Tag: 190.2

Hoppe, H. et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 1975 | CAS: 6333-43-3

2,3-Dimethoxyquinoxaline (cas: 6333-43-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Electric Literature of C10H10N2O2

Thiono and dithio esters. 17. Reaction of dithionoxalic esters with amines was written by Hoppe, H.;Hartke, Klaus. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1975.Electric Literature of C10H10N2O2 This article mentions the following:

ROC(S)C(S)OR (I, R = Me, Et) reacted with primary amines to give R1R2NC(S)C(S)NR1R2 (II, R1 and R2 = H, alkyl, aryl). In dilute alc. solution ROC(:NR1)C(S)OR and ROC(:NR1)C(:NR1)OR were obtained. Reaction of I with secondary amines gave ROC(S)C(S)NR1R2 (III) intermediate to II. III was substituted by primary amines to give R3NHC(S)C(S)NR1R2. On heating in base III rearranged to RSC(O)C(S)NR1R2, which reacted with primary amines to give R3NHC(O)C(S)NR1R2. Reaction of I with o-H2NC6H4XH (X = O, S) gave bibenzazolyls IV (R4 = H, Cl). With o-(H2N)2C6H4 quinoxalines V were obtained. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxyquinoxaline (cas: 6333-43-3Electric Literature of C10H10N2O2).

2,3-Dimethoxyquinoxaline (cas: 6333-43-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Electric Literature of C10H10N2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Mahgoub, S. A. et al. published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 1991 | CAS: 6333-43-3

2,3-Dimethoxyquinoxaline (cas: 6333-43-3) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.COA of Formula: C10H10N2O2

Synthesis and reactions of some new thieno[2,3-b]quinoxalines and their related compounds was written by Mahgoub, S. A.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 1991.COA of Formula: C10H10N2O2 This article mentions the following:

Several thienoquinoxalines, e.g. I [R = cyano, R1 = NH2, NHAc; R = COMe, R1 = NH2; RR1 = CONHCH:N, C(NH2):C(CN)CONH; etc.] have been prepared Thus, 2-chloroquinoxaline-3-carbonitrile reacted with H2NC(S)NH2 in EtOH to give 3-cyano-2(1H)-quinoxalinethione (II). II cyclocondensed with BrCH2COC6H4R2 (R2 = H, 4-Cl, 4-Me) to give I (R = COC6H4R2, R1 = NH2). II also reacted with ClCH2CN to give I (R = cyano, R1 = NH2) (III). III cyclocondensed with NCCH2CO2Et to give I [RR1 = C(NH2):C(CN)CONH]. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxyquinoxaline (cas: 6333-43-3COA of Formula: C10H10N2O2).

2,3-Dimethoxyquinoxaline (cas: 6333-43-3) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.COA of Formula: C10H10N2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Hayashi, Eisaku et al. published their research in Yakugaku Zasshi in 1964 | CAS: 6333-43-3

2,3-Dimethoxyquinoxaline (cas: 6333-43-3) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.COA of Formula: C10H10N2O2

Quinoxaline N-oxides. II. 3-Phenyl-2-quinoxalinecarbonitrile was written by Hayashi, Eisaku;Iijima, Chihoko. And the article was included in Yakugaku Zasshi in 1964.COA of Formula: C10H10N2O2 This article mentions the following:

Various reactions of 3-phenyl-2-quinoxalinecarbonitrile (I) were reported. I (300 mg.) in 20 ml. Me2CO was kept overnight with 4 ml. 31% H2O2 and 10 ml. 10% K2CO3 to give 300 mg. 3-phenyl-2-quinoxalinecarboxamide, m. 198-9掳 (Me2CO). I (500 mg.) in 15 ml. AcOH was heated with 2 ml. 35% H2O2 to give 430 mg. 3-phenyl-2-quinoxalinecarbonitrile 4-oxide (II) [pale yellow, m. 183-4掳 (petr. ether)] and 70 mg. 3-phenyl-2-quinoxalinecarboxamide 1-oxide (III), m. 277掳 (decomposition) (MeOH). A solution of 700 mg. 3-phenyl-2-quinoxalinecarboxaldehyde 1-oxide in 5 ml. AcOEt was refluxed 3 hrs. with 560 mg. SeO2 to give 520 mg. 3-phenyl-2-quinoxalinecarboxaldehyde 1-oxide (IV), orange, m. 175-6掳 (C6H6). Refluxing 500 mg. IV in 5 ml. MeOH with 180 mg. NH2OH.HCl, 230 mg. AcONa, and 4 ml. H2O 10 min. gave 500 mg. 2-hydroxyimino-3-phenylquinoxaline 1-oxide (V), pale yellow, m. 210-11掳 (decomposition) (MeOH). Heating 200 mg. V with 1 ml. Ac2O 30 min. at 100掳 gave 170 mg. 3-phenyl-2-quinoxalinecarbonitrile 1-oxide (VI), yellow, m. 200.5掳 (C6H6-petr. ether). A solution of 50 mg. VI in 8 ml. Me2CO was heated with 1 ml. 35% H2O2 and 1.5 ml. 10% K2CO3 to give III; monohydrate m. 236掳 (MeOH). A solution of 150 mg. II in 8 ml. Me2CO was kept with 1 ml. 35% H2O2 and 3 ml. 10% K2CO3 1 hr. to give 150 mg. 3-phenyl-2-quinoxalinecarboxamide 4-oxide, m. 223-4掳 (MeOH). Reaction of I with monoperphthalic acid gave a mixture of II, III, and 3-phenyl-2-quinoxalinecarboxamide (VII). Heating 100 mg. I with 1 ml. concentrated H2SO4 gave 90 mg. VII. Refluxing 200 mg. I with 8 ml. 10% NaOH 2 hrs. gave 60 mg. 3-phenyl-2(1H)-quinoxalinone (VIII) [pale yellow, m. 247掳 (MeOH)] and 10 mg. VII. Reaction of I with NaOMe gave VIII and 2-methoxy-3-phenylquinoxaline (oil). Refluxing 500 mg. I in a mixture of C6H6 and Et2O with PhMgBr gave 2-benzoyl-3-phenylquinoxaline (IX) [yellow, m. 152掳 (MeOH)] and 1-phenyl-1-(3-phenyl-2-quinoxalinyl)methylenimine (X) [yellow, m. 137掳 (MeOH)]. Hydrolysis of X with HCl-gave IX. Refluxing I with MeMgBr gave 2-acetyl-3-phenylquinoxaline [pale yellow, m. 110掳 (MeOH)]; no corresponding ketimine was obtained. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxyquinoxaline (cas: 6333-43-3COA of Formula: C10H10N2O2).

2,3-Dimethoxyquinoxaline (cas: 6333-43-3) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.COA of Formula: C10H10N2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider