated for C32 H41 N7 O5.1.25H2 O (molecular weight: 626.22): C, 61.37%; H, 7.00%; N, 15.66%. Found: C, 61.64%; H, 7.41%; N, 15.02%. Mass spectrum (m/z): 590, 503, 429, 327, 228, 163, 133, 70. Infrared Absorption Spectrum (KBr), numax cm-1: 3338, 1668, 1513., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Sankyo Company, Limited; US5629406; (1997); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10., 1593-08-4

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 18 (3.2 g, 0.02 mol) was dissolved in 250 mL ethanol. To the solution was added freshly prepared N-tert-butyl-hydroxylamine (2.67 g, 0.03 mol). The reaction was allowed to proceed for 4 h. After the workup, solvent was removed in vacuo and the crude product was purified by column chromatography (petroleum ether/ethyl acetate 4:1) to afford compound 19 as a red solid, (3.49 g, 75.2% yield), mp: 88-89 C. 1H NMR (CDCl3): 1.70 (s, 9H), 7.77 (m, 2H), 8.03 (m, 2H), 8.14 (s, 1H), 10.49 (s, 1H). ESI-MS: 230 [M+H]+. Anal. (C13H15N3O) C, H, N.

1593-08-4, As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Conference Paper; Sun, Yewei; Zhang, Gaoxiao; Zhang, Zaijun; Yu, Pei; Zhong, Haijing; Du, Jing; Wang, Yuqiang; Bioorganic and Medicinal Chemistry; vol. 20; 12; (2012); p. 3939 – 3945;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1593-08-4

General procedure: To a stirred solution of amine (6) (100 mg,0.407 mmol) in ethanol was added amines (7.1-7.9) (0.407mol) followed by anhydrous sodium sulphate (0.407 mmol) and stirred at 50 C for 1 h. The hot homogenous solution was filtered and cooled to 5 C to isolate the corresponding imines (8.1-8.9) in quantitative yields.

As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Article; Sreedhar, Pandiri; Srinivas, Gudipati; Raju, Rallabandi Madhusudan; Asian Journal of Chemistry; vol. 28; 7; (2016); p. 1603 – 1606;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.,1593-08-4

The piperazine template (0.075 g, 0.213 mmol) of Example 24 was dissolved in 1,2-dichloroethane (3 mL) and treated with quinoxaline-2-carbaldehyde (0.044 g, 0.277 mmol) and glacial acetic acid (2 drops). Sodium triacetoxyborohydride (0.090 g, 0.426 mmol) was added, and the mixture was stirred at room temperature until the reaction was complete by LCMS analysis. The solvent was removed under reduced pressure, and the resulting residue was purified by RP-HPLC to yield the free base (0.0578 g, 55% yield). MS (ESI) m/z 494.

As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Patent; Wyeth; US2006/264631; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: Two drops of glacial acetic acid as a catalyst were added to themixtures of thiosemicarbazides (0.5 mmol) and di(2-pyridyl) ketone,2-pyridinecarboxaldehyde, 2-quinolinecarboxaldehyde, 8-hydroxy-2-quinolinecarboxaldehyde or 2-quinoxalinecarbaldehyde (0.5 mmol) in ethanol (5 ml). The glasstubes were sealed and placed into a microwave reactor at 83 C for20 min (the reactor power did not exceed 50W). The final productswere crystallized from dry methanol.

As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Article; Mrozek-Wilczkiewicz, Anna; Malarz, Katarzyna; Rejmund, Marta; Polanski, Jaroslaw; Musiol, Robert; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 180 – 194;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1593-08-4,2-Formylquinoxaline,as a common compound, the synthetic route is as follows.

Step 1: (S)-2-{[(7-Methoxy-2,2-dimethyl-benzo[1,3]dioxole-5-carbonyl)-quinoxalin-2-ylmethyl-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester Experimental conditions analogous Example 1, 0.12 g (0.81 mmol) of quinoxaline-2-carbaldehyde, 0.24 g (1.22 mmol) of (S)-2-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester, 5 mL dichloromethane, and 0.25 g (1.22 mmol) of sodium triacetoxyborohydride. The reaction was quenched with aqueous sodium bicarbonate. The residue from the organic layer was purified using reverse phase HPLC, mobile phase with a gradient 10-70% acetonitrile in 40 min. Fractions containing pure product were evaporated in vacuum and dissolved in 3 mL dichloromethane. To this solution were added 0.34 mL (2.43 mmol) of triethylamine and 196 mg (0.81 mmol) of 7-methoxy-2,2-dimethyl-benzo[1,3]dioxole-5-carbonyl chloride. After 4 hours the reaction mixture was purified using flash chromatography (ethyl acetate in hexane), gave 280 mg as a yellow solid. LC-MSD, m/z for C30H36N4O6 [M+H]+: 549.7.

1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; ChemoCentryx, Inc.; US2006/74071; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This procedure is based on our previous report27 and vogels procedure36. To a conical flask containing NaOH solution (1.5eq, 10 mL H2O) was added substituted acetophenones (1mmole) in ethanol (10 mL), and the reaction mixture was stirred for 10 minutes to allow enolate formation, to this was added quinoxaline-2- carbaldehyde 1 (1mmole) and the reaction mixture was stirred till completion. After completion of the reaction, as monitored by TLC the reaction mixture was poured in an ice bath and was acidified using conc. HCl. The solid obtained was then filtered, dried and recrystallized using Ethanol. The quinoxalinyl chalcone 2a-n were then characterized using IR, NMR (1H, 13C) and HR-MS spectroscopy. The purity was checked by HPLC measurements using mobile phase consisting methanol and water in the ratio 90:10.

As the paragraph descriping shows that 1593-08-4 is playing an increasingly important role.

Reference£º
Article; Desai, Vidya; Desai, Sulaksha; Gaonkar, Sonia Naik; Palyekar, Uddesh; Joshi, Shrinivas D.; Dixit, Sheshagiri K.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2174 – 2180;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider